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Auth.r correction to“Cascade two-stage tumor re-oxygenation and immune re-sensitization mediated by self-assembled albumin-sorafenib nanoparticles for enh.nced ph.todynamic immunoth.rapy”[Acta Ph.rm Sin b(2022)4204-4223]

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Acta Ph.rmaceutica Sinica b 2024年第2期14卷 900-903页

作者： Zaigang Zh.u Jiash. Ch.n Yu Liu Ch.njuan Zh.ng Wenjuan Luo Lele Ch.n shen Zh.u Zh.ming Li Jianliang shen State Key Laboratory of Oph.h.lmology Optometry and Vision ScienceSchool of Ophthalmology and OptometrySchool of Biomedical EngineeringWenzhou Medical UniversityWenzhou 325027China Department of th. First Affiliated h.spital of Wenzh.u Medical University Wenzhou325000China Sch.ol&h.spital of Stomatology Wenzhou Medical UniversityWenzhou 325027China Wenzh.u Institute University of Chinese Academy of SciencesWenzhou325000China Oujiang Laboratory(Zh.jiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang325000China

Th. auth.rs regret th.t th.re are errors in th. article Fig.8A and Fig.S22A due to th. mistake of copying and pasting in th. process of assembling figures and negligence in th. *** it does not affect th. conclusion,th.se are obvious *** auth.rs h.ve now modified as *** original data of th.se figures h.ve been provided to th. Editorial Office,and th. corresponding auth.rs or th. Editorial Office can be contacted for original data *** auth.rs apologize for any inconvenience caused to th. journal and readers.

关键词： journal correction conclusion

b-COPNA resin formation from eth.lene tar ligh. fractions:Process development and mech.nical exploration by molecular simulation

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Ch.nese Journal of Ch.mical Engineering 2024年第6期70卷 118-129页

作者： h.ngyan shen Lingrui Cui Xingguo Wei Yuanqin Zh.ng Lian Cen Jun Xu Fah.i Cao Engineering Research.Center of Large Scale Reactor East China University of Science and TechnologyShanghai 200237China

An efficient utilization strategy of eth.lene tar(ET),th. main by-product of th. eth.lene cracking unit,is urgently required to meet demands for modern petroch.mical *** th. oth.r h.nd,condensed polynuclear aromatic resin of moderate condensation degree(b-COPNA)is a widely used carbon material due to its superb processability,th. production of wh.ch.is,h.wever,seriously limited by th. h.gh.cost of raw *** such.context,an interesting strategy was proposed in th.s study for producing b-COPNA resin using crosslinked ligh. fractions of eth.lene tar(ETLF,boiling pointby molecular simulation.1,4-benzenedimeth.nol(PXG)was first selected as th. crosslinking agent according to th. findings of molecular *** effects of operating conditions,including reactions temperature,crosslinking agent,and catalyst content on th. softening point and yield of b-COPNA resin products were th.n investigated to optimize th. *** reaction mech.nism of resin production was studied by analyzing th. molecular structure and transition state of ETLF and crosslinking *** was sh.wn th.t PXG exh.bited a superior capacity of with.rawing electrons and a h.gh.r electroph.lic reactivity th.n oth.r crosslinking *** addition to th. h.gh.st yield and greatest h.at properties,PXG-prepared resin contained th. most condensed *** corresponding optimized conditions of resin preparation were 180℃,1:1.9(PXG:ETLF),and 3%(mass)of catalyst content with.a resin yield of 78.57%.It was th. electroph.lic substitution reaction th.t occurred between th. ETLF and crosslinking agent molecules th.t were responsible for th. resin formation,according to th. experimental ch.racterization and molecular ***,it was confirmed th.t th. proposed strategy and demonstrated process can ach.eve a clean and h.gh.value-added utilization of ETLF via b-COPNA resin preparation,bringing h.ge economic value to th. current petroch.mical industry.

关键词： Eth.lene tar Crosslinking COPNA resin Molecular simulation Transient state

Large reversible magnetocaloric effect in antiferromagnetic Er_(3)Si_(2)C_(2) compound

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Journal of Rare Earth. 2024年第8期42卷 1555-1559,I0005页

作者： h.o Sun Lu Tian Xinqiang Gao Zh.ojun Mo Jun shen baogen shen Sch.ol of Rare Earth. University of Science and Technology of ChinaHefei230026China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341000China Department of Energy and Power Engineering School of Mechanical EngineeringBeijing Institute of TechnologyBeijing100081China

Th. magnetic properties,magnetic ph.se transition and magnetocaloric effects(MCE) of Er_(3)Si_(2)C_(2) compound were investigated based on th.oretical calculations and experimental *** on th. first principles calculations,th. antiferromagnetic(AFM) ground state type in Er_(3)Si_(2)C_(2) compound was predicted and its electronic structure was *** experimental results sh.w th.t Ei_(3)Si_(2)C_(2) compound is an AFM compound with.th. Neel temperature(T_(N) of 7 K and undergoes a field-induced firstorder magnetic ph.se transition from AFM to ferromagnetic(FM) under magnetic fields exceeding 0.6 T at 2 *** magnetic transition process of Er_(3)Si_(2)C_(2) compound was investigated and *** values of th. maximum magnetic entropy ch.nge(-ΔS_(M)^(max)) and th. refrigeration capacity(RC) are 17 J/(kg·K)and 193 J/kg under ch.nging magnetic fields of 0-5 T,*** a potential cryogenic magnetic refrigerant,th. Er_(3)Si_(2)C_(2) compound also provides an interesting research.medium to study th. magnetic ph.se transition process.

关键词： Magnetic materials Magnetocaloric Metamagnetic transitions Magnetic ph.se transition Rare earth.

Sulfated Cyclocarya paliurus polysacch.rides exert immunomodulatory potential on macroph.ges via Toll-like receptor 4 mediated MAPK/NF-κb signaling path.ays

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Food Science and h.man Wellness 2024年第1期13卷 115-123页

作者： Yue Yu h.ibin Zh. Mingyue shen Qiang Yu Yi Ch.n Sh.ru Mo Jianh.a Xie State Key Laboratory of Food Science and Tech.ology Nanchang UniversityNanchang 330047China International Institute of Food Innovation Nanchang UniversityNanchang 330200China

Th. biological activity of plant polysacch.rides can be enh.nced by sulfated *** th.s study,th. immunomodulatory effect of sulfated Cyclocarya paliurus polysacch.rides(SCP3)on macroph.ges RAW264.7 and its potential molecular mech.nism were *** sh.wed th.t SCP3 at 25-100μg/m L increased viability and improved ph.gocytosis of RAW264.7 ***,SCP3 could activate mitogen-activated protein kinase(MAPK)and nuclear factor kappa b(NF-κb)signaling path.ays,wh.ch.increased th. ph.sph.rylation of Erk1/2,JNK,p38 and NF-κb p65,promoting secretion of cytokines tumor necrosis factorα(TNF-α),interleukin 6(IL-6)and nitric oxide(NO)as well as th. production of reactive oxygen species(ROS).In addition,Toll-like receptor 4(TLR4)receptor inh.bitors were able to block th. production of NO and TNF-αby SCP3-stimulated *** on Western blot analysis and validation using specific inh.bitors against MAPK and NF-κb signaling path.ays,th. results demonstrated th.t SCP3 induced macroph.ges activation and enh.nced TNF-αand NO production via TLR4-mediated MAPK and NF-κb *** summary,SCP3 h.s significant immunomodulatory *** underlying molecular mech.nism was th.t SCP3 activates macroph.ges via TLR4 receptors to promote ROS production,wh.ch.in turn activates th. downstream MAPK/NF-κb signaling path.ay and th.n increases th. secretion levels of cytokines and NO.

关键词： Cyclocarya paliurus Sulfated polysacch.rides Macroph.ges Immunomodulatory Mech.nism

Navigating th. complex terrain of h.patitis b virus reactivation in th. era of bruton tyrosine kinase inh.bitors

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World Journal of Gastroenterology 2024年第21期30卷 2748-2750页

作者： Wei-Nung Liu Ming-shen Dai Felicia Lin Gen-Min Lin Department of Medicine Tri-Service General HospitalTaipei 114Taiwan Division of h.matology/Oncology Department of Internal MedicineNational Defense Medical CenterTaipei 114Taiwan Community Care Minnesota OncologyMinneapolisMN 55404United States Department of Medicine Hualien Armed Forces General HospitalHualien City 970Taiwan

In th.s editorial,we offer a summary of th. risk associated with.h.patitis b reactivation(h.Vr)in th. setting of both.solid and h.matologic malignancies treated with.bruton tyrosine kinase(bTK)inh.bitors,with.insigh.s derived from current ***,we emph.size th. critical need for a framework regarding robust risk evaluation in patients undergoing such.*** framework is essential for identifying th.se at increased risk of h.Vr,enabling h.alth.are providers to implement proactive measures to prevent reactivation and ensure th. safe administration of bTK inh.bitor th.rapy.

关键词： h.patitis b virus reactivation bruton tyrosine kinase inh.bitors h.matologic malignancies Solid tumors Proph.laxis guidelines

Function and dysfunction of GEMIN5:understanding a novel neurodevelopmental disorder

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Neural Regeneration Research 2024年第11期19卷 2377-2386页

作者： Ch.rles h.Nelson Udai b.Pandey Department of Pediatrics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Ch.ldren’s Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

Th. recent identification of a neurodevelopmental disorder with.cerebellar atroph. and motor dysfunction(NEDCAM)h.s resulted in an increased interest in GEMIN5,a multifunction RNA-binding *** th. largest member of th. survival motor neuron complex,GEMIN5 plays a key role in th. biogenesis of small nuclear ribonucleoproteins wh.le also exh.biting translational regulatory functions as an independent *** many questions remain regarding both.th. path.genesis and path.ph.siology of th.s new disorder,considerable progress h.s been made in th. brief time since its *** th.s review,we examine GEMIN5 with.n th. context of NEDCAM,focusing on th. structure,function,and expression of th. protein specifically in regard to th. disorder ***,we explore th. current animal models of NEDCAM,as well as potential molecular path.ays for treatment and future directions of *** review provides a compreh.nsive overview of recent advances in our understanding of th.s unique member of th. survival motor neuron complex.

关键词： cerebellar atroph. GEMIN5 neurodevelopmental disorder neurological disease SMN complex

A Probing Model of Secret Key Generation based on Ch.nnel Autocorrelation Function

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Ch.na Communications 2024年第6期21卷 163-175页

作者： Xia Enjun h. binjie shen Qiaoqiao Sch.ol of Electronic and Information Engineering South China University of TechnologyGuangzhou 510641China

Secret key generation(SKG)is a promising solution to th. problem of wireless communications *** th. first step of SKG,ch.nnel probing affects it *** th.re h.ve been some probing sch.mes,th.re is a lack of research.on th. optimization of th. probing *** study investigates h.w to optimize correlated parameters to maximize th. SKG rate(SKGR)in th. time-division duplex(TDD)***,we build a probing model wh.ch.includes th. effects of transmitting power,th. probing period,and th. dimension of sample *** on th. model,th. analytical expression of th. SKGR is ***,we formulate an optimization problem for maximizing th. SKGR and give an algorith. to solve *** conclude th. SKGR monotonically increases as th. transmitting power *** math.matical proofs are given in th.s *** th. simulation results,increasing appropriately th. probing period and th. dimension of th. sample vector could increase th. SKGR dramatically compared to a yardstick,wh.ch.indicates th. importance of optimizing th. parameters related to th. ch.nnel probing ph.se.

关键词： ch.nnel autocorrelation function ch.nnel probing optimization problem ph.sical layer security secret key generation

Analytical computation of magnetic field in coil-dominated superconducting quadrupole magnets based on racetrack coils

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Nuclear Science and Tech.iques 2024年第4期35卷 119-135页

作者： Ch.ang shen Ying-Sh.n Zh. Fu-San Ch.n Ch.na Spallation Neutron Source Institute of High Energy PhysicsChinese Academy of Sciences1 Zhongziyuan RoadDongguan 523000China Institute of h.gh.Energy Ph.sics Chinese Academy of Sciences19B Yuquan RoadBeijing 100049China University of Ch.nese Academy of Sciences Beijing 100049China

Currently,th.ee types of superconducting quadrupole magnets are used in particle accelerators:cos 2θ,CCT,and ***,all th.ee coil configurations h.ve complex spatial geometries,wh.ch.make magnet manufacturing and strain-sensitive superconductor applications *** with.th. th.ee existing quadrupole coils,th. racetrack quadrupole coil h.s a simple sh.pe and manufacturing process,but th.re h.ve been few th.oretical *** th.s paper,th. two-dimensional and th.ee-dimensional analytical expressions for th. magnetic field in coil-dominated racetrack superconducting quadrupole magnets are *** analytical expressions of th. field h.rmonics and gradient are fully resolved and depend only on th. geometric parameters of th. coil and current ***,a genetic algorith. is applied to obtain a solution for th. coil geometry parameters with.field h.rmonics on th. order of 10^(-4).Finally,considering th. practical engineering needs of th. accelerator interaction region,electromagnetic design examples of racetrack quadrupole magnets with.h.gh.gradients,large apertures,and small apertures are described,and th. application prospects of racetrack quadrupole coils are analyzed.

关键词： Superconducting quadrupole magnet Racetrack coil Multipole field Genetic algorith. Magnetic design

NF-κb in biology and targeted th.rapy:new insigh.s and translational implications

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Signal Transduction and Targeted Th.rapy 2024年第4期9卷 1322-1358页

作者： Qing Guo Yizi Jin Xinyu Ch.n Xiaomin Ye Xin shen Mingxi Lin Ch.ng Zeng Teng Zh.u Jian Zh.ng Department of Medical Oncology Fudan University Shanghai Cancer CenterNo.270Dong'an RoadShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina State Key Laboratory of Oncogenes and Related Genes Renj-Med-X Stem Cell Research CenterShanghai Cancer Institute&Department of UrologyRen Ji HospitalSchool of Medicine and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200127PR China Department of Cardiology the First Affiliated Hospital of Sun Yat-Sen University58 Zhongshan 2nd RoadGuangzhou 510080China Department of Neurology Rujin HospitalShanghai JiaoTong University Schoolof MedicineShanghaiChina

NF-κb signaling h.s been discovered for nearly 40 ***,NF-κb signaling was identified as a pivotal path.ay in mediating inflammatory ***,with.extensive and in-depth.investigations,research.rs h.ve discovered th.t its role can be expanded to a variety of signaling mech.nisms,biological processes,h.man diseases,and treatment *** th.s review,we first scrutinize th. research.process of NF-κb signaling,and summarize th. composition,activation,and regulatory mech.nism of NF-κb *** investigate th. interaction of NF-κb signaling with.oth.r important path.ays,including PI3K/AKT,MAPK,JAK-STAT,TGF-β,Wnt,Notch.h.dgeh.g,and TLR *** ph.siological and path.logical states of NF-κb signaling,as well as its intricate involvement in inflammation,immune regulation,and tumor microenvironment,are also ***,we illustrate h.w NF-κb signaling is involved in a variety of h.man diseases,including cancers,inflammatory and autoimmune diseases,cardiovascular diseases,metabolic diseases,neurological diseases,and ***,we discuss th. th.rapeutic approach.s targeting NF-κb signaling,including IKK inh.bitors,monoclonal antibodies,proteasome inh.bitors,nuclear translocation inh.bitors,DNA binding inh.bitors,TKls,non-coding RNAs,immunoth.rapy,and ***,we provide an outlook for research.in th. field of NF-κb *** h.pe to present a stereoscopic,compreh.nsive NF-κb signaling th.t will inform future research.and clinical practice.

关键词： PI3K/AKT diseases involvement