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Spontaneous emergence of overgrow. molar teeth in a colony of Prairie voles(Microtus ochrogaster)

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International Journal of Oral Science 2015年第1期7卷 23-26页

作者： Andrew.H Jheon Michaela Prochazkova Michael sherman Devanand S Manoli Nirao M Shah Law.ence Carbone Ophir Klein Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology University of California San Francisco (UCSF) Department of Anthropology and Human Genetics Faculty of Science Charles University in Prague Laboratory Animal Resource Center UCSF Department of Psychiatry UCSF Department of Anatomy UCSF

Continuously grow.ng incisors are common to all rodents, w.ich include the Microtus genus of voles. How.ver, unlike many rodents, voles also possess continuously grow.ng molars. Here, w. report spontaneous molar defects in a population of Prairie voles （Microtus ochrogaster）. w. identified bilateral protuberances on the ventral surface of the mandible in several voles in our colony. In some cases, the protuberances broke through the cortical bone. The mandibular molars became exposed and infected, and the maxillary molars entered the cranial vault. Visualisation upon soft tissue removal and microcomputed tomography （microCT） analyses confirmed that the protuberances w.re caused by the overgrow.h of the apical ends of the molar teeth. w. speculate that the unrestricted grow.h of the molars w.s due to the misregulation of the molar dental stem cell niche. Further study of this molar phenotype may yield additional insight into stem cell regulation and the evolution and development of continuously grow.ng teeth.

关键词： continuously grow.ng teeth molar phenotype mutation stem cell regulation voles

Simultaneous Voltammetric Determination of Cd^(2+), Pb^(2+), and Hg^(2+) Ions Using Aminosepiolite-Coated Glassy Carbon Electrode: Optimization of Detection Parameters via Response Surface Methodology

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Journal of Analysis and Testing 2019年第4期3卷 295-305页

作者： Ervice Ymélé sherman Lesly Zambou Jiokeng Divine Bup Nde Théophile Kamgaing Ignas Kenfack Tonlé Electrochemistry and Chemistry of Materials Department of ChemistryFaculty of ScienceUniversity of DschangP.O.Box 67DschangCameroon Higher Institute of the Sahel University of MarouaP.O.Box 46MarouaCameroon

Adsorptive stripping voltammetry using a glassy carbon electrode modified by a film of aminosepiolite w.s utilized for simultaneous pre-concentration and trace detection of cadmium,lead,and mercury ions in aqueous *** modified sepiolite exploited as electrode material w.s obtained by grafting on its surface of[(3-(2-aminoethylamino)propyl)]trimethoxysilane(AEPTMS).The results demonstrated that the amine groups on sepiolite efficiently affected the voltammetric detection of heavy *** full factorial design matrix and response surface methodology w.re applied in designing experiments,to determine the optimal conditions and to evaluate their mutual *** high values of adjusted R2 obtained of the fitted model show.that the experiments data w.re w.ll explained by the model,w.ich then allow.d to acquire optimum parameters for the electroanalysis and detection of the analytes by differential pulse *** pH 6.5 of accumulating medium,w.th an electrolysis potential of-0.9 V and in the concentration range of 10^(−8) M to 10^(−9) M,calibration plots w.re *** limits of detection(3Sd/m)w.re 8.689×10^(−10) M,8.197×10^(−10) M,and 8.099×10^(−10) M,respectively,for Cd^(2+),Pb^(2+),and Hg^(2+)*** interference effect of several cations and anions on the response of the analytes w.s also evaluated,and finally,the sensor w.s applied to the simultaneous detection of metal ions in tap w.ter w.th satisfactory recovery rates.

关键词： Aminosepiolite Surface response methodology Factorial design Differential pulse voltammetry Heavy metals

Endoscopy:Have w. gastroenterologists lessened our value through the perception of us as professional proceduralists?

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w.rld Journal of Gastrointestinal Endoscopy 2010年第1期2卷 1-2页

作者： sherman M Chamberlain Section of Gastroenterology Medical College of GeorgiaAugustaGA 30912United States

This is a commentary on the recently published metaanalysis by w.lkins et al w.ich concluded that primary care physicians are able to provide comparable quality in performing colonoscopic colon cancer screening as gas... 详细信息

关键词： Gastroenterologist Endoscopy Proceduralist Professional

Increases in Mortality for All Causes and All Cancers Combined before and after Startup of a Nuclear Pow.r Plant in New.Jersey, USA

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Journal of Environmental Protection 2019年第4期10卷 488-499页

作者： Joseph Mangano Janette sherman Radiation and Public Health Project New York NY USA

The Salem/Hope Creek nuclear plant in southern New.Jersey is one of just four U.S. plants w.th three large reactors (all others consist of one or tw.). These reactors started operations in 1976, 1980, and 1986 and routinely released toxic radioactive gases and particles into the environment. Only a single study has been performed by federal officials on cancer near nuclear plants—a study now.30 years old. A review.of official mortality data using four-year periods show. the Salem County cancer death rate w.s consistently just below.that of other New.Jersey counties up to the mid-1980s. How.ver, from 1983-1986 to 2015-2017, the county rate soared from -5.4% below.the rest of the state to +32.6% above. The county/state mortality ratio for all causes also increased rapidly in these periods, from +0.6% above to +28.4% above the state. Salem now.has the highest cancer death rate, and the 2nd highest total death rate of any New.Jersey county. Had the 1983-1986 county-state ratios not changed in the follow.ng 31 years, 3493 few.r deaths (1018 of them from cancer) w.uld have occurred among Salem County residents. The lack of any apparent etiologies that could have caused such a dramatic and unexpected change, plus the fact that the Salem/Hope Creek reactors are aging, corroding, and more prone to leaking radionuclides, emphasizes the immediate need for more studies of this type, and the inclusion of local health as a crucial factor in public decisions on the plant’s future.

关键词： Radiation Nuclear Pow.r Nuclear Reactors Radioactivity Cancer

乙酰胆碱减小猫外膝体中继细胞低阈值T—型钙电导

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生理学报 1997年第3期49卷 307-313页

作者：罗荪 S.M.sherman 中国科学院上海脑研究所上海200031

在离体猫丘脑脑片上观察了乙酰胆碱对外膝体中继神经元膜的低阈值T-型钙电导的影响。电流箝位和电压箝位实验结果都显示：将膜电位箝制到给药前的对照水平，排除了乙酰胆碱的去极化作用后，大多数（82％）外膝体神经元的低阈值钙电导仍... 详细信息

在离体猫丘脑脑片上观察了乙酰胆碱对外膝体中继神经元膜的低阈值T-型钙电导的影响。电流箝位和电压箝位实验结果都显示：将膜电位箝制到给药前的对照水平，排除了乙酰胆碱的去极化作用后，大多数（82％）外膝体神经元的低阈值钙电导仍然被乙酰胆碱所抑制。说明这种抑制作用独立于乙酰胆碱引起的膜电位变化，而是对低阈值T-型钙通道的直接作用。

关键词：外膝体乙酰胆碱 T型钙通道钙电导

Rising Thyroid Cancer Incidence Proximate to a New.York City-Area Nuclear Pow.r Plant

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Journal of Environmental Protection 2017年第12期8卷 1446-1459页

作者： Joseph Mangano Janette sherman Radiation and Public Health Project New York NY USA

Thyroid cancer incidence has risen steadily in the US for several decades. w.ile any cause of this trend has yet to be clearly identified, most analyses have concluded that there are factors other than improved detection accounting for the increase. Since exposure to radioactive iodine is the only acknow.edged root cause of thyroid cancer, a review.of temporal trends in incidence since the late 1970s near the Indian Point nuclear pow.r plant, just 23 miles from the New.York City border, w.s conducted. Rates in the four counties closest to Indian Point, w.ere virtually the entire population resides w.thin 20 miles of the plant, w.re compared w.th national trends in the US. The relative ratio in the local area w.s 0.778 in the period 1976-1981, or 22.2 percent low.r than the national rate. This ratio increased steadily, to 1.579 (57.9 percent greater than the US) by the period 2000-2004, w.ich slightly declined to 1.515 (51.5 percent greater) in the latest period available (2010-2014). Significant increases occurred for both males and females, and in each of the four counties. Annual new.cases diagnosed among residents of the four counties increased from 51 to 412 betw.en 1976-1981 and 2010-2014. Because the tw. large reactors at Indian Point began operations in 1973 and 1976, and exposures to radioiodine isotopes can manifest as cancer from five years to several decades after exposure, iodine emissions from Indian Point emissions should be considered as a potential factor in these trends. More studies near Indian Point and other nuclear installations should be conducted to further explore this potential association.

关键词： Thyroid Cancer Radiation Iodine Nuclear Pow.r Nuclear Reactor

Chen Yao-huang, Integrate and Divide： The Communist Revolution in Hebei Area, 1921-1949 （in Chinese）

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Frontiers of History in China 2013年第4期8卷 621-624页

作者： sherman Xiaogang Lai Royal Military College of Canada

For decades, the victory of the Chinese Communist Party （CCP） has been fascinating historians of modem China w.o w.rk outside of the People＇s Republic of China. After recognizing the complexity of the Chinese Revolution, they have tended to focus on specific regions, applying the approaches of a variety of disciplines including sociology, a trend that gave rise to the field of ＂base area studies,＂ marked by the publishing of Mark Sheldon＇s The Yenan w.y in 1971. This new.book by Chen Yao-huang is another remarkable contribution to the study of base areas.

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The tempest

Total pancreatectomy w.th islet cell transplantation vs intrathecal narcotic pump infusion for pain control in chronic pancreatitis

作者： w.lliam Shakespeare edited by Peter Hulme and w.lliam H. sherman.

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w.rld Journal of Gastroenterology 2016年第16期22卷 4160-4167页

作者： Mohamad Mokadem Lama Noureddine Thomas How.rd Lee Mc Henry Stuart sherman Evan L Fogel James L w.tkins Glen A Lehman Division of Gastroenterology and Hepatology Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa IA 52242 United States Division of Nephrology and Hypertension Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa IA 52242 United States Community Health Netw.rk Indianapolis IN 46219 United States Division of Gastroenterology and Hepatology Indiana University Medical Center Indianapolis IN 46202 United States

AIM: To evaluate pain control in chronic pancreatitis patients w.o underw.nt total pancreatectomy w.th islet cell transplantation or intrathecal narcotic pump ***: w. recognized 13 patients w.o underw.nt intrathecal narcotic pump(ITNP) infusion and 57 patients w.o underw.nt total pancreatectomy w.th autologous islet cell transplantation(TP + ICT) for chronic pancreatitis(CP) pain control betw.en 1998 and 2008 at Indiana University Hospital. All patients had already failed multiple other modalities for pain control and the decision to proceed w.th either intervention w.s made at the discretion of the patients and their treating physicians. All patients w.re evaluated retrospectively using a questionnaire inquiring about their pain control(using a 0-10 pain scale), daily narcotic dose usage, and hospital admission days for pain control before each intervention and during their last follow.up. RESULTS: All 13 ITNP patients and 30 available TP + ICT patients w.re evaluated. The mean age w.s approximately 40 years in both groups. The median duration of pain before intervention w.s 6 years and 7 years in the ITNP and TP + ICT groups, respectively. The median pain score dropped from 8 to 2.5(on a scale of 0-10) in both groups on their last follow.up. The median daily dose of narcotics also decreased from 393 mg equivalent of morphine sulfate to 8 mg in the ITNP group and from 300 mg to 40 mg in the TP + ICT group. No patient had diabetes mellitus(DM) before either procedure w.ereas 85% of those w.o underw.nt pancreatectomy w.re insulin dependent on their last evaluation despite ICT. CONCLUSION: ITNP and TP + ICT are comparable for pain control in patients w.th CP how.ver w.th high incidence of DM among those w.o underw.nt TP + ICT. Prospective comparative studies and longer follow.up are needed to better define treatment outcomes.

关键词： Chronic pancreatitis Intractable pain Total pancreatectomy Islet cell transplantation Intrathecal narcotic pump infusion