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Journal of Bionic Engineering 2021年第1期18卷 103-117页

作者： shailendra singh shera Rathindra Mohan Banik Bioprocess Technology Laboratory Sschool of Biochemical Engineeringndian Institute of Technology(Banaras Hindu University)Varanasi 221005India Department of Biotechnology Faculty of Engineering&TechnologyRAMA Universit Uittar PradeshKanpur 209217India

Skin acts as protective barrier against a number of factors such as dust,opportunistic microbial and viral infections,regulates body temperature and waste *** cell population plays an important role in devclopment of skin architecturc.A scaffold having capability to support and enhance fibroblast growth is a viable option for wound dressing material which can shorten the time for wound to *** this work,Silk Fibroin(SF)and Xanthan(Xa)were blended in three ratios 80 SF:20 Xa(SFX82),60 SF:40 Xa(SFX64),and 50SF:50 Xa(SFX55)to create SF/Xa *** and other physicochemical properties of SF/Xa scaffold are functions of blending ratios and blend with the ratio 80 SF:20 Xa has the highest *** properties of SF/Xa blends are a function of miscibility with SFX82 having superior thermal propertis of all fabricated *** porosity of SF/Xa scaffolds is in the range of 67%to 50%,with pore size of 58.1 um-45.5 um,water uptake capacity of 92%-86%,and surface roughness of 49.95 nm-385 ***82 shows highest growth rate of L929 fibroblast cells indicating its superiority over other scaffolds for providing biological cues for the growth and proliferation of fibroblastic cells in natural ***82 scaffold is found to be most suitable for fibroblastic cells thereby enhancing the tissue regeneration at wound site.

关键词： blends miscibility FTIR imaging Atomic Force Microscopy(AFM) cytocompatibility wound healing

Invitro Biodegradability of Silk Fibroin/Xanthan Biopolymeric Composite Scaffolds

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Journal of Bionic Engineering 2019年第2期16卷 299-310页

作者： shailendra singh shera Shraddha Sahu Rathindra Mohan Banik Bioprocess Technology Laboratory School of Biochemical Engineering Indian Institute of TechnologyBanaras Hindu UniversityVaranasi 221005India

Silk fibroin/xanthan scaffolds were prepared by blending silk fibroin and xanthan in the ratios 80SF:20Xa(SFX82),60SF:40Xa(SFX64),and 50SF:50Xa(SFX55)using freeze drying ***-vitro degradation behavior of the prepared scaffolds was studied for 37 days in phosphate buffer *** degradation rate was the function of silk fibroin,xanthan and^-crystallite contents in the silk fibroin/xanthan ***82 degraded extremely slowly whereas SFX55 showed faster degradation *** xanthan was the main contributor of weight ***82 and SFX64 exhibited surface degradation whereas SFX55 showed bulk degradation which indicated that higher silk fibroin ratios favor surface *** to bulk degradation,SFX55 showed maximum surface roughness among the composite *** FTIR spectrum revealed total loss of xanthan from the composites after *** broad and low-intensity peaks in the FTIR spectrum of composite scaffolds con finned reduction in 0-sheet crystallite content during *** analysis also confirmed reduction in 0-sheet crystals and revealed that degraded composite scaffold had predominantly amorphous *** degraded scaffold showed higher porous structure than the non-degraded *** in vitro degradability testing gives a good approximation of degradation of scaffold in vivo and helps in designing a robust biopolymeric composite scaffold for tissue engineering.

关键词： biopolymer composites surface roughness biopolymer degradation surface degradation tissue engineering

Artificial Neural Network Modeling to Predict the Non-Linearity in Reaction Conditions of Cholesterol Oxidase from <i>Streptomyces olivaceus</i><i>MTCC</i>6820

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Journal of Biosciences and Medicines 2019年第4期7卷 14-24页

作者： Shraddha Sahu shailendra singh shera Rathindra Mohan Banik Bioprocess Technology Laboratory School of Biochemical Engineering Indian Institute of Technology (Banaras Hindu University) Varanasi India

Cholesterol oxidase (COX) is widely used enzyme for total cholesterol estimation in human serum and for the fabrication of electro-chemical biosensors. COX is also used for the bioconversion of cholesterol;for the production of precursors of steroidal drugs and hormones. Enzyme activity depends decisively on defined conditions with respect to pH, temperature, ionic strength of the buffer, substrate concentration, enzyme concentration, reaction time. Standardization of these parameters is desirable to attain optimum activity of the enzyme. The present work aims to build a neural network model using five input parameters (pH, cholesterol concentration, 4-aminoantipyrine concentration, crude COX volume and horseradish peroxidase) and one output i.e., COX activity (U/ml) as a response. A feed forward back propagation neural network with Levenberg-Marquardt training algorithm was used to train the network. The network performance was assessed in terms of regression (R2), Mean Squared Error (MSE) and Mean Absolute Percentage Error (MAPE). A network topology of 5-10-1 was found to be optimum. The MSE, MAPE and R2 values of the neural model were 0.0075%, 0.12% and 0.9792% respectively. The maximum predicted activity of COX was 1.073 U/ml, which was close to the experimental value i.e., 1.1 U/ml at simulated optimum assay conditions. MSE and MAPE depicted the precision in the prediction efficiency of the developed ANN model. Higher R2 value showed a good correlation between the experimental and ANN predicted values. This proved the robustness of the ANN model to predict similar type of system (COX from other Streptomyces sp.) within the limits of the trained data set. The COX activity was enhanced by 1.71 folds after optimization of the reaction conditions.

关键词： Cholesterol Oxidase Artificial Neural Network Optimization Streptomyces olivaceus Prediction

State of the art in finite element approaches for milling process:a review

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Advances in Manufacturing 2023年第4期11卷 708-751页

作者： shailendra Chauhan Rajeev Trehan Ravi Pratap singh Department of Industrial and Production Engineering Dr.B R Ambedkar National Institute of TechnologyJalandharPunjabIndia

Over a century,metal cutting has been observed as a vital process in the domain of *** the numerous available metal-cutting processes,milling has been considered as one of the most employable processes to machine a variety of engineering materials *** the milling process,material removal occurs when the workpiece is fed against a rotating tool with multiple cutting *** order to maximize the profitability of metal cutting operations,it is essential that the various input and output variable relationships are analyzed and *** experimental method of studying milling processes is costly and time demanding,particularly when a large variety of elements such as cutting tool shape,materials,cutting conditions,and so on,are *** to these issues,other alternatives emerged in the form of mathematical simulations that employ numerical *** finite element approaches have well-proven to be the most practical and commonly utilized numerical *** finite element model(FEM)can be used to determine the various physical interactions occurring during the machining process along with the prediction of various milling characteristics,such as cutting forces,cutting temperature,stresses,etc.,with the help of milling *** the present article,various research studies in the broad milling process domain practiced with numerous finite element approaches have been critically reviewed and *** further highlights the several experimental and finite element approaches-based research studies that attempted to analyze and optimize the overall performance of the different milling *** recent years,various investigators have explored numerous ways to enhance milling performance by probing the different factors that influence the quality *** of the studies have also been found to be focused on the economic impacts of milling and various process inputs that affect milling ***,various milli

关键词： Milling Finite element modeling(FEM) Micro milling Turn-milling

Numerical Analysis of Phase Change and Container Materials for Thermal Energy Storage in the Storage Tank of Solar Water Heating System

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Journal of Thermal Science 2024年第2期33卷 408-421页

作者： singh shailendra ANAND Abhishek SHUKLA Amritanshu SHARMA Atul Non-Conventional Energy Laboratory Rajiv Gandhi Institute of Petroleum TechnologyJais Amethi229304India

This study evaluates the effectiveness of phase change materials(PCMs) inside a storage tank of warm water for solar water heating(SWH) system through the theoretical simulation based on the experimental model of *** et *** model is explained by five fundamental equations for the calculation of various parameters like the effectiveness of PCMs,the mass of hot water,total heat content,and duration of *** study simulated eleven PCMs to analyze their effectiveness like Sodium hydrogen phosphate dodecahydrate(SHPD),OM 37,N-Eicosane(NE),Lauric acid(LA),Paraffin wax(PW),OM 48,Paraffin wax C_(20-33)(PW-C20-33),Sodium acetate trihydrate(SAT),Palmitic acid(PA),Myristic acid(MA),and Stearic acid(SA).Among all PCMs,the SHPD has found the highest value of effectiveness factor of ***,it is the most recommended PCM for the storage tank of the SWH *** study also includes the melt fraction analysis of all enumerated PCMs corresponding to container materials of stainless steel,glass,aluminum mixed,tin,aluminum,and *** melt fraction analysis is performed by making a coding program in the FORTRAN programming *** the analysis,copper container material is found to have high melting rate for all PCMs so it is superior to other container materials.

关键词： theoretical model solar water heating system phase change material effectiveness factor melt fraction

Painlevé analysis,auto-Bäcklund transformation and new exact solutions of(2+1)and(3+1)-dimensional extended Sakovich equation with time dependent variable coefficients in ocean physics

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Journal of Ocean Engineering and Science 2023年第3期8卷 246-262页

作者： shailendra singh S.Saha Ray National Institute of Technology Department of MathematicsRourkela 769008India

This article considers time-dependent variable coefficients(2+1)and(3+1)-dimensional extended Sakovich ***éanalysis and auto-Bäcklund transformation methods are used to examine both the considered ***éanalysis is appeared to test the integrability while an auto-Bäcklund transformation method is being presented to derive new analytic soliton solution families for both the considered *** new family of exact analytical solutions are being obtained success-fully for each of the considered *** soliton solutions in the form of rational and exponential functions are being *** results are also expressed graphically to illustrate the potential and physical behaviour of both *** the considered equations have applications in ocean wave theory as they depict new solitary wave soliton solutions by 3D and 2D graphs.

关键词： (2+1)-dimensional extended Sakovich equation (3+1)-dimensional extended Sakovich equation Auto-Bäcklund transformation Painlevéanalysis Solitary wave solution

Painlevéintegrability,auto-Bäcklund transformations,new abundant analytic solutions including multi-soliton solutions for time-dependent extended KdV8 equation in nonlinear physics

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Journal of Ocean Engineering and Science 2024年第5期9卷 489-507页

作者： shailendra singh S.Saha Ray National Institute of Technology Department of MathematicsRourkela 769008India

In this paper,a new eighth-order(1+1)-dimensional time-dependent extended KdV equation has been *** considered equation is being found completely integrable by using the Painlevéanalysis ***,three auto-Bäcklund transformations have been generated by truncating the Painlevéseries at a constant *** auto-Bäcklund transformations have been used to derive various analytic solution families for the newly developed *** solutions include the kink-antikink soliton,kink-soliton,antikink-soliton,periodic-soliton,complex kink-soliton and complex periodic-soliton ***-soliton solutions including N-soliton solution,have been obtained by using the simplified Hirota’s method for the considered *** the results are being expressed graphically to signify the physical importance of the considered equation.

关键词： Higher-order KdV equation Painlevéanalysis Auto-Bäcklund transformation Simplified Hirota method

Biomedical Perspective of Electrochemical Nanobiosensor

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Nano-Micro Letters 2016年第3期8卷 193-203页

作者： Priti singh shailendra Kumar Pandey Jyoti singh Sameer Srivastava Sadhana Sachan Sunil Kumar singh Department of Biotechnology Motilal Nehru National Institute of Technology Department of Chemical Engineering Motilal Nehru National Institute of Technology

Electrochemical biosensor holds great promise in the biomedical area due to its enhanced specificity, sensitivity, label-free nature and cost effectiveness for rapid point-of-care detection of diseases at bedside. In this review, we are focusing on the working principle of electrochemical biosensor and how it can be employed in detecting biomarkers of fatal diseases like cancer, AIDS, hepatitis and cardiovascular diseases. Recent advances in the development of implantable biosensors and exploration of nanomaterials in fabrication of electrodes with increasing the sensitivity of biosensor for quick and easy detection of biomolecules have been elucidated in detail. Electrochemical-based detection of heavy metal ions which cause harmful effect on human health has been discussed. Key challenges associated with the electrochemical sensor and its future perspectives are also addressed.

关键词： Biomarkers Point-of-care detection Nanomaterials Electroactive species Potentiometric Amperometric Implantable

Role of endoscopic ultrasound in liver disease: Where do we stand in 2017?

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World Journal of Hepatology 2017年第24期9卷 1013-1021页

作者： Hamzeh A Saraireh Mohammad Bilal shailendra singh Department of Internal Medicine University of Texas Medical Branch Division of Gastroenterology and Hepatology University of Texas Medical Branch Division of Gastroenterology Hepatology and Nutrition Allegheny General Hospital

Endoscopic ultrasound(EUS) was first introduced into medical practice in 1980 s as a diagnostic imaging modality for pancreatic pathology. EUS has the unique advantage of combining ultrasound and endoscopy to obtain detailed information of the gastrointestinal tract. Over the past decade, the use of EUS in liver diseases has been increasing. EUS, which was initially used as a diagnostic tool, is now having increasing therapeutic role as well. We provide a review of the application of EUS in the diagnostic and therapeutic aspects of liver disease. We also look at the evolving future research on the role of EUS in liver diseases.

关键词： Endoscopic ultrasound Liver disease Portal hypertension Liver lesions

Variations in the medical treatment of inflammatory bowel disease among gastroenterologists

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Gastroenterology Report 2018年第1期6卷 61-64,I0002,I0003页

作者： shailendra singh Monica Chowdhry Shifa Umar Mohammad Bilal Kofi Clarke Division of Gastroenterology Allegheny Health NetworkAllegheny General HospitalPittsburghPAUSA Department of Internal Medicine Charleston Area Medical CenterWest Virginia UniversityCharlestonWVUSA

Background and aims:With expanding available treatment options and evolving understanding of the risks and benefits of medical therapies for inflammatory bowel disease(IBD),there is the possibility of significant variations in treatment and *** is known about the variation in treatment between IBD specialists and other gastroenterology(GI)*** possible variations is an important first step to help address standardized care and optimize *** studied the differences in use of biologics and immunomodulators in the management of IBD patients at a tertiary care hospital between IBD-trained physicians and other ***:A total of 325 IBD patients were included in the *** these,216 patients received care with an IBD physician and 109 had other GI/non-IBD physicians as their main ***:The unadjusted use of immunomodulators(35.6%vs 16.5%,p¼0.001),biologics(45.8%vs 22.9%,p¼0.001)and dual therapy(biologics and immunomodulator)(14.4%vs 3.7%,p¼0.001)was significantly higher in the IBD-physician *** differences in therapy between the two groups remained after adjusting for patient and disease ***:There are significant variations in the treatment of patients with IBD by GI *** use of biologics and immunomodulators is higher in GI physicians with dedicated IBD interest and training.

关键词： variation in treatment inflammatory bowel disease Crohn’s disease,ulcerative colitis biologics immunomodulator