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Journal of Environmental Sciences 2009年第6期21卷 858-864页

作者： sharma ashwani THAKUR Indu Shekhar Environmental Biotechnology Laboratory School of Environmental SciencesJawaharlal Nehru UniversityNew Mehrauli Road

A bacterial consortium was developed by continuous enrichment of microbial population isolated from sediment core of pulp and paper mill effluent in mineral salts medium（MSM） supplemented with pentachlorophenol（PCP） as sole source of carbon and energy in the *** consortia contained three bacterial *** were identified as Escherichia coli,Pseudomonas aeruginosa and Acinetobacter *** 16S rRNA gene sequence *** *** degraded PCP through the formation of tetrachloro-p-hydroquinone（TecH）,2-chloro-1,4-benzenediol and products of ortho ring cleavage detected by gas chromatograph/mass spectrometer（GC-MS）.Out of the three acclimated PCP degrading bacterial strains only one strain,Acinetobacter *** the presence of integron gene cassette as a marker of its stability and antibiotic *** strain possessed a 4.17 kb amplicon with 22 ORF＇*** plasmid isolated from the Acinetobacter *** subjected to shotgun cloning through restriction digestion by BamHI,HindIII and SalI,ligated to pUC19 vector and transformed into *** XLBlue1α,and finally selected on MSM containing PCP as sole source of carbon and energy with ampicillin as antibiotic *** sequence analysis of recombinant clones indicated homology with integron gene cassette and multiple antibiotic resistance genes.

关键词： Acinetobacter sp. antibiotic resistance gene chemostat integron gene cassette pentachlorophenol recombinant clone

Emerging leishmaniasis in southern Himalayas:A mini-review

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World Journal of Clinical Infectious Diseases 2023年第2期13卷 11-23页

作者： ashwani sharma Santosh Kumar Prasan Kumar Panda Sweety Yadav Deepjyoti Kalita Department of Community and Family Medicine All India Institute of Medical SciencesRishikesh 249203India Department of Medicine All India Institute of Medical SciencesRishikesh 249203India Department of Internal Medicine All India Institute of Medical SciencesRishikesh 249203India Department of Microbiology All India Institute of Medical SciencesRishikesh 249203India

Leishmaniasis is a vector-borne parasitic disease affecting millions of people ***,in the last decade,the number of cases has been reduced from well-documented endemic parts,but sporadic cases have been reported widely from various non-endemic areas,especially from the southern Himalayan *** raises concerns about the emergence of new ecological *** warrants a critical evaluation of key factors causing this rapid spread and possibly indigenous *** mini-review article is aimed to briefly address the parasite,the vector,and the environmental aspects in the transmission of leishmaniasis in these new foci against a background of worldwide endemic leishmaniasis with a special focus on the southern Himalayan *** the lack of knowledge about the causative parasites,vectors,reservoir hosts,atypical presentations,and their management make the problem serious and may lead to the emergence of public health *** present works also reviewed the existing information regarding clinical variations,diagnostic methods,treatment,its outcome,and ignite for further research in these aspects of the disease.

关键词： Anthroponosis Kala azar sandfly Sporadic transmission Southern Himalaya

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal sharma Sehwan Kim Hyemi Eo Sang Ryong Kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

Estimation of composite load model with aggregate induction motor dynamic load for an isolated hybrid power system

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Frontiers in Energy 2015年第4期9卷 472-485页

作者： Nitin Kumar SAXENA ashwani Kumar sharma Deptment of Electrical Engineering NIT Kumkshetra Haryana 136119 India

It is well recognized that the voltage stability of a power system is affected by the load model and hence, to effectively analyze the reactive power compensation of an isolated hybrid wind-diesel based power system, the loads need to be considered along with the generators in a transient analysis. This paper gives a detailed mathematical modeling to compute the reactive power response with small voltage perturbation for composite load. The composite load is a combination of the static and dynamic load model. To develop this composite load model, the exponential load is used as a static load model and induction motors （IMs） are used as a dynamic load model. To analyze the dynamics of IM load, the fifth, third and first order model of IM are formulated and compared using differential equations solver in Matlab coding. Since the decentralized areas have many small consumers which may consist large numbers of IMs of small rating, it is not realistic to model either a single large rating unit or all small rating IMs together that are placed in the system. In place of using a single large rating IM, a group of motors are considered and then the aggregate model of IM is developed using the law of energy conservation. This aggregate model is used as a dynamic load model. For different simulation studies, especially in the area of voltage stability with reactive power compensation of an isolated hybrid power system, the transfer function AQ/AV of the composite load is required. The transfer function of the composite load is derived in this paper by successive derivation for the exponential model of static load and for the fifth and third order IM dynamic load model using state space model.

关键词： isolated hybrid power system (IHPS) compo- site load model static load dynamic load induction motorload model aggregate load

In vivo antianxiety and antidepressant activity of Murraya paniculata leaf extracts

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Journal of Integrative Medicine 2017年第4期15卷 320-325页

作者： Pragya sharma Sonali Batra ashwani Kumar Anupam sharma University Institute of Pharmaceutical Sciences Panjab University

OBJECTIVE： Different parts of Murraya paniculata have been used traditionally for treating several ailments including mental disorders. The present study was designed to evaluate the antianxiety and antidepressant potential of M. paniculata leaves using elevated plus maze model and forced swim test, respectively. METHODS： Extracts of M. panicu/ata made with petroleum ether （60-80 ℃）, chloroform, ethanol and water were evaluated for antianxiety and antidepressant activity. The anxiolytic chloroform extract was subjected to column chromatography, yielding five fractions （F1-F5）. Fraction F5 （100 mg/kg）, which showed notable anxiolytic activity, was further chromatographed to get four subfractions （F5.1-F5.4）. Simultaneously, the ethano extract was partitioned with ethyl acetate to obtain ethyl acetate soluble fraction （EASF） and ethyl acetate insoluble fraction. Phytochemical screening of bioactive extracts/fractions and detection of mahanimbine in M paniculata leaf extract by thin-layer chromatography was also carried out. RESULTS： Fraction F5.3 （25 mg/kg） and EASF （20 mg/kg） showed significant anxiolytic and antidepressant activity, respectively. Thin-layer chromatography and phytochemical screening demonstrated the absence of mahanimbine in M. paniculata leaves. Coumarins were observed to be responsible for the anxiolytic activity. CONCLUSION： The results validate the traditional use of M. paniculata leaves in the treatment of menta disorders.

关键词： Murraya paniculata anxiety depressant coumarins mahanimbine plants, medicinal

Recognition and quality mapping of traditional herbal drugs:way forward towards artificial intelligence

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Traditional Medicine Research 2025年第1期10卷 12-26页

作者： Sanyam sharma Subh Naman Ashish Baldi Faculty of Pharmacy Pacific Academy of Higher Education and Research UniversityUdaipur 313024India Pharma Innovation Lab Department of Pharmaceutical Sciences and TechnologyMaharaja Ranjit Singh Punjab Technical UniversityBathinda 151001India Faculty of Pharmaceutical Sciences The ICFAI UniversityBaddi 174103India.

The use of traditional herbal drugs derived from natural sources is on the rise due to their minimal side effects and numerous health ***,a major limitation is the lack of standardized knowledge for identifying and mapping the quality of these herbal *** article aims to provide practical insights into the application of artificial intelligence for quality-based commercialization of raw herbal *** focuses on feature extraction methods,image processing techniques,and the preparation of herbal images for compatibility with machine learning *** article discusses commonly used image processing tools such as normalization,slicing,cropping,and augmentation to prepare images for artificial intelligence-based *** also provides an overview of global herbal image databases and the models employed for herbal plant/drug *** will gain a comprehensive understanding of the potential application of various machine learning models,including artificial neural networks and convolutional neural *** article delves into suitable validation parameters like true positive rates,accuracy,precision,and more for the development of artificial intelligence-based identification and authentication techniques for herbal *** article offers valuable insights and a conclusive platform for the further exploration of artificial intelligence in the field of herbal drugs,paving the way for smarter identification and authentication methods.

关键词： artificial intelligence Ayurveda machine learning models herbal drugs image pre-processing medicinal plants

Metal nanocomposites-based electrochemical sensor for the detection of Vanillin (food additives): Experimental and theoretical approach

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Food Bioscience 2023年第2期52卷 1451-1465页

作者： Rajni Kumari Harish Kumar Ankita Yadav Rahul sharma Anita Kumari ashwani Kumar Dept.of Chemistry Central University of HaryanaMahendergarhIndia Dept.of Nutrition Biology School of Interdisciplinary SciencesCUHMahendergarhIndia

A sensitive and selective electrochemical sensor was developed to detect Vanillin using Mn/Zn/V(MZV)*** nanocomposites were synthesized by modified Sol-gel technique and characterized by FT-IR,UV-VIS,SEM,and XRD *** Voltammetry,Linear Sweep Voltammetry,and Differential Pulse Voltammetry experiments were performed on a three-electrode-based electrochemical system.A computational study(DFT)was used to support experimental data and understand chemistry at the working electrode/electrolyte *** specially designed working electrode showed a good sensing ability toward Vanillin in real and reference *** working electrode displays a linear response between the current density and concentration of Vanillin(20-120μM)with a lowest detection limit of 120μ*** characteristic oxidative(0.051 V)and reductive peak(0.47 V),formal potential(0.270 V),open circuit potential(-570 mV),current density,and Emid potential(0.025 V)of Vanillin help in qualitative *** and stability of working electrodes were tested for 60 days.

关键词： Metal oxide nanocomposite Electrochemical sensor Vanillin Cyclic voltammetry

A review of ecological risk assessment and associated health risks with heavy metals in sediment from India

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International Journal of Sediment Research 2020年第5期35卷 516-526页

作者： Vinod Kumar Anket sharma Shevita Pandita Renu Bhardwaj ashwani Kumar Thukral Artemi Cerda Department of Botany Government Degree College Ramban State Key Laboratory of Subtropical Silviculture Zhejiang Agriculture & Forest University Department of Botany University of Jammu Department of Botanical and Environmental Sciences Guru Nanak Dev University Soil Erosion and Degradation Research Group Department of GeographyUniversity of Valencia

Heavy metal(HM) pollution in sediment is a serious concern particularly in developing nations,warranting an extensive survey to understand the current situation and propose possible remedial *** paper compiles the data of HMs cadmium(Cd),iron(Fe),cobalt(Co),manganese(Mn),arsenic(As),lead(Pb),chromium(Cr),copper(Cu),zinc(Zn) and nickel(Ni) in aquatic sediment from India from 1979 to *** was found that mean values of Cu,Co,Zn,Pb,As,and Cr in Indian sediment were high in comparison to the Australian Interim Sediment Quality Guidelines,World Surface Rock Average,and the Threshold Effect Level for freshwater *** activities,lithogenic factors,and sand intrusion are the main factors associated with HM pollution as observed using cluster analysis and principal component *** results of contamination indices indicate that HM contamination ranged from average to high,in the *** ecological risk assessment results showed that 11%HMs present very high *** cancer risk,due to the high contents of Cd,As,and Cr the ingestion pathway,showed high risk of cancer through food/water contaminated with *** source reduction of HMs in industrial effluents by effluent treatment plants,and plantation of phytoremediating rooted macrophytes in sediment may help in HM mitigation of the sediment.

关键词： Sediments Heavy metal pollution Ecological risk assessment Cancer risk Health risk

A novel method to investigate voltage stability of IEEE-14 bus wind integrated system using PSAT

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Frontiers in Energy 2020年第2期14卷 410-418页

作者： Satish KUMAR ashwani KUMAR N.K.sharma Department of Electrical Engineering National Institute of Technology(NIT)KurukshetraHaryana 136119India Department of Electrical Engineering G L Bajaj Institute of Technology and ManagementGreater NoidaUtter Pradesh 201306India

The maximum demand of power utilization is increasing exponentially from base load to peak load in day to day *** power demand may be either industrial usage or household *** meet this high maximum power demand by the consumer,one of the options is the integration of renewable energy resources with conventional power generation *** the present scenario,wind energy system is one of the methods to generate power in connection with the conventional power *** the load on the conventional grid system increases,various bus voltages of the system tend to decrease,causing serious voltage drop or voltage instability within the *** view of this,identification of weak buses within the system has become *** paper presents the line indices method to identify these weak buses,so that some corrective action may be taken to compensate for this drop in *** attempt has been made to compensate these drops in voltages by integration of renewable energy *** wind energy system at one of the bus in the test system is integrated and the performance of the system is verified by calculating the power flow(PF)using the power system analysis tool box(PSAT)and line indices of the integrated test *** PF and load flow results are used to calculate line indices for the IEEE-14 bus test system which is simulated on PSAT.

关键词： voltage stability line indices power system analysis tool box(PSAT) wind system line loading power flow(PF)

Acousto-Diffusive Waves in a Piezoelectric-Semiconductor-Piezoelectric Sandwich Structure

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World Journal of Mechanics 2011年第5期1卷 247-255页

作者： Jagan Nath sharma Kuldeep Kumar sharma ashwani Kumar 不详

The propagation of acoustic waves in a homogeneous isotropic semiconducting layer sandwiched between two homogeneous transversely isotropic piezoelectric halfspaces has been investigated. The mathematical model of the problem is depicted by a set of partial differential equations of motion, Gauss equation in piezoelectric material and electron diffusion equation in semiconductor along with the boundary conditions to be satisfied at the piezoelectric-semiconductor interfaces. The secular equations describing the symmetric and asymmetric modes of wave propagation have been derived in compact form after obtaining the analytical expressions for various field quantities that govern the wave motion. The complex secular equation has been solved numerically using functional interaction method along with irreducible cardano method. The computer simulated results are obtained with the help of MATLAB software for 6 mm cadmium selenide (CdSe) piezoelectric material and n-type silicon (Si) semiconductor in respect of dispersion curve, attenuation and specific loss factor of energy dissipation for symmetric (sym) and asymmetric (asym) modes of wave propagation. The study may find applications in non-destructive testing, resonators, waveguides etc.

关键词： Acousto-Diffusive Sandwich Structure Halfspace Piezoelectricity