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Interpretable Machine Learning Method for Compressive Strength Prediction and Analysis of Pure Fly Ash-based Geopolymer Concrete

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 65-78页

作者： shi Yuqiong LI Jingyi zHANG Yang LI Li Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid Areas of Ministry of Education Northwest A&F Uni-versityYangling 712100China College of Water Resources and Architectural Engineering Northwest A&F UniversityYangling 712100China Chongqing Key Laboratory of Public Big Data Security Technology Chongqing 401420China Chongqing College of Mobile Communication Chongqing 401520China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina National Rail Transit Electrification and Automation Engineering Technology Research Center(Hong Kong Branch) The Hong Kong Polytechnic UniversityKowloonHung HomHong KongChina

In order to study the characteristics of pure fly ash-based geopolymer concrete(PFGC)conveniently,we used a machine learning method that can quantify the perception of characteristics to predict its compressive *** this study,505 groups of data were collected,and a new database of compressive strength of PFGC was *** order to establish an accurate prediction model of compressive strength,five different types of machine learning networks were used for comparative *** five machine learning models all showed good compressive strength prediction performance on *** them,R2,MSE,RMSE and MAE of decision tree model(DT)are 0.99,1.58,1.25,and 0.25,*** R2,MSE,RMSE and MAE of random forest model(RF)are 0.97,5.17,2.27 and 1.38,*** two models have high prediction accuracy and outstanding generalization *** order to enhance the interpretability of model decision-making,we used importance ranking to obtain the perception of machine learning model to 13 *** 13 variables include chemical composition of fly ash(SiO_(2)/Al_(2)O_(3),Si/Al),the ratio of alkaline liquid to the binder,curing temperature,curing durations inside oven,fly ash dosage,fine aggregate dosage,coarse aggregate dosage,extra water dosage and sodium hydroxide *** temperature,specimen ages and curing durations inside oven have the greatest influence on the prediction results,indicating that curing conditions have more prominent influence on the compressive strength of PFGC than ordinary Portland cement *** importance of curing conditions of PFGC even exceeds that of the concrete mix proportion,due to the low reactivity of pure fly ash.

关键词： machine learning pure fly ash geopolymer compressive strength feature perception

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Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie z.Li Nagendran Ramalingam Shaomin Li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

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长江河口北槽的周期性层化对潮流椭圆垂向结构的影响鏯

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海洋科学进展 2018年第3期36卷 352-362页

作者：浦祥时钟胡国栋上海交通大学船舶海洋与建筑工程学院上海200030 海洋工程国家重点实验室上海200030 高新船舶与深海开发装备协同创新中心上海200030 长江口水文水资源勘测局上海200136

基于现场观测流速、盐度资料,通过采用整体理查森计算公式、潮汐调和分析理论,本项研究定量分析了长江河口北槽的周期性层化对M2半日分潮潮流椭圆垂向结构的影响。结果显示:小潮期间层化显著强于大潮,仅小潮出现密度跃层。在向陆端位于... 详细信息

基于现场观测流速、盐度资料,通过采用整体理查森计算公式、潮汐调和分析理论,本项研究定量分析了长江河口北槽的周期性层化对M2半日分潮潮流椭圆垂向结构的影响。结果显示:小潮期间层化显著强于大潮,仅小潮出现密度跃层。在向陆端位于导堤和丁坝内的各站位,各层的潮流椭圆均退化为往复流形式;然而,在向海端位于导堤和丁坝外的站位,各层的潮流椭圆均呈顺时针旋转。小潮期间整体理查森数与表、底层潮流椭圆率之差呈现清晰的正线性相关关系,表明层化对潮流椭圆的垂向结构有显著影响。在向海端位于导堤和丁坝外的站位,小潮期间表、底层潮流椭圆倾角差达到约40°,而大潮为10°以下。小潮期间大多数站位的表、底层潮流椭圆相角差达到20°~50°,而大潮为10°以下,小、大潮周期性变化明显。潮流椭圆倾角和相角都在密度跃层处存在明显的垂向突变。在强层化的小潮期间,层化导致的密度跃层处垂向涡动粘性系数的剧烈衰减可能是潮流椭圆椭圆率、倾角和相角垂向变化的主要物理因素。

关键词：潮流椭圆层化密度跃层椭圆率长江口北槽

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Single-cell technologies: current and near future

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Science China Life Sciences 2025年第1期68卷 1-4页

作者： Chenfei Wang Qi Liu Xiaohui Fan Tieliu shi Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration Ministry of EducationOrthopedics DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Key Laboratory of Advanced Theory and Application in Statistics and Data Science (MOE) School of StatisticsEast China Normal University

Single-cell technologies enable the indepth exploration of multiple biological hierarchies at the scale of individual cells,which have deepened our knowledge of cellular diversity, tissue organization, and overall organism function(Sun et al.,2024). In 2009, single-cell RNA sequencing(sc RNA-seq) was first developed as a powerful tool to dissect gene expression and uncover transcriptional *** the rapid advancement of technology, single-cell approaches have expanded to encompass other omics, such as genomics, epigenomics, proteomics,and metabolomics.

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长江河口北槽弯道环流的涡度研究

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海洋与湖沼 2017年第4期48卷 682-694页

作者：李为时钟浦祥胡国栋上海交通大学船舶海洋与建筑工程学院海洋工程国家重点实验室和高新船舶与深海开发装备协同创新中心上海200030 长江口水文水资源勘测局上海200136

基于ADCP走航观测得到长江河口北槽弯道附近3个横向断面(AD3、AD5和AD6)的流速资料,采用涡度方法,本文计算、分析了弯道环流与混合在垂直横向上的时空分布、影响因素及其重要性。3个横向断面上均存在由不规则界面分开的二层结构的横向... 详细信息

基于ADCP走航观测得到长江河口北槽弯道附近3个横向断面(AD3、AD5和AD6)的流速资料,采用涡度方法,本文计算、分析了弯道环流与混合在垂直横向上的时空分布、影响因素及其重要性。3个横向断面上均存在由不规则界面分开的二层结构的横向环流。半拉格朗日余流的计算结果显示:(1)小潮期间,AD3、AD5和AD6断面呈现表层向海、底层向陆的纵向环状半拉格朗日余流;大潮期间,呈现表、底层均向海的纵向半拉格朗日余流;(2)小潮期间,AD3断面呈现表层向北导堤、底层向南导堤的横向环状半拉格朗日余流;大潮期间,AD3断面中间区域呈现表层向北导堤、底层向南导堤的、而断面两端区域则呈现表层向南导堤、底层向北导堤的横向环状半拉格朗日余流;(3)小、大潮期间,横向断面AD5和AD6均呈现表层向北导堤、底层向南导堤的横向环状半拉格朗日余流;(4)"纵向半拉格朗日余流"在–0.2—0.7m/s;横向半拉格朗日余流"在–0.15—0.2m/s;(5)纵向半拉格朗日余流在横向上有明显变化。对弯道环流的进一步分析表明:(1)斜压梯度、内部摩擦致混合和底部摩擦致混合这三项各自的纵向分量是驱动纵向环流形成的主要因素,"纵向动量的横向重新分布项"次之,离心力和地转的影响可忽略;(2)横向斜压梯度和内部摩擦致混合项是驱动横向环流形成的主要因素,离心力、地转和底部摩擦致混合次之;(3)横向环流可能通过"纵向动量的横向重新分布项"减弱纵向动量,从而可能减弱纵向环流。

关键词：长江河口北槽弯道横向环流纵向环流涡度方法半拉格朗日余流

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通过MRI识别BRAF基因突变型颅咽管瘤

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中国现代神经疾病杂志 2020年第3期20卷 185-185页

作者： Yue Q Yu Y shi z Wang Y zhu W Du z Yao z Chen L Mao Y 吴向宸(编译) Departments of Neurosurgery School of Basic Medical Sciences and Institutes of Brain ScienceFudan UniversityShanghaiChina Radiology School of Basic Medical Sciences and Institutes of Brain ScienceFudan UniversityShanghaiChina Pathology Huashan HospitalFudan UniversitySchool of Basic Medical Sciences and Institutes of Brain ScienceFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology School of Basic Medical Sciences and Institutes of Brain ScienceFudan UniversityShanghaiChina 天津市环湖医院神经外科

研究背景BRAF基因突变抑制剂对部分难治性颅咽管瘤具有缩小肿瘤体积的作用,是一种具有临床应用前景的治疗方法,可用于颅咽管瘤的术前治疗,有助于切除肿瘤。本研究探讨基于MRI特征的BRAF基因突变型颅咽管瘤的非侵袭性诊断技术。方法共纳... 详细信息

研究背景BRAF基因突变抑制剂对部分难治性颅咽管瘤具有缩小肿瘤体积的作用,是一种具有临床应用前景的治疗方法,可用于颅咽管瘤的术前治疗,有助于切除肿瘤。本研究探讨基于MRI特征的BRAF基因突变型颅咽管瘤的非侵袭性诊断技术。方法共纳入52例经术后病理确诊的颅咽管瘤患者,采用聚合酶链反应(PCR)检测肿瘤标本BRAF和CTNNB1基因突变。由两位不知晓患者身份和BRAF基因突变等临床信息的神经影像学专家对颅咽管瘤患者的MRI表现(包括肿瘤部位、大小、形状和成分,囊肿信号强度和强化特征,垂体柄形态,颈内动脉毗邻关系)以及临床特征(包括BRAF基因突变)进行分析。比较BRAF基因突变型与野生型颅咽管瘤的MRI表现。BRAF基因突变型颅咽管瘤中具有明显特征(P<0.05)的MRI表现定义为诊断特征。采用受试者工作特征(ROC)曲线确定临床诊断BRAF基因突变型颅咽管瘤所需的最少MRI诊断特征。结果52例患者中8例为BRAF基因突变型颅咽管瘤,44例为野生型颅咽管瘤,二者临床特征无显著差异。两位神经影像学专家的MRI数据分析结果具有较高的一致性,Kappa一致性检验(κ值)为0.65~0.97。与野生型颅咽管瘤相比,BRAF基因突变型颅咽管瘤表现为向鞍上生长(P<0.001)、呈球形(P=0.005)、主要为实性结构(P=0.003)、均匀强化(P<0.001)和垂体柄增粗(P=0.014)等5项MRI特征。当这5项特征中至少存在3项时可诊断为BRAF基因突变型颅咽管瘤,其灵敏度为100%、特异度为91%,ROC曲线下面积为0.989(P<0.001)。结论通过MRI特征诊断BRAF基因突变型颅咽管瘤具有较高的敏感性和特异性,从而为BRAF基因突变抑制剂的术前应用提供指导意见。

关键词：突变型颅咽管瘤 MRI

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Efficient photocatalytic reduction of CO2 to formate by a molecular noble metal-free system

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Science China Chemistry 2025年第1期68卷 152-156页

作者： Lihua zhang Lingjing Chen Huatian shi Yue Wei Gui Chen Tai-Chu Lau School of Environment and Civil Engineering Research Center for Eco-environmental Engineering Dongguan University of Technology Department of Chemistry and Institute of Molecular Functional Materials City University of Hong Kong

Reducing CO2to carbon-neutral solar fuels can not only alleviate the energy demand but also mitigate the greenhouse *** present,developing an efficient non-noble metal photo/electrocatalytic system for converting CO2to a specific product beyond CO is still a big ***,we report a new cobalt complex bearing 2,2′-bi-1,10-phenanthroline ligand that can photocatalytically reduce CO2to formate （HCOO-）.Turnover number （TON） for HCOO-up to 677 with 99%selectivity can be achieved using organic dyes purpurin as photosensitizer and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole （BIH） as sacrificial reductant in a CO2-saturated NMP/TEA （v/v,3:1） solution under visible light *** potential electrolysis at-1.41 V （***/Ag Cl） in the presence of 12 m M Et3NHBF4also produced HCOO-with Faradaic efficiency of 39%.Spectroscopic and electrochemical studies suggest that a[CoI-H]species is the key intermediate for CO2reduction.

关键词： photocatalysis noble metal-free CO2 reduction formate cobalt hydride

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Wafer‑Scale Ag_(2)S‑Based Memristive Crossbar Arrays with Ultra‑Low Switching‑Energies Reaching Biological Synapses

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Nano-Micro Letters 2025年第3期17卷 328-339页

作者： Yuan zhu Tomas Nyberg Leif Nyholm Daniel Primetzhofer Xun shi zhen zhang Division of Solid‑State Electronics Department of Electrical EngineeringUppsala University75121 UppsalaSweden Department of Chemistry Uppsala UniversityUppsalaSweden Department of Physics and Astronomy Uppsala UniversityUppsalaSweden State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China

Memristive crossbar arrays(MCAs)offer parallel data storage and processing for energy-efficient neuromorphic ***,most wafer-scale MCAs that are compatible with complementary metal-oxide-semiconductor(CMOS)technology still suffer from substantially larger energy consumption than biological synapses,due to the slow kinetics of forming conductive paths inside the memristive *** we report wafer-scale Ag_(2)S-based MCAs realized using CMOS-compatible processes at temperatures below 160℃.Ag_(2)S electrolytes supply highly mobile Ag+ions,and provide the Ag/Ag_(2)S interface with low silver nucleation barrier to form silver filaments at low energy *** further enhancing Ag+migration in Ag_(2)S electrolytes via microstructure modulation,the integrated memristors exhibit a record low threshold of approximately−0.1 V,and demonstrate ultra-low switching-energies reaching femtojoule values as observed in biological *** low-temperature process also enables MCA integration on polyimide substrates for applications in flexible ***,the intrinsic nonidealities of the memristive units for deep learning can be compensated by employing an advanced training *** impressive accuracy of 92.6%in image recognition simulations is demonstrated with the MCAs after the *** demonstrated MCAs provide a promising device option for neuromorphic computing with ultra-high energy-efficiency.

关键词： Wafer-scale Ag_(2)S films Reactive sputter Silver nucleation Ag^(+)migration Energy-efficient neuromorphic computing

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Revealing and predicting the long-term biomechanical response of orthokeratology by developing a patient-specific computational model

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 156-168页

作者： Yifeng Li zhuoran Yang ziming Yan Huibin shi zhanli Liu Kaijie Wang Department of Engineering Mechanics School of Aerospace Engineering Tsinghua University Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Lab

Orthokeratology(OK) is widely used for effective myopia correction and control. However, the incomplete understanding of its biomechanical mechanisms makes OK lens fitting rely heavily on clinician judgment, complicating accurate predictions of treatment outcomes. In this paper, we performed clinical experiments and numerical analysis to study corneal deformation modes and long-term changes in central corneal thickness. Clinical experiments were conducted on 194 Chinese myopic patients under OK treatment for 3 months. Based on the experimental data, a patient-specific computational biomechanical model for OK was established and validated. Specifically, the anisotropic mechanical properties of the cornea were incorporated into the model to describe the significant difference between its shear modulus(29.5 kPa) and tensile modulus(768.4 kPa). Additionally, a viscohyperelastic material model with a prolonged corneal relaxation time of 5.6 h was developed to capture the long-term deformation response. The results show that corneal thickness reduction in OK is primarily due to out-of-plane shear deformation,influenced by the cornea's low shear resistance. Modeling the extended corneal relaxation time is crucial for predicting long-term biomechanical responses. The computational model effectively captures long-term changes in central corneal thickness, potentially improving OK lens fitting accuracy.

关键词： orthokeratology computational biomechanical model long-term viscoelasticity myopia correction

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偶偶核结构相变的微观相互作用玻色子模型方案的分类与特征

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四川大学学报（自然科学版） 2012年第5期49卷 1060-1066页

作者：汪红石筑一童红杨亚碧贵州民族大学理学院贵阳550025

本文基于相互作用玻色子模型的微观方案,探讨了从自由价核子到构建出Arima哈密顿量的两次结构突变:核子配对成理想玻色子(玻色化)和理想玻色子集体化(有序化),据此将原子核相变划分为基准态重组型和玻色子破对型两类.最后,讨论了微观相... 详细信息

本文基于相互作用玻色子模型的微观方案,探讨了从自由价核子到构建出Arima哈密顿量的两次结构突变:核子配对成理想玻色子(玻色化)和理想玻色子集体化(有序化),据此将原子核相变划分为基准态重组型和玻色子破对型两类.最后,讨论了微观相互作用玻色子模型研究原子核相变的特点与不足.

关键词：偶偶核微观IBM方案原子核相变基准态重组型相变玻色子破对型相变

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