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Cath-KP,a novel peptide derived from frog skin,prevents oxidative stress damage in a Parkinson’s disease model

Zoological Research 2024年第1期45卷 108-124页

作者： Huanpeng Lu Jinwei Chai Zijian Xu Jiena Wu Songzhe He Hang Liao Peng Huang Xiaowen Huang Xi Chen Haishan Jiang shaogang qu Xueqing Xu Department of Neurology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence GuangzhouGuangdong 510515China Key Laboratory of Mental Health of the Ministry of Education Southern Medical UniversityGuangzhouGuangdong 510515China Department of Dermatology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Neurology Ganzhou Hospital-Nanfang HospitalSouthern Medical UniversityGanzhouJiangxi 341001China

Parkinson’s disease(PD)is a neurodegenerative condition that results in dyskinesia,with oxidative stress playing a pivotal role in its *** peptides may thus present therapeutic potential for *** this study,a novel cathelicidin peptide(Cath-KP;GCSGRFCNLF NNRRPGRLTLIHRPGGDKRTSTGLIYV)was identified from the skin of the Asiatic painted frog(Kaloula pulchra).Structural analysis using circular dichroism and homology modeling revealed a uniqueαββconformation for *** vitro experiments,including free radical scavenging and ferric-reducing antioxidant analyses,confirmed its antioxidant *** the 1-methyl-4-phenylpyridinium ion(MPP^(+))-induced dopamine cell line and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced PD mice,Cath-KP was found to penetrate cells and reach deep brain tissues,resulting in improved MPP^(+)-induced cell viability and reduced oxidative stress-induced damage by promoting antioxidant enzyme expression and alleviating mitochondrial and intracellular reactive oxygen species accumulation through Sirtuin-1(Sirt1)/Nuclear factor erythroid 2-related factor 2(Nrf2)pathway *** focal adhesion kinase(FAK)and p38 were also identified as regulatory *** the MPTP-induced PD mice,Cath-KP administration increased the number of tyrosine hydroxylase(TH)-positive neurons,restored TH content,and ameliorated *** the best of our knowledge,this study is the first to report on a cathelicidin peptide demonstrating potent antioxidant and neuroprotective properties in a PD model by targeting oxidative *** findings expand the known functions of cathelicidins,and hold promise for the development of therapeutic agents for PD.

关键词： Cath-KP Peptide Parkinson’s disease Oxidative stress Neuroprotection

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The biomarkers of immune dysregulation and inflammation response in Parkinson disease

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Translational Neurodegeneration 2016年第1期5卷 131-136页

作者： Li Chen Mingshu Mo Guangning Li Luan Cen Lei Wei Yousheng Xiao Xiang Chen Shaomin Li Xinling Yang shaogang qu Pingyi Xu Department of Neurology The First Affiliated Hospital of Guangzhou Medical UniversityGuangdong 510120China Department of Neurology The First Affiliated Hospital of Sun Yat-sen UniversityGuangdong 510080China Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangdong 510082China Ann Romney Center for Neurologic Disease Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of Neurology The Third Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830011China Department of Blood Transfusion The Fifth Affiliated HospitalSouthern Medical UniversityGuangzhouGuangdong 510900China Department of Neurology The Affiliated Huadu Hospital of Southern Medical UniversityGuangzhou 510800China

Parkinson’s disease(PD)is referring to the multi-systemicα-synucleinopathy with Lewy bodies deposited in *** ageing,the environmental and genetic factors work together and overactive major histocompatibility complex pathway to regulate immune reactions in central nerve system which resulting in neural degeneration,especially in dopaminergic *** a series of biomarkers,the human leukocyte antigen genes with its related proteomics play cortical roles on the antigen presentation of major histocompatibility complex molecules to stimulate the differentiation of T lymphocytes and i-proteasome activities under their immune response to the PD-related environmental alteration and genetic ***,dopaminergic drugs change the biological characteristic of T lymphatic cells,affect theα-synuclein presentation pathway,and inhibit T lymphatic cells to release cytotoxicity in PD *** together,the serum inflammatory factors and blood T cells are involved in the immune dysregulation of PD and inspected as the potential clinic biomarkers for PD prediction.

关键词： Parkinson’s disease α-synucleinopathy Inflammation Biomarkers

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Ligands induce the mutual movements between the HP1 and TM4 of the glutamate transporter EAAT1

Ligands induce the mutual movements between the HP1 and TM4 ...

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生命的分子机器及其调控网络——2012年全国生物化学与分子生物学学术大会

作者： shaogang qu Xiuping Zhang Department of Immunology Southern Medical University Teaching Center of Experimental Medicine Southern Medical University

Excitatory amino acid transporter 1(EAAT1) plays an importance role in uptaking glutam-ate from the synaptic cleft and keeping the extracellular glutamate concentration under the neurotoxic *** reentrant helical hairpin(HP) 1 is part of the intracellular gate of the *** of this intracellular gate,the transporter releases sodium and substrate to the ***

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Glutamate Induces Motion between TM4 and HP1 in the Glutamate Transporter EAAT1

Glutamate Induces Motion between TM4 and HP1 in the Glutamat...

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第一届国际暨第十三次中国生物物理学术大会

作者： shaogang qu Elia Zomot Xiuping Zhang Department of Immunology School of Basic Medical Sciences Southern Medical University Department of Computational & Systems Biology School of Medicine University of Pittsburgh Teaching Center of Experimental Medicine School of Basic Medical Sciences Southern Medical University

＜正＞Excitatory amino acid transporter 1（EAAT1）plays an important role in keeping the synaptic glutamate concentration below neurotoxic levels by translocating this neurotransmitter into the *** reentrant hairpin loop（HP）1 has been shown to take part in binding aspartate and the more deeply buried sodium ion,and might therefore be a part of the extra-or intracellular gate of

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Glutamate Induces Motion between TM4 and HP1 in the Glutamate Transporter EAAT1

Glutamate Induces Motion between TM4 and HP1 in the Glutamat...

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第八届全国医学生物化学与分子生物学第五届全国临床应用生物化学与分子生物学2013华东六省一市生物化学与分子生物学联合学术研讨会

作者： shaogang qu Elia Zomot Xiuping Zhang Department of Immunology School of Basic Medical SciencesSouthern Medical University Department of Computational & Systems Biology School of MedicineUniversity of Pittsburgh Teaching Center of Experimental Medicine School of Basic Medical SciencesSouthern Medical University

Excitatory amino acid transporter 1(EAAT1)plays an important role in keeping the synaptic glutamate concentration below neurotoxic levels by translocating this neurotransmitter into the *** reentrant hairpin loop(HP)1 has been shown to take part in binding aspartate and the more deeply buried sodium ion,and might therefore be a part of the extra-or intracellular gate of the ***,the motion of HP 1 relative to transmembrane

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Peripheral Lymphocyte Subsets as a Marker of Parkinson's Disease in a Chinese Population

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Neuroscience Bulletin 2017年第5期33卷 493-500页

作者： Luan Cen Chaohao Yang Shuxuan Huang Miaomiao Zhou Xiaolu Tang Kaiping Li Wenyuan Guo Zhuohua Wu Mingshu Mo Yousheng Xiao Xiang Chen Xinling Yang Qinhui Huang Chaojun Chen shaogang qu Pingyi Xu Department of Neurology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Department of Neurology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Neurology The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510080China State Key Laboratory of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Neurology The Second Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830011China Department of Neurology Guangzhou Chinese MedicalIntegrated Hospital(Huadu)Guangzhou 510800China Clinical Medicine Research Centre Shunde Hospital of Southern Medical UniversityFoshan 528300China

In this study, we conducted a clinical analysis of lymphocyte subtypes in 268 patients with Parkinson＇s disease （PD） to assess their clinical impact as a potential marker of advanced PD in Chinese patients. The participants comprised 268 sporadic PD patients and 268 healthy controls. The numbers of natural killer （NK） cells and CD3＋, CD3＋CD4＋, CD3＋CD8＋, and CD19＋ lympho- cytes from peripheral blood were determined by immunos- taining and flow cytometric analysis and the percentages of these CD＋ T cells were calculated. The ratio of regulatory T （Treg）/helper T 17 （Thl7） lymphocytes from 64 PD patients and 46 controls was determined by flow cytometric analysis. The results showed that the percentage of NK cells was higher in advanced PD patients than in controls （22.92% ± 10.08% versus 19.76% ±10.09%, P= 0.006）, while CD3＋ T cells are decreased （62.93% ±9.27% versus 65.75% ± 9.13%, P = 0.005）. The percentage of CD19＋ B cells in male patients was lower （P = 0.021） than in female patients, whereas NK cells were increased （P 〈 0.0001）. The scores on the Unified Parkinson＇s Disease Rating Scale （UPDRS） and the Non-Motor Symptoms Scale in late-onset PD patients were significantly higher than those in earlyonset patients （P = 0.024 and P = 0.007, respectively）. The percentage of CD19＋ B cells in patients with UPDRS scores 〉24 was lower than in those with scores 〈24 （10.17% ± 4.19% versus 12.22% ± 5.39%, P = 0.009）. In addition, the Treg/Th17 ratio in female patients was higher than that in female controls （13.88 ± 6.32 versus 9.94 ±4.06, P = 0.042）. These results suggest that the percentages of NK cells, CD3＋ T cells, and CD19＋ B cells along with the Treg/Th17 ratio in peripheral blood may be used to predict the risk of PD in Chinese individuals and provide fresh avenues for novel diagnostic biomarkers and therapeutic designs.

关键词： Parkinson's disease · Biological marker ·Lymphatic cell

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基于完成时间的任务分配方案与性能分析

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计算机研究与发展 2005年第8期42卷 1397-1402页

作者：曲绍刚杨广文林闯史树明清华大学计算机科学与技术系北京100084

网络计算的迅速发展对网络资源的调度问题提出了新的挑战,用户对于服务质量的要求越来越高.大规模的复杂系统,如何能在现有硬件资源的基础之上提高整个系统的响应时间和吞吐量是当前的一个研究热点.基于完成时间的任务分配方案(SEF,OSE... 详细信息

网络计算的迅速发展对网络资源的调度问题提出了新的挑战,用户对于服务质量的要求越来越高.大规模的复杂系统,如何能在现有硬件资源的基础之上提高整个系统的响应时间和吞吐量是当前的一个研究热点.基于完成时间的任务分配方案(SEF,OSEF),以多服务器多队列模型为基础,通过这种方案与现有方案之间的性能比较和分析,利用随机Petri网进行模拟实验,结果表明这种方案是高效可行的.

关键词：请求选择请求分配随机Petri网

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pEGFP-IL-24对B16F0细胞抑制效应的实验研究

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陕西医学杂志 2006年第7期35卷 801-803页

作者：张秀萍瞿少刚广东医学院临床技能培训中心湛江524023 广东医学院微生物与免疫学教研室

目的:构建IL-24真核表达质粒,研究其体内外表达对肿瘤细胞生长的抑制作用。方法:用重组DNA技术构建IL-24真核表达质粒pEGFP-IL-24。用脂质体法将重组质粒及空载体体外转染B16F0细胞后,经激光扫描共聚焦显微镜观察其表达,用MTT法检测B16F... 详细信息

目的:构建IL-24真核表达质粒,研究其体内外表达对肿瘤细胞生长的抑制作用。方法:用重组DNA技术构建IL-24真核表达质粒pEGFP-IL-24。用脂质体法将重组质粒及空载体体外转染B16F0细胞后,经激光扫描共聚焦显微镜观察其表达,用MTT法检测B16F0细胞的体外增殖能力。用小鼠实体瘤模型研究基因转染对肿瘤生长的抑制。结果:pEGFP-IL-24转染B16F0细胞后,LSM可观察到其表达。IL-24基因转染的B16F0细胞体外增殖能力明显受到抑制。转染IL-24的B16F0细胞体内致瘤率降低。结论:IL-24基因转染的肿瘤细胞体外生长受抑。IL-24基因转染的肿瘤细胞体内生长能力显著降低。

关键词：肿瘤/治疗白细胞介素24/免疫学黑色素瘤实验性小鼠

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高亲和力谷氨酸转运体与神经系统变性疾病关系的研究进展

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中华神经医学杂志 2014年第2期13卷 208-210页

作者：张云龙瞿少刚南方医科大学基础医学院免疫学教研室广州510515

谷氨酸是中枢神经系统主要的兴奋性神经递质，释放到突触间隙的谷氨酸若不被及时清除，会过度兴奋谷氨酸受体．介导“兴奋性毒性效应”对神经系统产生损伤。细胞外没有分解谷氨酸的酶，因此谷氨酸主要由高亲和力谷氨酸转运体（excitator... 详细信息

谷氨酸是中枢神经系统主要的兴奋性神经递质，释放到突触间隙的谷氨酸若不被及时清除，会过度兴奋谷氨酸受体．介导“兴奋性毒性效应”对神经系统产生损伤。细胞外没有分解谷氨酸的酶，因此谷氨酸主要由高亲和力谷氨酸转运体（excitatoryaminoacidtransporters，EAATs）所摄取。

关键词：高亲和力谷氨酸转运体神经系统变性疾病

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佛山市妊娠妇女碘营养及甲状腺疾病的初步研究

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国际检验医学杂志 2015年第15期36卷 2199-2201页

作者：刘伟旗瞿少刚南方医科大学基础医学院免疫学教研室广东广州510515

目的了解佛山地区妊娠妇女碘营养状况及甲状腺激素变化的特点,为临床合理补充膳食提供依据。方法收集2013年6月至2014年11月在禅城区中心医院进行门诊产检孕妇血液及尿液标本各442例,采用电化学发光法检测血清游离三碘甲状腺原氨酸(FT3... 详细信息

目的了解佛山地区妊娠妇女碘营养状况及甲状腺激素变化的特点,为临床合理补充膳食提供依据。方法收集2013年6月至2014年11月在禅城区中心医院进行门诊产检孕妇血液及尿液标本各442例,采用电化学发光法检测血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺激素(FT4)、促甲状腺激素(TSH)水平,采用碘催化砷铈反应原理检测尿碘。结果 442例孕妇尿碘中位数为174μg/L。中度碘缺乏、轻度碘缺乏、碘充足、碘过量分别为4.30%、29.86%、39.59%、26.24%;孕早期、孕中期、孕晚期尿碘水平异常率分别为72.41%、45.89%、62.91%,不孕周期尿碘水平异常与碘适量水平进行两两比较,差异有统计学意义(P<0.05)。碘充足组FT3、TSH结果均低于碘缺乏组、碘过量组,碘充足组与碘缺乏组进行比较,FT4差异有统计学意义(P<0.05),碘充足组与碘过量组进行比较,TSH差异有统计学意义(P<0.05)。结论佛山地区妊娠妇女碘营养水平异常率及甲状腺疾病的患病率较高,应及时对妊娠妇女进行筛查干预,以达到优生优育的目的。

关键词：妊娠妇女碘营养尿碘甲状腺激素

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