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Genes & Diseases 2024年第1期11卷 84-86页

作者： Ke Gong Zhiping Tan Haidan Liu Xiaobo Liao Xinmin Zhou Bangliang Yin shi zeng Yao Yao Yifeng Yang Li Xie Department of Cardiovascular Surgery The Second Xiangya Hospital of Central South UniversityCentral South UniversityChangshaHunan410011China Department of Ultrasound The Second Xiangya Hospital of Central South UniversityCentral South UniversityChangshaHunan 410011China Department of Blood Transfusion The Second Xiangya Hospital of Central South UniversityCentral South UniversityChangshaHunan 410011China

Dilated cardiomyopathy(DCM)is a frequently inherited heart condition.A familial transmission rate of 20%-35%has been documented,and most of these cases are autosomal *** condition has a high rate of morbidity and mort... 详细信息

关键词： GSK3β cardiomyopathy mortality

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多普勒超声评估法洛四联症胎儿肺动脉阻力

中华超声影像学杂志 2024年第3期33卷 236-241页

作者：刘玉姗曾施徐冉周丹杨阳徐赣琼中南大学湘雅二医院超声诊断科长沙410011 中南大学湘雅二医院泌尿外科长沙410011

目的应用多普勒超声心动图评估法洛四联症(TOF)胎儿的肺动脉干(MPA)及左、右分支远段的血流阻力特征。方法前瞻性收集2022年8月至2023年1月中南大学湘雅二医院42例TOF胎儿(TOF组)和84例胎龄匹配的正常胎儿(对照组)。按肺动脉瓣环Z score... 详细信息

目的应用多普勒超声心动图评估法洛四联症(TOF)胎儿的肺动脉干(MPA)及左、右分支远段的血流阻力特征。方法前瞻性收集2022年8月至2023年1月中南大学湘雅二医院42例TOF胎儿(TOF组)和84例胎龄匹配的正常胎儿(对照组)。按肺动脉瓣环Z score将TOF分为轻度(Z score≥-2)、中度(-40.05),重度TOF组DLPA-PI明显低于轻度TOF组(P<0.05)。结论中晚孕期TOF胎儿的肺动脉干阻力明显大于正常胎儿。TOF胎儿肺动脉分支远段的阻力降低,尤其是左肺动脉远段。需要进一步的大型随访研究证明TOF患者的血管阻力改变与肺动脉发育之间的关系。

关键词：超声心动描记术肺动脉阻力法洛四联症胎儿搏动指数

唑来膦酸注射液可能致横纹肌溶解综合征一例报告

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中华骨质疏松和骨矿盐疾病杂志 2024年第3期17卷 252-258页

作者：曾施琪翟琳娜陈文辉广西中医药大学南宁530001 广西中医药大学第一附属医院内分泌科南宁530023

唑来膦酸注射液是临床上治疗骨质疏松的一线用药,使用唑来膦酸后出现横纹肌溶解综合征的情况罕有发生。本文报道一例老年骨质疏松女性患者,在使用唑来膦酸后出现横纹肌溶解伴肝肾功能损害。基于诺氏(Naranjo's)药物不良反应评估量表判... 详细信息

唑来膦酸注射液是临床上治疗骨质疏松的一线用药,使用唑来膦酸后出现横纹肌溶解综合征的情况罕有发生。本文报道一例老年骨质疏松女性患者,在使用唑来膦酸后出现横纹肌溶解伴肝肾功能损害。基于诺氏(Naranjo's)药物不良反应评估量表判定该患者使用唑来膦酸与横纹肌溶解综合征发生的因果关系为可能。其发病机制可能与唑来膦酸诱发低磷血症,导致组织细胞氧化磷酸化受阻,红细胞存储损伤造成组织器官严重缺氧缺血有关。现报道该罕见病例的病情及治疗经过,探讨该特殊情况的防治策略。

关键词：唑来膦酸双膦酸盐类横纹肌溶解综合征骨质疏松症

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林果园鸡舍横向通风系统优化设计及仿真验证

机械设计与制造 2024年第2期396卷 139-143页

作者：张学军张宝安史增录新疆农业大学机电工程学院新疆乌鲁木齐市830052 新疆农业工程装备创新设计实验室重点实验室新疆乌鲁木齐830052

为探究新疆南疆地区推广使用的林果园鸡舍冬季最小通风口的设置,使鸡舍达到及时换气且保温的效果。对舍内危害较高的NH_(3)、H_(2)S的扩散和浓度分布情况进行了CFD仿真分析,通过数值建模、网格划分,采用标准k~ε湍流模型和SIMPLE的有限... 详细信息

为探究新疆南疆地区推广使用的林果园鸡舍冬季最小通风口的设置,使鸡舍达到及时换气且保温的效果。对舍内危害较高的NH_(3)、H_(2)S的扩散和浓度分布情况进行了CFD仿真分析,通过数值建模、网格划分,采用标准k~ε湍流模型和SIMPLE的有限元体积求解法分析,结果显示密闭鸡舍侧墙近壁面区域气体扩散速率较高,上层近两侧墙壁面区气体浓度较高;18℃室温实际测量试验,验证了CFD气体分布仿真的准确性,同时测得NH_(3)浓度普遍高于H_(2)S;禽舍上层近壁面区开设通风口,CFD验证结果表明在0.01m/s的初始扩散速率下,禽舍气体低浓度均匀分布无死角,浓度均值为1.18mg/m^(3)。借助SiemensPLC搭建基于气体浓度传感器通风系统,贯穿式间歇性通风,控制舍内气体浓度,可使冬季鸡舍内通风达到良好的效果。

关键词：林果园鸡舍封闭式通风口 CFD 仿真模拟通风控制

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Application of k-means clustering to environmental risk zoning of the chemical industrial area

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Frontiers of Environmental Science & Engineering 2014年第1期8卷 117-127页

作者： Weifang shi Weihua zeng State Key Joint Laboratory of Environmental Simulation and Pollution Control School of Environment Beijing Normal University Beijing 100875 China

The homogeneous risk characteristics within a sub-area and the heterogeneous from one sub-area to another are unclear using existing environmental risk zoning methods. This study presents a new zoning method by determining and categorizing the risk characteristics using the k-means clustering data mining technology. The study constructs indices and develops index quantification models for environmental risk zoning by analyzing the mechanism of environmental risk occurrence. We calculate the source risk index, air risk field index, water risk field index, and target vulnerability of the study area with Nanjing Chemical Industrial Park using a 100 m - 100 m mesh grid as the basic zoning unit, and then use k-means clustering to analyze the environmental risk in the area. We obtain the optimal clustering number with the largest average silhouette coefficient by calculating the average silhouette coefficients of clustering at different k-values. The clustering result with the optimal clustering number is then used for the environmental risk zoning, and the zoning result is mapped using the geographic information system. The study area is divided into five sub-areas. The common environmental risk characteristics within the same sub-area, as well as the differences between sub- areas, are presented. The zoning is helpful in risk management and is convenient for decision makers to distribute limited resources to different sub-areas in the design of risk reducing intervention.

关键词： environmental risk zoning k-means cluster-ing silhouette coefficient chemical industrial park riskmanagement

正常中晚孕胎儿左心室流入道与流出道夹角的正常参考值

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中华超声影像学杂志 2024年第5期33卷 421-426页

作者：谭贺依曾施杨阳周丹刘玉姗周嘉炜徐赣琼中南大学湘雅二医院超声科长沙410011

目的建立中晚孕期正常胎儿左心室流入道与流出道夹角(LIOA)参考范围,观察胎儿LIOA与孕周、心轴、心腔大血管内径、估测胎儿体重(EFW)的相关性。方法前瞻性收集2022年11月至2023年4月于中南大学湘雅二医院行胎儿超声检查的中晚孕期(16~3... 详细信息

目的建立中晚孕期正常胎儿左心室流入道与流出道夹角(LIOA)参考范围,观察胎儿LIOA与孕周、心轴、心腔大血管内径、估测胎儿体重(EFW)的相关性。方法前瞻性收集2022年11月至2023年4月于中南大学湘雅二医院行胎儿超声检查的中晚孕期(16~39+6周)单胎胎儿651例。二维超声获取胎儿LIOA,建立中晚孕正常LIOA范围。采用Pearson相关分析法分析胎儿LIOA与孕周、心轴、心腔大血管内径、EFW的相关性。结果651例正常胎儿LIOA范围为(44.39±7.67)°。LIOA与心轴呈轻度正相关(r=0.22,P0.05)。结论正常胎儿LIOA在妊娠中晚期是恒定的,其与心轴呈轻度正相关。建立胎儿LIOA正常参考值可为深入研究胎儿主动脉生物力学和血流动力学提供有效数据。

关键词：超声心动描记术胎儿胎儿左心室流入道与流出道夹角心轴心腔大血管内径

Radioactive source terms for the Fukushima nuclear accident

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Science China Earth Sciences 2016年第1期59卷 214-222页

作者： LIN WuHui CHEN LiQi YU Wen MA Hao zeng Zhi zeng shi School of Marine Seienee Guangxi University Nanning 530004China Laboratory of Marine lsotopie Technology and Environmental Risk Assessment Third Institute of OceanographyXiamen 361005China Key Laboratory of Global Change and Marine-Atmospheric Chemistry State Oceanic AdministrationXiamen 361005China Department of Engmeering Physics Tsinghua UniversityBeijing 100084China

A large amount of radioactivity was released into the environment after the Fukushima nuclear accident （FNA） in Japan in 2011. This radioactivity had a significant impact on the global environment, and there was much public concern about its effects. The subsequent assessment of the FNA and the environmental remediation required are proving to be long and complicated tasks. The assessments are based on the radioactive source terms for the FNA, which determine the level of damage caused by the nuclear accident. We investigated the radioactive source terms from three aspects： the amount and composition of the radionuclides; the activity and atomic ratio of the radionuclides; and comparison with other historical events. The total amount of radioactivity, excluding the radioactive noble gases （85Kr and 133Xe）, released by the FNA was about 10% of that released by the Chernobyl nuclear accident in 1986 and 〈1%o of the global fallout from the atmosphere nuclear explosion. However, the FNA was the most serious nuclear accident in terms of radioactive pollution of the marine environment. The recovery actions carried out after the FNA have been evaluated and the environmental impacts of the FNA are discussed.

关键词： Fukushima Nuclear Accident Chernobyl Nuclear Accident Global fallout Radioactivity Atmospheric pollution Marine pollution

荔枝落果中A型低聚原花青素抑制类甜蛋白促炎机制

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食品科学 2024年第8期45卷 145-152页

作者：罗杨合曾诗蔼李洛欣谢翀闫景坤李玉婷罗英捷赵雷广西康养食品科学与技术重点实验室(贺州学院) 广西贺州542899 华南农业大学食品学院广东广州510642 东莞理工学院生命健康技术学院广东东莞523808 营家健康科技(广东)有限公司广东东莞523000

以荔枝落果中的A型低聚原花青素为研究对象,探讨其对荔枝类甜蛋白(litchi thaumatin-like protein,LcTLP)促炎的抑制机理。采用乙醇提取、大孔吸附树脂纯化以及制备液相色谱仪等从荔枝落果中分离得到A型低聚原花青素(A-type oligomeric ... 详细信息

以荔枝落果中的A型低聚原花青素为研究对象,探讨其对荔枝类甜蛋白(litchi thaumatin-like protein,LcTLP)促炎的抑制机理。采用乙醇提取、大孔吸附树脂纯化以及制备液相色谱仪等从荔枝落果中分离得到A型低聚原花青素(A-type oligomeric proanthocyanidins,A-OPC)纯化物,并对A-OPC结构鉴定,主要成分为原花青素A2、2个A型原花青素三聚体和1个A型四聚体,纯度达88.69%。利用LcTLP诱导构建RAW264.7细胞炎症模型,A-OPC的添加可抑制LcTLP诱导RAW264.7细胞的一氧化氮、细胞炎症因子白细胞介素-6和肿瘤坏死因子-α的分泌,在120μg/mL质量浓度下,抑制率分别可达58.38%、39.80%和86.31%(P<0.01)。蛋白免疫印迹分析发现,在120μg/mL质量浓度下A-OPC可降低诱导型一氧化氮合酶和环氧合酶2的表达量,并显著降低p65、核因子κB抑制蛋白、c-Jun氨基末端激酶、细胞外信号调节蛋白激酶和p38的磷酸化水平,说明A-OPC通过下调核转录因子-κB和丝裂原活化蛋白激酶通路中下游蛋白的磷酸化水平抑制LcTLP诱导的炎症反应。

关键词：荔枝落果 A型低聚原花青素荔枝类甜蛋白抗炎机制

Observations of the Singlets of Higher-Degree Modes Based on the OSE

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Journal of Earth Science 2018年第6期29卷 1398-1408页

作者： shi-Yu zeng Wen-Bin Shen School of Geodesy and Geomatics/Key Laboratory of the Geospace Environment and Geodesy Wuhan University State Key Laboratory for Information Engineering in Surveying Mapping and Remote SensingWuhan University

In this study,we selected 18 SG（superconducting gravimeter）records from 15 GGP stations with 99 vertical and 69 horizontal components of IRIS broad-band seismograms during 2004 Sumatra Earthquake to detect the splitting of higher-degree Earth’s free oscillations modes（0S4,0S7〈sub〉0S10,2S4,1S5,2S5,1S6）and 12 inner-core sensitive modes（25S2,27S2,6S3,9S3,13S3,15S3,11S4,18S4,8S5,11S5,23S5,16S6）by using OSE（optimal sequence estimation）method which only considers *** indicate that OSE can completely isolate singlets of high-degree modes in time-domain,effectively resolve the coupled multiplets independently,and reduce the possibility of mode mixing and end effect,showing that OSE could improve some signals’signal-to-noise *** the results of SG records with seismic data sets suggests that the number of SG records is inadequate to detect all singlets of higher *** we mainly selected plentiful seismograms of IRIS to observe the multiplets of higher *** estimate frequencies of the singlets using AR method and evaluate the measurement error using bootstrap ***,we compared the observations with the predictions of PREM-tidal *** study demonstrates that OSE is effective in isolating singlets of Earth’s free oscillations with higher *** experimental results may provide constraints to the construction of 3D Earth model.

关键词： free oscillation mode splitting detection high-degree modes OSE

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多种超声模式在前列腺癌诊断中的应用

医学影像学杂志 2024年第3期34卷 104-108页

作者：刘玉姗徐冉曾施中南大学湘雅二医院超声诊断科湖南长沙410011 中南大学湘雅二医院泌尿外科湖南长沙410011

前列腺癌(prostate cancer,PCa)的临床诊断方法正朝着影像学方向发展。超声影像新技术包括微多普勒超声、超声弹性成像、超声造影和微超声(micro ultrasound)等。多参数超声(multiparameter ultrasound,mpUS)作为两种或两种以上超声技... 详细信息

前列腺癌(prostate cancer,PCa)的临床诊断方法正朝着影像学方向发展。超声影像新技术包括微多普勒超声、超声弹性成像、超声造影和微超声(micro ultrasound)等。多参数超声(multiparameter ultrasound,mpUS)作为两种或两种以上超声技术的组合模式,可为临床诊断PCa提供补充的影像学信息,在PCa的诊断中具有很大的潜力。本文就多种超声影像技术在PCa诊断中的应用及发展进行综述。

关键词：多参数超声前列腺癌超声造影超声弹性成像超声分子成像