Role of adherent invasive Escherichia coli in pathogenesis of inflammatory bowel disease
作者机构：Department of GastroenterologyShaanxi Provincial Hospital of Traditional Chinese MedicineXi’an 322000Shaanxi ProvinceChina Department of GastroenterologyShanghai Traditional Chinese Medicine Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China Department of ProctologyGansu Academy of Traditional Chinese MedicineGansu Hospital of Traditional Chinese MedicineLanzhou 730050Gansu ProvinceChina
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2022年第10卷第32期
页 面：11671-11689页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by the General Research of Xi’an Science and Technology Planning Project,No.2022JH-YBYJ-0265 the Shaanxi Province Natural Science Basic Research Program-General Project,No.2019JM-580 Project of Shaanxi Administration of Traditional Chinese Medicine,No.2019-ZZ-JC010 the Shaanxi Provincial Hospital of Traditional Chinese Medicine,No.2018-04 and No.2021-07
主 题：Adherent invasive Escherichia coli Inflammatory bowel disease Crohn's disease Ulcerative colitis Prevention
摘 要：Gut microbiota imbalances play an important role in inflammatory bowel disease(IBD),but no single pathogenic microorganism critical to IBD that is specific to the IBD terminal ileum mucosa or can invade intestinal epithelial cells has been *** Escherichia coli(***)adhesion to macrophages is considered to be closely related to the pathogenesis of inflammatory bowel *** study of the specific biological characteristics of adherent invasive ***(AIEC)may contribute to a further understanding of IBD *** review explores the relationship between AIEC and the intestinal immune system,discusses the prevalence and relevance of AIEC in Crohn s disease and ulcerative colitis patients,and describes the relationship between AIEC and the disease site,activity,and postoperative ***,we highlight potential therapeutic strategies to attenuate AIEC colonization in the intestinal mucosa,including the use of phage therapy,antibiotics,and anti-adhesion *** strategies may open up new avenues for the prevention and treatment of IBD in the future.
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