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新能源 1990年第12期12卷 35-38页

作者： sham.,ah 戚文定

Effects of In-Situ Cadmium Exposure on Morphometric Indices of Anabas testudineus

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Journal of Environmental Protection 2024年第4期15卷 485-496页

作者： Mohd sham.Othman Sharifah Nadrah Syed Idrus Fazlin Hazirah Mohd Mohd Riduan Abdullah Center for Toxicology & Health Risk Studies (CORE) Faculty of Health Sciences Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia

Anthropogenic activities have greatly affected water resources on a global scale where the world is experiencing water quality and resources issues. Heavy metal is a crucial group of pollutants that is toxic to the environment even at low concentrations due to its bioaccumulation and biomagnification capabilities in living organisms. The detrimental effects of heavy metals on living organisms are due to their bioaccumulation in the aquatic ecosystem. Cadmium may result in adverse health effects due to its high toxicity. The study is conducted to determine the cadmium exposure effects on the morphometric indices of Anabas testudineus which are the Scaling Coefficient (SC) and Condition Factor (K) of such species. Anabas testudineus is exposed to four different cadmium treatment groups namely the control group, cadmium treatment group of 0.005 mg/L, 0.010 mg/L, and 0.015 mg/L for 16 weeks. The findings of the study have reported inconsistent trends in the values of SC and a decrease in the value of K with increasing cadmium concentration. The trend for the average SC has shown an overall decrease in value while the pattern of the K value is inconsistent in each treatment group with exposure time. Collectively, no significant differences for SC and K of A. testudineus in different treatment groups as well as comparison between treatment groups with time exposure.

关键词： Cadmium Anabas testudineus Scaling Coefficient Condition Factor

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化学杀配子剂对水稻花粉不育和结实的影响

国外作物育种 1998年第2期17卷 18-19页

作者： sham.,MA 向平

Attenuation of mitochondrial,but not cytosolic,Ca2+ overload reduces myocardial injury induced by ischemia and reperfusion

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Acta Pharmacologica Sinica 2006年第7期27卷 911-918页

作者： Kenneth WL KAM James SK sham.Tlak-ming WONG Department of Physiology the University of Hong KongHong Kong SARChina Division of Pulmonary Critical Care Medicine Johns Hopkins School of MedicineBaltimoreMaryland 21224USA

Aim:Attenuation of mitochondrial Ca2+([Ca2+]m),but not cytosolic Ca2+([Ca2+]c),overload improves contractile *** hypothesized that attenuation of[Ca2+]m,but not[Ca2+]c,overload confers cardioprotection against ischemia/reperfusion-induced ***:Infarct size from isolated perfused rat heart,cell viability,and electrically-induced Ca2+transient in isolated rat ventricularmyocytes were *** determined the effects of BAPTA-AM,a Ca2+chelator,at concentrations that abolish the overload of both[Ca2+]cand[Ca2+]m,and ruthenium red,an inhibitor of mitochondrial uniporter of Ca2+transport,atconcentrations that abolish the overload of[Ca2+]m,but not[Ca2+]c,on cardiacinjury induced by ischemia/***:Attenuation of both[Ca2+]mand[Ca2+]cby BAPTA-AM,and attenuation of[Ca2+]m,but not[Ca2+]c,overloadby ruthenium red,reduced the cardiac injury observations,indicating the impor-tance of[Ca2+]min cardioprotection and contractile recovery in response to is-chemia/***:The study has provided unequivocal evidenceusing a cause-effect approach that attenuation of[Ca2+]m,but not[Ca2+]c,over-load is responsible for cardioprotection against ischemia/*** also confirmed the previous observation that attenuation of[Ca2+]m,but not[Ca2+]c,by ruthenium red improves contractile recovery following ischemia/reperfusion.

关键词： ruthenium red BAPTA-AM infarct size electrically-induced Ca2+transient isolated perfused rat heart cardiac myocytes

Statistical issues and approaches in endophenotype research

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Chinese Science Bulletin 2011年第32期56卷 3403-3408页

作者： sham.Pak Chung CHERNY Stacey S HALL Mei-Hua Department of Psychiatry and The State Key Laboratory of Brain and Cognitive Sciences The University of Hong Kong Hong Kong China Psychology Research Laboratory McLean Hospital Harvard Medical School Boston MA 02115-6092 USA

The endophenotype concept was initially proposed to enhance the power of genetic studies of complex disorders. It is closely related to the genetic component in a liability-threshold model; a perfect endophenotype should have a correlation of 1 with the genetic component of the liability to disease. In reality, a putative endophenotype is unlikely to be a perfect representation of the genetic component of disease liability. The magnitude of the correlation between a putative endophenotype and the genetic component of disease liability can be estimated by fitting multivariate genetic models to twin data. A number of statistical methods have been developed for incorporating endophenotypes in genetic linkage and association analyses with the aim of improving statistical power. The most recent of such methods can handle multiple endophenotypes simultaneously for the greatest increase in power. In addition to increasing statistical power, endophenotype research plays an important role in helping to understand the mechanisms which connect the associated genetic variants with disease occurrence. Novel statistical approaches may be required for the analysis of the complex relationships between endophenotypes at different levels and how they converge to cause the occurrence of disease.

关键词：统计问题稳定遗传疾病 COM组件复杂疾病组成部分模型估计统计方法

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ATP-dependent chromatin remodeling complex SWI/SNF in cardiogenesis and cardiac progenitor cell development

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Frontiers in Biology 2012年第3期7卷 202-211页

作者： Ienglam LEI Mai Har sham.Zhong WANG Cardiovascular Research Center Massachusetts General Hospital Boston MA 02114 USA Harvard Stem Cell Institute 185 Cambridge Street Boston MA 02114 USA Department of Biochemistry Li Ka Shing Faculty of Medicine The University ofHong Kong Hong Kong China

The recent identification of cardiac progenitor cells （CPCs） provides a new paradigm for studying and treating heart disease. To realize the full potential of CPCs for therapeutic purposes, it is essential to understand the genetic and epigenetic mechanisms guiding CPC differentiation into cardiomyocytes, smooth muscle, or endothelial cells. ATP-dependent chromatin remodelers mediate one critical epigenetic mechanism. These large multiprotein complexes open up chromatin to modulate transcription factor access to DNA. SWI/SNF, one of the major types of chromatin remodelers, plays a key role in various aspects of development （de la Serna et al., 2006; Wu et al., 2009）, including heart development and disease （Lickert et al., 2004; Wang et al., 2004; Huang et al., 2008; Stankunas et al., 2008; Hang et al., 2010）. In this review, we describe the specific function of various SWI/SNF components in cardiogenesis and cardiac progenitor cell （CPC） self-renewal and differentiation. We envision that a detailed understanding of the SWI/SNF in heart development and CPC formation and differentiation will generate novel insights into epigenetic mechanisms that govern CPC differentiation and may have significant implications in understanding and treating heart disease.

关键词： ATP-dependent chromatin remodeling SWI/SNF cardiogenesis and cardiac progenitor cell

Maintain Optimal Configurations for Large Configurable Systems Using Multi-Objective Optimization

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Computers, Materials & Continua 2022年第11期73卷 4407-4422页

作者： Muhammad Abid Jamil Deafallah Alsadie Mohamed K.Nour Normi sham.Awang Abu Bakar Department of Computer Science Umm Al-Qura UniversityMakkahSaudi Arabia Kulliyyah of Information and Communication Technology International Islamic UniversityMalaysia

To improve the maintenance and quality of software product lines,efficient configurations techniques have been ***,due to the complexity of derived and configured products in a product line,the configuration process of the software product line(SPL)becomes timeconsuming and *** product line consists of a various number of feature models that need to be *** different approaches have been presented by Search-based software engineering(SBSE)to resolve the software engineering issues into computational solutions using some metaheuristic ***,multiobjective evolutionary algorithms help to optimize the configuration process of *** this paper,different multi-objective Evolutionary Algorithms like Non-Dominated Sorting Genetic algorithms II(NSGA-II)and NSGA-III and Indicator based Evolutionary Algorithm(IBEA)are applied to different feature models to generate optimal results for large *** proposed approach is also used to generate the optimized test suites with the help of different multi-objective Evolutionary Algorithms(MOEAs).

关键词： Software product line search-based software engineering metaheuristic multiobjective evolutionary algorithms feature model

Reproductive Mode of Fejervarya limnocharis (Anura:Ranidae) Caught from Mae Sot,Thailand Based on Its Gonadosomatic Indices

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Asian Herpetological Research 2011年第1期2卷 41-45页

作者： Mohd sham.OTHMAN Wichase KHONSUE Jirarach KITANA Kumthorn THIRAKHUPT Mark Gregory ROBSON Noppadon KITANA International Postgraduate Programs in Environmental Management Graduate SchoolChulalongkorn University National Center of Excellence for Environmental and Hazardous Waste Management (NCE-EHWM) Chulalongkorn University Department of Biology Faculty of ScienceChulalongkorn University Environmental Health Program Faculty of Allied Health SciencesUniversiti Kebangsaan MalaysiaJalan Raja Muda Abdul Aziz50300 Kuala LumpurMalaysia School of Environmental and Biological Sciences RutgersThe State University of New JerseyNew Jersey 08901-8525USA Thai Fogarty International Training and Research in Environmental and Occupational Health Center NIH FIC 43TW007849 Chulalongkorn University

Amphibians show a variety of reproductive modes and strategies. The cyclicity and continuity of reproduction can often be predicted from the annual gonadosomatic index trends in a species specific manner. This research aims to document the female and male gonadosomatic index profiles and to ascertain the reproductive cyclicity or continuity of Fejervarya lirnnocharis （Anura： Ranidae） caught in Mac Sot, Tak Province, Thailand. Frogs were collected monthly between November 2007 and October 2009 in rice fields and their surrounding areas in the study site. For each frog, total weight and ovarian/testicular weight were measured to obtain the female and male gonadosomatic index. The number of female individuals with mature eggs （postvitellogenic eggs） was also counted. The results showed that female frogs had two main surges of increased GSI in March and September of 2008. Alternatively, male frogs showed a more gradual increase and decrease in gonadosomatic index, thus the index remaining high throughout the year. This study concluded that while F. limnocharis in this area is essentially a continuous breeder, it is more optimized for a cyclic reproduction mode with two breeding cycles during the rainy season.

关键词： rice flog cyclic reproduction egg deposition GSI profile

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A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings

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Chinese Science Bulletin 2011年第32期56卷 3394-3397页

作者： LUI Simon S Y sham.Pak CHAN Raymond C K CHEUNG Eric F C Neuropsychology and Applied Cognitive Neuroscience Laboratory Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences Castle Peak Hospital Department of Psychiatry the University of Hong Kong

The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011.

关键词：精神病患者稳定家庭早期原理预计香港面部表情识别

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New Initiatives in Treatmnt of Nasopharyngeal Carcinoma

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New Initiatives in Treatmnt of Nasopharyngeal Carcinoma