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International Journal of Ophthalmology(English edition) 2021年第3期14卷 448-455页

作者： Xian-Ning liu sheng-li mi Yun Chen Yao Wang Department of Ophthalmology First Hospital of Xi'anShaanxi Institute of OphthalmologyShaanxi Provincial Key Lab of OphthalmologyClinical Research Center for Ophthalmology Diseases of Shaanxi Provincethe First Affiliated Hospital of Northwest UniversityXi'an 710002Shaanxi ProvinceChina Open FIESTA Center Graduate School at ShenzhenTsinghua UniversityShenzhen 518055Guangdong ProvinceChina Biomanufacturing Engineering Laboratory Graduate School at ShenzhenTsinghua UniversityShenzhen 518055Guangdong ProvinceChina

Corneal stroma-derived mesenchymal stem cells(CS-MSCs) are mainly distributed in the anterior part of the corneal stroma near the corneal limbal stem cells(LSCs). CS-MSCs are stem cells with self-renewal and multidirectional differentiation potential. A large amount of data confirmed that CS-MSCs can be induced to differentiate into functional keratocytes in vitro, which is the motive force for maintaining corneal transparency and producing a normal corneal stroma. CS-MSCs are also an important component of the limbal microenvironment. Furthermore, they are of great significance in the reconstruction of ocular surface tissue and tissue engineering for active biocornea construction. In this paper, the localization and biological characteristics of CS-MSCs, the use of CS-MSCs to reconstruct a tissue-engineered active biocornea, and the repair of the limbal and matrix microenvironment by CS-MSCs are reviewed, and their application prospects are discussed.

关键词： corneal stroma-derived mesenchymal stem cells bioactive cornea corneal limbus tissue-engineered active biocornea stromal microenvironment

Theoretical study on the stability of nanobubbles and its verification in molecular dynamics simulation

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Particuology 2024年第4期87卷 99-105页

作者： sheng mi Chaofeng Hou Wei Ge School of Chemical Engineering and Technology Tianjin UniversityTianjin300072China State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing.100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

The stability of vapor nanobubbles in bulk liquid was investigated theoretically and the critical bubble size was derived from macroscale thermodynamic equations,below which the system destabilizes with sharp drop in *** critical size was quantitatively verified in molecular dynamic simulation using the Lennard-Jones model of argon,where stronger attraction between the molecules at lower density is found to contribute most to the drop of system pressure and,as the Laplace pressure on the curved bubble interface fails to balance the pressure difference across the interface,the bubbles become *** theoretical model could be extended to other systems where reliable equations of state and interfacial tension are available.

关键词： Nanobubble Stability Phase diagram Critical size

Corneal ulcer caused by nocardia brasiliensis in a patient with diabetes

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 381-383页

作者： Xian-Ning liu Na An Jie Wu Kun Xu Xiu-Ping Zh sheng-li mi Department of Ophthalmology the First Hospital of Xi'an Shaanxi Provincial Key Laboratory of Ophthalmology Ophthalmological Institute of Shaanxi Province Biomanufacturing Engineering Laboratory Graduate School at Shenzhen Tsinghua University

Dear Sir,Iam ***-li mi,from the Biomanufacturing engineering laboratory,Graduate School at Shenzhen,Tsinghua University,Shenzhen,China.I write to present a case report of nocardia brasiliensis in a patient with *** is part of a group of aerobic actinomycetes,widely distributed in *** asteroids and nocardia brasiliensis are the most common human *** infected by nocardia asteroids through the respiratory tract mainly suffer from primary suppurative pulmonary *** of nocardia brasiliensis often occurs in the advanced stages of a progressive disease or immune disorder,especially Cushing syndrome,diabetes,or in patients using corticosteroids,immunosuppressive agents and broad-spectrum antibiotics for long time[1].To our knowledge,the reports of nocardia keratitis was very rare

关键词： Corneal ulcer caused by nocardia brasiliensis in a patient with diabetes

Improving antioxidant activities of water-soluble lignin-carbohydrate complex isolated from wheat stalk through prolonging ball-milling pretreatment and homogeneous extraction

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Journal of Bioresources and Bioproducts 2024年第1期9卷 113-125页

作者： Di Xie Zhulan liu Yunfeng Cao sheng-I Yang Chen Su mi li Jiangsu Co-innovation Center for Efficient Processing and Utilization of Forest Products Nanjing Forestry UniversityNanjing 210037China International Innovation Center for Forest Chemicals and Materials Nanjing Forestry UniversityNanjing 210037China Center for Renewable Carbon School of Natural ResourcesUniversity of TennesseeKnoxvilleTN 37996USA Shandong Huatai Paper Co. Ltd.Dongying 257000China School of Natural Resources University of TennesseeKnoxvilleTN 37996USA Key Lab of Biomass Energy and Material Institute of Chemical Industry of Forest ProductsChinese Academy of ForestryJiangsu ProvinceNanjing 210042China

Water-soluble lignin-carbohydrate complex(LCC)rich in polysaccharides exhibits benign in vitro antioxidant activities and distinguishes high biocompatibility from lignin-rich LCC and ***,the antioxidant activity of water-soluble LCCs remains to be improved and its structure-antioxidant relationship is still ***,structurally diversified water-soluble LCCs were isolated under different ball-milling pretreatment durations(4,6,8 h),extraction pathways(ho-mogeneous and heterogeneous),and isolation routines(water extracts and residues after water extraction).Their structures were characterized by wet chemistry,chromatography and *** activities were evaluated by ferric reducing antioxidant power and 1,1-diphenyl-2-picrylhydrazyl radicals scavenging rate(RDPPH).Results show that altering ball-milling duration and isolation procedures cause varied structures and antioxidant activities of the water-soluble ***,prolonging ball-milling duration to 8 hours and homogeneous extrac-tion can enhance their antioxidant activity through releasing more phenolic structures and pro-moting the extraction of high-molecular-weight LCCs via reducing mass-transfer resistance,*** a result,the RDPPH of water-soluble LCCs reaches up to 97.35%,which is associated with the arabinan content with statistical significance(P<0.05).This study provides new insights into the structure-antioxidation relationship of herbaceous LCC as potential antioxidants.

关键词： LCC Homogeneous extraction Ball-milling Structure-antioxidation relationship Wheat straw

Acellular ostrich corneal stroma used as scaffold for construction of tissue-engineered cornea

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 325-331页

作者： Xian-Ning liu Xiu-Ping Zhu Jie Wu Zheng-Jie Wu Yong Yin Xiang-HuaXiao Xin Su Bin Kong Shi-Yin Pan Hua Yang Yan Cheng Na An sheng-li mi Shaanxi Institute of Ophthalmology Xi'an 710002 Shaanxi Province China Shaanxi Key Laboratory of Eye Xi'an 710002 Shaanxi Province China Xi'an First Hospital Xi'an 710002 Shaanxi Province China Biomanufacturing Engineering Laboratory Graduate School at Shenzhen Tsinghua University Shenzhen 518055Guangdong Province China

AIM： To assess acellular ostrich corneal matrix used as a scaffold to reconstruct a damaged cornea. METHODS： A hypertonic saline solution combined with a digestion method was used to decellularize the ostrich cornea. The microstructure of the acellular corneal matrix was observed by transmission electron microscopy （TEM） and hematoxylin and eosin （H＆E） staining. The mechanical properties were detected by a rheometer and a tension machine. The acellular corneal matrix was also transplanted into a rabbit cornea and cytokeratin 3 was used to check the immune phenotype, RESULTS： The microstructure and mechanical properties of the ostrich cornea were well preserved after the decellularization process, in vitro, the methyl thiazolyl tetrazoUum results revealed that extracts of the acellular ostrich corneas （AOCs） had no inhibitory effects on the proliferation of the corneal epithelial or endothelial cells or on the keratocytes, The rabbit lamellar keratoplasty showed that the transplanted AOCs were transparent and completely incorporated into the host cornea while corneal turbidity and graft dissolution occurred in the acellular porcine cornea （APC） transplantation, The phenotype of the reconstructed cornea was similar to a normal rabbit cornea with a high expression of cytokeratin 3 in the superficial epithelial cell layer, CONCLUSION： We first used AOCs as scaffolds to reconstruct damaged corneas. Compared with porcine corneas, the anatomical structures of ostrich corneas are closer to those of human corneas. In accordance with the principle that structure determines function, a xenograft lamellar keratoplasty also confirmed that the AOC transplantation generated a superior outcome compared to that of the APC graft.

关键词： ostrich acellular corneal stroma tissue engineering cornea

Numerical Study on the Aerodynamic and Fluid−Structure Interaction of An NREL-5MW Wind Turbine

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China Ocean Engineering 2024年第3期38卷 363-378页

作者： ZHAO mi YU Wan-li WANG Pi-guang QU Yang DU Xiu-li Key Laboratory of Urban Security and Disaster Engineering of ministry of Education Beijing University of TechnologyBeijing 100124China State Key Laboratory of Bridge Engineering Safety and Resilience Beijing University of TechnologyBeijing 100124China

A 5-MW wind turbine has been modeled and analyzed for fluid-structure interaction and aerodynamic *** this study, a full-scale model of a 5-MW wind turbine is first developed based on a computational fluid dynamics(CFD) approach, in which the unsteady, noncompressible Reynolds Averaged Navier-Stokes(RANS) method is used. The main focus of the study is to analyze the tower shadow effect on the aerodynamic performance of the wind turbine under different inlet flow conditions. Subsequently, the finite element model is established by considering fluid/structure interactions to study the structural stress, displacement, strain distributions and flow field information of the structure under the uniform wind speed. Finally, the fluid-structure interaction model is established by considering turbulent wind and the tower shadow effect. The variation rules of the dynamic response of the one-way and two-way fluid-structure interaction(FSI) models under different wind speeds are analyzed, and the numerical calculation results are compared with those of the centralized mass model. The results show that the tower shadow effect and structural deformation are the main factors affecting the aerodynamic load fluctuation of the wind turbine, which in turn affects the aerodynamic performance and structural stability of the blades. The structural dynamic response of the coupled model shows significant similarity, while the structural displacement response of the former exhibits less fluctuation compared with the conventional centralized mass model. The one-way fluid-structure interaction(FSI)model shows a higher frequency of stress-strain and displacement oscillations on the blade compared with the two-way FSI model.

关键词： computational fluid dynamics methods(CFD) tower shadow effect aerodynamic performance fluidstructure interaction space flow field

Arbitrary topological charge vortex beams from carbon dots random lasers

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Rare Metals 2024年第8期43卷 3844-3853页

作者： Xiang-Dong Wang Xiao-Bo mi Jiu-Ru He Feng-Ying Ma Jun-Qiao Wang li Song Yong-Qiang Zhang Si-Yu Lu Yong-sheng Hu School of Physics and microelectronics Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Reliability and Intelligence of Electrical Equipment and Tianjin Key Laboratory of Electronic Materials and Devices School of Electronics and Information EngineeringHebei University of TechnologyTianjin 300401China Green Catalysis Center College of ChemistryZhengzhou UniversityZhengzhou450001China

Vortex beams have attracted great attention due to their promising applications in the fields of high-capacity optical communication,optical micromanipulation,and quantum information ***,we demonstrate vortex beams with flexible control of the topological charge and modes in a carbon dots random laser for the first *** beams with different types,including the Laguerre-Gaussian(LG),Bessel-Gaussian(BG),LG-superposition,and polarized vortex beams with topological charges up to 50,have been successfully ***,vortex beams can be well realized in carbon dots random lasers with different emission wavelengths covering from 465 to 612 *** work would not only enrich the types of vortex laser,especially for solution-processable lasers,but also provide a new route to realizing multicolor and wavelength-tunable vortex lasers.

关键词： Carbon dots Random lasers Vortex beam Topological charge Spatial light modulator

Distributed power conditioning unit of large-scale space solar power station

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Chinese Journal of Aeronautics 2024年第8期37卷 421-434页

作者： Xintong li Jianwei mi Yiqun ZHANG Guanheng FAN Jie DU School of Mechano-electronic Engineering Xidian UniversityXi’an 710071China Shaanxi Key Laboratory of Space Solar Power Station System Xidian UniversityXi’an 710071China Academy of Advanced Interdisciplinary Research Xidian UniversityXi’an 710071China

In this paper,a multi-bus distributed Power Conditioning Unit(PCU)is proposed for the Space Solar Power Station with large scale photovoltaic(PV)array and power levels reaching MW *** this unit,there are multiple independent PV *** each PV array,there are multiple independent PV *** this paper,a V-P droop control method with adaptive droop coefficient is proposed,which modifies the droop intercept based on the bus voltage deviation and the power per unit value of the PV *** method ensures the accuracy of bus voltage and achieves proportional distribution of power between PV arrays based on the proposed topology structure in this *** the load changes or the output power of the PV array fluctuates,this method can ensure that power is distributed *** principle and control method of the proposed droop control method is analyzed in this *** effectiveness of the method is verified through MATLAB/Simulink simulation and *** and experimental results show that the proposed method can achieve power distributed proportionally when load changes and PV output power fluctuates,reduce bus voltage error caused by line impedance and differences in rated power of different PV arrays,and improve the performance of PV power generation system applied to space.

关键词： Space Solar Power Station Photovoltaics Droop control DC confluence Power conditioning unit

Pulmonary embolism secondary to acute anterior ST-elevation myocardial infarction:a case report

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World Journal of Emergency Medicine 2024年第2期15卷 139-141页

作者： lin Yuan Hong li Yuhong mi Ying liang Emergency Critical Center Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Thrombophilia denotes a condition,whether acquired or hereditary,characterized by increased susceptibility to hypercoagulation.[1]This condition was first described in 1965,coinciding with the discovery of an inherited predisposition to venous thromboembolism(VTE)in patients deficient in antithrombin III.[2]While arterial and venous thromboses are common in hospitalized patients,acute myocardial infarction(Ami)and pulmonary embolism(PE)stand out as ***,theoccurrenceof Ami complicated by PE is exceedingly rare,especially when considering cases where paradoxical embolism originating from a patent foramen ovale is *** report presents a case of Ami complicated with PE.A comprehensive understanding of the pathophysiology of this rare yet critical condition is important for ensuring prompt diagnosis and treatment.

关键词： embolism infarction acute

Latest assessment methods for mitochondrial homeostasis in cognitive diseases

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Neural Regeneration Research 2024年第4期19卷 754-768页

作者： Wei You Yue li Kaixi liu Xinning mi Yitong li Xiangyang Guo Zhengqian li Department of Anesthesiology Peking University Third Hospital Peking University Third Clinical Medical College Beijing Center of Quality Control and Improvement on Clinical Anesthesia Anesthesia and Perioperative Medicine Branch of China International Exchange and Promotive Association for Medical and Health Care(CPAM)

mitochondria play an essential role in neural function,such as supporting normal energy metabolism,regulating reactive oxygen species,buffering physiological calcium loads,and maintaining the balance of morphology,subcellular distribution,and overall health through mitochondrial *** the recent technological advances in the assessment of mitochondrial structure and functions,mitochondrial dysfunction has been regarded as the early and key pathophysiological mechanism of cognitive disorders such as Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,mild cognitive impairment,and postoperative cognitive *** review will focus on the recent advances in mitochondrial medicine and research methodology in the field of cognitive sciences,from the perspectives of energy metabolism,oxidative stress,calcium homeostasis,and mitochondrial dynamics(including fission-fusion,transport,and mitophagy).

关键词： cognitive disorders mitochondrial dysfunction mitochondrial energy metabolism mitochondrial dynamics mitochondrial transport mitophagy mitochondrial biogenesis oxidative stress calcium homeostasis