Production and pathogenicity of hepatitis C virus core gene products

作     者：Hui-Chun Li Hsin-Chieh Ma Chee-Hing Yang Shih-Yen Lo 

作者机构：Department of BiochemistryTzu Chi University Department of Laboratory Medicine and BiotechnologyTzu Chi University Department of Laboratory MedicineBuddhist Tzu Chi General Hospital 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第23期

页      面：7104-7122页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Supported by Grants from the National Science Council of Taiwan,NSC 101-2320-B-320-011 to Lo SY from the Tzu Chi University,TCMRC-P-101015 and TCRPP101017 to Li HC and Lo SY 

主　　题：Hepatitis C virus Core protein Alternative reading frame/core+1 proteins Insulin resistance Steatosis Hepatocellular carcinoma Interferon 

摘      要：Hepatitis C virus(HCV)is a major cause of chronic liver diseases,including steatosis,cirrhosis and hepatocellular carcinoma,and its infection is also associated with insulin resistance and type 2 diabetes ***,belonging to the Flaviviridae family,is a small enveloped virus whose positive-stranded RNA genome encoding a *** HCV core protein is cleaved first at residue 191 by the host signal peptidase and further cleaved by the host signal peptide peptidase at about residue 177 to generate the mature core protein(a.a.1-177)and the cleaved peptide(a.a.178-191).Core protein could induce insulin resistance,steatosis and even hepatocellular carcinoma through various *** peptide(a.a.178-191)may play a role in the immune *** polymorphism of this peptide is associated with the cellular lipid drop accumulation,contributing to steatosis *** addition to the conventional open reading frame(ORF),in the+1 frame,an ORF overlaps with the core proteincoding sequence and encodes the alternative reading frame proteins(ARFP or core+1).ARFP/core+1/F protein could enhance hepatocyte growth and may regulate iron *** this review,we briefly summarized the current knowledge regarding the production of different core gene products and their roles in viral pathogenesis.