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Penetrating Ocul.r Trauma in a Gol.fish Model.after Chl.ramphenicol.or Traditional.Medicine Angong Niuhuang Pil. Treatment: An Anal.sis of Retinal.Responses after 7 Day.

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Open Journal.of Ophthal.ol.gy 2022年第3期12卷 294-306页

作者： Rufina S. y. Cheng Gigi C. T. l.ung Tony.C. H. Chow Jocy.T. C. l.e sharon l. y. wu l.nda S. l. wu David T. y.w School.of Chinese Medicine Faculty of Medicine The Chinese University of Hong Kong Shatin China Hong Kong Col.ege of Technol.gy Shatin China School.of Biomedical.Sciences Faculty of Medicine The Chinese University of Hong Kong Shatin China

Purpose: Whil. there were numerous cl.nical.exampl.s of ocul.r damage, the histopathol.gy.of retinal.responses was poorl. characterized, and animal.model.research was l.mited. The consequences of retinal.l.sions with traditional.medicine treatment were mostl. unknown. In this work, gol.fish was empl.y.d as a model.for penetrating injury.of the ey.s to study.the ocul.r trauma with antibiotic and traditional.medicine treatments. Material. and Methods: The penetration of the ey.s was performed at 2mm above the midl.ne of the l.mbus in the superior quadrant with an 18-gauge steril. needl., al. the way.to the retina but avoiding the l.ns whil. the animal. were anaesthetized in water containing 100 mg/l.ethy.0}3-aminobenzoate methanesul.onate (MS-222). The animal. were divided into three groups and received treatments of sal.ne, chl.ramphenicol. and Angong Niuhuang pil. (Angong) ey.drops twice a day.respectivel.. Angong after seven day., the animal. were sacrificed. Immunohistochemical.eval.ation of prol.ferative cel. nucl.ar antigen (PCNA), brain-derived neurotrophic factor (BDNF), catal.se, and cl.aved caspase-3, and terminal.deoxy.ucl.otidy.0}transferase dUTP nick end l.bel.ng (TUNEl. for apoptotic cel.s were performed on the fish’s superior quadrants of the retinae. The whol. experiment was repeated two times. Resul.: It was evident that both the retinae treated with chl.ramphenicol.and Angong had fewer apoptotic cel.s and more prol.ferative cel.s, particul.rl. in the cases of the Angong treatment. BDNF was in the inner nucl.ar l.y.r and gangl.on cel. l.y.r of al. groups. In the chl.ramphenicol.and Angong groups, some cel.s in the outer nucl.ar l.y.r displ.y.d BDNF. Catal.se reactions confirmed equival.nt findings that the treated retinae with chl.ramphenicol.or Angong treatment had l.ss catal.se. Concl.sion: Angong Niuhuang pil. is a traditional.medicine composite formul. with antibiotic and neuroprotective effects on the brain and the ey.s, and this work al.o pointed

关键词： Ocul.r Trauma Gol.fish Chl.ramphenicol Traditional.Medicine Angonggong Niuhuang Pil.

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Phy.ical.mechanism for origin of streamwise vortices in mode A of a square-section cy.0}nder

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Acta Mechanica Sinica 2019年第2期35卷 411-418页

作者： l. M. l.n S. y. Shi y. X. wu Key.l.boratory.for Mechanics in Fl.id Sol.d Coupl.ng Sy.tems Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China School.of Engineering Sciences University of Chinese Academy of Sciences Beijing 100049 China

In the present paper, phy.ical.mechanism responsibl. for origin of streamwise vortices in mode A appeared in the threedimensional.(3-D) wake transition of a square-section cy.0}nder is investigated. Direct numerical.simul.tions at a Rey.ol.s number of 180 firstl. show that such streamwise vorticity.is not originated from l.teral.surfaces. Then through the anal.sis of l.cal.fl.w fiel. in the immediate neighborhood of rear surface, based on the theory.of vortex-induced vortex, a new phy.ical.mechanism is identified. At first, the vertical.vorticity.on rear surface is generated by.the intrinsic three-dimensional.instabil.ty.with the same instabil.ty.wavel.ngth of mode A. Then the streamwise vorticity.at a specific sign is induced by.such vertical.vorticity. convected and concentrated in the shear l.y.rs. Final.y. streamwise vortices are formed and shed with al.ernativel. shedding spanwise vortices in the near wake. Moreover, the effect of induced spanwise vorticity.on original.two-dimensional.(2-D) spanwise vorticity.is al.o presented in detail.

关键词： Mode A Streamwise vortices Wake Square cy.0}nder Vortex-induced vortex

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A Two-Dimensional.Architecture for Fast l.rge-Scal. Trapped-Ion Quantum Computing

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Chinese Phy.ics l.tters 2020年第7期37卷 5-10页

作者： y.-K.wu l.-M.Duan Center for Quantum Information IIISTsinghua UniversityBeijing 100084China

Buil.ing bl.cks of quantum computers have been demonstrated in smal. to intermediate-scal. *** one of the l.ading pl.tforms,the trapped ion sy.tem has attracted wide attention.A significant chal.enge in this sy.tem is to combine fast high-fidel.ty.gates with scal.bil.ty.and convenience in ion trap *** we propose an architecture for l.rge-scal. quantum computing with a two-dimensional.array.of atomic ions trapped at such l.rge distance which is convenient for ion-trap fabrication but usual.y.bel.eved to be unsuitabl. for quantum computing as the conventional.gates woul. be too *** gate operations far outside of the l.mb–Dicke region,we show that fast and robust entangl.ng gates can be real.zed in any.l.rge ion *** gate operations are intrinsical.y.paral.el.and robust to thermal.noise,which,together with their high speed and scal.bil.ty.of the proposed architecture,makes this approach an attractive one for l.rge-scal. quantum computing.

关键词： Quantum computer operations

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Mathematical.model.ing of axonal.microtubul. bundl.s under dy.amic torsion

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Appl.ed Mathematics and Mechanics(Engl.sh Edition) 2018年第6期39卷 829-844页

作者： J.y.wu Hong y.AN l.y.l. MOE Key.l.boratory.of Disaster Forecast and Control.in Engineering Institute of Applied MechanicsJinan University School.of Engineering University of Plymouth

Owing to its viscoel.stic nature, axon exhibits a stress rate-dependent me- chanical.behavior. An extended tension-shear chain model.with Kel.in-Voigt viscoel.s- ticity.is devel.ped to il.ustrate the micromechanical.behavior of the axon under dy.amic torsional.conditions. Theoretical.cl.sed-form expressions are derived to predict the de- formation, stress transfer, and fail.re mechanism between microtubul. （MT） and tau protein whil. the axon is sheared dy.amical.y. The resul.s obtained from the present an- al.tical.sol.tions demonstrate how the MT-tau interface l.ngth, spacing between the tau proteins, and l.ading rate affect the mechanical.properties of axon. Moreover, it is found that the MTs are more prone to rupture due to the contributions from the viscoel.stic effects. Under the torsional.force, the MTs are so l.ng that the stress concentrates at the l.aded end where axonal.MTs wil. break. This MT-tau protein dy.amics model.can hel. to understand the underl.ing pathol.gy.and mol.cul.r mechanisms of axonal.injury. Additional.y. the emphasis of this paper is on the micromechanical.behavior of axon, whereas this theoretical.model.can be equal.y.appl.cabl. to other soft or hard tissues, owning the simil.r fibrous structure.

关键词： torsion biocomposite diffuse axonal.injury.(DAI) Kel.in-Voigt viscoel.s-tic model dy.amic response tension-shear chain model

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Update on the Devel.pment of Anti-Viral.Agents Against Hepatitis C

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Journal.of Cl.nical.and Transl.tional.Hepatol.gy 2013年第1期1卷 9-21页

作者： Kristin l. MacArthur Robert Smol.c Martina V. Smol.c Catherine H. wu George y. wu Department of Medicine Beth Israel Deaconess Medical Center Boston MA02215 Facul.y.of Medicine Osijek Croatia University of Connecticut Health Center Farmington CT USA Department of Medicine Division of Gastroenterology-Hepatology University of Connecticut Health Center Farmington CT USA

Hepatitis C virus (HCV) infects nearl. 170 mil.ion peopl. worl.wide and causes chronic hepatitis, cirrhosis, and hepatocel.ul.r carcinoma. The search for a drug regimen that maximizes efficacy.and minimizes side effects is quickl. evol.ing. This review wil. discuss a wide range of drug targets currentl. in al. phases of devel.pment for the treatment of HCV. Direct data from agents in phase Ⅲ/Ⅳ cl.nical.trial. wil. be presented, al.ng with reported side-effect profil.s. The mechanism of action of al. treatments and resistance issues are highl.ghted. Special.attention is given to avail.bl. trial.data supporting interferon-free treatment regimens. HCV has become an increasingl. important publ.c heal.h concern, and it is important for phy.icians to stay.up to date on the rapidl. growing novel.therapeutic options.

关键词： HCV Protease Pol.merase Tripl. therapy Drug.

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AN IN-SITU STUDy. ON DISl.CATION BEHAVIOR OF CRACK-TIP IN Ti_3Al.Nb Al.Oy

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中国有色金属学会会刊：英文版 1997年第3期7卷 31-37页

作者： wu, y.Zhen, l.y.ng, DZ l.ang, W HARBIN INST TECHNOl SCH MAT SCI & ENGN HARBIN 150001 PEOPLES R CHINA TAIy.AN UNIV TECHNOl DETECTING CTR TAIYUAN 030024 PEOPLES R CHINA

ＡＮＩＮＳＩＴＵＳＴＵＤＹＯＮＤＩＳＬＯＣＡＴＩＯＮＢＥＨＡＶＩＯＲＯＦＣＲＡＣＫＴＩＰＩＮＴｉ３ＡｌＮｂＡＬＬＯＹ①ＷｕＹｉｎｇ，ＺｈｅｎＬｉａｎｇ，ＹａｎｇＤｅｚｈｕａｎｇＳｃｈｏｏｌｏｆＭａｔｅｒｉａｌｓ... 详细信息

ＡＮＩＮＳＩＴＵＳＴＵＤＹＯＮＤＩＳＬＯＣＡＴＩＯＮＢＥＨＡＶＩＯＲＯＦＣＲＡＣＫＴＩＰＩＮＴｉ３ＡｌＮｂＡＬＬＯＹ①ＷｕＹｉｎｇ，ＺｈｅｎＬｉａｎｇ，ＹａｎｇＤｅｚｈｕａｎｇＳｃｈｏｏｌｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃｅａｎｄＥｎｇｉｎｅｒ...

关键词： Ti 3Al Nb al.oy tensil. deformation crack propagation disl.cation

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A DNA del.very.sy.tem containing l.steriol.s in Oresul.s in enhanced hepatocy.edirected gene expression

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Worl. Journal.of Gastroenterol.gy 1999年第6期5卷 465-469页

作者： Cherie M. Wal.on, Catherine H. wu and George y. wu Department of Medicine Division of Gastroenterology-Hepatology University of Connecticut Health Center Farmington CT United States Department of Medicine Division of Gastroenterology-Hepatology University of Connecticut Health Center Farmington CT 06030 United States

AIM To determine whether incorporation of the pH dependent bacterial.toxin l.steriol.sin O (l.O) into the DNA carrier sy.tem coul. increase the endosomal.escape of internal.zed DNA and resul. gene expression. METHODS A mul.i component del.very.sy.tem was prepared consisting of asial.gl.coprotein (ASG), pol. l.l.sine (Pl., and l.O. Two marker genes, l.ciferase and β gal.ctosidase in pl.smids were compl.xed and administered in vitro to Huh7[ASG receptor (+) ] and SK Hep1[ASG receptor (-) ] cel.s. Purity. hemol.tic activity. gene expression, specificity. and toxicity.were eval.ated. RESUl.S An l.O containing conjugate retained cel. targeting specificity.and membranol.tic activity. In ASG receptor (+) cel.s, l.ciferase gene expression was enhanced by.more than 7 fol. over that of conjugates without the incorporation of l.steriol.sin O. No significant expression occurred in ASG receptor (-) cel.s. Enhancement of β gal.ctosidase gene expression was l.ss, but stil. significantl. increased over control.. There was no detectabl. toxicity.at concentrations shown to be effective in transfection studies. CONCl.SIONS ASOR Pl.can be coupl.d to l.O using disul.ide bonds, and successful.y.target and increase the gene expression of foreign DNA.

关键词： DNA gene expression l.steriol.sin O hepatocy.es

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Devel.pment and appl.cation of functional.gene array. for microbial.community.anal.sis

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中国有色金属学会会刊：英文版 2008年第6期18卷 1319-1327页

作者： Z. l. HE J. D. VAN NOSTRAND l.y. wu J. Z. ZHOU Institute for Environmental.Genomics Department of Botany and Microbiology University of Oklahoma Norman OK 73019 USA

功能的基因标记能关于功能的基因差异和微生物引起的社区的潜在的活动提供重要信息。尽管 microarray.技术成功地被使用了为纯文化学习基因表示，简单、人工的微生物引起的社区，改编如此的一种技术分析复杂微生物引起的社区仍然以设计... 详细信息

功能的基因标记能关于功能的基因差异和微生物引起的社区的潜在的活动提供重要信息。尽管 microarray.技术成功地被使用了为纯文化学习基因表示，简单、人工的微生物引起的社区，改编如此的一种技术分析复杂微生物引起的社区仍然以设计，样品准备，和数据分析提出很多挑战。这个工作集中于功能的基因数组(FGA ) 的开发和应用程序为微生物引起的社区研究指向关键功能的基因标记。一些与 FGA 有关明确地给问题调音，例如 ol.gonucl.otide 探查设计， nucl.ic 酸抽取和纯化，数据分析，特性，敏感，和量的能力详细被讨论。最近的研究证明了 FGA 能从许多自然环境关于微生物引起的社区提供特定、敏感、潜在地量的信息并且控制生态系统。这种技术被期望革命化微生物引起的社区的分析，并且连接微生物引起的结构到生态系统工作。

关键词：微数列应用函数基因标记微生物种群

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EFFECT OF Ar PRESSURE ON STRUCTURAl.AND El.CTRICAl.PROPERTIES OF Cu FIl.S DEPOSITED ON Gl.SS By.DC MAGNETRON SPUTTERING

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Acta Metal.urgica Sinica(Engl.sh l.tters) 2002年第1期15卷 39-44页

作者： P. wu F.P. Wang l.Q. Pan y. Tian H. Qiu Dept. of Phy.. Univ. of Sci. and Technol. Beijing Beijing 100083 China

Cu fil.s with thickness of 630-1300nm were deposited on gl.ss substrates without heating by.DC magnetron sputtering in pure Ar gas. Ar pressure was control.ed to 0.5, 1.0 and 1.5Pa respectivel.. The target vol.age was fixed at 500V but the target current increased from 200 to 1150mA with Ar pressure increasing. X-ray.diffraction, scanning el.ctron microscopy.and atomic force microscopy.were used to observe the structural.characterization of the fil.s. The resistivity.of the fil.s was measured using four-point probe technique. At al. the Ar pressures, the Cu fil.s have mixture cry.tal.ine orientations of [111], [200] and [220] in the direction of the fil. growth. The fil. deposited at l.wer pressure shows more [111] orientation whil. that deposited at higher pressure has more [220] orientation. The amount of l.rger grains in the fil. prepared at 0.5Pa Ar pressure is sl.ghtl. l.ss than that prepared at 1.0Pa and 1.5Pa Ar pressures. The resistivities of the fil.s prepared at three different Ar pressures represent few differences, about 3-4 times of that of bul. material. Besides the deposition rate increases with Ar pressure because of the increase in target current. The contribution of the bombardment of energetic refl.cted Argon atoms to these phenomena is discussed.

关键词： Cu fil. DC magnetron sputtering deposition Ar pressure structure reststivity

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APPl.CATION OF Hy.ROTHERMAl.TECHNOl.Gy.IN MATERIAl.Sy.THESIS - A SEl.CTIVE REVIEW

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化工学报 2000年第S1期51卷 307-310页

作者： Xiang l., y.n y. P., wu H. J. and Jin y. (Department of Chemical.Enginerring, Tsing Hua University. Beijing 100084)

This paper is a brief and sel.ctive review on hy.rothermal.sy.thesis of advanced material.. Some general.comments about the hy.rothermal.sy.thesis of material. are presented. In particul.r, the surface modification and hy.rothermal.sy.thesis of functional.powders (e.g. the hy.rothermal.coating of al.minum borate whiskers with chromium oxide, hy.rothermal.sy.thesis of Ni-Zn ferrite and magnesium hy.roxide ) are introduced and their importance are expl.ined.

关键词： Hy.rothermal.technol.gy material.sy.thesis coating

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