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基于特征提取法塑料模具成本评价系统的建立

机床与液压 2010年第15期38卷 106-108页

作者：谢少芳卢晓春阮锋广东交通职业技术学院广东广州510650 华南理工大学广东广州510640

基于特征提取法,根据模具的最基本信息和塑料制件的形状特征科学、方便快捷地估算塑料模具的价格,并计算出模具成本评价等级和评价分,可靠地评价模具成本。

关键词：模具成本塑料模具评价系统

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水环境微塑料污染现状及处置技术研究进展

净水技术 2024年第7期43卷 10-21,156页

作者：周智勇卢帅良马涛刘贵彩孙绍芳谢康济南大学土木建筑学院山东济南250022 山东省环境保护科学研究设计院有限公司山东济南250022

微塑料具有粒径小、比表面积大和疏水性强等特点,在水体环境中分布广泛、难以被降解,并且能够作为其他有毒污染物的载体,进一步增强了微塑料的危害性。深入研究微塑料的危害及其分析、处理途径是有效控制微塑料污染的关键。针对水环境... 详细信息

微塑料具有粒径小、比表面积大和疏水性强等特点,在水体环境中分布广泛、难以被降解,并且能够作为其他有毒污染物的载体,进一步增强了微塑料的危害性。深入研究微塑料的危害及其分析、处理途径是有效控制微塑料污染的关键。针对水环境微塑料污染这一热点问题,文章介绍了水环境中微塑料的污染现状和生物效应,阐述了微塑料的分析鉴定方法,分析了水体微塑料常规和新兴去除技术的优势及潜在问题。并进一步探讨了未来水环境中微塑料研究的前景,为水环境中微塑料的去除与污染控制研究提供参考与指导。

关键词：微塑料污染现状生物效应分析方法常规技术新兴技术

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凉山州某地HIV-1感染育龄妇女获得性耐药情况及相关因素分析

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中国艾滋病性病 2024年第6期30卷 573-578页

作者：刘镓鑫刘梅宋绍芳谢芳杨在琴耿忠敏黄永茂黄富礼曹汴川西南医科大学附属医院感染病科四川泸州646000 西南医科大学附属医院结核病科四川泸州646000 西南医科大学附属医院感染与免疫实验室四川泸州646000 越西县第一人民医院抗病毒治疗中心四川凉山616650 越西县妇幼保健计划生育服务中心四川凉山616650 越西县卫生健康局四川凉山616650

目的分析凉山地区某县HIV-1感染育龄妇女获得性耐药(ADR)情况及其相关因素。方法以2023年1-9月在凉山地区某县治疗随访的105例HIV-1感染育龄妇女为研究对象,采集并分离血液标本,将标本用于HIV-1 RNA和HIV-1 DNA定量检测以及HIV-1基因... 详细信息

目的分析凉山地区某县HIV-1感染育龄妇女获得性耐药(ADR)情况及其相关因素。方法以2023年1-9月在凉山地区某县治疗随访的105例HIV-1感染育龄妇女为研究对象,采集并分离血液标本,将标本用于HIV-1 RNA和HIV-1 DNA定量检测以及HIV-1基因型耐药检测。结果 105例研究对象中,HIV-1 RNA以0~50 copies/mL为主(69.5%),HIV-1 DNA以101~1 000 copies/10^(6) cells为主(67.6%),HIV-1亚型以CRF07_BC重组型为主(88.6%),初始cART方案以2 NRTIs+1 NNRTIs为主(90.5%)。105例研究对象中,21例发生ADR(20.0%),其中HIV-1 RNA基因型耐药检出发生ADR的11例(10.5%),HIV-1 DNA基因型耐药检出发生ADR的10例(9.5%)。105例研究对象中,32例(30.5%)出现耐药突变位点。与NNRTIs有关的耐药突变有9例(8.6%),K103KN/N/S是主要耐药突变位点;与NRTIs有关的耐药突变有3例(2.9%),M184MV/MI/V是主要耐药突变位点;与整合酶抑制剂(INSTIs)有关的耐药突变有7例(6.7%),A128T是主要耐药突变位点;11例(10.5%)同时针对NNRTIs和NRTIs出现耐药突变;1例同时针对NNRTIs、NRTIs及INSTIs出现耐药突变;1例同时针对NNRTIs及INSTIs出现耐药突变。无针对PIs的耐药突变出现。经单因素Logistic回归分析显示cART时间、年龄、初始cART方案、HIV-1感染途径及HIV-1亚型与ADR发生无统计学关联。结论凉山地区某县HIV-1感染育龄妇女ADR发生率与凉山地区总体耐药率接近,但耐药突变位点复杂多样,耐药突变导致的耐药主要以单纯NNRTIs耐药、NRTIs和NNRTIs同时耐药为主,而NNRTIs和NRTIs作为cART的一线用药,在HIV治疗中占据重要地位,因此需加强耐药监测,进一步提升治疗质量。

关键词：育龄妇女获得性耐药艾滋病病毒抗反转录病毒治疗

A telomere-to-telomere reference genome provides genetic insight into the pentacyclic triterpenoid biosynthesis in Chaenomeles speciosa

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Horticulture Research 2023年第10期10卷 250-261页

作者： shaofang He Duanyang Weng Yipeng Zhang Qiusheng Kong Keyue Wang Naliang Jing Fengfeng Li Yuebin Ge Hui Xiong Lei Wu De-Yu xie Shengqiu Feng Xiaqing Yu Xuekui Wang Shaohua Shu Zhinan Mei College of Plant Science&Technology Huazhong Agricultural UniversityWuhan 430070China Wuhan Carboncode Biotechnologies Co. Ltd.Wuhan 430070China Sinopharm Zhonglian Pharmaceutical Co. Ltd.Wuhan 430070China College of Horticulture&Forestry Huazhong Agricultural UniversityWuhan 430070China School of Pharmaceutical Science South-Central Minzu UniversityWuhan 430074China Department of Plant and Microbial Biology North Carolina State UniversityRaleighNC 27695USA College of Horticulture Nanjing Agricultural UniversityNanjing 210095China

Chaenomeles speciosa(2n=34),a medicinal and edible plant in the Rosaceae,is commonly used in traditional Chinese *** date,the lack of genomic sequence and genetic studies has impeded efforts to improve its medicinal ***,we report the use of an integrative approach involving PacBio HiFi(third-generation)sequencing and Hi-C scaffolding to assemble a high-quality telomere-to-telomere genome of *** genome comprised 650.4 Mb with a contig N50 of 35.5 *** these,632.3 Mb were anchored to 17 pseudo-chromosomes,in which 12,4,and 1 pseudo-chromosomes were represented by a single contig,two contigs,and four contigs,*** pseudo-chromosomes had telomere repeats at both ends,and four had telomere repeats at a single *** sequences accounted for 49.5%of the genome,while a total of 45515 protein-coding genes have been *** genome size of *** was relatively similar to that of Malus *** or contracted gene families were identified and investigated for their association with different plant metabolisms or biological *** particular,functional annotation characterized gene families that were associated with the biosynthetic pathway of oleanolic and ursolic acids,two abundant pentacyclic triterpenoids in the fruits of *** together,this telomere-to-telomere and chromosome-level genome of *** not only provides a valuable resource to enhance understanding of the biosynthesis of medicinal compounds in tissues,but also promotes understanding of the evolution of the Rosaceae.

关键词： value. insight metabolism

Influence of proximity to the Qinghai-Tibet highway and railway on variations of soil heavy metal concentrations and bacterial community diversity on the Tibetan Plateau

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Research in Cold and Arid Regions 2019年第6期11卷 407-418页

作者： Xia Zhao JunFeng Wang Yun Wang Xiang Lu shaofang Liu YuBao Zhang ZhiHong Guo ZhongKui xie RuoYu Wang Gaolan Station of Agricultural and Ecological Experiment Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China Key Laboratory of Stress Physiology and Ecology in Cold and Arid Regions of Gansu Province LanzhouGansu 730000China State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China

An understanding of soil microbial communities is crucial in roadside soil environmental *** 16S rRNA se quencing of a stressed microbial community in soil adjacent to the Qinghai-Tibet Highway(QTH)revealed that the accu mulation of heavy metals(over about 10 years)has affected the diversity of bacterial abundance and microbial community *** proximity of a sampling site to the QTH/Qinghai-Tibet Railway(QTR),which is effectively a measure of the density of human engineering,was the dominant factor influencing bacterial community *** diversity of bacterial communities shows that 16S rRNA gene abundance decreased in relation to proximity to the QTH and QTR in both alpine wetland and meadow *** dominant phyla across all samples were Actinobacteria and *** concentration of Cr and Cd in the soil were positively correlated with proximity to the QTH and QTR(MC/WC sam pling sites),and Ni,Co,and V were positively correlated with proximity to the QTH and QTR(MA/WA sampling sites).The results presented in this study provide an insight into the relationships among heavy metals and soil microbial commu nities,and have important implications for assessing and predicting the impacts of human-induced activities from the QTH and QTR in such an extreme and fragile environment.

关键词： Qinghai-Tibet Highway(QTH) Qinghai-Tibet Railway(QTR) soil bacterial community alpine wetland

Insomnia and Coronary Artery Diseases:A Mendelian Randomisation Study

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Cardiology Discovery 2021年第3期1卷 154-162页

作者： Wenjuan Zhang Lingfeng Zha Jiangtao Dong Qianwen Chen Jianfei Wu Tingting Tang Ni Xia Min Zhang Jiao Jiao Tian xie Chengqi Xu Xin Tu shaofang Nie Department of Geriatrics The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Hubei Maternal and Child Health Hospital WuhanHubei 430070China Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and TechnologyCenter for Human Genome ResearchCardio-X InstituteHuazhong University of Science and TechnologyWuhanHubei 430074China

Objective:Observational studies indicate that insomnia may increase the risk of developing and/or dying from cardiovascular diseases,especially coronary artery disease(CAD).Our purpose is to explore the underlying causal relationship between genetic variants susceptible to insomnia and the risk of CAD by Mendelian randomization ***:The study was conducted using publicly available statistical data on genetic variants identified from a genome-wide association meta-analysis of insomnia(n=113,006 individuals)and a genome-wide association meta-analysis of CAD(n=184,305 individuals),which consisted of both cases and *** genetic association between variants and CAD was assessed by the variants’association with insomnia,and estimations were integrated by an inverse-variance weighted ***:Among the Mendelian randomized analytical sample,8 variants were associated with insomnia complaints and *** there was no pleiotropic association with the latent *** addition,in the inverse-variance weighted meta-analysis(the estimations combined from the 8 variants),the odds ratio was 1.15(95%CI:1.05–1.25;P=0.002)for CAD,and in the weighted method analysis,the odds ratio was 1.14(95%CI:1.03–1.27;P=0.015)for ***:All of the data indicated that some valuable variants might involve in the development of CAD by leading the ***,insomnia might be a causal factor for CAD,and improving the quality of sleep might be a new way for populations with insomnia to prevent CAD.

关键词： Coronary artery diseases Genetic variants Insomnia Mendelian randomization

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新形势下省域综合医改的实施路径研究

宿州学院学报 2022年第11期37卷 30-34页

作者：谢瑞瑾刘少芳程进桂亮安徽医科大学安徽合肥230000 安徽卫生健康职业学院安徽池州247099

在全面深化改革进入系统集成新阶段,为推进以省域为单位开展系统集成改革,建立更加完备、更加稳定、更加管用的总体性医改制度体系,在更高起点、更高层次、更高标准上推进综合医改,开辟医改新局面,对2015年以来11个综合医改试点省实施... 详细信息

在全面深化改革进入系统集成新阶段,为推进以省域为单位开展系统集成改革,建立更加完备、更加稳定、更加管用的总体性医改制度体系,在更高起点、更高层次、更高标准上推进综合医改,开辟医改新局面,对2015年以来11个综合医改试点省实施路径进行了分析总结,着眼探索中国特色基本医疗卫生制度,同时结合当前医改重点任务和要求,提出进一步深化省域综合医改的工作要求和推进措施,为全面推开省级综合医改做好政策储备。

关键词：综合医改实施路径省域

基于L形谐振腔MIM波导结构滤波特性的研究

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光学学报 2015年第6期35卷 272-277页

作者：庞绍芳屈世显张永元解忧郝丽梅西安科技大学理学院陕西西安710054 陕西师范大学物理学与信息技术学院陕西西安710062

设计了一种基于表面等离极化激元金属-介质-金属的L形谐振腔波导结构,并应用有限元方法研究了该结构的传输特性。数值计算结果表明,透射光谱中出现了明显的阻带,其滤波特性强烈地依赖于L形谐振腔结构的尺寸。相比于同尺度的水平放置的... 详细信息

设计了一种基于表面等离极化激元金属-介质-金属的L形谐振腔波导结构,并应用有限元方法研究了该结构的传输特性。数值计算结果表明,透射光谱中出现了明显的阻带,其滤波特性强烈地依赖于L形谐振腔结构的尺寸。相比于同尺度的水平放置的矩形谐振腔,L形谐振腔结构具有更高的品质因子,滤波效果更佳。随着L形谐振腔结构尺寸的增大,透射光谱发生红移;在L形谐振腔中充入折射率不同的介质,根据表面等离极化激元共振对L形谐振腔内折射率变化敏感特性,通过探测透射光谱中共振波长来探测介质折射率,该结构可广泛用于传感器方面。

关键词：光学器件表面等离极化激元有限元方法滤波器

结构性拷贝数增加的解读标准:来自美国医学遗传学与基因组学学会(ACMG)和临床基因组资源中心(ClinGen)的建议

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中华医学遗传学杂志 2022年第1期39卷 1-10页

作者：陈晓丽上官少方谢华刘浩然刘维强安宇沈亦平首都儿科研究所遗传研究室北京100020 广州医科大学附属第三医院产科重大疾病重点实验室广州510150 复旦大学人类表型组研究院上海200433 广西妇幼保健院遗传代谢中心实验室南宁530005 上海儿童医学中心医学遗传科上海200127 波士顿儿童医院遗传及基因组部美国波士顿MA 02115

基因组拷贝数变异(copy number variants,CNVs)是人类遗传病的重要致病原因,也是儿科神经发育障碍和多种先天性畸形、产前胎儿超声异常等疾病的必检项目。尽管CNVs的检测技术日趋成熟,但其临床意义的解读却仍不够规范。2020年,美国医学... 详细信息

基因组拷贝数变异(copy number variants,CNVs)是人类遗传病的重要致病原因,也是儿科神经发育障碍和多种先天性畸形、产前胎儿超声异常等疾病的必检项目。尽管CNVs的检测技术日趋成熟,但其临床意义的解读却仍不够规范。2020年,美国医学遗传学与基因组学学会(American College of Medical Genetics and Genomics,ACMG)和临床基因组资源中心(Clinical Genome Resource,ClinGen)基于循证原则,采用定量计分,就结构性(constitutional)基因组CNVs的致病性评估和临床报告制定了推荐指南。本文对该指南中涉及拷贝数增加的分析要点进行了详细的解读,并利用6个不同类型的案例来展示如何正确使用打分系统,以鼓励临床诊断实验室根据这一专业标准对检测出的基因组变异开展解读、报告,以期提升遗传诊断报告中拷贝数增加临床评估的正确性和一致性。

关键词：结构性拷贝数增加解读标准美国医学遗传学和基因组学学会临床基因组资源中心