检索结果-南通市图书馆

Cellular factors involved in the hepatitis C virus life cycle

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第28期27卷 4555-4581页

作者： Hui-Chun Li Chee-Hing Yang shih-yen lo Department of Biochemistry Tzu Chi UniversityHualien 970Taiwan Department of Laboratory Medicine and Biotechnology Tzu Chi UniversityHualien 970Taiwan Department of Laboratory Medicine Buddhist Tzu Chi General HospitalHualien 970Taiwan

The hepatitis C virus(HCV),an obligatory intracellular pathogen,highly depends on its host cells to propagate *** HCV life cycle can be simply divided into several stages including viral entry,protein translation,RNA replication,viral assembly and *** of cellular factors involved in the HCV life cycle have been identified over more than thirty years of *** of these cellular factors has provided extensive insight into HCV replication *** of these cellular factors are targets for anti-HCV *** this review,we summarize the well-characterized and recently identified cellular factors functioning at each stage of the HCV life cycle.

关键词： Hepatitis C virus Cellular factor Viral entry Translation Replication Assembly Release

Production and pathogenicity of hepatitis C virus core gene products

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第23期20卷 7104-7122页

作者： Hui-Chun Li Hsin-Chieh Ma Chee-Hing Yang shih-yen lo Department of Biochemistry Tzu Chi University Department of Laboratory Medicine and Biotechnology Tzu Chi University Department of Laboratory Medicine Buddhist Tzu Chi General Hospital

Hepatitis C virus(HCV)is a major cause of chronic liver diseases,including steatosis,cirrhosis and hepatocellular carcinoma,and its infection is also associated with insulin resistance and type 2 diabetes ***,belonging to the Flaviviridae family,is a small enveloped virus whose positive-stranded RNA genome encoding a *** HCV core protein is cleaved first at residue 191 by the host signal peptidase and further cleaved by the host signal peptide peptidase at about residue 177 to generate the mature core protein(a.a.1-177)and the cleaved peptide(a.a.178-191).Core protein could induce insulin resistance,steatosis and even hepatocellular carcinoma through various *** peptide(a.a.178-191)may play a role in the immune *** polymorphism of this peptide is associated with the cellular lipid drop accumulation,contributing to steatosis *** addition to the conventional open reading frame(ORF),in the+1 frame,an ORF overlaps with the core proteincoding sequence and encodes the alternative reading frame proteins(ARFP or core+1).ARFP/core+1/F protein could enhance hepatocyte growth and may regulate iron *** this review,we briefly summarized the current knowledge regarding the production of different core gene products and their roles in viral pathogenesis.

关键词： Hepatitis C virus Core protein Alternative reading frame/core+1 proteins Insulin resistance Steatosis Hepatocellular carcinoma Interferon

Hepatitis C virus:Virology,diagnosis and treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2015年第10期7卷 1377-1389页

作者： Hui-Chun Li shih-yen lo Department of Biochemistry Tzu Chi University Department of Laboratory Medicine and Biotechnology Tzu Chi University Department of Laboratory Medicine Buddhist Tzu Chi General Hospital

More than twenty years of study has provided a better understanding of hepatitis C virus(HCV) life cycle,including the general properties of viral RNA and proteins. This effort facilitates the development of sensitive diagnostic tools and effective antiviraltreatments. At present,serologic screening test is recommended to perform on individuals in the high risk groups and nucleic acid tests are recommended to confirm the active HCV infections. Quantization and genotyping of HCV RNAs are important to determine the optimal duration of anti-viral therapy and predict the likelihood of response. In the early 2000 s,pegylated interferon plus ribavirin became the standard antiHCV treatment. However,this therapy is not ideal. To 2014,boceprevir,telaprevir,simeprevir,sofosbuvir and Harvoni are approved by Food and Drug Administration for the treat of HCV infections. It is likely that the new all-oral,interferon-free,pan-genotyping anti-HCV therapy will be available within the next few years. Majority of HCV infections will be cured by these antiviral treatments. However,not all patients are expected to be cured due to viral resistance and the high cost of antiviral treatments. Thus,an efficient prophylactic vaccine will be the next challenge in the fight against HCV infection.

关键词： Hepatitis C virus Diagnosis Treatment Hepatocellular carcinoma Nucleic acid test Enzymeimmunoassay Interferon Direct acting antivirals Hosttargetedagents Sofosbuvir

A path planning algorithm for a crop monitoring fixed-wing unmanned aerial system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第8期67卷 5-23页

作者： longhao QIAN Yi lok lo Hugh Hong-tao LIU Institute of Aerospace Studies University of Toronto Department of Mechanical Engineering The University of Hong Kong

With the growing demand for automation in agriculture, industries increasingly rely on drones to perform crop monitoring and surveillance. In this regard, fixed-wing unmanned aerial systems(UASs)are viable platforms for scanning a large crop field, given their payload capacity and range. To achieve maximum coverage without landing for battery replacement, an algorithm for producing a minimal required energy survey path is essential. Hence, an energy-aware coverage path planning algorithm is proposed *** constraints for a fixed-wing UAS to fly at low altitudes while achieving full coverage of the crop field are first analyzed. Then, the full path is decomposed into straight-line and U-turn primitives. Finally, an algorithm to calculate a combination of straight-line segments and U-turns is proposed to obtain the path with minimum required energy consumption. The genetic algorithm is used to efficiently determine the order of the straight-line paths to traverse. Case studies show that the proposed algorithm can produce planning results for a convex-polygon-shaped crop field.

关键词： path planning genetic algorithm energy minimization fixed-wing UAS aerial survey

Tau in the pancreas:understanding the link between type 2 diabetes mellitus and Alzheimer's disease

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第1期9卷 6-7页

作者： Wenlu Li Steffen Tiedt Eng H.lo Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA02129USA Consortium International pour la Recherche Circadienne sur l’AVC(CIRCA) BostonUSA Institute for Stroke and Dementia Research LMU University HospitalLMU MunichMunichGermany

A recent study published in Molecular Psychiatry proposes a cellular mechanism that may contribute to decreased insulin production in individuals with type 2 diabetes mellitus(T2DM).1 Using a combination of cell culture experiments,animal models and studies in T2DM patients,the authors show that an up-regulation of tau inβ-islet cells can inhibit pancreatic insulin secretion through changes in microtubule assembly.

关键词： T2DM Alzheimer tau

Fault Diagnosis Scheme for Railway Switch Machine Using Multi-Sensor Fusion Tensor Machine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第6期79卷 4533-4549页

作者： Chen Chen Zhongwei Xu Meng Mei Kai Huang Siu Ming lo School of Electronic and Information Engineering Tongji UniversityShanghai201804China Department of Architecture and Civil Engineering City University of Hong KongHong KongChina School of Computer Engineering Jimei UniversityXiamen361021China

Railway switch machine is essential for maintaining the safety and punctuality of train operations.A data-driven fault diagnosis scheme for railway switch machine using tensor machine and multi-representation monitoring data is developed *** existing methods,this approach takes into account the spatial information of the time series monitoring data,aligning with the domain expertise of on-site manual ***,a multi-sensor fusion tensor machine is designed to improve single signal data’s limitations in insufficient ***,one-dimensional signal data is preprocessed and transformed into two-dimensional ***,the fusion feature tensor is created by utilizing the images of the three-phase current and employing the CANDE-COMP/PARAFAC(CP)decomposition ***,the tensor learning-based model is built using the extracted fusion feature *** developed fault diagnosis scheme is valid with the field three-phase current *** experiment indicates an enhanced performance of the developed fault diagnosis scheme over the current approach,particularly in terms of recall,precision,and F1-score.

关键词： Railway switch machine tensor machine fault diagnosis

Mathematical Modeling of Cell Polarity Establishment of Budding Yeast

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications on Applied Mathematics and Computation 2024年第1期6卷 218-235页

作者： Yue Liu Jun Xie Hay-Oak Park Wing-Cheong lo Department of Mathematics City University of Hong KongTat Chee AvenueKowloonHong KongChina Department of Molecular Genetics The Ohio State UniversityColumbusOHUSA

The budding yeast Saccharomyces cerevisiae is a powerful model system for studying the cell polarity *** cell polarization process is regulated by signaling molecules,which are initially distributed in the cytoplasm and then recruited to a proper location on the cell membrane in response to spatial cues or *** of these signaling molecules involves complex regulation,so the mathematical models become a useful tool to investigate the mechanism behind the *** this review,we discuss how mathematical modeling has shed light on different regulations in the cell *** also propose future applications for the mathematical modeling of cell polarization and morphogenesis.

关键词： Budding yeast Cdc42 Morphogenesis Septin Mathematical models

Autolysosomal acidification impairment as a mediator for TNFR1 induced neuronal necroptosis in Alzheimer’s disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第9期19卷 1869-1870页

作者： Evridiki Asimakidou Richard Reynolds Anna M.Barron Chih Hung lo Department of Clinical Neurosciences University of CambridgeCambridgeUK Department of Brain Sciences Faculty of MedicineImperial College LondonLondonUK Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

Neuronal necroptosis-an emerging form of regulated cell death associated with neuroinflammatory signaling:Alzheimer’s disease(AD)is characterized by the presence of extracellular amyloid-β(Aβ)plaques and intracellular tau neurofibrillary tangles as well as progressive neuronal *** evidence has suggested that prolonged neuroinflammation with increased levels of cytokines,arising from neuronal injury,innate immune responses from glial cells,and peripheral inflammation,leads to neuronal death and AD progression.

关键词： Alzheimer death tau Aβ

Refill friction stir spot welding (RFSSW): a review of processing, similar/dissimilar materials joining, mechanical properties and fracture mechanism

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第8期31卷 1825-1839页

作者： Yun-qiang Zhao Hao-kun Yang Aloshyn Andriia Hong-hang lo Jia-xin Li Guangdong Provincial Key Laboratory of Advanced Welding Technology China-Ukraine Institute of WeldingGuangdong Academy of SciencesGuangzhou 510000GuangdongChina Smart Manufacturing Division Hong Kong Productivity CouncilHong Kong 999077China E.O.Paton Electric Welding Institute of National Academy of Sciences of Ukraine Kiev 01001KievanUkraine

Refill friction stir spot welding(RFSSW)provides a novel method to join similar and/or dissimilar metallic materials without a key-hole in the center of the *** the key-hole free characterization,the similar/dissimilar RFSSW joint exhibits remarkable and endurable characteristics,including high shear strength,long fatigue life,and strong corrosion *** the meanwhile,as the key-hole free joint has different microstructures compared with conventional friction stir spot welding,thus the RFSSW joint shall possess different shear and fatigue fracture mechanisms,which needs further *** explore the underlying failure mechanism,the similar/dissimilar metallic material joining parameters and pre-treatment,mechanical properties,as well as fracture mechanisms under this novel technology will be *** details,the welding tool design,welding parameters setting,and the influence of processing on the lap shear and fatigue properties,as well as the corrosion resistance will be mainly ***,the roadmap of RFFSW is also discussed.

关键词： Refill friction stir spot welding Processing Mechanism Similar materials joining Dissimilar materials joining Microstructure Mechanical property Fracture mechanism