Invitro Biodegradability of Silk Fibroin/Xanthan Biopolymeric Composite Scaffolds

作     者：Shailendra Singh Shera Shraddha Sahu Rathindra Mohan Banik 

作者机构：Bioprocess Technology LaboratorySchool of Biochemical Engineering Indian Institute of TechnologyBanaras Hindu UniversityVaranasi 221005India 

出 版 物：《Journal of Bionic Engineering》 (仿生工程学报（英文版）)

年 卷 期：2019年第16卷第2期

页      面：299-310页

核心收录：

学科分类：08[工学] 

基　　金：Ministry of Human Resource Development  MHRD 

主　　题：biopolymer composites surface roughness biopolymer degradation surface degradation tissue engineering 

摘      要：Silk fibroin/xanthan scaffolds were prepared by blending silk fibroin and xanthan in the ratios 80SF:20Xa(SFX82),60SF:40Xa(SFX64),and 50SF:50Xa(SFX55)using freeze drying ***-vitro degradation behavior of the prepared scaffolds was studied for 37 days in phosphate buffer *** degradation rate was the function of silk fibroin,xanthan and^-crystallite contents in the silk fibroin/xanthan ***82 degraded extremely slowly whereas SFX55 showed faster degradation *** xanthan was the main contributor of weight ***82 and SFX64 exhibited surface degradation whereas SFX55 showed bulk degradation which indicated that higher silk fibroin ratios favor surface *** to bulk degradation,SFX55 showed maximum surface roughness among the composite *** FTIR spectrum revealed total loss of xanthan from the composites after *** broad and low-intensity peaks in the FTIR spectrum of composite scaffolds con finned reduction in 0-sheet crystallite content during *** analysis also confirmed reduction in 0-sheet crystals and revealed that degraded composite scaffold had predominantly amorphous *** degraded scaffold showed higher porous structure than the non-degraded *** in vitro degradability testing gives a good approximation of degradation of scaffold in vivo and helps in designing a robust biopolymeric composite scaffold for tissue engineering.