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International Journal of Clinical Medicine 2016年第9期7卷 566-576页

作者： Banu Bilezikçi seyfettin ilgan Serdar Özbaş Savaş Koçak Departments of Pathology Guven Hospital Ankara Turkey Departments of Nuclear Medicine Guven Hospital Ankara Turkey Departments of Endocrine Surgery Guven Hospital Ankara Turkey

Background: Central lymph node dissection (CLND) for papillary thyroid carcinoma (PTC) allows correct pathologic staging of lymph nodes and planning of postoperative management. The purpose of this study was to determine the number of the lymph nodes in the CLND and the relationship to presence of chronic lymphocytic thyroiditis (CLT) and thymic tissue (TT). Methods: Total thyroidectomy and CLND materials from 153 patients with PTC were included in this study. Two histopathologic features (presence of CLT and TT) were evaluated for their value in adequacy of CLND. Results: Histopathologic examination revealed CLT and TT in CLND materials in 70 (46%) and 63 (41%) patients, respectively. Total number of lymph nodes in CLND materials was significantly higher in CLT (+) and TT (+) groups (p Conclusions: Our study demonstrates that presence of CLT in thyroid gland has been associated with higher number of central lymph nodes mainly due to increased number of benign hyperplastic lymph nodes. It may be possible to conclude that upper limit of lymph nodes for satisfactory CLND would be higher to correctly evaluate central lymph node status in existing staging systems if specimens have CLT. Results of this study also show that the presence of TT in surgical materials may represent the adequacy of CLND.

关键词： Thyroid Papillary Carcinoma Central Lymph Node Dissection Thyroiditis Thymus

Relationship between serum cytokine levels and histopathological changes of liver in patients with hepatitis B

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World Journal of Gastroenterology 2005年第21期11卷 3260-3263页

作者： Nusret Akpolat seyfettin Yahsi Ahmet Godekmerdan Kutbettin Demirbag Mehmet Yalniz Departments of Pathology Faculty of Medicine Firat University ElazigTurkey Departments of Immunology Faculty of Medicine Firat UniversityElazigTurkey Departments of Infection Diseases Faculty of Medicine Firat University Elazig Turkey Departments of Gastroenterology Faculty of Medicine Firat University Elazig Turkey

AIM: To investigate whether there was a relationship between the liver functions and fibrosis scores of hepatitis B patients and their TNF-α, IFN-γ,IL-4, and TGF-β1 serum levels based on the studies of liver biopsies. METHODS: Thirty patients with chronic hepatitis B (CHB) receiving no treatment and 30 healthy individuals with negative hepatitis serology and normal values of liver biochemistry were studied. After serum samples of the patients were collected, liver needle biopsy was performed on each patient. Cytokine levels were studied by ELISA. The biopsy materials were scored based on Knodell's histological activity index. RESULTS: In comparison of cytokine levels between CHB patients and control group, TNF-α,IL-4, and TGPβ1 levels of the patients were higher in CHB patients than in the controls, while IFN-γ level was lower in the patients than in the controls. There were significant differences between the groups in TNF-α, IL-4, TGF-β1, and IFN-γ(P0.05). TGF-β1 was correlated with fibrosis (P0.05). CONCLUSION: In the course of HBV infection and its chronic progress, cytokines play an important role. IL-4 and IFN-γ are effective in the chronic progression, while TGF-β1 is effective in the development of fibrosis. Serum cytokine levels may be effective tools in the estimation of chronic progression and fibrosis development.

关键词： Hepatitis B Cytokine

Serum beta 2-microglobulin as a biomarker in inflammatory bowel disease

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World Journal of Gastroenterology 2014年第31期20卷 10916-10920页

作者： Bülent Y|lmaz seyfettin Kklü Osman Yüksel Serap Arslan Department of Gastroenterology Faculty of Medicine Hacettepe University

AIM: To investigate the diagnostic utility of beta 2 microglobulin (B2-M) levels and analyze this correlation with the activity of inflammatory bowel disease (IBD).

关键词： Beta 2 microglobulin Ulcerative colitis Crohn disease Inflammatory bowel disease

Alverine citrate induced acute hepatitis

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World Journal of Gastroenterology 2004年第15期10卷 2303-2304页

作者： Mehmet Arhan seyfettin Kklü Aydln S Kksal mer F Yoicu Senem Koruk Irfan Koruk Ertugrul Kayacetin Kavaklik mah Ahmet Apaydln cadSultan ApartmentNo 39/7Sahinbey 27060GaziantepTurkey

Alverine dtrate is a commonly used smooth muscle relaxant agent.A MEDLINE search on January 2004 revealed only 1 report implicating the hepatotoxicity of this agent.A 34- year-old woman was investigated because of the finding of elevated liver function tests on biochemical *** etiologies of hepatitis were appropriately ruled out and elevated enzymes were ascribed to alverine citrate treatment. Although alverine citrate hepatotoxicity was related to an immune mechanism in the first case,several features such as absence of predictable dose-dependent toxicity of alverine citrate in a previous study and absence of hypersensitivity manifestations in our patient are suggestive of a metabolic type of idiosyncratic toxicity.

关键词： Acute Disease Adult Female Hepatitis, Toxic Humans Propylamines

Viral and host causes of fatty liver in chronic hepatitis B

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World Journal of Gastroenterology 2005年第20期11卷 3056-3059页

作者： Emin Altiparmak seyfettin K(o|¨)klü Mesut Yalinkilic Osman Yüksel Bahattin Cicek Ertugrul Kayacetin Tülin Sahin Department of Gastroenterohepatology Yüksek Ihtisas Hospital Sihhiye Ankara Turkey

AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver ***: A total of 164 patients (113 males and 51 females, average age 35±11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with ＜5% hepatosteatosis) and group with steatosis (64 patients with ＞5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with ＞25% steatosis). RESULTS: In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and triglyceride levels were significantly higher than those in the group without steatosis (P＜0.05). Steatosis was found in 53 (46.9%) of male patients and 11 (22%) of female patients (P＜0.05). No significant difference was found in the positivity of ALT, AST, ALP, GGT, HBeAg, viral load, histological activity index (HAI) and stage between the two groups (P＞0.05). In the group with severe steatosis, the BMI was significantly higher than that in the group with mild steatosis (P＜0.05). No significant difference was found in the other parameters between the groups (P＞0.05). CONCLUSION: Steatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses. Steatosis is unrelated to the HAI and degree of fibrosis, which are considered as the histological indicators of liver damage.

关键词： Chronic hepatitis B Steatosis

No significant association between halitosis and upper gastrointestinal endoscopic findings： a prospective study

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Chinese Medical Journal 2011年第22期124卷 3707-3710页

作者： Adnan Tas seyfettin Koklu Ilhami Yuksel Omer Basar Erdem Akbal Ahmet Cimbek Department of Gastroenterology Etlik Yiiksek ihtisas Hospital Ankara Turkey

Background Previous studies have focused on the relationship between halitosis, gastroesophageal reflux disease and Helicobacterpylori. In this study we aimed to investigate the interaction between halitosis and upper gastrointestinal endoscopic findings. Methods Patients who previously had dyspepsia and had undergone endoscopic examination were included in the study. Symptoms of dyspepsia were investigated by means of a questionnaire that investigated halitosis. Patients who suffered from objective halitosis （confirmed by questions both to the patient and their relatives） were further investigated. Patients with known local or systemic causes of halitosis or structural disorders at endoscopy were excluded. Results The study included 358 patients （121 men and 237 women） with dyspeptic symptoms. The patients with and without halitosis had mean ages of （39.4±13.5） and （43.1±14.9） years, respectively. Patients without halitosis were significantly older than those in the halitosis group （P 〈0.05）. Patients in the halitosis group had significantly higher frequencies of regurgitation, bloating and nausea （P 〈0.05） when compared to patients without halitosis. Endoscopic findings, including esophagitis, open cardia, hiatal hernia, gastritis and duodenitis, were comparable in the two groups. Conclusions The frequency of halitosis was high in patients with dyspepsia who underwent upper gastrointestinal endoscopy. Halitosis had a close relationship with several upper gastrointestinal symptoms, including regurgitation, nausea and bloating. There was no significant association between upper gastrointestinal endoscopic findings and halitosis.

关键词： halitosis endoscopic findings gastroesophageal reflux disease

Air leak syndrome after endoscopic retrograde cholangiopancreatography:A rare and fatal complication

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World Journal of Gastroenterology 2015年第15期21卷 4770-4772页

作者： Bulent Yilmaz Emir Charles Roach seyfettin Koklu Onur Aydin Ozan Unlu Yusuf Alper Kilic Department of Gastroenterology Hacettepe University School of Medicine Department of General Surgery Hacettepe University School of Medicine

Endoscopic retrograde cholangiopancreatography(ERCP) is a state of the art diagnostic and therapeutic procedure for various pancreatic and biliary problems. In spite of the well-established safety of the procedure, there is still a risk of complications such as pancreatitis, cholangitis, bleeding and perforation. Air leak syndrome has rarely been reported in association with ERCP and the optimal management of this serious conditioncan be difficult to establish. Our group successfully managed a case of air leak syndrome following ERCP which was caused by a 3cm Stapfer type I perforation in the posterolateral aspect of the second part of the duodenum and was repaired surgically. Hereby, we describe the presentation and subsequent therapeutic approach.

关键词： Air leak syndrome Endoscopic retrogradecholangiopancreatography Complication Perforation Stapfer

Allium^TM Bulbar Urethral Stent: An Updated Long-Term Multi-Center Study with New Treatment Modality for Bulbar Urethral Stricture

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Open Journal of Urology 2016年第3期6卷 43-48页

作者： Melih Culha Zaher Bahouth Unsal Ozkuvanci Sarel Halachmi Levend Ozkan Ofer Nativ Ali Saribacak Murat Ustuner Ufuk Yavuz seyfettin Ciftci Hasan Yilmaz Boaz Moskovitz Department of Urology School of Medicine Kocaeli University &Igrave zmit Turkey Department of Urology Bnai-Zion Medical Center Technion Faculty of Medicine Haifa Israel Department of Urology Haseki Research and Training Hospital Turkey Department of Urology Izmit Konak Hospital &Igrave zmit Turkey

Objectives: To report the 2-years follow-up of patients with bulbar urethral strictures treated with the new AlliumTM Bulbar Urethral Stent (Allium BUS). Methods: The stent is a fully covered, self-expendable, large caliber metal stent specially designed for the treatment of bulbar urethral strictures. The stent is comprised of a coiled super-elastic structure covered by a polymeric coating designed to prevent mucosal hyperplasia. The indwelling time is 12 months, after which the stent should have been removed. Sixty-four patients with recurrent bulbar stricture were treated with Allium BUS in 3 worldwide centers. Results: All stents were successfully inserted with no perioperative complications. In a median follow-up of 25.5 months, the mean maximal flow rate following stent insertion was significantly higher compared to the pre-surgical flow rate (14 ml/sec vs 6.6 ml/sec, p < 0.0001). Longer indwelling time and shorter stricture length were significantly related to success rate. The main complications were stent migration, stent re-stenosis and urinary tract infections. Conclusions: The temporary placement of the AlliumTM BUS showed encouraging results with long-term failure rate of only 25%.

关键词： Allium BUS Bulbar Stricture Urethral Stent Urethral Stricture Urethroplasty

Psoriatic colitis mimicking ulcerative proctitis in an elderly patient

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Chinese Medical Journal 2012年第11期125卷 2080-2080页

作者： Adnan Tas seyfettin Koklu Basak Cakal Fatih Yildiz Selma Aktas Department of Gastroenterology Osmaniye Public Hospital Osmaniye Turkey Department of Gastroenterology Ankara Education and Research HospitalAnkara Turkey Faculty of Medicine Cukurova University Adana Turkey Department of Chest Diseases Atatürk Oogüs Hastaliklari ve G(o)güs Cerrahisi E(g)itim Ara(s)tirma Hastanesi Ankara Turkey

To the editor： Psoriasis is a chronic inflammatory, immune-mediated skin disease. Current research suggests that the inflammatory mechanisms are immune-based and maintained primarily by T cells in the dermis） The more common disorders associated with psoriasis are psoriatic arthropathy and inflammatory bowel diseases. It is reported that more than 30% of patients with psoriasis have arthritis which may be accompanied by microscopic inflammatory changes of colonic mucosa even in absence of bowel symptoms.2

关键词： Psoriatic colitis ulcerative proctitis elderly patient

Treatment of glomerulonephritis associated with hepatitis C virus in patient with cirrhosis： only pegylated interferon and ribavirin

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Chinese Medical Journal 2011年第10期124卷 1600-1600页

作者： Adnan Ta(s) Erdem Ko(c)ak Erdem Akbal seyfettin K(o)klü Department of Gastroenterology Ankara Education and Research Hospital Ankara Turkey）

To the editor： Hepatitis C virus （HCV） is a hepatotropic virus and a common cause of chronic hepatitis. Several extrahepatic complications have been associated with HCV including autoimmune and kidney diseases. It ... 详细信息

关键词： glomerulonephritis hepatitis C virus interferon and ribavirin MPGN mixed cryoglobulinemia