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Journal of Biosciences and Medicines 2024年第4期12卷 60-68页

作者： Qiulu nie College of Medical Qinghai University Xining China

Stomachache is one of the most common diseases of digestive system, among which stomach pain of deficiency cold of spleen and stomach is the most common. Acupuncture and moxibustion therapy as an external treatment of traditional Chinese medicine for relieving stomach pain due to deficiency of spleen and stomach, has the advantages of convenient operation, small adverse reactions and remarkable curative effect, which is easy for patients to accept. In this paper, acupuncture and moxibustion therapy such as moxibustion and warm acupuncture therapy for stomach pain of spleen and stomach deficiency cold type is summarized to provide evidence-based basis for clinical treatment of stomach pain of spleen and stomach deficiency cold type.

关键词： Traditional Chinese Medicine Stitch Moxibustion Spleen and Stomach Deficiency Cold Type Stomach Pain

Construction of millimeter-scale vascularized engineered myocardial tissue using a mixed gel

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Regenerative Biomaterials 2024年第3期3卷 56-67页

作者： Ming Ke Wenhui Xu Yansha Hao Feiyang Zheng Guanyuan Yang Yonghong Fan Fangfang Wang Zhiqiang nie Chuhong Zhu Department of Anatomy Third Military Medical UniversityChongqing 400038China State Key Laboratory of Trauma Burn and Combined InjuryChongqing 400038China Department of Plastic and Aesthetic Surgery Southwest HospitalThird Military Medical UniversityChongqing 400038China Engineering Research Center of Tissue and Organ Regeneration and Manufacturing Ministry of EducationChongqing 400038China

Engineering myocardium has shown great clinal potential for repairing permanent myocardial ***,the lack of perfusing blood vessels and difficulties in preparing a thick-engineered myocardium result in its limited clinical *** prepared a mixed gel containing fibrin(5 mg/ml)and collagen I(0.2 mg/ml)and verified that human umbilical vein endothelial cells(HUVECs)and human-induced pluripotent stem cell-derived cardiomyocytes(hiPSC-CMs)could fom microvascular lumens and myocardial cell clusters by harnessing the low-hardness and hyperelastic characteristics of ***-CMs and HUVECs in the mixed gel formed self-organized cell clusters,which were then cultured in different media using a three-phase *** successfully constructed vascularized engineered myocardial tissue had a spherical structure and final diameter of *** tissue exhibited autonomous beats that occured at a frequency similar to a normal human heart *** internal microvascular lumen could be maintained for 6 weeks and showed good results during preliminary surface re-vascularization in vitro and vascular remodeling in *** summary,we propose a simple method for constructing vascularized engineered myocardial tissue,through phased cultivation that does not rely on high-end manufacturing equipment and cutting-edge preparation *** constructed tissue has potential value for clinical use after preliminary evaluation.

关键词： engineered myocardium vascularized hiPSC-CM HUVEC fibrin

Time trends and disparities of obesity and related national policies and programs in Nepal:a systematic review

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Global Health Journal 2024年第2期8卷 46-57页

作者： Junxiang Wei Peng nie Liwang Gao Yang Mi Youfa Wang Department of Obstetrics Northwest Women's and Children's HospitalXi'anShaanxiChina School of Economics and Finance Xi'an Jiaotong UniversityXi'anShaanxiChina Center for Non-Communicable Disease Management Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Global Health Institute No.21 Hongren BuildingWest China Science and Technology lnnovation Harbour(iHarbour)Xi'anShaanxiChina School of Public Health Xi'an Jiaotong UniversityXi'anShaanxiChina

Objective Overweight and obesity prevalence has increased in low-income *** study systematically reviewed the obesity trend,disparities,and prevention and control efforts in *** We searched PubMed and Google Scholar for articles and reports published between January 1,2004 and December 31,*** information on National policies and programs related to obesity prevention was retrieved from governmental websites and consultation with relevant *** and obesity were defined using the World Health Organization body mass index cut ***-two studies and reports were *** Overall,overweight and obesity rates increased in all groups in Nepal although nationally representative data remained *** combined overweight and obesity(OW/OB)and obesity rates in women aged 15-49 years increased from 8.5%to 22.2%and from 0.9%to 5.1%between 2006 and 2016,***/OB and obesity rates in men were 17.1%and 2.5%based on data from the 2016 Demographic and Health ***/OB rate in under-five children increased from 0.6%to 2.8%between 2006 and *** rates for school-age(5-9 years)boys and girls in 2016 were 2.4%and 2.8%,respectively,and were 1.1%and 1.4%for male and female adolescents aged 10-19 years,***/OB prevalence was much higher among women,residents in urban areas and central provinces,and in higher socioeconomic status *** prevalence of OW/OB and obesity for 2030 in adults aged 15-49 was 44.7%and 8.3%,respectively,while it was 2.2%for OW/OB in preschool *** and direct interventions that specifically focused on obesity prevention and control are *** OW/OB prevalence in Nepal has increased during the past 1.8 decades,disproportionately affecting population *** interventions mostly focused on undernutrition with some indirect implications for obesity *** the future,Nepal needs to develop population-based programs for obesity

关键词： Nutrition transition Overweight Obesity Obesity prevention Systematic review Nepal

Effect of Ti_(p) Content on the Work Hardening and Softening Behavior of Mg-Zn-Ca Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 551-560页

作者： Jin-Kai Zhang Cui-Ju Wang Yi-Dan Fan Chao Xu Kai-Bo nie Kun-Kun Deng Shanxi Key Laboratory of Advanced Magnesium-Based Materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China

The Ti_(p)/ZX60 composites with different Ti_(p) contents were prepared by semi-solid stirring *** extrusion,the microstructure,work hardening and softening behavior of the Ti_(p)/ZX60 composites were analyzed compared with the ZX60(Mg-6Zn-0.2Ca)*** results showed that the addition of Ti_(p) could not only promote the nucleation of dynamic recrystallized(DRXed)grains,but also be propitious to the refinement of DRXed *** increasing Ti_(p) content,the size of DRXed grains decreased accompanied with increasing volume fraction of DRXed *** the Ti_(p) content increased to 15 vol.%,the average size and volume fraction of DRXed grains reached to~0.32μm and 93.2%,***,both the strength and elongation were improved by the addition of Ti_(p).With increasing content of Ti_(p),a substantial increase in the strength was achieved with little change in the ***,the elongation decreased sharply when the Ti_(p) content further increased to 15 vol.%.The addition of Ti_(p) led to an increase in the work hardening rate,which gradually increased with increasing Ti_(p) ***,the softening rate did not demonstrate the same tendency with increasing Ti_(p) *** the conventional ceramic particles,the Ti_(p) can be deformed in coordination with the matrix alloy,which imparted a higher softening rate to the matrix *** though the softening rate improved as the Ti_(p) content increased from 5 to 10 vol.%,it dropped deeply as the Ti_(p) content increased to 15 vol.%owing to the fracture of Ti_(p) during extrusion.

关键词： Titanium particle content Particle reinforced magnesium matrix composites Work hardening Softening behavior Mechanical properties

Anchoring Ru clusters to highly defective N-doped carbon nanotubes via a thermal-shock strategy for stable industrial hydrogen evolution

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Nano Research 2024年第6期17卷 5261-5269页

作者： Zhiming Li Xinyu Li Haiqing Ma Chenliang Ye Hongan Yu Long nie Meng Zheng Jin Wang College of Materials Science and Engineering Shenzhen UniversityShenzhen 518060China School of Chemistry and Materials Science Anhui Normal UniversityWuhu 241002China Department of Power Engineering North China Electric Power UniversityBaoding 071003China

Non-Pt or low-Pt catalysts capable for stable generation of hydrogen via water electrolysis at an industrial level of current density are highly *** of strong metal-support connection is beneficial to improve the performance stability of *** we employed highly defective N-doped carbon nanotubes(d-N-CNT)as the support to achieve uniform and firm anchoring of Ru clusters(~1.9 nm)via a thermal-shock *** as-prepared Ru/d-N-CNT catalyst shows excellent catalytic activity for hydrogen evolution reaction(HER)in alkaline media and requires an overpotential(ƞ)of 12 mV at 10 mA·cm^(−2)and 116 mV at 200 mA·cm^(−2)with a Ru loading of 0.025 mg·cm^(−2).Impressively,Ru/d-N-CNT presents robust stability for HER at both low current density(stable for at least 1000 h at 10 mA·cm^(−2))and the industrial level of current density(stable for at least 100 h at 1000 mA·cm^(−2)),remarkably outperforming commercial Pt/C and Ru/*** highly defective nature of the N-CNT support endowed the as-prepared Ru/d-N-CNT catalyst with strong metal-support adhesion that efficiently suppressed agglomeration as well as obscission of Ru ***,the rich defects increased the surface energy of the N-CNT support and resulted in improved hydrophilicity as evidenced by the liquid contact angle measurement and the bubble evolution process,which also played an important role in stabilizing the HER performance especially at large current density.

关键词： thermal-shock method hydrogen evolution reaction large-current-density Ru cluster

Tumor necrosis factor α deficiency promotes myogenesis and muscle regeneration

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Zoological Research 2024年第4期45卷 951-960页

作者： Yu Fu Jing-Ru nie Peng Shang Bo Zhang Da-Wei Yan Xin Hao Hao Zhang State Key Laboratory of Animal Biotech Breeding China Agricultural UniversityBeijing 100193China College of Animal Science Xizang Agricultural and Animal Husbandry UniversityLinzhiXizang 860000China College of Animal Science and Technology Yunnan Agricultural UniversityKunmingYunnan 650201China

Tumor necrosis factorα(TNFα)exhibits diverse biological functions;however,its regulatory roles in myogenesis are not fully *** the present study,we explored the function of TNFαin myoblast proliferation,differentiation,migration,and myotube fusion in primary myoblasts and C2C12 *** this end,we constructed TNFαmuscle-conditional knockout(TNFα-CKO)mice and compared them with flox mice to assess the effects of TNFαknockout on skeletal *** indicated that TNFα-CKO mice displayed phenotypes such as accelerated muscle development,enhanced regenerative capacity,and improved exercise endurance compared to flox mice,with no significant differences observed in major visceral organs or skeletal *** label-free proteomic analysis,we found that TNFα-CKO altered the distribution of several muscle development-related proteins,such as Hira,Casz1,Casp7,Arhgap10,Gas1,Diaph1,Map3k20,Cfl2,and Igf2,in the nucleus and *** set enrichment analysis(GSEA)further revealed that TNFαdeficiency resulted in positive enrichment in oxidative phosphorylation and MyoD targets and negative enrichment in JAK-STAT *** findings suggest that TNFα-CKO positively regulates muscle growth and development,possibly via these newly identified targets and pathways.

关键词： TNFα Muscle-conditional knockout Myogenesis Regeneration Muscle development

Three-phase Enriched Environment Improves Post-stroke Gait Dysfunction via Facilitating Neuronal Plasticity in the Bilateral Sensorimotor Cortex:A Multimodal MRI/PET Analysis in Rats

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Neuroscience Bulletin 2024年第6期40卷 719-731页

作者： Yun Lu Ziyue Lin Mingcong Li Yuming Zhuang Binbin nie jianfeng Lei Yuanyuan Zhao Hui Zhao School of Traditional Chinese Medicine Capital Medical UniversityBeijing100069China Beijing Key Lab of TCM Collateral Disease Theory Research Beijing100069China Beijing Engineering Research Center of Radiographic Techniques and Equipment Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China Medical Imaging Laboratory of Core Facility Center Capital Medical UniversityBeijing100069China

The three-phase Enriched Environment(EE)paradigm has been shown to promote post-stroke functional improvement,but the neuronal mechanisms are still *** this study,we applied a multimodal neuroimaging protocol combining magnetic resonance imaging(MRI)and positron emission tomography(PET)to examine the effects of post-ischemic EE treatment on structural and functional neuroplasticity in the bilateral sensorimotor *** were subjected to permanent middle cerebral artery *** motor function of the rats was examined using the DigiGait *** was applied to investigate the EE-induced structural modifications of the bilateral sensorimotor cortex.[^(18)F]-fluorodeoxyglucose PET was used to detect glucose *** oxygen level-dependent(BOLD)-functional MRI(fMRI)was used to identify the regional brain activity and functional connectivity(FC).In addition,the expression of neuroplasticity-related signaling pathways including neurotrophic factors(BDNF/CREB),axonal guidance proteins(Robo1/Slit2),and axonal growth-inhibitory proteins(NogoA/NgR)as well as downstream proteins(RhoA/ROCK)in the bilateral sensorimotor cortex were measured by Western *** results showed the three-phase EE improved the walking *** T2 mapping imaging and diffusion tensor imaging demonstrated that EE benefited structure integrity in the bilateral sensorimotor ***-MRI fused images showed improved glucose metabolism in the corresponding regions after EE ***,the BOLD-based amplitude of low-frequency fluctuations showed that EE increased spontaneous activity in the bilateral motor cortex and ipsilateral sensory *** addition,FC results showed increased sensorimotor connectivity in the ipsilateral hemisphere and increased interhemispheric motor cortical connectivity and motor cortical-thalamic connectivity following EE *** addition,a strong correlation was found between increased functional connectivity and improv

关键词： Enriched environment Gait function Neuronal plasticity Structural integrity Glucose metabolism Functional connectivity Microenvironmental molecules Axonogenesis

Visible-light-activated aziridination reaction enables simultaneous resolving of C=C bond location and the sn-position isomers in lipids

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Chinese Chemical Letters 2024年第4期35卷 481-485页

作者： Qiongqiong Wan Yanan Xiao Guifang Feng Xin Dong Wenjing nie Ming Gao Qingtao Meng Suming Chen The Institute for Advanced Studies Renmin Hospital of Wuhan UniversityWuhan UniversityWuhan 430072China

There is a close relationship between the biological functions of lipids and their structures, and various isomers greatly increases the complexity of lipid structures. The C=C bond location and sn-position are two of the essential attributes that determine the structures of unsaturated lipids. However, simultaneous identification of both attributes remains challenging. Here, we develop a visible-light-activated aziridination reaction system, which enables the dual-resolving of the C=C bond location and sn-position isomerism of in lipids when combines with liquid chromatography-mass spectrometry(LC-MS). Based on the derivatization of C=C bonds with Ph I=NTs, their location in lipids could be easily identified by tandem MS. Especially, the sn-position isomers of unsaturated phosphatidylcholine(PC) can be separated and quantified by LC-MS after the derivatization. By using the proposed method, the significant changes of the sn-position isomers ratios of PC in mouse brain ischemia were revealed. This study offers a powerful tool for deep lipid structural biology.

关键词： Aziridination Lipid isomers C=C bond location sn-Position Mass spectrometry

Schottky infrared detectors with optically tunable barriers beyond the internal photoemission limit

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The Innovation 2024年第3期5卷 69-76页

作者： Jintao Fu Zhongmin Guo Changbin nie Feiying Sun Genglin Li Shuanglong Feng Xingzhan Wei Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China University of Chinese Academy of Sciences Beijing 100049China Chongqing School University of Chinese Academy of SciencesChongqing 400714China

Internal photoemission is a prominent branch of the photoelectric effect and has emerged as a viable method for detecting photons with energies below the semiconductor *** breakthrough has played a significant role in accelerating the development of infrared imaging in one chip with state-of-the-art silicon ***,the performance of these Schottky infrared detectors is currently hindered by the limit of internal photoemission;specifically,a low Schottky barrier height is inevitable for the detection of low-energy infrared ***,a distinct paradigm of Schottky infrared detectors is proposed to overcome the internal photoemission limit by introducing an optically tunable *** device uses an infrared absorbing material-sensitized Schottky diode,assisted by the highly adjustable Fermi level of graphene,which subtly decouples the photon energy from the Schottky barrier ***,a broadband photoresponse spanning from ultraviolet to mid-wave infrared is achieved,with a high specific detectivity of 9.83×1010 cm Hz1/2 W−1 at 2,700 nm and an excellent specific detectivity of 7.2×109 cm Hz1/2 W−1 at room temperature under blackbody *** results address a key challenge in internal photoemission and hold great promise for the development of the Schottky infrared detector with high sensitivity and room temperature operation.

关键词： Schottky tunable beyond

Metal–Organic Gel Leading to Customized Magnetic‑Coupling Engineering in Carbon Aerogels for Excellent Radar Stealth and Thermal Insulation Performances

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Nano-Micro Letters 2024年第3期16卷 36-52页

作者： Xin Li Ruizhe Hu Zhiqiang Xiong Dan Wang Zhixia Zhang Chongbo Liu Xiaojun Zeng Dezhi Chen Renchao Che Xuliang nie Key Laboratory of jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063People’s Republic of China School of Environmental and Chemical Engineering Nanchang Hangkong UniversityNanchang 330063People’s Republic of China Laboratory of Advanced Materials Department of Materials Science and Collaborative Innovation Center of Chemistry for Energy Materials and Collaborative Innovation Center of Chemistry for Energy MaterialsFudan UniversityShanghai 200438People’s Republic of China School of Materials Science and Engineering Jingdezhen Ceramic UniversityJingdezhen 333403People’s Republic of China College of Chemistry and Materials Jiangxi Agricultural UniversityNanchang 330045People’s Republic of China

Metal–organic gel(MOG)derived composites are promising multi-functional materials due to their alterable composition,identifiable chemical homogeneity,tunable shape,and porous ***,stable metal–organic hydrogels are prepared by regulating the complexation effect,solution polarity and curing ***,collagen peptide is used to facilitate the fabrication of a porous aerogel with excellent physical properties as well as the homogeneous dispersion of magnetic particles during ***,two kinds of heterometallic magnetic coupling systems are obtained through the application of Kirkendall ***/nitrogen-doped carbon(NC)aerogel demonstrates an ultra-strong microwave absorption of−85 dB at an ultra-low loading of 5%.After reducing the time taken by atom shifting,a FeCo/Fe3O4/NC aerogel containing virus-shaped particles is obtained,which achieves an ultra-broad absorption of 7.44 GHz at an ultra-thin thickness of 1.59 mm due to the coupling effect offered by dual-soft-magnetic ***,both aerogels show excellent thermal insulation property,and their outstanding radar stealth performances in J-20 aircraft are confirmed by computer simulation *** formation mechanism of MOG is also discussed along with the thermal insulation and electromagnetic wave absorption mechanism of the aerogels,which will enable the development and application of novel and lightweight stealth coatings.

关键词： Metal-organic gels Heterometallic magnetic coupling Radar stealth Thermal insulation Computer simulation technology