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Influence of systemic immune and cytokine responses during the acute phase of zoster on the development of postherpetic neuralgia

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第8期10卷 625-630页

作者： sheng-mei zhu Yong-min LIU Er-dan AN Qing-lian CHEN Department of Anesthesiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Department of Anesthesiology the Second People's Hospital Jiaxing 314000 China

Postherpetic neuralgia(PHN) is a severe sequela of herpes zoster(HZ).Until now,only age and pain severity were considered predisposing factors for the development of *** evaluated 49 patients with acute phase HZ,10 of whom developed PHN(Group A) and 39 of whom did not develop PHN(Group B).Twenty-five healthy volunteers similar in age and gender distribution to the study group were recruited as controls(Group C).Numbers of serum CD3+(pan-T lymphocytes),CD4+(helper/inducer),and CD8+(suppressor/cytotoxic) lymphocytes were decreased significantly in Groups A and B relative to the control group,but there were no statistical differences between Groups A and ***(IL)-1β,IL-6,tumor necrosis factor(TNF)-α,IL-8,and IL-10 were significantly elevated in Groups A and B relative to Group ***-6 was significantly higher in Group A than in Group B,and was significantly positively correlated with pain severity scored on a visual analog ***,we suggest that the inflammatory response,especially that of IL-6,in the acute phase of HZ may be associated with hyperalgesia and the development of PHN.

关键词： T lymphocyte Cytokines Postherpetic neuralgia (PHN) Herpes zoster (HZ)

Persistent postoperative hypotension caused by subclinical empty sella syndrome after a simple surgery:A case report

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世界临床病例杂志 2023年第24期11卷 5817-5822页

作者： Kang-mei Zhao Jia-sheng Hu sheng-mei zhu Ting-Ting Wen Xiang-Ming Fang Department of Anesthesiology The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Anesthesiology Sanmen People’s HospitalSanmen 317100Zhejiang ProvinceChina

BACKGROUND Empty sella is an anatomical and radiological finding of the herniation of the subarachnoid space into the pituitary fossa leading to a flattened pituitary *** with empty sella may present with various symptoms,including headache due to intracranial hypertension and endocrine symptoms related to the specific pituitary hormones ***,we report a female patient who developed persistent postoperative hypotension caused by subclinical empty sella syndrome after a simple *** SUMMARY A 47-year-old woman underwent vocal cord polypectomy under general anesthesia with endotracheal *** denied any medical history,and her vital signs were normal before the *** and surgery were ***,she developed dizziness,headache and persistent hypotension in the ***,intravenous dopamine was started to maintain normal blood pressure,which improved her ***,she remained dependent on dopamine for over 24 h without any obvious anesthesia-and surgery-related *** endocrine etiology was then suspected,and further examination showed a high prolactin level,a low normal adrenocorticotropic hormone level and a low cortisol *** resonance imaging of the brain revealed an empty ***,she was diagnosed with empty sella syndrome and secondary adrenal *** symptoms disappeared one week later after daily glucocorticoid *** Endocrine etiologies such as pituitary and adrenal-related dysfunction should be considered in patients showing persistent postoperative hypotension when anesthesia-and surgery-related factors are excluded.

关键词： Empty sella syndrome Perioperative hypotension Secondary adrenal insufficiency Adrenocorticotropic hormone Cortisol Case report

Effect of tramadol on immune responses and nociceptive thresholds in a rat model of incisional pain

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第11期9卷 895-902页

作者： Yong-min LIU sheng-mei zhu Kui-rong WANG Zhi-ying FENG Qing-lian CHEN Department of Anesthesiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective： To evaluate the effects oftramadol on the proinflammatory responses in a rat model of incisional pain by investigating its effects on nociceptive thresholds and serum interleukin-6 （IL-6） and IL-2 levels. Methods： Forty-two male Sprague-Dawley （SD） rats scheduled for plantar incision were randomly divided into 7 groups 01=6 in each group）. Rats in Group 1 receiving general anesthesia with no incision were served as control; At 30 min before skin incision, Groups 2-5 were given 5 ml normal saline or 1, 10, and 20 mg/kg tramadol, respectively, intraperitoneally （i.p.）; Group 6 received 10 mg/kg tramadol after operation; Group 7 received 10 mg/kg tramadol before incision, followed by 200 μg/kg naloxone after operation. Mechanical allodynia was measured by electronic yon Frey filament to evaluate the nociceptive thresholds 1 h before incision, and 1 h and 2 h after operation. Serum IL-6 and IL-2 levels were measured by enzyme-linked immunosorbent assay （ELISA） 2 h after operation. Results： Mechanical thresholds decreased significantly and serum IL-6 level increased significantly after operation in Group 2 compared with control （P〈0.01）, and these changes were reversed respectively by tramadol in a dose-dependent manner （P〈0.05 and P〈0.01, respectively）. IL-2 level remained unchanged after operation in Group 2, but decreased in Group 3 （P〈0.05）, then gradually returned to the normal level in Groups 4 and 5. The intraperitoneally injected tramadol （10 and 20 mg/kg） produced a potent and dose-dependent antinocicptive effect on the lesioned paw. The antinocicptive effects of tramadol were partially an- tagonized by naloxone （200 μg/kg）, suggesting an additional non-opioid mechanism. Conclusion： The results suggest that tramadol could be a good choice for the treatment of pain under the conditions that immunosuppression may be particularly contraindicated.

关键词： Tramadol Pain Mechanical allodynia lnterleukin-6 (IL-6) Interleukin-2 (IL-2) Rat

Propofol inhibits the adhesion of hepatocellular carcinoma cells by upregulating microRNA-199a and downregulating MMP-9 expression

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Hepatobiliary & Pancreatic Diseases International 2013年第3期12卷 305-309页

作者： Jian Zhang Dan Zhang Guo-Qing Wu Zhi-Ying Feng sheng-mei zhu Department of Anesthesiology First Affiliated Hospital Zhejiang University School of Medicine Department of Gynaecology and Obstetrics Hangzhou Cancer Hospital Department of Oncology Zhejiang Provincial People's Hospital

BACKGROUND: Propofol is one of the extensively and commonly used intravenous anesthetics and has the ability to influence the proliferation, motility, and invasiveness of many cancer cells. In this study, the effects of propofol on hepatocellular carcinoma cells invasion ability were examined. METHODS: We assessed the invasion ability of HepG2 cells in vitro by determining enzyme activity and protein expression of MMP-9 using gelatin zymography assay and Western blot. The real-time PCR was used to evaluate the effect of propofol on microRNA-199a (miR-199a) expression, and miR-199a-2 precursor to evaluate whether over-expression of miR-199a can affect MMP-9 expression. Finally, the effect of miR-199a on propofol-induced anti-tumor activity using anti-miR-199a was assessed. RESULTS: Propofol significantly elevated the expression of miR-199a and inhibited the invasiveness of HepG2 cells. Propofol also efficiently decreased enzyme activity and protein expression of MMP-9. Moreover, the over-expression of miR-199a decreased MMP-9 protein level. Interestingly, the neutralization of miR-199a by anti-miR-199a antibody reversed the effect of propofol on alleviation of tumor invasiveness and inhibition of MMP-9 activity in HepG2 cells. CONCLUSION: Propofol decreases hepatocellular carcinoma cell invasiveness, which is partly due to the down-regulation of MMP-9 expression by miR-199a.

关键词： propofol invasion MMP-9 HepG2 cells microRNA-199a hepatocellular carcinoma

Perioperative Single-Donor Platelet Apheresis and Red Blood Cell Transfusion Impact on 90-Day and Overall Survival in Living Donor Liver Transplantation

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Chinese Medical Journal 2018年第4期131卷 426-434页

作者： Wei Zheng Kang-mei Zhao Li-Hui Luo Yang Yu sheng-mei zhu Department of Anesthesiology The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou Zhejiang 310003 China

Background： Although many previous studies have confirmed that perioperative blood transfusion is associated with poor outcomes after liver transplantation （LT）, few studies described the influence of single-donor platelet apheresis transfusion in living donor LT （LDLT）. This study aimed to assess the effect of blood products on outcomes for LDLT recipients, focusing on apheresis platelets. Methods： This retrospective study included 126 recipients who underwent their first adult-to-adult LDLT. Twenty-four variables including consumption of blood products of 126 LDLT recipients were assessed for their link to short-term outcomes and overall survival. Kaplan-meier survival curve and the log-rank test were used for recipient survival analysis. A multivariate Cox proportional-hazard model and a propensity score analysis were applied to adjust confounders after potential risk factors were identified by a univariate Cox analysis. Results： Patients who received apheresis platelet transfusion had a lower 90-day cumulative survival （78.9% vs. 94.2%, P = 0.009）, but had no significant difference in overall survival in the Cox model, compared with those without apheresis platelet transfusion. Units of apheresis platelet transfusion（hazard ratio[HR]=3.103,95% confidence interval[CI]：1.720–5.600,P〈0.001）and preoperative platelet count（HR=0.170,95% CI：0.040–0.730,P=0.017）impacted 90-day survival *** Cox regression analysis also found that units of red blood cell（RBC）transfusion（HR=1.036,95% CI：1.006–1.067,P=0.018）,recipient＇s age（HR=1.045,95% CI：1.005–1.086,P=0.025）,and ABO blood group comparison（HR=2.990,95% CI：1.341–6.669,P=0.007）were independent risk factors for overall survival after LDLT. Conclusions： This study suggested that apheresis platelets were only associated with early mortality but had no impact on overall survival in LDLT. Units of RBC, recipient＇s age, and ABO group comparison were independent predictors of long-term outcomes.

关键词： Apheresis Platelets Blood Transfusion Living Donor Liver Transplantation Outcome Red Blood Cell

Relationship between genetic variation in the α2A-adrenergic receptor and the cardiovascular effects of dexmedetomidine in the Chinese Han population

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第7期20卷 598-604页

作者： Shao-jun zhu Kui-rong WANG Xiong-xin ZHANG sheng-mei zhu Department of Anesthesiology the First Affiliated Hospital School of Medicine Zhejiang University

There are differences in individual cardiovascular responses to the administration of dexmedetomidine,a highly selective α2A-adrenergic receptor(ADRA2A) *** aim of this study was to investigate ADRA2A gene polymorphisms in the Chinese Han population and their association with the cardiovascular response to intravenous dexmedetomidine *** elective surgery patients of Chinese Han nationality were administered 1 μg/kg dexmedetomidine intravenously over 10 min as a ***2A C-1291G and A1780G polymorphism status was determined in these patients,and their relationships to changes in blood pressure and heart rate after dexmedetomidine administration were *** were neither significant differences in systolic or diastolic blood pressure changes in individuals with different A1780G and C-1291G genotypes after dexmedetomidine administration,nor in heart rates among the different A1780G ***,there were significant differences in changes in heart rates in patients with different C-1291G *** were no significant differences in the sedative effects of dexmedetomidine among different A1780G and C-1291G *** regression revealed that the C-1291G polymorphism was associated with differential decreases in heart rate after intravenous infusion of *** findings indicate that the ADRA2A C-1291G polymorphism can affect heart rate changes in patients after in-utravenous infusion of dexmedetomidine.

关键词： Dexmedetomidine α2A-Adrenergic receptor Polymorphism Blood pressure Heart rate

C-F insertion reaction sheds new light on the construction of fluorinated compounds

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Chinese Chemical Letters 2024年第8期35卷 163-169页

作者： Dong-sheng Deng Su-Qin Tang Yong-Tu Yuan Ding-Xiong Xie Zhi-Yuan zhu Yue-mei Huang Yun-Lin Liu Henan Key Laboratory of Function-Oriented Porous Materials and College of Chemistry and Chemical EngineeringLuoyang Normal UniversityLuoyang 471934China School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

The atom-economical C-F insertion chemistry is emerged as a promising technology for the synthesis of various fluorinated scaffolds,which have wide applications both in the academic and the industrial *** past three years have witnessed rapid developments in this *** highlight provides an overview on the evolution according to the fluorinating agents used.

关键词： C-F insertion Benzyl fluoride Acyl fluoride gem-Difluorocyclopropane Fluorinated scaffold

Structural and magnetic properties of micropolycrystalline cobalt thin films fabricated by direct current magnetron sputtering

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 384-394页

作者： Kerui Song Zhou Li mei Fang zhu Xiao Qian Lei School of Materials Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Hunan Key Laboratory of Super-Microstructure and Ultrafast Process School of Physics and electronicsCentral South UniversityChangsha 410083China Key Laboratory of Non-Ferrous Metal Materials Science and Engineering Ministry of EducationChangsha 410083China

Pure cobalt(Co)thin films were fabricated by direct current magnetron sputtering,and the effects of sputtering power and pres-sure on the microstructure and electromagnetic properties of the films were *** the sputtering power increases from 15 to 60 W,the Co thin films transition from an amorphous to a polycrystalline state,accompanied by an increase in the intercrystal pore ***,the resistivity decreases from 276 to 99μΩ·cm,coercivity increases from 162 to 293 Oe,and in-plane magnetic aniso-tropy *** the sputtering pressure decreases from 1.6 to 0.2 Pa,grain size significantly increases,resistivity significantly de-creases,and the coercivity significantly increases(from 67 to 280 Oe),which can be attributed to the increase in defect ***-pondingly,a quantitative model for the coercivity of Co thin films was *** polycrystalline films sputtered under pressures of 0.2 and 0.4 Pa exhibit significant in-plane magnetic anisotropy,which is primarily attributable to increased microstress.

关键词： cobalt thin film magnetron sputtering microstructure electromagnetic properties

Recent progress of in-situ characterization of LiNi_(1−x−y)Co_(x)Mn_(y)O_(2) cathodes for lithium metal batteries: A mini review

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Nano Research 2024年第3期17卷 1384-1401页

作者： Huanzhu Lv Xiaoqi zhu Jun mei Yuanhua Xia Bin Wang Institute of Fundamental and Frontier Science University of Electronic Science and Technology of ChinaChengdu 611731China Chengdu Development Center of Science and Technology China Academy of Engineering PhysicsChengdu 610200China Key Laboratory of Neutron Physics and Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics(CAEP)Mianyang 621999China

In the context of the gradual popularity of electric vehicles(EVs),the development of lithium battery systems with high energy density and power density is regarded as the foremost way to improve the range of ***_(1-x-y)Co_(x)Mn_(y)O_(2)(NCM)cathodes have been the focus of researchers due to their high energy density,excellent power performance,and low-temperature ***,the elaboration of the decay mechanism of NCM cathode based on lithium metal batteries(LMBs)is still being restricted to the primary *** the past decades,the development and application of advanced in-situ characterization tools have facilitated researchers'understanding of the internal operation mechanism of batteries during charging and *** this minireview,the latest progress of in-situ observation of the NCM cathode by X-ray diffraction(XRD),fourier transform infrared(FT-IR)spectroscopy,Raman spectroscopy,atomic force microscopy(AFM),transmission electron microscope(TEM),optical microscope,and other characterization tools is *** mechanisms of structural degradation,cathode-electrolyte interfaces(CEIs)composition,and dynamic changes of NCM,electrolyte breakdown,and gas production are ***,based on the existing research progress,the opportunities and challenges for future in-situ characterization technology in the study of the mechanism of LMBs are discussed in ***,the purpose of this minireview is to summarize recent work that focuses on the outstanding application of in-situ characterization techniques in the mechanistic study of LMBs,and pointing the way to the future development of high energy density and power density LMBs systems.

关键词： lithium metal batteries(LMBs) In-situ characterization LiNi_(1-x-y)Co_(x)Mn_(y)O_(2)(NCM)