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Herb pair of Huangqi-Danggui exerts anti-tumor immunity to breast cancer by upregulating PIK3R1

Animal Models and Experimental Medicine 2024年第3期7卷 234-258页

作者： Hai-Xin liu li lian li-li Hou Cai-Xia liu Jin-Hong Ren Yuan-Biao Qiao shi-Yuan Wen Qing-Shan li College of Traditional Chinese Medicine and Food Engineering Shanxi University of Chinese MedicineTaiyuanChina Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation College of Traditional Chinese Medicine and Food EngineeringShanxi University of Chinese MedicineTaiyuanChina College of Basic Medical Sciences Shanxi Medical UniversityTaiyuanChina

Background:According to traditional Chinese medicine(TCM),drugs supplementing the vital energy,Qi,can eliminate tumors by restoring host *** objective of this study is to investigate the underlying immune mechanisms of anti-tumor activity associated with Qi-supplementing herbs,specifically the paired use of Huangqi and ***:Analysis of compatibility regularity was conducted to screen the combination of Qi-supplementing *** the MTT assay and a transplanted tumor mice model,the anti-tumor effects of combination TCMs were investigated in vitro and in *** content analysis and flow cytometry were then used to evaluate cellular immunity,followed by network pharmacology and molecular docking to dissect the significant active compounds and potential ***,the anti-tumor activity and the mechanism of the active ingredients were verified by molecular ***:There is an optimal combination of Huangqi and Danggui that,administered as an aqueous extract,can activate immunity to suppress tumor and is more effective than each drug on its own in vitro and in *** on network pharmacology analysis,PIK3R1 is the core target for the anti-tumor immunity activity of combined Huangqi and *** docking analysis shows 6 components of the combined Danggui and Huangqi extract(quercetin,jaranol,isorhamnetin,kaempferol,calycosin,and suchilactone)that bind to *** is the most important component against breast *** suchilactone/jaranol combination and,especially,the suchilactone/kaempferol combination are key for immunity enhancement and the anti-tumor effects of the ***:The combination of Huangqi and Danggui can activate immunity to suppress breast cancer and is more effective than the individual drugs alone.

关键词： anti-tumor Danggui Huangqi immunity

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Construction ofcastorfunctionalmarkers fingerprint andanalysis of geneticdiversity

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BIOCELL 2020年第3期44卷 381-388页

作者： TING YANG JIANNONG LU AKWASI YEBOAH SHUAILEI GU DONGNA li YUZHEN shi XUEGUI YIN Department of Crop Breeding and Genetics College of Agricultural SciencesGuangdong Ocean UniversityZhanjiang524088China

In order to provide a molecular basis for selecting good hybrid combinations for the identification of castor bean germplasm resources,fingerprint and genetic diversity analysis of 52 castor bean materials from 12 regions in 5 countries were constructed by using the Functinal Markers(FMs)associated with fatty acid metabolism-related genes.A total of 72 alleles were amplified by 29 pairs of FMs with an average of 2.483 per marker and the polymorphic information content was 0.103–***’s information index(I),observed heterozygosity(Ho)and expected heterozygosity(He)were 0.699,0.188 and 0.436 *** clustering results indicated that the castor germplasm could be divided into two groups with the genetic similarity coefficient of *** genetic similarity of 12 regions ranged from 0.518 to 0.917 and the genetic distance was between 0.087 and 0.658.A total of 5 pairs of core primers were screened to construct a digital fingerprint of different castor germplasm resources,which could distinguish all 52 *** study provides a scientific basis for screening high-quality castor germplasm resources and broadening the genetic basis of castor breeding at the molecular level.

关键词： Castor FMs (Functional Markers) Fingerprint Genetic diversity

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Leaf-meridian bio-inspired nanofibrous electronics with uniform distributed microgrid and 3D multi-level structure for wearable applications

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npj Flexible Electronics 2022年第1期6卷 372-381页

作者： Mingxu Wang li Dong Jiajia Wu Jian shi Qiang Gao Chunhong Zhu Hideaki Morikawa Graduate School of Medicine Science and TechnologyShinshu University3-15-1 TokidaUedaNaganoJapan Institute for Fiber Engineering(IFES) Interdisciplinary Cluster for Cutting Edge Research(ICCER)Shinshu University3-15-1 TokidaUedaNaganoJapan Faculty of Systems Science and Technology Akita Prefectural University84-4 Aza EbinokuchiTsuchiyaYurihonjoAkitaJapan School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhouChina Faculty of Textile Science and Technology Shinshu University3-15-1 TokidaUedaNaganoJapan

The interface between the active electronic and its osculatory target dominates the sensing response of high-sensitivity ***,the interface properties are difficult to be adjusted and preserved owing to the limited strategies for surface *** this work,inspired by nature frond leaf,a spatial multi-level nanofibrous membrane with grid-like microstructure of uniform distribution was fabricated,in which carboxylated carbon nanotubes(CCNTs)/poly(3,4-ethylenedioxythiophene)(PEDOT)was modified onto the surface of grid-like polyurethane(PU)nanofiber via the combination of metal mesh template,in situ polymerization and ultrasonic *** membrane enables a pressure sensor with high sensitivities(5.13 kPa−1),fast response/recovery time(80 ms and 120 ms),and ultralow detection limit of 1 *** addition,as a scalable and integrable platform,we also demonstrate its multifunctional applications for electro-thermal conversion and energy *** these results indicate the proposed nanofibrous membrane may potentially be applied to next-generation wearable devices.

关键词： treatment. template polyurethane

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Laparoscopic colonic anastomosis using a degradable stent in a porcine model

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World Journal of Gastroenterology 2016年第19期22卷 4707-4715页

作者： liang Ma Xiu-jun Cai Hai-Hong Wang Yan-Lan Yu Di-Yu Huang Guang-ju Ge Hai-Yi Hu shi-Cheng Yu Department of Gastroenterology Sir Run Run Shaw Hospital Zhejiang University School of Medicine Department of General Surgery Sir Run Run Shaw Hospital and The Institute of Minimally Invasive Surgery Zhejiang University School of Medicine Department of Anesthesia Sir Run Run Shaw Hospital Zhejiang University School of Medicine

AIM: To explore the feasibility and safety of laparoscopic colonic anastomosis using a degradable stent in a porcine ***: Twenty Bama mini-pigs were randomly assigned to a stent group(n = 10) and control group(hand-sewn anastomosis, n = 10). The anastomotic completion and operation times were recorded, along with histological examination, postoperative general condition, complications, mortality, bursting pressure, and the average anastomotic circumference(AC).RESULTS: All pigs survived postoperatively except for one in the stent group that died from ileus at 11 wk postoperatively. The operation and anastomotic completion times of the stent group were significantly shorter than those of the control group(P = 0.004 and P = 0.001, respectively). There were no significant differences in bursting pressure between the groups(P = 0.751). No obvious difference was found between the AC and normal circumference in the stent group, but AC was significantly less than normal circumferencein the control group(P = 0.047, P < 0.05). No intestinal leakage and luminal stenosis occurred in the stent group. Histological examination revealed that the stent group presented with lower general inflammation and better ***: Laparoscopic colonic anastomosis with a degradable stent is a simple, rapid, and safe procedure in this porcine model.

关键词： Laparoscope Colon Anastomosis Stent Porcine model

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A 1kHz Fe:ZnSe Laser Gain-Switched by a ZnGeP2 Optical Parametric Oscillator at 77 K

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Chinese Physics Letters 2019年第7期36卷 39-42页

作者： Ying-Yi li Ke Yang Gao-You liu li-Wei Xu Bao-Quan Yao You-Lun ju Tong-Yu Bai Xiao-Ming Duan National Key Laboratory of Tunable Laser Technology Harbin Institute of Technology

We demonstrate a Fe:ZnSe laser gain-switched by a 2.9 m ZnGeP2 optical parametric oscillator under pulse repetition frequency of 1 kHz at liquid nitrogen temperature of 77 K. The maximum output power is 63 m W with pulse duration of 34.4 ns. The wavelength covers 3686.6–4088.6 nm and centers at 3897.7 nm. The output power decreases with increasing the temperature of the crystal in 77–222 K.

关键词： demonstrate optical parametric crystal in 77-222 K

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THE SECOND RECIPROCAL DERIVATIVE CHRONOPOTENTIOMETRY ANALYSIS

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Chinese Chemical Letters 1992年第3期3卷 205-206页

作者： Xiang Yuan RUAN ju Nan li Yi Hen li Jian Cheng DENG Department of chemistry Xiangtan UniversityXiangtanHunan

Theories of the second reciprocal derivative chronopotentiometry analysis were deduced and experimentally *** in this study show that chronopotentiometry is significantly developed in both sensitivity and resolution f... 详细信息

关键词： CPA FRD SRD THE SECOND RECIPROCAL DERIVATIVE CHRONOPOTENTIOMETRY ANALYSIS

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SHRIMP Zircon U-Pb Dating of the Tongshi Magmatic Complex in Western Shandong and Its Geological Implications

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Acta Geologica Sinica(English Edition) 2005年第4期79卷 491-496页

作者： HU Huabin MAO Jingwen liU Dunyi NIU Shuyin WANG Yanbin li Yongfeng shi Ruruo shijiazhuang University of Economics Shijiazhuang Hebei 050031 China University of Geosciences Beijing 100083 Institute of Geology Chinese Academy of Geological Science Beijing 100037

The SHRIMP U-Pb zircon dating result of the Tongshi magmatic complex in western Shandong is presented in this paper. The Tongshi magmatic complex comprises fine-grained porphyritic diorite and syenitic porphyry. Eighteen analyses for fine-grained porphyritic diorite gave two concordia ages, in which ten analyses constitute the young age group, giving ^206Pb/^238U ages ranging from 167.9 Ma to 183 Ma with a weighted mean age of 175.7±3.8 Ma, and the other eight yielded ^207Pb/^206Pb ages of 2502 Ma to 2554 Ma with a weighted mean 2518±11 Ma. Two analyses for syenitic porphyry gave ages of 2485 Ma and 2512 Ma, respectively. The age of 175.7±3.8 Ma indicates that the crystallization of the Tongshi magmatic complex occurred in the Middle jurassic, whereas that of 2518±11 Ma is interpreted as the age of inherited magmatic zircons in the Neoarchean Wutai period.

关键词： zircon SHRIMP U-Pb dating age Middle jurassic Tongshi magmatic complex western Shandong

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New cancer suppressor gene for colorectal adenocarcinoma:Filamin A

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World Journal of Gastroenterology 2015年第7期21卷 2199-2205页

作者： Zi-Qiang Tian Jian-Wei shi Xiao-Ran Wang Zhong li Gui-Ying Wang Department of Thoracic Surgery Fourth Hospital of Hebei Medical University Department of Surgical Oncology Affiliated Hospital of Hebei University Department of the Second General Surgery Fourth Hospital of Hebei Medical University

AIM:To determine the expression and significance of filamin A(FLNa)in colorectal adenocarcinoma ***:The expression of FLNa in 46 colorectal cancer tissues and normal tissues was detected by immunohistochemistry,reverse transcription polymerase chain reaction(RT-PCR)and Western blotting,and its relationship with clinical parameters and prognosis was ***:The positive expression of FLNa in cancer tissues was lower than that in normal mucosa,and the difference was statistically *** expression of FLNa correlated with liver metastasis,lymph node metastasis and rectal invasion depth,regardless of sex,age,tumor location,tumor size,gross shape and histological type of colorectal *** analysis showed that FLNa was an independent risk factor for postoperative survival of patients with colorectal ***,survival analysis showed that the expression level of FLNa was closely related with survival of patients with colorectal *** results of RT-PCR and Western blotting were consistent with those of ***:FLNa showed low expression in colorectal adenocarcinoma,high correlation with the incidence and development of colorectal cancer,and was considered an indicator of prognosis.

关键词： Colorectal carcinoma Filamin A Immunohistochemistr

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Study on Activated Bentonite Applied to tert-Butylation of Toluene

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China Petroleum Processing & Petrochemical Technology 2011年第1期13卷 38-44页

作者： Chen linbo shi li (Department of Petroleum Processing,East China University of Science and Technology,Shanghai 200237) E China Univ Sci & Technol Dept Petr Proc Shanghai 200237 Peoples R China

tert-Butylation of toluene with tert-butanol used as the alkylating agent was investigated over the activated bentonite and HY zeolite used as the *** influences of various butylation reaction parameters,including the toluene/tert-butanol ratio,the reaction temperature,and the space velocity were *** optimal results were obtained at a reaction temperature of 180 ℃,a space velocity of 4 h-1,and a mole ratio of toluene to tert-butanol equating to *** structure and acidic properties of catalyst were characterized by the BET method and the Fourier transform infrared (FTIR) *** with the HY zeolite,the activated bentonite possessed high activity for toluene conversion and high para-selectivity because it had larger pore diameter,smaller micropore surface area and higher ratio of total Lewis acids to total Br nsted acids.

关键词： t-butylation activated bentonite p-tert-butyltoluene pore diameter Lewis acid

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Advanced glycation end productions and tendon stem/progenitor cells in pathogenesis of diabetic tendinopathy

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World Journal of Stem Cells 2021年第9期13卷 1338-1348页

作者： liu shi Pan-Pan Lu Guang-Chun Dai Ying-juan li Yun-Feng Rui Department of Orthopaedics Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina Department of Geriatrics Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina

Tendinopathy is a challenging complication observed in patients with diabetes *** usually leads to chronic pain,limited joint motion,and even ruptured *** and histological analyses have revealed pathological changes in various tendons of patients with diabetes,including disorganized arrangement of collagen fibers,microtears,calcium nodules,and advanced glycation end product(AGE)***-derived stem/progenitor cells(TSPCs)were found to maintain hemostasis and to participate in the reversal of *** also discovered the aberrant osteochondrogenesis of TSPCs in ***,the relationship between AGEs and TSPCs in diabetic tendinopathy and the underlying mechanism remain *** this review,we summarize the current findings in this field and hypothesize that AGEs could alter the properties of tendons in patients with diabetes by regulating the proliferation and differentiation of TSPCs in vivo.

关键词： Tendinopathy Diabetes mellitus Tendon stem/progenitor cells Advanced glycation end products

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