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Symptom selection for multi-label data of inquiry diagnosis in traditional Chinese medicine

Science China(Information Sciences) 2013年第5期56卷 238-250页

作者： shao huan LI GuoZheng LIU GuoPing WANG YiQin School of Computer Engineering and Science Shanghai University Department of Control Science and Engineering Key Laboratory of Ministry of Education for Service Computing and Embedded SystemsTongji University Laboratory of Information Access and Synthesis of TCM Four Diagnosis Shanghai University of Traditional Chinese Medicine

In traditional Chinese medicine(TCM) diagnosis,a patient may be associated with more than one syndrome tags,and its computer-aided diagnosis is a typical application in the domain of multi-label learning of high-dimensional *** is common that a great deal of symptoms can occur in traditional Chinese medical diagnosis,which affects the modeling of diagnostic *** selection entails choosing the smallest feature subset of relevant symptoms,and maximizing the generalization performance of the *** present there are rare researches on feature selection on multi-label data.A hybrid optimization technique is introduced to symptom selection for multi-label data in TCM diagnosis in this paper,and modeling is made by means of four multi-label learning algorithms like k nearest neighbors,*** compare the performance of the algorithm with the current popular dimension reduction algorithms like MEFS(embedded feature selection for multi-Label learning),MDDM(multi-label dimensionality reduction via dependence maximization) on the UCI Yeast gene functional data set and an inquiry diagnosis dataset of coronary heart disease(CHD).Experimental results show that the algorithm we present has significantly improved the *** particular,the improvement on the average precision for the classifier is up to 10.62% and 14.54%.Syndrome inquiry modeling of CHD in TCM is realized in this paper,providing effective reference for the diagnosis of CHD and analysis of other multi-label data.

关键词： multi-label learning feature selection high-dimensionality inquiry of traditional Chinese medicine coronary heart disease

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Interpreting the dynamic effect of internal heat integration on reactive distillation columns

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Chinese Journal of Chemical Engineering 2017年第1期25卷 89-102页

作者： Yang Yuan Liang Zhang Haisheng Chen shaofeng Wang Kejin huang huan shao College of Information Science and Technology Beijing University of Chemical Technology Patent Examination Cooperation Center of the Patent Office SIPO

In this work,the impact of internal heat integration upon process dynamics and controllability by superposing reactive section onto stripping section,relocating feed locations,and redistributing catalyst within the reactive section is explored based on a hypothetical ideal reactive distillation system containing an exothermic reaction:A + BC + *** state operation analysis and closed-loop controllability evaluation are carried out by comparing the process designs with and without the consideration of internal heat *** superposing reactive section onto stripping section,favorable effect is aroused due to its low sensitivities to the changes in operating *** ascending the lower feed stage,somewhat detrimental effect occurs because of the accompanied adverse internal heat integration and strong sensitivity to the changes in operating *** descending the upper feed stage,serious detrimental effect happens because of the introduced adverse internal heat integration and strong sensitivity to the changes in operating *** redistributing catalyst in the reactive section,fairly small negative influence is aroused by the sensitivity to the changes in operating *** reinforcing internal heat integration with a combinatorial use of these three strategies,the decent of the upper feed stage should be avoided in process *** the conclusions are derived based on the hypothetical ideal reactive distillation column studied,they are considered to be of general significance to the design and operation of other reactive distillation columns.

关键词： Reactive distillation column Internal heat integration Process design Process dynamics Process control

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Functional changes in the hypothalamic-pituitary-adrenal axis after successful cardiopulmonary resuscitation

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Emergency and Critical Care Medicine 2023年第2期3卷 46-50页

作者： Le An Zhijiang Qi huan shao Chunsheng Li Emergency Department of Beijing Chao-Yang Hospital Capital Medical UniversityBeijingChina

Background:Cardiac arrest(CA)is a terminal event that results in a range of pathophysiological changes in the body,most notably,systemic ischemia-reperfusion *** hypothalamic-pituitary-adrenal(HPA)axis is an important neuroendocrine system that modulates adrenocortical hormone *** study was designed to investigate the changes in HPA-related hormone levels after successful cardiopulmonary resuscitation(CPR)and to explore possible etiologies to provide a basis for relevant clinical ***:We collected the clinical data of 96 patients with CA admitted to the Emergency Department of Beijing Chaoyang Hospital,Capital Medical University,between January 2016 and May *** samples were collected 6,24,and 72 hours after restoring spontaneous circulation(ROSC).The data were compared with those of the healthy control group(n=50).An enzyme-linked immunosorbent assay(ELISA)was performed to measure copeptin,adrenocorticotropic hormone(ACTH),corticotropin-releasing hormone(CRH),and total *** data were collected for both *** the CPR group,clinical data and the end-of-study cerebral performance category(CPC)were *** were followed up through day *** or survival after day 28 was used as the study *** values were expressed as medians and quartiles or ratios(%)for statistical *** variables are expressed as mean±standard *** variables were expressed as frequencies and *** mean values of normally distributed measurement data were analyzed using 1-way analysis of variance(ANOVA)for among-group comparisons and the least significant difference(LSD)test for between-group *** v17(SPSS,Chicago,IL,USA)was used for statistical analysis,and P<0.05 was considered statistically ***:No significant between-group differences were observed in terms of age or *** 28-day mortality rate in the CPR group was 71%.ACTH and CRH levels were signific

关键词： Cardiac arrest Cardiopulmonary resuscitation Cerebral performance category Hypothalamic-pituitary-adrenal axis Postcardiopulmonary resuscitation syndrome

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A hybrid WUDT-NAFnet for simultaneous source data deblending

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Petroleum Science 2024年第3期21卷 1649-1659页

作者： Chao-Fan Ke shao-huan Zu Jun-Xing Cao Xu-Dong Jiang Chao Li Xing-Ye Liu Key Laboratory of Earth Exploration and Information Technology of Ministry of Education Chengdu University of Technology State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of Technology College of Geophysics Chengdu University of Technology

Simultaneous source technology,which reduces seismic survey time and improves the quality of seismic data by firing more than one source with a narrow time interval,is compromised by the massive blended ***,deblending algorithms have been developed to separate this ***,deep learning(DL)has been proved its great potential in suppressing the *** most popular DL method employs neural network as a filter to attenuate the blended noise in an iterative estimation and subtraction framework(IESF).However,there are still amplitude distortion and blended noise residual problems,especially when dealing with weak signal submerged in strong *** address these problems,we propose a hybrid WUDT-NAFnet,which contains two *** first network is a wavelet based U-shape deblending transformer network(WUDTnet),incorporated into IESF as a robust regularization term to iteratively separate the blended *** second network is a nonlinear activate free network(NAFnet)designed to recover the event amplitude and further suppress the weak noise residual in *** the hybrid network,the blended noise can be separated purposefully and *** using synthetic and field seismic data demonstrate that the WUDTNAFnet outperforms traditional curvelet transform(CT)based method and the deblending transformer(DT)model in terms of ***,for field applications,the data augmentation method of bicubic interpolation is applied to mitigate the feature difference between synthetic and field ***,the trained network exhibits strong signal preservation ability in numerical field example without requiring additional training.

关键词： Simultaneous-source Deblending Deep learning Transformer

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Effect of neutrophil CD64 for diagnosing sepsis in emergency department

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World Journal of Emergency Medicine 2020年第2期11卷 79-86页

作者： Wen-peng Yin Jia-bao Li Xiao-fang Zheng Le An huan shao Chun-sheng Li Department of Emergency Medicine Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China

BACKGROUND:The aim of this study is to investigate the diagnostic and prognostic value of neutrophil CD64(nCD64)as a novel biomarker in sepsis ***:One hundred fifty-one adult patients diagnosed with sepsis and 20 age-matched healthy controls were enrolled in the *** with sepsis were further subdivided into a sepsis group and a septic shock ***64 expression,serum procalcitonin(PCT)level,C-reactive protein(CRP)level,and white blood cell(WBC)count were obtained for each patient,and Sequential Organ Failure Assessment(SOFA)scores were ***:nCD64 expression was higher in the sepsis group with confirmed infection than in the control *** receiver operating characteristic(ROC)curve of nCD64 was higher than those of SOFA score,PCT,CRP and WBC for diagnosing *** area under the curve(AUC)of nCD64 combined with SOFA score was the highest for all *** AUC of nCD64 for predicting 28-day mortality in sepsis was signifi cantly higher than those of PCT,CRP,and WBC,but slightly lower than that of SOFA *** AUC of nCD64 or PCT combined with SOFA score was signifi cantly higher than that of any single parameter for predicting 28-day ***:nCD64 expression and SOFA score are valuable parameters for early diagnosis of infection and prognostic evaluation of sepsis patients.

关键词： Neutrophil CD64 Sepsis Sequential Organ Failure Assessment score Procalcitonin Prognosis Biomarker

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Epinephrine in Out-of-hospital Cardiac Arrest： Helpful or Harmful？

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Chinese Medical Journal 2017年第17期130卷 2112-2116页

作者： huan shao Chun-Sheng Li Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China

Objective：Epinephrine is the primary drug administered during cardiopulmonary resuscitation （CPR） to reverse cardiac *** evidence for the use of adrenaline in out-of-hospital cardiac arrest （OHCA） and in-hospital resuscitation is *** conducted a systematic review on the clinical efficacy of adrenaline in adult OHCA patients to evaluate whether epinephrine provides any overall benefit for *** Sources：The EMBASE and PubMed databases were searched with the key words ＆quot;epinephrine,＆quot; ＆quot;cardiac arrest,＆quot; and variations of these *** Selection：Data from clinical randomized trials,meta-analyses,guidelines,and recent reviews were selected for ***：Sudden cardiac arrest causes 544,000 deaths in China each year,with survival occurring in 〈1% of cases （compared with 12% in the United States）.The American Heart Association recommends the use of epinephrine in patients with cardiac arrest,as part of advanced cardiac life *** is a clear evidence of an association between epinephrine and increased return of spontaneous circulation （ROSC）.However,there are conflicting results regarding long-term survival and functional recovery,particularly neurological outcome,after *** is currently insufficient evidence to support or reject epinephrine administration during *** believe that epinephrine may have a role in resuscitation,as administration of epinephrine during CPR increases the probability of restoring cardiac activity with pulses,which is an essential intermediate step toward long-term ***：The administration of adrenaline was associated with improved short-term survival （ROSC）.However,it appears that the use of adrenaline is associated with no benefit on survival to hospital discharge or survival with favorable neurological outcome after OHCA,and it may have a harmful *** placebo-controlled,double-blind,randomized control trials are required to definitively establis

关键词： Adrenaline Cardiac Arrest Cardiopulmonary Resuscitation: Epinephrine Return of Spontaneous Circulation

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Decreased human leukocyte antigen-D-related expression on CD14^(+)monocytes in patients with out-of-hospital cardiac arrest provided target temperature management therapy:a prospective observational study

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Emergency and Critical Care Medicine 2024年第1期4卷 16-21页

作者： huan shao Wei Yuan Ziren Tang Zhijiang Qi Le An Qiang Zhang Chunsheng Li Department of Emergency Medicine Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina.

Background:Post–cardiac arrest syndrome involves systemic inflammation,which causes subsequent neurological *** investigated the influence of targeted temperature management(TTM)therapy in patients with out-of-hospital cardiac arrest(OHCA)after return of spontaneous circulation(ROSC)by observing the changes in circulating CD14^(+)monocytes and the expression of human leukocyte antigen D–related(HLA-DR)and programmed cell death ligand 1(PD-L1)in CD14^(+)***:Adult patients admitted to the emergency department of Beijing Chao-Yang Hospital after OHCA between January 2017 and March 2018 were included in this *** control subjects,10 patients with OHCA,and 37 patients with OHCA who received 72 hours of TTM therapy were *** blood samples of patients in the OHCA and TTM groups were collected on Days 1 and 3(D1 and D3)after ROSC and evaluated for HLA-DR and PD-L1 expression on CD14^(+)monocytes using flow ***:Compared with control subjects,the percentage of circulating CD14^(+)monocytes,HLA-DR+/CD14^(+)monocyte ratios,and mean fluorescence intensity were significantly decreased in patients with *** ROSC,HLA-DR expression in CD14^(+)monocytes in the TTM group was lower than that in patients with ***,there were no significant differences in the percentage of PD-L1+/CD14^(+)monocytes or the mean fluorescence intensity between patients with OHCA and healthy ***:After ROSC,circulating CD14^(+)monocytes and HLA-DR+/CD14^(+)monocyte ratios decreased significantly in patients with *** leukocyte antigen D–related expression in CD14^(+)monocytes was lower in patients treated with TTM.

关键词： Human leukocyte antigen D-related Monocytes Out-of-hospital cardiac arrest Target temperature management

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农村基层治理的区域比较

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山西财经大学学报 2021年第S1期43卷 4-6,10页

作者：邵欢杭州改革研究与促进中心浙江杭州310000

在我国社会主义现代化的实现进程中,基层治理能力与治理体系发挥了重要作用,在逐渐转型至现代化乡村治理的进程中,乡村治理随着不同的经济社会发展阶段而呈现出不同的区域特征。文章主要是对构建我国乡村治理现代化转型的理想类型以及... 详细信息

在我国社会主义现代化的实现进程中,基层治理能力与治理体系发挥了重要作用,在逐渐转型至现代化乡村治理的进程中,乡村治理随着不同的经济社会发展阶段而呈现出不同的区域特征。文章主要是对构建我国乡村治理现代化转型的理想类型以及存在于转型进程中的困难与矛盾进行了分析,希望在未来能给相关人员提供参考借鉴意义。

关键词：农村基层治理区域比较

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Early Changes in Circulatory T Helper Type 1, 2, and 17 Cells of Patients with Out-of-Hospital Cardiac Arrest after Successful Cardiopulmonary Resuscitation

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Chinese Medical Journal 2018年第17期131卷 2071-2079页

作者： Zhi-Jiang Qi Qiang Zhang Bo Liu huan shao Chun-Sheng Li Department of Emergency Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Beijing Key Laboratoryo-f Cardiopulmonary Cerebral Resuscitation Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China

Background： Immune disorder is an important feature of patients with out-of-hospital cardiac arrest （OHCA） after the return of spontaneous circulation （ROSC）. We investigated the expression of circulatory T helper type （Th）1, Th2, and Th 17 cells to explore the early immune alteration in OHCA patients after ROSC. Methods： During July-September 2016 and March-September 2017, 65 consecutive OHCA patients with ROSC 〉 12 h and 30 healthy individuals were enrolled in this study. Clinical and 28-day survival data were collected. Peripheral blood samples were analyzed to evaluate the expression of Th1/Th2/Th 17 cells by flow cytometry from OHCA patients after ROSC on days l and 3 and from healthy individuals. Results： Compared with healthy individuals, T lymphocyte counts and Thl cell counts decreased on days 1 and 3 after ROSC （1464 [1198, 2152] vs. 779 [481, 1140] vs. 581 [324, 1118/μl,χ^2= 30.342, P 〈 0.001; 154 [90, 246] vs. 39 [19, 78] vs. 24 [12, 53]μl, χ^2 = 42.880, P〈 0.001）, and Th2 and Th17 cell counts decreased on day 3 （17.0 [10.8, 24.0] vs. 9.0 [3.0, 15.5]μl, Z= -3.228, P= 0.001; 4.7 [2.7, 9.1] vs. 2.7 [1.0, 6.5]μl, Z = -2.294, P = 0.022）. No change in CD4＋/CD3＋ lymphocyte ratio was seen on day 1 or day 3 （57.9 [49.4, 63.0] vs. 55.4 [46.5, 66.5] vs. 55.4 [50.2, 67.0]%, χ^2 = 0.171, P = 0.918）. Th1/CD4＋ lymphocyte ratio decreased on days 1 and 3 （19.0 [14.0, 24.9] vs. 9.3 [4.6, 13.9] vs. 9.5 [4.9, 13.6]%, χ^2= 25.754, P 〈 0.001）, and Th2/CD4＋ lymphocyte ratio increased on day 1 and decreased on day 3 （1.9 [1.2, 2.5] vs. 2.5 [1.6, 4.0] vs. 1.9 [1.6, 3.81%,χ^2= 6.913, P = 0.032）. Thl/Th2 cell ratio also decreased on both clays （9.4 [7.3, 13.5] vs. 3.1 [1.9, 5.6] vs. 4.2 [2.8, 5.9], χ^2 = 44.262, P 〈 0.001 ）. Despite an upward trend in the median of Th 17/CD4＋ lymphocyte ratio in OHCA patients, there was no significant difference compared with healthy individuals （0.9 [0.4, 1.2] vs. 0.7 [0.4, 1.2] vs. 0.6 [0.3, 1.01%, χ^2= 2.620, P = 0.270）. The dynamic expression

关键词： Out-of-Hospital Cardiac Arrest T Helper Type 1 Cell T Helper Type 17 Cell T Helper Type 2 Cell

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A mobile mass - a left atrial undifferentiated sarcoma mimicking myxoma： a case report

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Chinese Medical Journal 2008年第14期121卷 1339-1341页

作者： shao huan-zhang XIAO Xi-jun ZHU Peng QIAN Yong-jun YUAN Hong-sheng Department of Cardiovascular Surgery West China Hospital Sichuan University Chengdu Sichuan 610041 China

The incidence of primary cardiac tumors is extremely low, ranging from 0.0017% to 0.019%.^1 Primarytumors can be categorized into benign or malignant tumors, in which 75% of primary tumors are benign with myxomas comprising 50% of the cases. On the other hand, malignant tumors constitute less than 25% of primary cardiac neoplasms and are manifested predominantly as sarcoma in various forms.

关键词： heart neoplasms myxoma sarcoma surgery.

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