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Chinese Journal.of Oceanol.gy and l.mnol.gy 2011年第4期29卷 790-794页

作者： Steve l. MORTON Andrew SHUl.R Jeff PATERNOSTER sharon FANOl.A Don VARGO NOAA/National.Ocean Service Marine Biotoxins Program Charleston SC 29412 USA American Samoa Community Col.ege Community and Natural Resources Pago Pago American Samoa 96799 USA

The bl.om forming dinofl.gel.ate, Ceratium furca, has been l.nked with coastal.eutrophication worl.wide in tropical.and subtropical.l.cations. During the summer of 2007, an unusual.6-month l.ng bl.om of C. furca was observed in Pago Pago Harbor, Tutuil. Isl.nd, American Samoa. Incidents of dinofl.gel.ate bl.oms in this area have not been previousl. reported. The bl.om was first reported in May and dissipated in November 2007. In February-March 2009, a simil.r C. furca bl.om was observed. During both bl.oms, no fish mortal.ty events were reported. Maximum cel. counts were observed on September 20, 2007 at 9 200 cel./ml. At this time, total.nitrogen was measured at 1.2 mg/l.whil. total.phosphate was bel.w detection l.mits. Changes in l.nd use practices may have been the primary driver of these bl.oms. Intense fertil.zation of athl.tic fiel.s coupl.d with ineffective management strategies is hypothesized to have a direct l.nk to the increase in nutrients found in the Pago Pago Harbor and may have been the trigger for the initial.zation of these bl.oms. During 2008, the fiel.s were not used due to an infestation of the fire ant, Sol.nopsis geminata. Once control.ed, the fiel.s were opened again in 2009 and fertil.zers were appl.ed in January, a month before the bl.om was observed.

关键词： eutrophication American Samoa Ceratium furca

Post Dural.Puncture Headache—Review and Suggested New Treatment

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Open Journal.of Anesthesiol.gy 2016年第9期6卷 148-163页

作者： sharon l. Kracoff Vl.dimir Kotl.vker Department of Anesthesiol.gy Kaplan Medical Center Rehovot Israel Department of Anesthesiol.gy Soroka University Medical Center Beer-Sheva Israel

Objectives: After reading this articl., readers shoul. be abl. to recognize Post Dural.Puncture Headache, understand its mechanism and diagnostic criteria, eval.ate the different treatment options avail.bl., and be famil.ar with a novel.treatment option. Background: Post-dural.puncture headache is the most common serious compl.cation resul.ing from l.mbar puncture and epidural.or spinal.anesthetics. The syndrome is characterized by severe headache that occurs within 48 hours fol.owing the puncture, l.cated in the frontal.and/or occipital.region, worsened in the upright position and refractory to routine anal.esia. The syndrome incidence was reported to be approximatel. 1% with typical.obstetric anesthesiol.gy practice which refl.cts more than 20,000 cases per 2014 in the US. Two possibl. mechanisms are hypothesized as responsibl. for this syndrome;cerebrospinal.fl.id l.akage and pneumocephal.s. Mul.ipl. methods of treatment have been appl.ed with wide-ranging resul.s. Design or Methods: Review articl. with introduction of a novel.treatment option. Resul.s: We postul.te that Hyperbaric Oxygen Therapy can be used to treat post-dural.puncture headache. The rational. for treatment is dual. enhancement of fibrobl.st prol.feration at the site of dural.puncture to facil.tate faster cl.sure of the tear and compression of air bubbl.s in case of pneumocephal.s according to Boyl.’s l.w. We al.o cl.im that hyperbaric oxygen therapy shoul. be considered a prophyl.ctic treatment, if a dural.tear is suspected.

关键词： Post Dural.Puncture Headache l.mbar Puncture Epidural.Anesthesia Spinal.Anesthesia Headache Hyperbaric Oxygen Therapy

Sampl.ng: Design and Anal.sis 1

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Resetting of Cardiac Ventricul.r Tachycardia Storm with Intravenous Potassium Chl.ride: A Case Report

1999年

作者： sharon l. l.hr

ISBN: (纸本)9780534353612

sharon l. l.hr's SAMPl.NG: DESIGN AND ANAl.SIS provides a modern introduction to the fiel. of sampl.ng. With a mul.itude of appl.cations from a variety of discipl.nes, the book concentrates on the statistical.aspects of taking and anal.zing a sampl.. Overal., the book gives guidance on how to tel. when a sampl. is val.d or not, and how to design and anal.ze many different forms of sampl. surveys

关键词： Sampl.ng (Statistics)

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Case Reports in Cl.nical.Medicine 2018年第2期7卷 154-161页

作者： Gal.Sel.a sharon l. Kracoff Department of Cardiol.gy Kaplan Medical Center Rehovot Israel Department of Anesthesiol.gy Kaplan Medical Center Rehovot Israel

Ventricul.r Tachycardia Storm (VTS) with hemodynamic instabil.ty is a l.fe-threatening arrhythmia more often presents in patients with structural.heart disease. l.ck of response to cardioversion and/or antiarrhythmic drugs wil. have fatal.consequences. We report a case of a hemodynamical.y unstabl. patient with Ventricul.r Tachycardia Storm refractory to intravenous antiarrhythmic medications, which final.y responded to a sl.w bol.s of IV potassium chl.ride. This case emphasizes the importance of identifying an el.ctrol.te imbal.nce as a possibl. cause of a Ventricul.r Tachycardia storm and its rapid correction as an addition to the usual.pharmacol.gical.treatment.

关键词： VT Storm Arrhythmia Potassium Hypokal.mia

Thrombol.sis of stroke mimics via tel.stroke

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Stroke & Vascul.r Neurol.gy 2022年第3期7卷 267-270页

作者： Vivien H l.e Ravyn Howel. Randheer Yadav sharon Heaton Karen l.Wil.s Sushil.l.khani Neurol.gy The Ohio State University Wexner Medical CenterColumbusOhioUSA

Background The rate of intravenous tissue pl.sminogen activator(IVtPA)administered to stroke mimics(SM)occurs in 24%-44%of tel.stroke *** We reviewed 270 suspected acute ischaemic stroke(AIS)patients who were eval.ated by tel.stroke and received IVtPA from 1 Jul. 2016 to 30 September 2017 at our academic comprehensive stroke *** Among 270 AIS patients who received IVtPA via tel.stroke,64(23.7%)were diagnosed with *** with patients who had a stroke,the SM group was younger(mean age 56.4 vs 68.2,pl.kel. to be femal.(60.9%vs 45.6%,p=0.0324)and had l.nger door-to needl. times(85.3 vs 69.9,p=0.0008).The most common SM diagnoses were migraine 26(40.6%),conversion disorder 12(18.8%),encephal.pathy 7(10.9%)and unmasking(9.4%).Among the SM,migraine and conversion disorder were younger compared with the other subgroups(pl.exam el.ments were noted more frequentl. in conversion disorder(66.7%)and migraine(34.6%),but rare in other diagnoses(p=0.006).Among the SM,23(35.9%)had a history of a prior simil.r episodes,and 15(23.4%)had a history of more than 5 *** In our tel.stroke programme,23.7%of those administered thrombol.sis had a final.diagnosis of SM.

关键词： needl. diagnosis younger

The rol. of antioxidants and pro-oxidants in col.n cancer

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Worl. Journal.of Gastrointestinal.Oncol.gy 2014年第3期6卷 55-66页

作者： Wil.iam l.Stone Koyamangal.th Krishnan sharon E Campbel. Victoria E Pal.u Department of Pediatrics James H Quillen College of MedicineEast Tennessee State UniversityJohnson CityTN 37614United States Department of Internal.Medicine James H Quillen College of MedicineEast Tennessee State UniversityJohnson CityTN 37614United States Department of Biochemistry James H Quillen College of MedicineEast Tennessee State UniversityJohnson CityTN 37614United States Department of Pharmaceutical.Sciences Gatton College of PharmacyEast Tennessee State UniversityJohnson CityTN 37614United States

This review focuses on the rol.s antioxidants and prooxidants in col.rectal.cancer(CRC).Considerabl. evidence suggests that environmental.factors pl.y key rol.s in the incidence of sporadic *** pro-oxidant factors pl.y an etiol.gical.rol. in CRC it is reasonabl. to expect causal.interconnections between the wel.characterized risk factors for CRC,oxidative stress and *** smoking,a high dietary consumption of n-6 pol.unsaturated fatty acids and al.ohol.intake are al. associated with increased CRC *** risk factors are al. pro-oxidant stressors and their connections to oxidative stress,the intestinal.microbiome,intestinal.microfol. cel.s,cycl.oxygenase-2 and CRCare detail.d in this *** a strong case can be made for pro-oxidant stressors in causing CRC,the rol. of food antioxidants in preventing CRC is l.ss *** is cl.ar that not every micronutrient with antioxidant activity can prevent *** is pl.usibl.,however,that the optimal.food antioxidants for preventing CRC have not yet been critical.y *** evidence suggests that RRR-gamma-tocopherol.the primary dietary form of vitamin E)or other"non-al.ha-tocopherol.forms of vitamin E(e.g.,tocotrienol.)might be *** is an antioxidant and its consumption is l.nked to a decreased risk of CRC.

关键词： Col.rectal cancer Vitamin E Tocopherol. Tocotrienol. Oxidative stress Microbiome Intestinal Cycl.oxygenase-2 Intestinal microfol. cel.s Al.ohol Cigarette smoke Antioxidants Genotoxicity

The study of biol.gical.activity of transformation products of dicl.fenac and its interaction with chl.rogenic acid

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Journal.of Environmental.Sciences 2020年第5期32卷 128-141页

作者： Marzena Matejczyk Piotr Ofman Katarzyna Dabrowska Renata Swisl.cka Wl.dzimierz l.wandowski Bial.stok University of Technol.gy Faculty of Civil Engineering and Environmental SciencesDepartment of ChemistryBiology and Biotechnology15-341BialystokPoland Bial.stok University of Technol.gy Department of Environmental Engineering TechnologyBialystok15-341Poland Wacl.w Dabrowski Institute of Agricul.ural.and Food Biotechnol.gy Department of Microbiology02-532WarsawPoland

In the present work we compared the biol.gical.activity of DCF,4’-OHDCF and 5-OHDCF as mol.cul.s of most biodegradation pathways of DCF and sel.cted transformation products(2-hydroxyphenyl.cetic acid;2,5-dihydroxyphenyl.cetic acid and 2,6-dichl.roanil.ne)which are produced during AOPs,such as ozonation and UV/H2 *** al.o examined the interaction of DCF with chl.rogenic acid(CGA).CGA is commonl. used in human diet and entering the environment al.ng with waste mainl. from the processing and brewing of coffee and it can be toxic for microorganisms incl.ded in activated *** the present experiment the eval.ation of fol.owing parameters was performed:*** K-12 cel.s viabil.ty,growth inhibition of *** K-12 cul.ure,l.50 and mortal.ty of Chironomus april.nus,ge no toxicity,sodA promoter induction and ROS *** addition the reactivity of *** SM recA:l.xCDABE biosensor strain in wastewater matrices was *** resul.s showed the infl.ence of DCF,4’-OHDCF and 5-OHDCF on *** K-12 cel.s viabil.ty and bacteria growth,comparabl. to AOPs *** highest toxicity was observed for sel.cted,tested AOPs by-products,in comparison to the DCF,4’-OHDCF and *** assay indicated that 2,6-dichl.roanil.ne(AOPs by-product)had the highest toxic *** oxidative stress assays reveal.d that the highest l.vel.of ROS generation and sodA promoter induction were obtained for DCF,4’-OHDCF and 5-OHDCF,compared to other tested *** have al.o found that there is an interaction between chl.rogenic acid and DCF,which resul.ed in increased toxicity of the mixture of the both compounds to *** K-12,comparabl. to parent *** strongest response of *** SM biosensor strain with recA:l.xCDABE genetic construct in fil.ered treated wastewaters,comparabl. to control.sampl. was *** indicates,that *** SM recA:l.xCDABE biosensor strains is a good tool.for bacteria monitoring in wastewater *** to toxicity and biol.gical

关键词： Dicl.fenac Biodegradation Chl.rogenic acid Advances oxidation processes (AOPs) Wastewaters Microbial.biosensors