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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 602-604页

作者： Si-Yu shao Yi-Lan Wang Li-min feng Ying Zhao School of Laboratory Medicine and Life Science Wenzhou Medical UniversityWenzhou 325035China Department of Clinical Laboratory the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province Hangzhou 310003China

To the Editor:Nonalcoholic fatty liver disease(NAFLD)is a growing public health problem *** the primary liver pathology in NAFLD patients is associated with an increased risk of overall mortality,the majority of deaths in NAFLD patients are due to the cardiovascular disease(CVD)[1].With the change of lifestyle,the prevalence of NAFLD in China is increasing and patients tend to be younger[2].A relevant epidemiological survey has shown that the prevalence of NAFLD in adults is estimated to be 12%–24%in Asia[3].Non-high-density lipoprotein cholesterol(non-HDL-C)refers to the sum of all cholesterol subtracts high-density lipoprotein cholesterol(HDL-C),which can more comprehensively reflect the comprehensive metabolic changes of lipoproteins including low-density lipoprotein cholesterol(LDL-C),intermediate-density lipoprotein cholesterol(IDL-C),and very-low-density lipoprotein cholesterol(VLDL-C)[4].Recently,NAFLD that often coexists with dyslipidemia has been identified as a major modifiable risk factor of CVD,and non-HDL-C has become a new biomarker for assessing and predicting the risk of CVD[4].

关键词： patients cholesterol lipoprotein

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中老年人群肾脏损伤与心电图异常的关系

中华临床医师杂志（电子版） 2012年第21期6卷 6723-6727页

作者：牛福坤张路霞朱玲邵凤民王海燕北京大学第一医院肾内科北京大学肾脏病研究所卫生部肾脏疾病重点实验室 100034 河南省人民医院肾内科卫生部北京医院体检中心

目的探讨中老年人群中肾脏损伤指标与心电图异常的相关性。方法收集16 253名中老年人群的肾脏损伤指标(包括估计肾小球滤过率及尿蛋白)及心电图资料,进行相关性分析。结果合并肾脏损伤患者心电图异常、主要心电图异常、可疑心肌缺血、... 详细信息

目的探讨中老年人群中肾脏损伤指标与心电图异常的相关性。方法收集16 253名中老年人群的肾脏损伤指标(包括估计肾小球滤过率及尿蛋白)及心电图资料,进行相关性分析。结果合并肾脏损伤患者心电图异常、主要心电图异常、可疑心肌缺血、左心室高电压的百分比均高于无肾脏损伤组。在符合可疑心肌缺血心电图的参与者中,仅10.1%自我报告有冠心病史;而在报告冠心病史的受试者中,75.7%心电图合并可疑心肌缺血心电图。在校正了包括估计肾小球滤过率在内的多种混杂因素后,蛋白尿是心电图异常的独立危险因素:与无蛋白尿者相比,尿蛋白±、+、≥++者出现主要心电图异常的比值比(95%置信区间)分别为1.27(1.08,1.50)、1.66(1.27,2.18)、2.19(1.47,3.27)。尿蛋白(±)对于心电图异常的比值比不低于估计肾小球滤过率<60 ***-1.(1.73 m2)-1的比值比。结论本研究提示在中老年人群中,合并肾脏损伤者心电图异常显著增多;心电图异常有可能作为价廉可行的肾脏损伤患者心血管异常的检查指标。

关键词：心电描记术蛋白尿肾脏损伤

Quantitative relationship between visibility and mass concentration of PM2.5 in Beijing

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Journal of Environmental Sciences 2006年第3期18卷 475-481页

作者： WANG Jing-li ZHANG Yuan-hang shao min LIU Xu-lin ZENG Li-min CHENG Cong-lan XU Xiao-feng Institute of Urban Meteorology China Meteorological Administration Beijing 100089 China State Joint Key Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences Peking University Beijing 100871 China Beijing Meteorological Information and Network Center Beijing 100089 China

The pollution of particulate matter less than 2.5μm （PM2.5） is a serious environmental problem in Beijing. The annual average concentration of PM2.5 in 2001 from seasonal monitor results was more than 6 times that of the U,S, national ambient air quality standards proposed by U.S. EPA. The major contributors to mass of PM2.5 were organics, crustal elements and sulfate. The chemical composition of PM2.5 varied largely with season, but was similar at different monitor stations in the same season. The fine particles （PM2.5） cause atmospheric visibility deterioration through light extinction, The mass concentrations of PM2.5 were anti-correlated to the visibility, the best fits between atmospheric visibility and the mass concentrations of PM2.5 were somehow different： power in spring, exponential in summer, logarithmic in autumn, power or exponential in winter. As in each season the meteorological parameters such as air temperature and relative humidity change from day to day, probably the reason of above correlations between PM2.5 and visibility obtained at different seasons come from the differences in chemical compositions of PM2.5.

关键词： PM2.5 atmospheric urban aerosol air pollution meteorological factor visibility

Nonlinear Internal Damping of Wave Equations with Variable Coefficients

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Acta Mathematica Sinica,English Series 2004年第6期20卷 1057-1072页

作者： shao Ji feng De Xing feng Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100080P.R.China Institute of Systems Science Academy of Mathematics and Systems ScienceChinese Academy of Sciences

For wave equations with variable coefficients on regions which are not necessarily smooth, we study the energy decay rate when a nonlinear damping is applied on a suitable subrigion.

关键词： Wave equations Energy decay rate Nonlinear internal damping Riemannian manifold

Effect of SiO_2/Na_2O mole ratio on the properties of foam geopolymers fabricated from circulating fluidized bed fly ash

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International Journal of minerals,Metallurgy and Materials 2014年第6期21卷 620-626页

作者： Ze Liu Ning-ning shao Tian-yong Huang Jun-feng Qin Dong-min Wang Yu Yang School of Chemical and Environmental Engineering China University of Mining and Technology

Geopolymers are three-dimensional aluminosilicates formed in a short time at low temperature by geopolymerization. In this pa-per, alkali-activated foam geopolymers were fabricated from circulating fluidized bed fly ash （CFA）, and the effect of SiO2/Na2O mole ratio （0.91-1.68） on their properties was studied. Geopolymerization products were characterized by mechanical testing, scanning electron mi-croscopy （SEM）, energy-dispersive X-ray spectroscopy （EDX）, and X-ray diffraction （XRD）. The results show that SiO2/Na2O mole ratio plays an important role in the mechanical and morphological characteristics of geopolymers. Foam samples prepared in 28 d with a SiO2/Na2O mole ratio of 1.42 exhibit the greatest compressive strength of 2.52 MPa. Morphological analysis reveals that these foam geo-polymers appear the relatively optimized pore structure and distribution, which are beneficial to the structure stability. Moreover, a combina-tion of the Si/Al atomic ratio ranging between 1.47 and 1.94 with the Na/Al atomic ratio of about 1 produces the samples with high strength.

关键词： foamed products geopolyrners fly ash strength of materials morphology silicon oxide sodium oxide

腹膜透析患者营养不良与动脉僵硬度增高关系研究

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医药论坛杂志 2014年第8期35卷 9-11页

作者：顾玥张宏涛阎磊卢喜玲朱清邵凤民河南省人民医院肾内科郑州450003

目的研究持续性非卧床腹膜透析患者营养与动脉僵硬度的关系。方法应用自动脉搏波速度分析仪测定患者颈-股动脉脉搏波速度。评估营养状况(血白蛋白、主观综合性营养评估)。检测相关血生化指标。对相应指标进行相关及多元逐步回归分析,探... 详细信息

目的研究持续性非卧床腹膜透析患者营养与动脉僵硬度的关系。方法应用自动脉搏波速度分析仪测定患者颈-股动脉脉搏波速度。评估营养状况(血白蛋白、主观综合性营养评估)。检测相关血生化指标。对相应指标进行相关及多元逐步回归分析,探讨营养和脉搏波速度的关系。结果入选患者98例,男性43例,女性55例,平均年龄(60.34±12.13)岁,平均透析龄〔11.98(4.79,25.33)〕个月。与营养良好(主观综合性营养评估)患者相比,营养不良患者的脉搏波速度明显增高(12.11±1.62 m/s比10.66±1.89 m/s;P<0.01)。脉搏波速度与年龄(P<0.01)、收缩压(P<0.01)、C反应蛋白(P<0.01)、胆固醇(P<0.05)、低密度脂蛋白(P<0.05)呈正相关,与血白蛋白呈负相关(P<0.01)。多元逐步回归分析结果显示血白蛋白、主观综合性营养评估分别是脉搏波速度的独立影响因素。结论在持续性非卧床腹膜透析患者中营养不良与动脉僵硬度增高密切相关。

关键词：腹膜透析营养不良动脉僵硬度心血管疾病

Crack Fault Classification for Planetary Gearbox Based on Feature Selection Technique and K-means Clustering Method

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Chinese Journal of Mechanical Engineering 2018年第1期31卷 242-252页

作者： Li-ming Wang Yi-min shao State Key Laboratory of Mechanical Transmission Chongqing University

During the condition monitoring of a planetary gearbox, features are extracted from raw data for a fault ***, different features have different sensitivity for identifying different fault types, and thus, the selection of a sensitive feature subset from an entire feature set and retaining as much of the class discriminatory information as possible has a directly effect on the accuracy of the classification results. In this paper, an improved hybrid feature selection technique(IHFST) that combines a distance evaluation technique(DET), Pearson’s correlation analysis, and an ad hoc technique is proposed. In IHFST, a temporary feature subset without irrelevant features is first selected according to the distance evaluation criterion of DET, and the Pearson’s correlation analysis and ad hoc technique are then employed to find and remove redundant features in the temporary feature subset, respectively, and hence,a sensitive feature subset without irrelevant or redundant features is selected from the entire feature set. Further, the k-means clustering method is applied to classify the different kinds of health conditions. The effectiveness of the proposed method was validated through several experiments carried out on a planetary gearbox with incipient cracks seeded in the tooth root of the sun gear, planet gear, and ring gear. The results show that the proposed method can successfully distinguish the different health conditions of a planetary gearbox, and achieves a better classification performance than other methods. This study proposes a sensitive feature subset selection method that achieves an obvious improvement in terms of the accuracy of the fault classification.

关键词： Planetary gearbox Gear crack Feature selection technique K-means classification

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新乡医学院学报 2015年第6期32卷 522-525页

作者：苗艳阎磊朱清曹慧霞楚天舒邵凤民河南省人民医院肾病风湿免疫科河南郑州450003

目的探讨血清脂蛋白相关磷脂酶A2(Lp-PLA2)水平对糖尿病肾病(DN)患者尿白蛋白排泄率(UAER)及血肌酐(Scr)的影响。方法选择2011年1月至2014年1月在河南省人民医院就诊的2型糖尿病患者240例,根据UAER及Scr水平分为正常白蛋白尿组、微量白... 详细信息

目的探讨血清脂蛋白相关磷脂酶A2(Lp-PLA2)水平对糖尿病肾病(DN)患者尿白蛋白排泄率(UAER)及血肌酐(Scr)的影响。方法选择2011年1月至2014年1月在河南省人民医院就诊的2型糖尿病患者240例,根据UAER及Scr水平分为正常白蛋白尿组、微量白蛋白尿组、大量白蛋白尿组和终末期肾病组,每组60例。分析各组间患者UAER、Scr水平与临床表现、生物化学检查及Lp-PLA2的关系,并分析影响UAER及Scr的独立危险因素。结果正常白蛋白尿组、微量白蛋白尿组、大量白蛋白尿组及终末期肾病组组间两两比较,在Lp-PLA2、糖尿病病程、尿白蛋白-肌酐比值(ACR)方面差异均有统计学意义(P<0.05);Lp-PLA2、糖尿病病程、ACR在终末期肾病组最高,在正常白蛋白尿组最低。与正常白蛋白尿组比较,微量白蛋白尿组、大量白蛋白尿组及终末期肾病组糖化血红蛋白(Hb A1c)、三酰甘油(TG)、UAER显著升高(P<0.05)。Pearson相关分析显示,4组患者UAER与糖尿病病程、体质量指数、总胆固醇(TC)、Scr、C反应蛋白(CRP)、ACR及Lp-PLA2水平均呈正相关,与高密度脂蛋白(HDL)均呈负相关(P<0.05);Scr与年龄、糖尿病病程、TC、HDL、CRP、UAER、ACR及Lp-PLA2均呈正相关,与HDL呈负相关(P<0.05);多元线性回归分析结果显示,UAER与ACR及Lp-PLA2、糖尿病病程均呈正相关,与HDL呈负相关(P<0.05);Scr与ACR呈正相关(P<0.05);多元logistic回归分析显示,糖尿病病程、HDL、CRP、ACR和Lp-PLA2是影响UAER的独立危险因素(P<0.05),Lp-PLA2、UAER、ACR是影响Scr的独立危险因素(P<0.05)。结论 Lp-PLA2是DN蛋白尿发生及肾功能障碍的独立危险因素,可作为DN进展的指标。

关键词：糖尿病肾病脂蛋白相关磷脂酶A2 尿蛋白排泄率血肌酐

肝素结合蛋白在脓毒症相关急性肾损伤早期诊断中的价值

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中华实用诊断与治疗杂志 2021年第5期35卷 436-440页

作者：黄亚军顾玥张文雯高梅阎磊邵凤民郑州大学人民医院河南省人民医院肾内科河南省肾脏病免疫重点实验室河南郑州450003

目的观察脓毒症相关急性肾损伤(acute kidney injury, AKI)患者血浆肝素结合蛋白(heparin-binding protein, HBP)水平变化,探讨其早期诊断脓毒症相关AKI的价值。方法 48例脓毒症患者为脓毒症组,入组7 d内发生AKI者30例为脓毒症合并AKI组... 详细信息

目的观察脓毒症相关急性肾损伤(acute kidney injury, AKI)患者血浆肝素结合蛋白(heparin-binding protein, HBP)水平变化,探讨其早期诊断脓毒症相关AKI的价值。方法 48例脓毒症患者为脓毒症组,入组7 d内发生AKI者30例为脓毒症合并AKI组,未发生AKI者18例为脓毒症未合并AKI组;同期50例体检健康者为对照组。比较脓毒症合并AKI组和未合并AKI组年龄、男性比率、呼吸系统疾病发生率、序贯器官衰竭评分、ICU住院时间等临床资料及血肌酐、C反应蛋白、降钙素原水平等生化指标;采用ELISA法检测脓毒症患者确诊脓毒症0、12、24、48 h时血浆HBP水平及对照组血浆HBP水平;绘制ROC曲线,评估确诊脓毒症0、12、24、48 h时HBP水平对脓毒症患者发生AKI的诊断效能。结果脓毒症合并AKI组呼吸系统疾病发生率(86.7%)、序贯器官衰竭评分[10.0(8.0,12.0)分]均高于脓毒症未合并AKI组[(61.1%)、6.5(6.0,10.0)分](P<0.05),ICU住院时间[13.5(9.0,21.0)d]长于脓毒症未合并AKI组[7.0(5.0,12.0)d](P<0.05);脓毒症合并AKI组血肌酐[72.50(57.00,112.00)μmol/L]、C反应蛋白[179.85(108.13,200.00) mg/L]、降钙素原水平[5.97(1.36,24.91)μg/L]均高于脓毒症未合并AKI组[56.50(51.00,59.00)μmol/L、110.12(77.24,170.24) mg/L、0.73(0.27,3.63)μg/L](P<0.05);脓毒症组确诊脓毒症时血浆HBP水平[21.99(14.66,35.52)μg/L]高于对照组[15.43(9.40,20.52)μg/L](P<0.05)。脓毒症合并AKI组确诊脓毒症0、12、24、48 h时血浆HBP水平[24.67(17.27,54.36)、40.22(20.80,76.46)、24.08(12.45,37.77)、21.46(11.46,32.81)μg/L]均高于脓毒症未合并AKI组[16.61(10.16,25.84)、19.83(11.87,24.99)、17.57(13.64,21.67)、12.86(10.91,17.87)μg/L](P<0.05),2组血浆HBP水平在确诊脓毒症后开始升高并在12 h后逐渐下降,各时间点两两比较差异均有统计学意义(P<0.05)。确诊脓毒症0、12、24、48 h时血浆HBP诊断脓毒症患者发生AKI的最佳截断值分别为36.83、31.60、21.76、20.58μg/L,AUC分别为0.713(95%CI:0.567~0.859,P=0.014)、0.807(95%CI:0.687~0.928,P<0.001)、0.674(95%CI:0.522~0.826,P=0.045)、0.693(95%CI:0.544~0.841,P=0.027);确诊12 h时血浆HBP诊断脓毒症患者发生AKI的AUC最大,灵敏度为60.0%,特异度为94.4%。结论脓毒症确诊12 h时血浆HBP对脓毒症相关AKI的诊断效能最佳,动态检测脓毒症患者血浆HBP及血肌酐、C反应蛋白、降钙素原水平有助于脓毒症相关AKI的早期诊断。

关键词：脓毒症急性肾损伤肝素结合蛋白血肌酐降钙素原 C反应蛋白

Ligand-controlled NiH-catalyzed regiodivergent hydroalkylation of 2-alkenylazaarenes

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Science China Chemistry 2024年第6期67卷 1935-1940页

作者： Ya-Ping shao Zhuo-min Chi Yong-min Liang State Key Laboratory of Applied Organic Chemistry School of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou730000China

A nickel-hydride(Ni H)-catalyzed migratory and nonmigratory hydroalkylation reaction of 2-alkenyl azaarenes with alkyl iodines has been established through strategic modulation of N-or P-donor *** method enables the synthesis of diverseβ-orγ-branched aromatic *** mild regiodivergent protocols exhibit wide substrate scope,excellent functional tolerance,and great reaction yield with remarkable ***,deuterium labeling studies reveal Ni H-catalyzed interrupted chain-walking mode as the mechanism behind remotedβ-selective hydroalkylation reaction—an interesting phenomenon mediated through aromatic imine directing groups.

关键词： NiH regiodivergent hydroalkylation azaarenes interrupted chain-walking