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Antibody response and therapy in COVID-19 patients: what can be learned for vaccine development?

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Science China(life Sciences) 2020年第12期63卷 1833-1849页

作者： ligong Lu Hui Zhang Meixiao Zhan Jun Jiang Hua Yin Danielle JDauphars shi-you li Yong li you-Wen He Zhuhai Interventional Medical Center Zhuhai Precision Medical CenterZhuhai People's HospitalZhuhai Hospital Affiliated with Jinan UniversityZhuhai 519000China First Affiliated Hospital China Medical UniversityShenyang 110001China tricision Biotherapeutic Inc. Zhuhai 519041China Department of Immunology Duke University Medical University Medical CenterDurhamNC 27710USA

The newly emerged severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has infected millions of people and caused tremendous morbidity and mortality worldwide. Effective treatment for coronavirus disease 2019(COVID-19) due to SARSCoV-2 infection is lacking, and different therapeutic strategies are under testing. Host humoral and cellular immunity to SARSCoV-2 infection is a critical determinant for patients’ outcomes. SARS-CoV-2 infection results in seroconversion and production of anti-SARS-CoV-2 antibodies. The antibodies may suppress viral replication through neutralization but might also participate in COVID-19 pathogenesis through a process termed antibody-dependent enhancement. Rapid progress has been made in the research of antibody response and therapy in COVID-19 patients, including characterization of the clinical features of antibody responses in different populations infected by SARS-CoV-2, treatment of COVID-19 patients with convalescent plasma and intravenous immunoglobin products, isolation and characterization of a large panel of monoclonal neutralizing antibodies and early clinical testing, as well as clinical results from several COVID-19 vaccine candidates. In this review, we summarize the recent progress and discuss the implications of these findings in vaccine development.

关键词： COVID-19 seroconversion neutralizing antibody spike protein SARS-CoV-2 convalescent plasma vaccine

Synthesis and electrochemical properties of li_(1-x)V_xCr_yFe_(1-x)PO_4/C as a cathode material

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Chinese Chemical Letters 2008年第3期19卷 337-341页

作者： shi Tao Song Pei Hua Ma shi you li Xiao Chuan Deng Chun Yan Yan Qinghai Institute of Salt Lakes Chinese Academy of Sciences Xining 810008 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China

Composites li1-xVxCryFe1-yPO4/C（x=0.01, 0.02; y = 0.01, 0.02） were synthesized by solid-state reaction method. The influence of the content of doping vanadium and chromium on the structure of li1-xVxCryFe1-yPO4/C was investigated by XRD, while the morphology of powders was observed by SEM. The investigation of the electrochemical performances showed that the li0.99V0.01Cr0.02Fe0.98PO4/C material has a higher capacity. At 0.1 C discharging rate, it is capable of delivering reversible specific capacity of 163.8 mAh/g with fairly stable cycleability.

关键词： li1-xVxCryFe1-yPO4/C Cathode material Ion doping

Effect of temperature on formation and evolution of solid electrolyte in terphase on Si@Graphite@C anodes

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Journal of Energy Chemistry 2022年第1期31卷 190-200,I0006页

作者： Hong Dong Jie Wang Peng Wang Hao Ding Ru Song Ning-Shuang Zhang Dong-Ni Zhao li-Juan Zhang shi-you li College of Petrochemical Technology Lanzhou University of TechnologyLanzhou 730050GansuChina Gansu Key Laboratory of Low-Carbon Energy and Chemical Engineering Lanzhou 730050GansuChina College of Chemistry and Chemical Engineering Qinghai University for NationalitiesXining 810007QinghaiChina

Studies on the formati on and evolutio n of the solid electrolyte in terface(SEI)film under different ambient temperatures are important to understand the failure behavior of lithium-ion batteries(liBs).Herein,in-situ electrochemical impedance spectroscopy(EIS)test is performed on the whole discharge process of Si@Graphite@C/li cell at 0,25 and 55℃,*** with scanning electron microscopy,transmission electron microscopy and X-ray photoelectron spectroscopy characterizations,it is found that the SEI film undergoes a complicated evolution process of pre-formation,self-improvement and gradual decay in succession at 25℃.Besides,due to the dissolution of organo-alkyl lithium at high temperature,the formed film is mainly composed of liF,li_(2)CO_(3) and other in organic salts,which helps to decrease the ***,the electrolyte is consumed continuously on the new exposed in terface,leading to the degraded performance of the ***,the dyn amic properties of li^(+) ions are poor at low temperature,though the migration ability of li^(+) ions in the solid phase can be improved as the cycle goes ***,the development and application of in-situ EIS tech no logy are expected to become an important means to explain the electrochemical performance of batteries.

关键词： In-situ EIS Solid electrolyte in terphase Formation Evolution Si@Graphite@C anodes

Adjusting the solvation structure with tris(trimethylsilyl)borate additive to improve the performance of LNCM half cells

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Journal of Energy Chemistry 2022年第4期31卷 55-64页

作者： Jie Wang Hong Dong Peng Wang Xiao-Lan Fu Ning-Shuang Zhang Dong-Ni Zhao shi-you li Xiao-ling Cui School of Petrochemical Technology Lanzhou University of TechnologyLanzhou 730050GansuChina Gansu Key Laboratory of Low-Carbon Energy and Chemical Engineering Lanzhou 730050GansuChina Gansu Engineering Laboratory of Electrolyte Material for lithium-ion Battery Lanzhou 730050GansuChina

Tris(trimethylsilyl)borate(TMSB) has been intensively studied to improve the performances of lithiumion batteries. However, it is still an interesting issue needed to be resolved for the research on the li^(+) solvation structure affected by TMSB additive. Herein, the electrochemical tests, quantum chemistry calculations, potential-resolved in-situ electrochemical impedance spectroscopy measurements and surface analyses were used to explore the effects of li^(+) solvation structure with TMSB additive on the formation of the cathode electrolyte interface(CEI) film in liNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)/li half cells. The results reveal that the TMSB additive is easy to complex with li^(+) ion, thus weaken the intermolecular force between li^(+) ions and ethylene carbonate solvent, which is benefit for the cycle performance. Besides, the changed li^(+) solvation structure results in a thin and dense CEI film containing compounds with Si–O and B–O bonds which is favorable to the transfer of li^(+) ions. As a result, the performances of the LNCM811/li half cells are effectively improved. This research provides a new idea to construct a high-performance CEI film by adjusting the li^(+) solvation structures.

关键词： lithium-ion battery Solvation structure Tris(trimethylsilyl)borate Si-containing additive liNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) Cathode electrolyte interface film

Embolization of brain arteriovenous malformations with ethylene vinyl alcohol copolymer： technical aspects

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Chinese Medical Journal 2009年第16期122卷 1851-1856页

作者： GAO Kun YANG Xin-jian MU shi-qing li you-xiang ZHANG you-ping LU Ming WU Zhong-xue Department of Neuroradiosugery Beijing Neurosurgery Institute Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background Endovascular therapy plays an important role in the treatment of brain arteriovenous malformations （BAVMs）. Ethylene vinyl alcohol copolymer （Onyx） is a novel liquid embolic material. This study aimed to summarize our experience of using Onyx for embolization of BAVMs with the focus on embolization technique. Methods From September 2003 to November 2007, 115 patients （43 women and 72 men, with a mean age of 29 years） with BAVMs were endovascularly treated with Onyx in our department. The following features of all AVMs were evaluated prior to treatment： type of nidus and shunt, draining veins, and feeding arteries. A total of 196 endovascular procedures were performed. Results The course of endovascular treatment was completed in 88 patients. Additional sessions were planned in 27 patients. Of the 88 patients, total occlusion was obtained in 23 patients （26.1%）, near-total （〉80% of the original volume） occlusion was obtained in 35 patients （39.8%） and partial occlusion （〈80% of the original volume） was obtained in 30 patients （34.1%） using embolization as the sole therapeutic technique. Mean volume reduction was 72% （range 30%-100%） in 115 patients. Thirty four patients （38.6%, 34/88） underwent radiosurgical treatment. Additional embolization sessions were planned in 27 patients. Complications occurred in 19 patients （16.5%, 19/115）, leading to death in one patient （mortality 0.9%） and permanent disabling in 3 patients （morbidity 2.6%）. Conclusions Onyx was shown to be feasible and safe for embolization of BAVMs. Proper use of the Onyx injection technique largely improved the endovascular treatment of BAVMs. Large AVMs can be adequately reduced in size through the use of additional treatment.

关键词： brain arteriovenous malformations endovascular treatment Onyx copolymer

Combination immunotherapy of glioblastoma with dendritic cell cancer vaccines,anti-PD-1 and poly I:C

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Journal of Pharmaceutical Analysis 2023年第6期13卷 616-624页

作者： Ping Zhu shi-you li Jin Ding Zhou Fei Sheng-Nan Sun Zhao-Hui Zheng Ding Wei Jun Jiang Jin-lin Miao San-Zhong li Xing Luo Kui Zhang Bin Wang Kun Zhang Su Pu Qian-Ting Wang Xin-Yue Zhang Gao-liu Wen Jun Oliu John Thomas August Huijie Bian Zhi-Nan Chen you-Wen He Department of Clinical Immunology Xijing HospitalDepartment of Cell BiologyNational Translational Science Center for Molecular MedicineFourth Military Medical UniversityXi'an710032China Beijing Tricision Biotherapeutics Inc. Beijing100176China Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi'an710032China Zhuhai Tricision Biotherapuetics Inc. ZhuhaiGuangdong519040China Department of Pharmacology and Molecular Sciences Johns Hopkins University School of MedicineBaltimoreMD21205USA

Glioblastoma(GBM)is a lethal cancer with limited therapeutic *** cell(DC)-based cancer vaccines provide a promising approach for GBM *** studies suggest that other immunotherapeutic agents may be combined with DC vaccines to further enhance antitumor ***,we report a GBM case with combination immunotherapy consisting of DC vaccines,anti-programmed death-1(anti-PD-1)and poly I:C as well as the chemotherapeutic agent cyclophosphamide that was integrated with standard chemoradiation therapy,and the patient remained disease-free for 69 *** patient received DC vaccines loaded with multiple forms of tumor antigens,including mRNA-tumor associated antigens(TAA),mRNA-neoantigens,and hypochlorous acid(HOCl)-oxidized tumor ***,mRNA-TAAs were modified with a novel TriVac technology that fuses TAAs with a destabilization domain and inserts TAAs into full-length lysosomal associated membrane protein-1 to enhance major histocompatibility complex(MHC)class I and II antigen *** treatment consisted of 42 DC cancer vaccine infusions,26 anti-PD-1 antibody nivolumab administrations and 126 poly I:C injections for DC *** patient also received 28 doses of cyclophosphamide for depletion of regulatory T *** immunotherapy-related adverse events were observed during the *** antitumor CD4t and CD8t T-cell responses were *** patient remains free of disease *** is the first case report on the combination of the above three agents to treat glioblastoma *** results suggest that integrated combination immunotherapy is safe and feasible for long-term treatment in this patient.A large-scale trial to validate these findings is warranted.

关键词： Glioblastoma multiforme DC vaccine Tumor-associated antigens Neoantigens

Mechanism of aluminum corrosion in liFSI-based electrolyte at elevated temperatures

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Transactions of Nonferrous Metals Society of China 2021年第5期31卷 1439-1451页

作者： Chun-lei li Shuang-wei ZENG Peng WANG Zhao-juan li li YANG Dong-ni ZHAO Jie WANG Hai-ning liU shi-you li College of Petrochemical Technology Lanzhou University of TechnologyLanzhou 730050China CAS Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Institute of Salt LakeChinese Academy of SciencesXining 810008China

lithium bis(fluorosulfonyl)imide(liFSI) is a promising replacement for lithium hexafluorosphate due to its excellent properties. A solution to the corrosion of aluminum(Al) current collectors by liFSI at elevated temperatures is essential. The mechanisms of Al corrosion in liFSI-based electrolyte at 45 ℃ were studied with density functional theory calculations and spectroscopic investigations. It is found that the irregular, loose and unprotected AlF3 materials caused by the dissolution of co-generated Al(FSI)3 can exacerbate Al corrosion with the increase of temperature. lithium bis(oxalate)borate(liBOB) can effectively inhibit the Al corrosion with a robust and protective interphase;this can be attributed to the interfacial interactions between the Al foil and electrolyte. Boron-containing compounds promote the change from AlF3 to liF, which further reinforces interfacial stability. This work allows the design of an interface to Al foil using liFSI salt in lithium-ion batteries.

关键词： lithium-ion batteries liFSI-based electrolyte lithium bis(oxalate)borate(liBOB) corrosion inhibition elevated temperatures interfacial film

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四维空间中几何元素的旋转原理及作图规律

华北水利水电学院学报 1983年第2期 27-33页

作者：施礼有华北水利水电学院基础部制图教研室

本文对四维空间中几何元素绕平面旋转和绕直线旋转的基本原理及作图规律进行了探讨。绕平面旋转的目的是将几何元素及其相互关系变换到有利于解题的位置,绕置线旋转的目的是求解平面图形的实形。

关键词：投影面迹线地图平面超平面投影变换几何元素

Comparison of long-term clinical outcome after successful implantation of Firebird sirolimus-and Taxus paclitaxel-eluting stents in Chinese population： analysis of a large single center registry

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Chinese Medical Journal 2010年第7期123卷 810-815页

作者： DOU Ke-fei XU Bo YANG Yue-jin CHEN Ji-lin QIAO Shu-bin WANG Yang li Jian-jun QIN Xue-wen YAO Min liU Hai-bo WU Yong-jian CHEN Jue YUAN Jin-qing you shi-jie li Wei GAO Run-lin Department of Cardiology Cardiovascular Institute and Fu Wai Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100037 China

Background Recent studies have shown that drug eluting stent （DES） implantation improved clinical outcome concerning efficacy compared with bare-metal stent （BMS） implantation, and sirolimus-eluting stent （SES） seemed superior to paclitaxel-eluting stent （PES） in improving the outcomes. Firebird SES is the most widely used SES in China. Long-term comparison of safety and efficacy between Firebird SES and Taxus PES in Chinese popuation is still not available. The aim of this research was to compare the safety and efficacy at 24 months after the successful implantation of Firebird SES and TAXUS PES in Chinese *** From April 2004 to October 2006, 3110 consecutive patients who underwent successful DES （Firebird SES 2274; Taxus PES 836） implantation were prospectively enrolled into this study. All enrolled patients were divided into two groups based on stent type. By outpatient clinic visit and telephone interview, we obtained 24-month clinical outcome including death, myocardial infarction （Ml）, thrombosis, target lesion revascularization （TLR）, target vessel revascularization （TVR）, and major adverse cardiac events （MACE, the composite of death, Ml, and TVR）. We used Cox＇s proportional-hazards models to assess relative risks of all the outcome measures before and after propensity match. Results Unadjusted clinical outcomes indicated that the patients treated with Firebird SES were associated with lower risk of TLR （HR0.38, 95%CI 0.26-0.54）, TVR （HR 0.51,95%CI 0.38-0.68） and MACE （HR 0.53, 95%CI 0.41-0.68）. The results after propensity match were consistent with that before matching, lower risk of TLR （HR 0.33, 95%CI 0.19-0.58）, TVR （HR 0.41, 95%CI 0.26-0.64）, MACE （HR 0.48, 95%CI 0.33-0.68） in Firebird *** Compared with Taxus PES, the use of domestic Firebird SES may decrease the risk of TLR, TVR and MACE in daily practice.

关键词： treatment outcome Firebird sirolimus-eluting stent Taxus paclitaxel-eluting stent