Intersection of Inorganic Chemistry and Nanotechnology for the Creation of New Cancer Therapies
作者机构：Department of Biochemistry and Molecular BiologyUniversity of Miami Miller School of MedicineMiamiFlorida 33136United States Department of Immunology&Nano-MedicineHerbert Wertheim College of MedicineFlorida International UniversityMiamiFlorida 33199United States
出 版 物：《Accounts of Materials Research》 (材料研究述评（英文）)
年 卷 期：2022年第3卷第3期
页 面：283-296页
学科分类：1002[医学-临床医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 100214[医学-肿瘤学] 10[医学]
基 金：S.D.acknowledges funding from the Sylvester Comprehensive Cancer Center,Department of Defense Prostate Cancer Idea Award(W81XWH-12-1-0406) the Florida Department of Health Bankhead-Coley Cancer Research Award(8BC10) the Florida Department of Health Zika Research Grant Initiative(award number 7ZK28) the Barth Syndrome Foundation,the American Heart Association National Scientist Development Award(14SDG18690009) the Ralph E.Powe Junior Faculty Enhancement Award from ORAU,the NHLBI High Priority Bridge Award(R56HL121392) the Georgia Research Alliance,and the NCI-funded Sylvester Comprehensive Cancer Center(support grant 1P30CA240139)for supporting our laboratory projects on nanomedicine and anticancer therapeutics We extend our acknowledgement to our laboratory previous trainees and collaborators who participated in our projects.S.D.extends her gratitude to her academic mentors who helped her to realize the potential of metals in medicine
摘 要：CONSPECTUS:Since its discovery in 1965,the inorganic drug cisplatin has become a mainstay of cancer therapies and has inspired many platinum(Pt)-based compounds to solve various issues of toxicity and limitations associated with the original ***,many of these drugs/prodrugs continue to be plagued by an array of side effects,limited circulation,and half-life and off-target *** solve this issue,we have constructed an array of platinum-based prodrugs on a Pt(IV)skeleton,which provides more favorable geometry and hydrophobicity,easier functionalization,and ultimately better targeting *** of these Pt(IV)prodrugs aims to either combine cisplatin with other agents for a combination therapeutic effect or improve the targeting of cisplatin itself,all for the more effective treatment of specific *** developed prodrugs include Platin-A,which combines cisplatin with the anti-inflammatory agent aspirin,Platin-M,which is functionalized with a mitochondria-targeting moiety,and Platin-B and Platin-Cbl,which combine cisplatin with components to combat cellular resistance to *** the same time,however,we recognize the crucial role of nanotechnology in improving the efficacy of cisplatin prodrugs and other inorganic compounds for the treatment of *** describe several key benefits provided by nanomedicine that vastly improve the reach and utility of cisplatin prodrugs,including the ability of biodegradable polymeric nanoparticles(NPs)to deliver these agents with precision to the mitochondria,transport drugs across the blood−brain barrier,and target cisplatin prodrugs to specific cancers using various *** addition,we highlight our progress in the engineering of innovative new polymers to improve the release patterns,pharmacokinetics,and dosages of cancer *** this Account,we aim to describe the growing need for collaboration between the fields of inorganic chemistry and nanotechnology and how new advancements can n
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