Alverine citrate induced acute hepatitis

作     者：Mehmet Arhan Seyfettin Kklü Aydln S Kksal mer F Yoicu Senem Koruk Irfan Koruk Ertugrul Kayacetin 

作者机构：Kavaklik mahAhmet Apaydln cadSultan ApartmentNo 39/7Sahinbey 27060GaziantepTurkey 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2004年第10卷第15期

页      面：2303-2304页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Acute Disease Adult Female Hepatitis, Toxic Humans Propylamines 

摘      要：Alverine dtrate is a commonly used smooth muscle relaxant agent.A MEDLINE search on January 2004 revealed only 1 report implicating the hepatotoxicity of this agent.A 34- year-old woman was investigated because of the finding of elevated liver function tests on biochemical *** etiologies of hepatitis were appropriately ruled out and elevated enzymes were ascribed to alverine citrate treatment. Although alverine citrate hepatotoxicity was related to an immune mechanism in the first case,several features such as absence of predictable dose-dependent toxicity of alverine citrate in a previous study and absence of hypersensitivity manifestations in our patient are suggestive of a metabolic type of idiosyncratic toxicity.