Insomnia and Coronary Artery Diseases:A Mendelian Randomisation Study

作     者：Wenjuan Zhang Lingfeng Zha Jiangtao Dong Qianwen Chen Jianfei Wu Tingting Tang Ni Xia Min Zhang Jiao Jiao Tian Xie Chengqi Xu Xin Tu Shaofang Nie 

作者机构：Department of GeriatricsThe Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of CardiologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Cardiovascular SurgeryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Hubei Maternal and Child Health HospitalWuhanHubei 430070China Key Laboratory of Molecular Biophysics of Ministry of EducationCollege of Life Science and TechnologyCenter for Human Genome ResearchCardio-X InstituteHuazhong University of Science and TechnologyWuhanHubei 430074China 

出 版 物：《Cardiology Discovery》 (心血管病探索（英文）)

年 卷 期：2021年第1卷第3期

页      面：154-162页

学科分类：08[工学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：funded by grants from the National Natural Science Foundation of China(No.81500186 to S.Nie No.81670361 to T.Tang) 

主　　题：Coronary artery diseases Genetic variants Insomnia Mendelian randomization 

摘      要：Objective:Observational studies indicate that insomnia may increase the risk of developing and/or dying from cardiovascular diseases,especially coronary artery disease(CAD).Our purpose is to explore the underlying causal relationship between genetic variants susceptible to insomnia and the risk of CAD by Mendelian randomization ***:The study was conducted using publicly available statistical data on genetic variants identified from a genome-wide association meta-analysis of insomnia(n=113,006 individuals)and a genome-wide association meta-analysis of CAD(n=184,305 individuals),which consisted of both cases and *** genetic association between variants and CAD was assessed by the variants’association with insomnia,and estimations were integrated by an inverse-variance weighted ***:Among the Mendelian randomized analytical sample,8 variants were associated with insomnia complaints and *** there was no pleiotropic association with the latent *** addition,in the inverse-variance weighted meta-analysis(the estimations combined from the 8 variants),the odds ratio was 1.15(95%CI:1.05–1.25;P=0.002)for CAD,and in the weighted method analysis,the odds ratio was 1.14(95%CI:1.03–1.27;P=0.015)for ***:All of the data indicated that some valuable variants might involve in the development of CAD by leading the ***,insomnia might be a causal factor for CAD,and improving the quality of sleep might be a new way for populations with insomnia to prevent CAD.