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Revealing and predicting the long-term biomechanical response of orthokeratology by developing a patient-specific computational model

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 156-168页

作者： Yifeng Li Zhuoran yang Ziming Yan Huibin shi Zhanli Liu Kaijie Wang Department of Engineering Mechanics School of Aerospace Engineering Tsinghua University Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Lab

Orthokeratology(OK) is widely used for effective myopia correction and control. However, the incomplete understanding of its biomechanical mechanisms makes OK lens fitting rely heavily on clinician judgment, complicating accurate predictions of treatment outcomes. In this paper, we performed clinical experiments and numerical analysis to study corneal deformation modes and long-term changes in central corneal thickness. Clinical experiments were conducted on 194 Chinese myopic patients under OK treatment for 3 months. Based on the experimental data, a patient-specific computational biomechanical model for OK was established and validated. Specifically, the anisotropic mechanical properties of the cornea were incorporated into the model to describe the significant difference between its shear modulus(29.5 kPa) and tensile modulus(768.4 kPa). Additionally, a viscohyperelastic material model with a prolonged corneal relaxation time of 5.6 h was developed to capture the long-term deformation response. The results show that corneal thickness reduction in OK is primarily due to out-of-plane shear deformation,influenced by the cornea's low shear resistance. Modeling the extended corneal relaxation time is crucial for predicting long-term biomechanical responses. The computational model effectively captures long-term changes in central corneal thickness, potentially improving OK lens fitting accuracy.

关键词： orthokeratology computational biomechanical model long-term viscoelasticity myopia correction

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A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li yang Wei Kang Zhou Xin Huang Xing Zhou jie Xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

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Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu yang Lei Xiao Zhiyong Kan Jing Guo Qiang Li Wanqi jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

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Isolation of lipid raft from tissues and cells by iodixanol density gradient ultracentrifugation

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中国病理生理杂志 2012年第11期 2103-2103页

作者： WANG shi-jie,yang Qing,SONG Xin-ai,YU Xiao-jing,QI jie,SU Qing,LIN Na,LIN Yuan-xi(Xi’an Jiaotong University School of Medicine,Xi’an 710061,China)

AIM:Lipid rafts are cholesterol and sphingolipid-rich microdomains of the plasma membrane which concentrate components of certain signal transduction ***:The tissues and cells were treated with detergent-free method(i... 详细信息

关键词： Isolation of lipid raft from tissues and cells by iodixanol density gradient ultracentrifugation

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-jie Zhu Xiao-Jia yang Qian-Ru He Fei Ding Hai-Yan shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli Zhang Tian Li jie Miao Zhina Zhang Mingxuan yang Zhuoran Wang Bo yang Jiawei Zhang Haiting Li Qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

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Estimation of Dynamic VaR in Chinese Stock Markets Based on Time Scale and Extreme Value Theory

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Journal of Southwest Jiaotong University(English Edition) 2008年第1期16卷 73-80页

作者：林宇黄登仕杨洁魏宇 School of Economics and Management Southwest Jiaotong University

The accuracy and time scale invariance of value-at-risk （VaR） measurement methods for different stock indices and at different confidence levels are tested. Extreme value theory （EVT） is applied to model the extreme tail of standardized residual series of daily/weekly indices losses, and parametric and nonparametric methods are used to estimate parameters of the general Pareto distribution （GPD）, and dynamic VaR for indices of three stock markets in China. The accuracy and time scale invariance of risk measurement methods through back-testing approach are also examined. Results show that not all the indices accept time scale invariance; there are some differences in accuracy between different indices at various confidence levels. The most powerful dynamic VaR estimation methods are EVT-GJR-Hill at 97.5% level for weekly loss to Shanghai stock market, and EVT-GARCH-MLE （Hill） at 99.0% level for weekly loss to Taiwan and Hong Kong stock markets, respectively.

关键词： Chinese stock markets Dynamic VaR Time scaling Extreme value theory Back-testing

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有晶状体眼后房型人工晶状体植入术后早期拱高影响因素分析

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国际眼科杂志 2022年第10期22卷 1731-1735页

作者：席欢燕振国杨世杰郑思雨王小阳徐新花甘肃中医药大学第一临床医学院甘肃省兰州市730000 甘肃中医药大学附属兰州眼科中心兰州华厦眼科医院甘肃省兰州市730000

目的:观察有晶状体眼后房型人工晶状体(ICL/TICL V4c)植入术后拱高的早期变化趋势并分析相关影响因素。方法:回顾性研究。选取2020-10/2021-03于兰州华厦眼科医院接受ICL/TICL V4c植入术患者49例98眼。收集患者术前等效球镜度数(SE)、... 详细信息

目的:观察有晶状体眼后房型人工晶状体(ICL/TICL V4c)植入术后拱高的早期变化趋势并分析相关影响因素。方法:回顾性研究。选取2020-10/2021-03于兰州华厦眼科医院接受ICL/TICL V4c植入术患者49例98眼。收集患者术前等效球镜度数(SE)、眼压、眼轴、前房深度(ACD)、晶状体厚度(LT)、中央角膜厚度、前房角(ACA)、前房容积(ACV)、角膜白到白直径(WTW)、平均角膜曲率K1、K2,术中植入的ICL尺寸,术后1、3d, 1wk, 1mo用AS-OCT测量患者拱高(vault)。按术后1mo拱高值大小分为低拱高组(750μm)24眼,分析影响术后拱高的因素。结果:术后1、3d, 1wk, 1mo平均拱高值分别为591.05±293.44、599.62±309.78、592.22±301.49和586.69±285.63μm。术后1mo不同拱高间WTW、ACA、ACV、ACD、ICL尺寸、LT有差异(均P<0.05)。术后1mo拱高的回归方程=-3142.19+388.25×WTW+10.40×ACA-301.63×LT,R、R^(2)、调整R^(2)分别为0.674、0.454、0.436。WTW对术后1mo拱高影响最大(β=0.47,P<0.001),其次为LT(β=-0.34,P<0.001)和ACA(β=0.17,P=0.047)。结论:WTW、ACA、LT是影响和预测ICL/TICL V4c植入术后1mo拱高的主要因素。

关键词：近视有晶状体眼后房型人工晶状体植入术拱高眼前节参数

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复合法益下袭警罪解释与适用的双重限缩

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广西政法管理干部学院学报 2023年第3期38卷 42-50页

作者：赵天红施杰阳中国政法大学北京100088

袭警罪的保护法益包括人民警察的公务和人民警察的人身安全,以该双核心的复合法益为指导,实质解释袭警罪的构成要件并限缩其司法适用。“暴力袭警”限于危及人民警察人身安全的暴力,应达到通常情况下能够造成人民警察轻微伤以上后果的程... 详细信息

袭警罪的保护法益包括人民警察的公务和人民警察的人身安全,以该双核心的复合法益为指导,实质解释袭警罪的构成要件并限缩其司法适用。“暴力袭警”限于危及人民警察人身安全的暴力,应达到通常情况下能够造成人民警察轻微伤以上后果的程度,以“阻碍人民警察依法执行公务”为前提条件,同时,“暴力袭警”必须产生导致警察职务不能或者明显难以执行的具体危险,而“暴力袭击”违法执行职务或者职务行为存在重大瑕疵的人民警察的,则不构成袭警罪。

关键词：袭警罪警察公务说复合法益说暴力袭击双重限缩

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积极刑法观下法益立法批判机能的再检视

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江苏警官学院学报 2023年第4期38卷 28-34页

作者：赵天红施杰阳中国政法大学刑事司法学院

为回应社会治理需求,刑法进行了多次修正。其中,法益是否具有并发挥了立法批判机能面临广泛质疑,需要再次检视。法益立法批判机能具有积极与消极两个侧面:对于值得刑法保护但尚未纳入的法益,应及时增设新罪或扩充旧罪,这是积极侧面的实... 详细信息

为回应社会治理需求,刑法进行了多次修正。其中,法益是否具有并发挥了立法批判机能面临广泛质疑,需要再次检视。法益立法批判机能具有积极与消极两个侧面:对于值得刑法保护但尚未纳入的法益,应及时增设新罪或扩充旧罪,这是积极侧面的实现,而非立法批判机能的丧失;对于不保护法益的犯罪,法益事实上发挥了立法批判机能的消极侧面,对于部分犯罪已予以除罪化,但仍有赌博罪等极少数不保护法益的犯罪尚未废除。比例原则无法替代法益,为实现法益的立法批判机能,应将二者有机结合。借助比例原则,根据法益立法批判机能所提供的基础与依据,对于不保护法益的犯罪应及时通过违宪审查制度予以废除。

关键词：法益立法批判机能积极侧面消极侧面比例原则

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