检索结果-南通市图书馆

Role of metabolites derived from gut microbiota in inflammatory bowel disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第9期10卷 2660-2677页

作者： Lie Zheng Xin-Li Wen sheng-lei duan Department of Gastroenterology Shaanxi Hospital of Traditional Chinese MedicineXi’an 710003Shaanxi ProvinceChina

Over the past two decades,it is improved gut microbiota plays an important role in the health and disease ***,small molecules produced as intermediate or end products of microbial metabolism,is considered as one of the major interaction way for gut microbiota with the *** metabolisms of dietary substrates,modification of host molecules or bacteria are the major source of *** from microbial metabolites affect immune maturation and homeostasis,host energy metabolism as well as mucosal integrity *** on many researches,the composition and function of the microbiota can be changed,which is also seen in the metabolite profiles of patients with inflammatory bowel disease(IBD).Additionally,some specific classes of metabolites also can trigger *** this paper,definition of the key classes of microbialderived metabolites which are changed in IBD,description of the pathophysiological basis of association and identification of the precision therapeutic modulation in the future are the major contents.

关键词： Inflammatory bowel disease Microbial metabolites Short chain fatty acids Bile acids Tryptophan

Fecal microbiota transplantation in the metabolic diseases:Current status and perspectives

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第23期28卷 2546-2560页

作者： Lie Zheng Yong-Yi Ji Xin-Li Wen sheng-lei duan Department of Gastroenterology Shaanxi Hospital of Traditional Chinese MedicineXi’an 710003Shaanxi ProvinceChina Department of Neurology Xi’an Hospital of Traditional Chinese MedicineXi’an 710021Shaanxi ProvinceChina

With the development of microbiology and metabolomics,the relationship between the intestinal microbiome and intestinal diseases has been *** microbiota transplantation(FMT),as a new treatment method,can affect the course of many chronic diseases such as metabolic syndrome,malignant tumor,autoimmune disease and nervous system *** the mechanism of action of FMT is now well understood,there is some controversy in metabolic diseases,so its clinical application may be *** transplantation is recommended by clinical medical guidelines and consensus for the treatment of recurrent or refractory Clostridium difficile infection,and has been gradually promoted for the treatment of other intestinal and extraintestinal ***,the initial results are varied,suggesting that the heterogeneity of the donor stools may affect the efficacy of *** success of FMT depends on the microbial diversity and composition of donor ***,clinical trials may fail due to the selection of ineffective donors,and not to faulty indication selection for FMT.A new understanding is that FMT not only improves insulin sensitivity,but may also alter the natural course of type 1 diabetes by modulating *** this review,we focus on the main mechanisms and deficiencies of FMT,and explore the optimal design of FMT research,especially in the field of cardiometabolic diseases.

关键词： Fecal microbiota transplantation Metabolic diseases Inflammatory bowel disease Type 1 diabetes Metabolic syndrome

Role of adherent invasive Escherichia coli in pathogenesis of inflammatory bowel disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第32期10卷 11671-11689页

作者： Lie Zheng sheng-lei duan Yan-Cheng Dai Shi-Cheng Wu Department of Gastroenterology Shaanxi Provincial Hospital of Traditional Chinese MedicineXi’an 322000Shaanxi ProvinceChina Department of Gastroenterology Shanghai Traditional Chinese Medicine Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China Department of Proctology Gansu Academy of Traditional Chinese MedicineGansu Hospital of Traditional Chinese MedicineLanzhou 730050Gansu ProvinceChina

Gut microbiota imbalances play an important role in inflammatory bowel disease(IBD),but no single pathogenic microorganism critical to IBD that is specific to the IBD terminal ileum mucosa or can invade intestinal epithelial cells has been *** Escherichia coli(***)adhesion to macrophages is considered to be closely related to the pathogenesis of inflammatory bowel *** study of the specific biological characteristics of adherent invasive ***(AIEC)may contribute to a further understanding of IBD *** review explores the relationship between AIEC and the intestinal immune system,discusses the prevalence and relevance of AIEC in Crohn's disease and ulcerative colitis patients,and describes the relationship between AIEC and the disease site,activity,and postoperative ***,we highlight potential therapeutic strategies to attenuate AIEC colonization in the intestinal mucosa,including the use of phage therapy,antibiotics,and anti-adhesion *** strategies may open up new avenues for the prevention and treatment of IBD in the future.

关键词： Adherent invasive Escherichia coli Inflammatory bowel disease Crohn's disease Ulcerative colitis Prevention

Coupled conditional nonlinear optimal perturbations and their application to ENSO ensemble forecasts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第3期67卷 826-842页

作者： Wansuo duan lei HU Rong FENG LASG Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

Limitations are existed in current ensemble forecasting initial perturbation methods for describing the interactions among various spheres of the Earth system. In this study, a new method is proposed, namely, the coupled conditional nonlinear optimal perturbation(C-CNOP) method, which incorporates multisphere interactions much appropriately. The El Nino-Southern Oscillation(ENSO) is a typical ocean-atmosphere “coupling”(or “interaction”) phenomenon. The C-CNOP method is applied to ensemble forecasting of ENSO. It is demonstrated that the C-CNOP method can generate coupled initial perturbations(CPs) that appropriately consider initial ocean-atmosphere coupling uncertainty for ENSO ensemble forecasts. Results reveal that the CPs effectively improve the ability of ENSO ensemble-mean forecasts in both temporal variability of Nio3.4 sea surface temperature anomalies(SSTAs) and spatial variability of ENSO mature-phase SSTAs. Notably, despite the weakest ocean-atmosphere coupling strength in the tropical Pacific occurring during the boreal spring and summer, CPs still capture the uncertainties of this weak coupling when ENSO predictions are initialized at these seasons. This performance of CPs significantly suppresses the rapid increase of ENSO prediction errors due to the high ocean-atmosphere coupling instability during these seasons, and thus effectively extends the lead time of skillful ENSO forecasting. Hence, the C-CNOP method is a suitable initial perturbation approach for ENSO ensemble forecast that can describe initial ocean-atmosphere coupling uncertainty. It is expected that the CCNOP method plays a significant role in predictions of other high-impact climate phenomena, and even future Earth system predictions.

关键词： Ensemble forecast Multisphere interaction Initial perturbations ENSO

Effects of acid deposition control in China:a review based on responses of subtropical forests

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2024年第6期18卷 115-126页

作者： Danni Xie Xiaodong Ge lei duan Jan Mulder School of Land Engineering Chang’an UniversityXi’an 710064China State Key Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex Beijing 100084China Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life SciencesBox 5003NO-1432ÅsNorway

For many decades,acid deposition used to pose a significant regional air pollution challenge in *** substantial emission control of anthropogenically derived sulfur and nitrogen containing gasses,both sulfur and nitrogen deposition,as well as the acid rain-affected area,have significantly decreased compared to their peak ***,particularly in the humid subtropics,are sensitive to acid deposition,as evidenced by soil acidification,sulfate and nitrate leaching in stream water,and elevated soil nitrous oxide *** in the total deposition of sulfur and nitrogen,caused a significant decline in sulfate and nitrate leaching from subtropical forest and subsequently in sulfate and nitrate concentrations in stream water,although there was about a 5-year *** delay may be attributed to the desorption of accumulated sulfate and continued elevated mineralization of accumulated nitrogen *** of nitrous oxide,a potent greenhouse gas,also declined in nitrogen-saturated subtropical forest soils,as soil water nitrate concentration ***,subtropical forests in China suffering from elevated acid deposition have begun to ***,the current levels of sulfur and nitrogen deposition continue to exceed the critical loads,i.e.,the assigned threshold levels in accordance with emission control policies,in more than 10%of the country’s land area,respectively,indicating remaining risks of acidification and ***,further emission reductions are urgently needed,also because they will help achieving goals related to air quality and nitrous oxide emissions.

关键词： Acidification Critical load Nitrous oxide Surface water chemistry Recovery

Evidence of guide field magnetic reconnection in flapping current sheets

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2024年第4期8卷 650-658页

作者： YunTian Hou SuPing duan lei Dai Chi Wang State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Key Laboratory of Solar Activity and Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

Based on current sheet flapping motion on 27 August 2018 in the dusk flank magnetotail,as recorded by instruments aboard Magnetospheric Multiscale(MMS)spacecraft,we present the first study of guide field reconnection observed in the flux rope embedded in kink-like flapping current sheets near the dusk-side flank of the *** more common magnetotail reconnections,which are symmetric,these asymmetric small-scale(λ_(i)~650 km)reconnections were found in the highly twisted current sheet when the direction normal to the sheet changes from the Z direction into the Y *** unique feature of this unusual reconnection is that the reconnection jets are along the Z direction-different from outflow in the X direction,which is the more usual *** vertical reconnection jet is parallel or antiparallel to the up-and-down motion of the tail’s current *** normalized reconnection rate R is estimated to be~*** results indicate that such asymmetric reconnections can significantly enlarge current sheet flapping,with large oscillation *** letter presents direct evidence of guide field reconnection in a highly twisted current sheet,characterized by enlarged current sheet flapping as a consequence of the reconnection outflow.

关键词： magnetic reconnection magnetotail current sheet

Day-ahead P2P Energy Sharing Strategy Among Energy Hubs Considering Flexibility of Energy Storage and Loads

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2024年第3期10卷 1105-1118页

作者： Penghua Li Wanxing sheng Qing duan Jun Liang Cunhao Zhu China Electric Power Research Institute Beijing 100192China School of Engineering Cardiff UniversityUK IEEE

Multi-energy systems are one of the key technologies to tackle energy crisis and environmental *** energy hub(EH)is a minimum multi-energy *** of multiple EHs through energy routers(ERs)can realize mutual energy *** paper proposes a peer-to-peer(P2P)energy sharing strategy between EHs including ERs in an interconnected system,which is divided into two *** the lower level,a method of determining the charging/discharging constraints of energy storage devices is *** on the Lyapunov optimization method,virtual queues are used to model the energy storage devices and flexible loads in the *** objective is to minimize the overall operating cost of the interconnected *** the upper level,a non-cooperative game model is introduced to minimize the cost of purchasing power from other EHs for each EH.A best response-based method is adapted to find the Nash *** simulation outcomes demonstrate that application of the proposed strategy can reduce operating costs of an interconnected system and each *** basis of a real-world dataset of interconnected EHs,both analytical and numerical results show the effectiveness of the proposed strategy.

关键词： Energy hub energy router Lyapunov optimization non-cooperative game peer to peer virtual queue

An Elite-Class Teaching-Learning-Based Optimization for Reentrant Hybrid Flow Shop Scheduling with Bottleneck Stage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第4期79卷 47-63页

作者： Deming lei Surui duan Mingbo Li Jing Wang College of Automation Wuhan University of TechnologyWuhan430070China

Bottleneck stage and reentrance often exist in real-life manufacturing processes;however,the previous research rarely addresses these two processing conditions in a scheduling *** this study,a reentrant hybrid flow shop scheduling problem(RHFSP)with a bottleneck stage is considered,and an elite-class teaching-learning-based optimization(ETLBO)algorithm is proposed to minimize maximum completion *** produce high-quality solutions,teachers are divided into formal ones and substitute ones,and multiple classes are *** teacher phase is composed of teacher competition and teacher *** learner phase is replaced with a reinforcement search of the elite *** adjustment on teachers and classes is established based on class quality,which is determined by the number of elite solutions in *** experimental results demonstrate the effectiveness of new strategies,and ETLBO has a significant advantage in solving the considered RHFSP.

关键词： Hybrid flow shop scheduling reentrant bottleneck stage teaching-learning-based optimization

Synergistic promotion of particulate matter reduction and production performance via adjusting electrochemical reactions in the zinc electrolysis industry

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2024年第1期18卷 23-33页

作者： Zizhen Ma Jingkun Jiang lei duan Jianguo Deng Fuyuan Xu Zehui Li Linhua Jiang Ning duan School of Environmental and Municipal Engineering Qingdao University of TechnologyQingdao 266520China State Key Joint Laboratory of Environmental Simulation and Pollution Control School of the EnvironmentTsinghua UniversityBeijing 100084China State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China School of Physics Peking UniversityBeijing 100871China

Heavy particulate matter (PM) pollution and high energy consumption are the bottlenecks of hydrometallurgy, especially in the electrolysis process. Therefore, an urgent need is to explore PM reduction methods with production performance co-benefits. This study presents three PM reduction methods based on controlling operating parameters, i.e., lowering electrolyte temperature, H2SO4 concentration, and current density of the cathode. The optimized conditions were also investigated using the response surface methodology to balance the PM reduction effect and Zn production. The results showed that lowering electrolyte temperature is the most efficient, with an 89.0% reduction in the PM generation flux (GFPM). Reducing H2SO4 concentration led to the minimum side effects on the current efficiency of Zn deposition (CEZn) or power consumption (PC). With the premise of non-deteriorating CEZn and PC, GFPM can be reduced by 86.3% at the optimal condition (electrolyte temperature = 295 K, H2SO4 = 110 g/L, current density = 373 A/m^(2)). In addition, the reduction mechanism was elucidated by comprehensively analyzing bubble characteristics, electrochemical reactions, and surface tension. Results showed that lower electrolyte temperature inhibited the oxygen evolution reaction (OER) and compressed gas volume. Lower H2SO4 concentration inhibited the hydrogen evolution reaction (HER) and reduced electrolyte surface tension. Lower current density inhibited both OER and HER by decreasing the reaction current. The inhibited gas evolutions reduced the microbubbles’ number and size, thereby reducing GFPM. These results may provide energy-efficient PM reduction methods and theoretical hints of exploring cleaner PM reduction approaches for industrial electrolysis.

关键词： Zinc electrolysis Particulate matter Energy consumption Operating parameters Bubble characteristic Electrochemical reaction