检索结果-南通市图书馆

Intersection of Inorganic Chemistry and Nanotechnology for the Creation of New Cancer Therapies

Accounts of Materials Research 2022年第3期3卷 283-296页

作者： Anuj S.Shah Bapurao Surnar Nagesh Kolishetti shanta dhar Department of Biochemistry and Molecular Biology University of Miami Miller School of MedicineMiamiFlorida 33136United States Department of Immunology&Nano-Medicine Herbert Wertheim College of MedicineFlorida International UniversityMiamiFlorida 33199United States

CONSPECTUS:Since its discovery in 1965,the inorganic drug cisplatin has become a mainstay of cancer therapies and has inspired many platinum(Pt)-based compounds to solve various issues of toxicity and limitations associated with the original ***,many of these drugs/prodrugs continue to be plagued by an array of side effects,limited circulation,and half-life and off-target *** solve this issue,we have constructed an array of platinum-based prodrugs on a Pt(IV)skeleton,which provides more favorable geometry and hydrophobicity,easier functionalization,and ultimately better targeting *** of these Pt(IV)prodrugs aims to either combine cisplatin with other agents for a combination therapeutic effect or improve the targeting of cisplatin itself,all for the more effective treatment of specific *** developed prodrugs include Platin-A,which combines cisplatin with the anti-inflammatory agent aspirin,Platin-M,which is functionalized with a mitochondria-targeting moiety,and Platin-B and Platin-Cbl,which combine cisplatin with components to combat cellular resistance to *** the same time,however,we recognize the crucial role of nanotechnology in improving the efficacy of cisplatin prodrugs and other inorganic compounds for the treatment of *** describe several key benefits provided by nanomedicine that vastly improve the reach and utility of cisplatin prodrugs,including the ability of biodegradable polymeric nanoparticles(NPs)to deliver these agents with precision to the mitochondria,transport drugs across the blood−brain barrier,and target cisplatin prodrugs to specific cancers using various *** addition,we highlight our progress in the engineering of innovative new polymers to improve the release patterns,pharmacokinetics,and dosages of cancer *** this Account,we aim to describe the growing need for collaboration between the fields of inorganic chemistry and nanotechnology and how new advancements can n

关键词： dosage platinum entirely

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：