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Association between HLA alleles and sub-phenotype of childhood steroid-sensitive nephrotic syndrome

World Journal of Pediatrics 2022年第2期18卷 109-119页

作者： Hao Lee Li Wang Fen-Fen Ni Xue-Ying Yang shi-Pin Feng Xiao-Jie Gao Huan Chi Ye-Tao Luo Xue-Lan Chen Bao-Hui Yang Jun-Li Wan Jia Jiao Dao-Qi Wu Gao-Fu Zhang Mo Wang Hai-Ping Yang Han Chan qiu Li Pediatric Research Institute Department of NephrologyMinistry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation base of Child development and Critical DisordersChongqing Key Laboratory of PediatricsChildren's Hospital of Chongqing Medical UniversityChongqingChina Department of Nephrology Chengdu Women and Children Central HospitalChengdu 610041China Department of Nephrology Shenzhen Children's Hospital.ShenzhenChina Department of Statistics Children's Hospital of Chongqing Medical UniversityChongqingChina

BACKGROUND Few studies have addressed the effects of human leukocyte antigen(HLA)alleles on different clinical sub-phenotypes in childhood steroid-sensitive nephrotic syndrome(SSNS),including SSNS without recurrence(SSNSWR)and steroid-dependent nephrotic syndrome/frequently relapse nephrotic syndrome(SDNS/FRNS).In this study,we investigated the relationship between HLA system and children with SSNSWR and SDNS/FRNS and clarified the value of HLA allele detection for precise typing of childhood *** A total of 241 Chinese Han individuals with SSNS were genotyped using GenCap-WES Capture Kit,and four-digit resolution HLA alleles were imputed from available Genome Wide Association *** distribution and carrying frequency of HLA alleles in SSNSWR and SDNS/FRNS were ***,logistic regression and mediating effects were used to examine the relationship between risk factors for disease process and HLA *** Compared with SSNSWR,significantly decreased serum levels of complement 3(C3)and complement 4(C4)at onset were detected in SDNS/FRNS(C3,P<0.001;C4,P=0.018).The average time to remission after sufficient initial steroid treatment in SDNS/FRNS was significantly longer than that in SSNSWR(P=0.0001).Low level of C4 was further identified as an independent risk factor for SDNS/FRNS(P=0.008,odds ratio=0.174,95% confidence interval 0.048-0.630).The HLA-A*11:01 allele was independently associated with SSNSWR and SDNS/FRNS(P=0.0012 and P=0.0006,respectively).No significant HLA alleles were detected between SSNSWR and SDNS/*** addition,a mediating effect among HLA-I alleles(HLA-B*15:11,HLA-B*44:03 and HLA-C*07:06),C4 level and SDNS/FRNS was *** HLA-I alleles provide novel genetic markers for SSNSWR and SDNS/***-I antigens may be involved in steroid dependent or frequent relapse in children with SSNS as mediators of immunoregulation.

关键词： Human leukocyte antigen Immunoregulation Mediating effect Steroid-sensitive nephrotic syndrome Sub-phenotypes

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Facile formation of tetragonal-Nb2O5 microspheres for high-rate and stable lithium storage with high areal capacity

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Science Bulletin 2020年第14期65卷 1154-1162,M0003页

作者： Zhiquan Hu qiu He Ziang Liu Xiong Liu Mingsheng Qin Bo Wen Wenchao shi Yan Zhao Qi Li Liqiang Mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing International School of Materials Science and EngineeringWuhan University of TechnologyWuhan 430070China State Key Laboratory of Silicate Materials for Architectures International School of Materials Science and EngineeringWuhan University of TechnologyWuhan 430070China

Niobium pentoxide;Ion and electron transport;Mass loading;Areal capacity;Lithium-ion batteryNiobium pentoxide(Nb2 O5) has attracted great attention as an anode for lithium-ion battery, which is attributed to the high-rate and good stability performances. In this work, TT-, T-, M-, and H-Nb2 O5 microspheres were synthesized by a facile one-step thermal oxidation method. Ion and electron transport properties of Nb2 O5 with different phases were investigated by both electrochemical analyses and density functional theoretical calculations. Without nanostructuring and carbon modification, the tetragonal Nb2 O5(M-Nb2 O5) displays preferable rate capability(121 m Ah g^-1 at 5 A g^-1), enhanced reversible capacity(163 m Ah g^-1 at 0.2 A g^-1) and better cycling stability(82.3% capacity retention after 1000 cycles)when compared with TT-, T-, and H-Nb2 O5. Electrochemical analyses further reveal the diffusioncontrolled Li+intercalation kinetics and in-situ X-ray diffraction analysis indicates superior structural stability upon Li+intercalation/deintercalation. Benefiting from the intrinsic fast ion/electron transport, a high areal capacity of 2.24 m Ah cm^-2 is obtained even at an ultrahigh mass loading of 22.51 mg cm^-*** work can promote the development of Nb2 O5 materials for high areal capacity and stable lithium storage towards practical applications.

关键词： Niobium pentoxide Ion and electron transport Mass loading Areal capacity Lithium-ion battery

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Formation,evolution,reconstruction of black shales and their influence on shale oil and gas resource

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China Geology 2024年第3期7卷 551-585页

作者： shi-zhen Li qiu-chen Xu Mu Liu Guo-heng Liu Yi-fan Li Wen-yang Wang Xiao-guang Yang Wei-bin Liu Yan-fei An Peng Sun Tao Liu Jiang-hui Ding Qian-chao Li Chao-gang Fang State Key Laboratory of Continental Shale Oil Beijing 100083China The Key Laboratory of Unconventional Oil and Gas Geology China Geological SurveyBeijing 100083China Oil and Gas Survey China Geological SurveyMinistry of Natural ResourcesBeijing 100083China State Key Laboratory of Lithospheric and Environmental Coevolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China School of Geosciences China University of Petroleum(East China)Qingdao 266580China School of Energy Resources China University of Geosciences(Beijing)Beijing 100083China Key Laboratory of Petroleum Resources Research Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China School of Resource and Environment Engineering Anhui UniversityHefei 230601China Yangtze University Wuhan 430100China Nanjing Center China Geological SurveyNanjing 210016China National Elite Institute of Engineering CNPCBeijing 100096China

Black shales are important products of material cycling and energy exchange among the lithosphere,atmosphere,hydrosphere,and *** are widely distributed throughout geological history and provide essential energy and mineral resources for the development of human *** also record the evolution process of the earth and improve the understanding of the *** review focuses on the diagenesis and formation mechanisms of black shales sedimentation,composition,evolution,and reconstruction,which have had a significant impact on the formation and enrichment of shale oil and *** terms of sedimentary environment,black shales can be classified into three types:Marine,terrestrial,and marine-terrestrial transitional *** formation processes include mechanisms such as eolian input,hypopycnal flow,gravity-driven and offshore bottom *** a geological perspective,the formation of black shales is often closely related to global or regional major geological *** enrichment of organic matter is generally the result of the interaction and coupling of several factors such as primary productivity,water redox condition,and sedimentation *** terms of evolution,black shales have undergone diagenetic evolution of inorganic minerals,thermal evolution of organic matter and hydrocarbon generation,interactions between organic matter and inorganic minerals,and pore *** terms of reconstruction,the effects of fold deformation,uplift and erosion,and fracturing have changed the stress state of black shale reservoirs,thereby having a significant impact on the pore *** activity promotes the formation of veins,and have changed the material composition,stress structure,and reservoir properties of black *** resource effects,the deposition of black shales is fundamental for shale oil and gas resources,the evolution of black shales promotes the shale oil and gas formation and storage,and the reconstruction of black shales wou

关键词： Black shales Shale oil and gas Resource effects Sedimentary environment Sedimentary process Organic matter accumulation Diagenetic evolution Thermal evolution Organic matter and inorganic minerals Tectonic reconstruction Oil and gas exploration engineering Veins Fluid activity

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最优认知用户配对与协作感知算法研究

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通信学报 2012年第1期33卷 128-135页

作者：包志华张士兵张晓格邱恭安南通大学电子信息学院江苏南通226019

针对协作算法频谱感知和时隙消耗方面的不足,提出一种最优用户配对与协作感知算法。采用接收信噪比最优的认知用户为感知用户且以接收信噪比次优的认知用户为其中继的配对准则,获得最佳频谱感知性能。通过优化设置协作门限,选择性地采... 详细信息

针对协作算法频谱感知和时隙消耗方面的不足,提出一种最优用户配对与协作感知算法。采用接收信噪比最优的认知用户为感知用户且以接收信噪比次优的认知用户为其中继的配对准则,获得最佳频谱感知性能。通过优化设置协作门限,选择性地采用非协作或协作模式,获得更低的时隙消耗。同时,推导了在瑞利平坦衰落环境下该算法的频谱检测概率下界与时隙消耗。数值计算结果表明,与原有算法相比,该算法不仅检测概率更高且时隙消耗更低。

关键词：频谱感知协作分集检测概率时隙消耗

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Rat model for study of the essence of spleen deficiency and dampness in Chinese medicine

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Traditional Medicine Research 2018年第5期3卷 251-257页

作者： Xiao-Chun Han Xu-Ming Ji Lin Liu Shuang Zhang Li Sun qiu-Jian Feng shi-Jun Wang College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinanChina Department of Special Examination Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinanChina

Objective:To explore the essence of spleen deficiency and dampness in Chinese medicine by successfully constructing a rat model with this ***:Rat models with the syndrome of dampness and spleen deficiency were established with the use of a high-fat,low-protein diet and excessive fatigue induced by loaded swimming.A total of 25 common clinical serological markers were *** T test,rank test,and partial least squares regression-discriminant analysis were used to analyze the ***:Total protein,albumin,motilin,interferon-γ,interleukin-2,immunoglobulin A,immunoglobulin G,and complement 3 levels in the model rats were lower than those in the control group(P=0.029,P=0.032,P<0.001,P<0.001,P<0.001,P<0.001,P<0.001,P<0.001,respectively).The serum creatinine,total cholesterol,aldosterone,antidiuretic hormone,gastrin,interleukin-4,somatostatin,atrial natriuretic peptide,and vasoactive intestinal peptide levels in the model group were higher than those in the control group(P<0.001,P=0.015,P<0.001,P<0.001,P<0.001,P<0.001,P<0.001,P<0.001,P<0.001,respectively).There was no statistical difference between the two groups in aspartate transaminase,alanine aminotransferase,globulin,albumin/globulin,blood urea nitrogen,high-density lipoprotein,and low-density *** model animal syndrome used two important variables in analysis with partial least squares regression-discriminant *** the same time,the two dimensions were difficult to distinguish for each biological ***:Spleen deficiency is often associated with *** index that represents spleen deficiency can also represent ***,immunoglobulins,and gastrointestinal hormones play a major causative role in both spleen deficiency and dampness.

关键词： Spleen deficiency Dampness Animal model

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金银花的体外抑菌作用研究

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时珍国医国药 2003年第5期14卷 269-269页

作者：宋海英邱世翠王志强张群杨新滨州医学院山东滨州256603

目的 :探讨金银花体外抑菌作用。方法 :用 K- B纸片扩散法 10 0 %金银花浸出液滤纸片对金黄色葡萄球菌、白色葡萄球菌、甲型链球菌、乙型链球菌抑菌作用进行了研究。结果 :金银花对以上细菌均有明显抑菌作用。结论

关键词：金银花体外抑菌作用 K-B纸片扩散法中药药理

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基于横向磁通的包装机横封感应加热建模及仿真

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上海交通大学学报 2011年第6期45卷 831-836,841页

作者：李雷王石刚莫锦秋韦晓晖上海交通大学机械与动力工程学院上海200240

针对包装机横封时的温度分布问题,对横封感应加热的温度场进行了数值建模和计算.在横向磁通原理的基础上,结合横封过程和所用铝塑复合包材的特点,研究了横封感应加热的电磁场和温度场描述方程和边界条件,建立了适用于包装机横封感应加... 详细信息

针对包装机横封时的温度分布问题,对横封感应加热的温度场进行了数值建模和计算.在横向磁通原理的基础上,结合横封过程和所用铝塑复合包材的特点,研究了横封感应加热的电磁场和温度场描述方程和边界条件,建立了适用于包装机横封感应加热的电磁场和温度场的数学模型.利用大型通用有限元分析软件ANSYS对感应加热的涡流场和温度场进行了仿真.通过分析包材封合截面的各向温度分布情况,证明模拟实际工况下的温度分布满足封合要求.仿真结果为工程应用提供了参考.

关键词：包装机横封横向磁通感应加热涡流场温度场

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改进虚拟信号注入永磁同步电机MTPA控制

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电机与控制学报 2022年第9期26卷 1-8页

作者：邱建琪宋攀陈卓易史涔溦浙江大学电气工程学院浙江杭州310027 浙大宁波理工学院信息科学与工程学院浙江宁波315100

虚拟信号注入最大转矩电流比(MTPA)控制能够自寻优到电机MTPA工作点,相比于传统的公式法受到电机参数变化的影响较小。但传统的虚拟信号注入控制策略需要经过复杂的坐标变换过程,从d-q坐标系转到极坐标系,再由极坐标系转回d-q坐标系进... 详细信息

虚拟信号注入最大转矩电流比(MTPA)控制能够自寻优到电机MTPA工作点,相比于传统的公式法受到电机参数变化的影响较小。但传统的虚拟信号注入控制策略需要经过复杂的坐标变换过程,从d-q坐标系转到极坐标系,再由极坐标系转回d-q坐标系进行解算,运算量较大。本文提出一种新的虚拟信号注入方法,可以避免原虚拟信号注入方法所需的复杂的坐标变换过程,简化了运算过程。并且新的虚拟信号注入方法可以避免原虚拟信号注入方法因忽略电磁转矩泰勒展开的高阶偏导项而引入的误差。在不同工况下对电机进行了仿真和实验,验证了所提虚拟信号注入MTPA控制策略的动静态性能。实验结果表明所提方法不影响控制精度,同时可以显著减少程序运算量,具有更好的实用价值。

关键词：永磁同步电机矢量控制最大转矩电流比控制自寻优虚拟信号注入

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多属性泛化的K-匿名算法

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电子科技大学学报 2017年第6期46卷 896-901页

作者：宋明秋王琳姜宝彦邓贵仕大连理工大学系统工程研究所大连辽宁116024

针对现有的K-匿名模型中存在泛化属性选取不唯一和数据过度泛化的问题,提出多属性泛化的K-匿名算法。在K-匿名模型实现的过程中,引入属性近似度概念,定量刻画准标识符属性的离散程度,进而确定泛化的准标识符属性;同时采用广度优先泛化... 详细信息

针对现有的K-匿名模型中存在泛化属性选取不唯一和数据过度泛化的问题,提出多属性泛化的K-匿名算法。在K-匿名模型实现的过程中,引入属性近似度概念,定量刻画准标识符属性的离散程度,进而确定泛化的准标识符属性;同时采用广度优先泛化的方法,避免数据被过度泛化,最终实现数据表的K-匿名要求。实验结果表明,多属性泛化的K-匿名模型可以提高泛化后数据精度,其处理效率和Datafly算法相当。该算法有效地解决了取值最多准标识符属性存在多个时的泛化属性选取问题,并且防止属性被过度泛化,提高数据的可用性。

关键词：泛化 K-匿名隐私保护关系型数据

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甘肃临夏盆地椒子沟组上部满散村小哺乳动物群

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古脊椎动物学报（中英文） 2023年第2期61卷 123-141页

作者：王伴月邱占祥王世骐中国科学院古脊椎动物与古人类研究所北京100044

记述了中国科学院古脊椎动物与古人类研究所一野外队于2015年在甘肃临夏盆地东乡县满散村附近的椒子沟组上部首次发现的6属10种小哺乳动物化石。其中4个属(Sinolagomys, Litodonomys, Heterosminthus和Yindirtemys)已知最早出现于晚渐新... 详细信息

记述了中国科学院古脊椎动物与古人类研究所一野外队于2015年在甘肃临夏盆地东乡县满散村附近的椒子沟组上部首次发现的6属10种小哺乳动物化石。其中4个属(Sinolagomys, Litodonomys, Heterosminthus和Yindirtemys)已知最早出现于晚渐新世;两个种(Sinolagomys kansuensis和Heterosminthus lanzhouensis)仅在晚渐新世出现过。该动物群(及其产出地层)的时代很可能为晚渐新世,可称为晚渐新世满散村动物群。该动物群中有一些在牙沟动物群(产于椒子沟组下部)中尚未出现的更晚的属种,并且缺少那些在牙沟动物群中存在的较古老的属种。结合两个动物群的产出层位,满散村动物群的时代要比牙沟动物群晚。如果牙沟动物群的时代为晚渐新世早期,满散村动物群的时代很可能为晚渐新世晚期。这样,椒子沟组可能代表了整个晚渐新世时期的沉积。满散村动物群与亚洲已知的生物带和中国已知的晚渐新世哺乳动物群比较,比我国内蒙古乌兰塔塔尔生物带III和蒙古湖谷地区的生物带C和C1的时代要晚,而与我国西北地区峡沟、塔奔布鲁克、伊克布拉格和铁尔斯哈巴合动物群(或组合)时代相近,比石羌子沟动物群的时代稍晚。

关键词：甘肃临夏满散村晚渐新世椒子沟组小哺乳动物化石

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