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复发性前列腺癌患者血清PSA水平、Gleason评分与68Ga-PSMA PET/CT显像的关系

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中华核医学与分子影像杂志 2018年第5期38卷 380-380页

作者：李慧玲兰晓莉 Yasemin Sanli Serkan Kuyumcu Oner Sanli Fikret Buyukkaya Ayca Iribas Goksel Alcin Emin Darendeliler Yasemin Ozluk sevda ozel yildiz Cüneyt Turkmen 华中科技大学同济医学院附属协和医院核医学科 Department of Nuclear Medicine Istanbul Faculty of MedicineIstanbul University

目的探讨复发性前列腺癌(PCa)患者血清前列腺特异性抗原(PSA)水平、Gleason评分与68Ga-前列腺特异性膜抗原(PSMA)PET/CT显像的关系。方法纳入109例患者(中位年龄为71岁,范围48～89岁),所有患者均为根治手术和(或)激素治疗和(或)放疗后PS... 详细信息

目的探讨复发性前列腺癌(PCa)患者血清前列腺特异性抗原(PSA)水平、Gleason评分与68Ga-前列腺特异性膜抗原(PSMA)PET/CT显像的关系。方法纳入109例患者(中位年龄为71岁,范围48～89岁),所有患者均为根治手术和(或)激素治疗和(或)放疗后PSA复发的患者。记录局部复发、淋巴结转移[盆腔、腹部和(或)膈上]、骨转移(单处转移、多处转移)和其他部位转移(肺、肝、脑等)。结果在91例(83.4%)患者中,68Ga-PSMA PET/CT至少检测到1处PCa病灶。血清总PSA(tPSA)中位值为6.5(0.2～640)μg/L。68Ga-PSMA PET/CT阳性与阴性患者血清tPSA差异有统计学意义,而Gleason评分差异无统计学意义。56例患者有局部复发,46例有淋巴结转移。盆腔淋巴结转移最常见,其次是腹部和膈上淋巴结。55例患者存在骨转移(20例为单发,35例为多处转移)。受试者工作特征曲线分析示血清tPSA区分阳性和阴性68Ga-PSMA PET/CT显像的最佳临界值为0.67μg/L,曲线下面积为0.952(95%CI:0.911～0.993)。结论68Ga-PSMA PET/CT是一种有效检测PCa复发的方法。尽管Gleason评分和68Ga-PSMA PET/CT显像之间无明显相关性,血清tPSA可用于预估68Ga-PSMA PET/CT阳性的可能性。

关键词： 68Ga-PSMA 复发性前列腺癌 PSA值 Gleason评分

Levels of vocational satisfaction,burnout and compassion fatigue of health professionals working in pediatric clinics

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World Journal of Clinical Pediatrics 2022年第1期11卷 38-47页

作者： Oğuz Koyuncu sevda Arslan Department of Nursing Sakarya Training and Research HospitalSakarya 0080DüzceTurkey Department of Nursing Düzce University Faculty of Health SciencesMerkez 81100DüzceTurkey

BACKGROUND Burnout and compassion fatigue are affecting the quality of professional *** To investigate the levels of vocational satisfaction,burnout,and compassion fatigue and factors that may be related to health professionals working in children’s *** The study sample was in the west of *** were collected using the questionnaire form and the quality of life scale for *** The findings obtained in this study showed that the level of vocational satisfaction of female health professionals and the burnout level of male health professionals were *** professional satisfaction of the doctors was lower than that of the nurses and midwives,and the mean score of burnout and fatigue was *** Further studies are needed on this topic to help improve the factors that may affect the professional quality of life of health professionals.

关键词： Health professionals Professional life quality Professional satisfaction Burnout Compassion fatigue

Efficacy of custom-made soft keratoconus lenses on corneal aberrations and photic phenomena in patients with keratoconus:a corneal topography imaging based study

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 67-74页

作者： Aysegul Penbe Hatice Selen Kanar Aysu Karatay Arsan sevda Aydın Kurna Department of Ophthalmology Kartal Dr.Lutfi Kirdar Training and Research HospitalHealth Science UniversitySemsi Denizer CaddesiE-5Kartal Istanbul 34890Turkey Department of Ophthalmology Fatih Sultan Mehmet Training and Research HospitalHealth Science UniversityE-5Icerenkoy 34752IstanbulTurkey

AIM:To evaluate the efficacy of custom-made soft keratoconus(KC)lenses on corneal aberrations and photic phenomena in two different optical zones in patients with ***:Sixty eyes of 42 patients with KC were examined at baseline and after fitting HydroCone(Toris K)soft silicone hydrogel *** spectacle-corrected visual acuity(BSCVA)and contact lens-corrected visual acuity(CLCVA)were ***-and higher-order corneal aberrations(LOAs and HOAs)were measured with and without Toris K lenses and compared in central 4.5 mm and 7 mm *** pupil diameter and subjective photic phenomena were also ***:Mean CLCVA was significantly improved compared to BSCVA(P6.00 mm(85.7%).CONCLUSION:Toris K lenses provide good visual results and a significant reduction in central corneal aberrations in patients with KC but could cause an increase in peripheral *** practical and nonsurgical approach appears to be an effective method for the visual management of KC.

关键词： corneal aberrations custom-made soft keratoconus lenses higher-order aberrations keratoconus lower-order aberrations pupillography

Effect of environmental factors on species diversity of the Yenice Hot Spot Forests in Turkey

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Journal of Forestry Research 2018年第6期29卷 1719-1730页

作者： sevda Turkis Emire Elmas Faculty of Education Ordu UniversityOrduTurkey Faculty of Science and Art Sinop UniversitySinopTurkey

We quantified the diversity of vascular plant species and described soil properties and topographical and climatic conditions of the Citdere and Kavakli Nature Reserves in the Yenice Forest of Turkey. We used the Shannon-Weiner and Simpson's indices of diversity,Margalef's index of species richness and Pielou's evenness index to quantify the structure of vascular plant assemblages. We measured soil parameters(NO_3^-, NH_4^+,available P, Mg^(++), K^+, Na^+, Ca^(++), organic matter, pH,soil moisture), elevation, slope gradient and aspect and their correlations with plant community parameters. In total, we recorded and identified 207 species and subspecies in the study area. Species cover, richness and diversity indices varied significantly by vegetation type(P < 0.01). Available NO_3^- and Ca++ in the soil were important factors for the area and species representation in the species-environment correlations estimated for the Kavakli area. Available NO_3^-,pH, organic matter, Ca^(++) and K^+ in the soil were important factors for the area and species representation in the species-environment correlations analysed for the Citdere area.

关键词： Diversity Forest ecosystems Yenice hotspot Species richness

Clearance angle and evolution of depth of cut in actuated disc cutting

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第3期11卷 644-658页

作者： sevda Dehkhoda Bryce Hill CSIRO Minerals Resources Queensland Centre for Advanced Technologies

This paper investigates the effect of cutter clearance angle on variation of depth of cut and cutting process with an actuated disc cutting(ADC).ADC is a cyclic cutting method with two main characteristics:(i)a disk-shape cutter is used to attack the rock in an undercutting mechanism;and(ii)the cutter is dynamically actuated as it is moved across the ***,the cutting process of such system is periodic,each recurrence known as actuation *** first ADC model,developed in 2016,represented an idealization of the technology with a flat disc cutter,where no clearance angle was *** evolution of the contact between the disc and the rock was,therefore,computed only on horizontal x-y plane,ignoring the effect of normal component of the force acting on *** article reports on a study that incorporates the cutter inclination angle in derivation of cutter/rock interface *** extends the proposed kinematic and geometry based model to take into account the variable depth of cut in estimating the forces associated with cutting in one actuation *** were conducted using Wobble to test the predictions of the improved model at various operating *** model predictions are matched with the experimental results and effects of various factors are analysed.

关键词： Actuated disc cutting Undercutting Force model Wobble Hard rock cutting

A narrative overview of utilizing biomaterials to recapitulate the salient regenerative features of dental-derived mesenchymal stem cells

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International Journal of Oral Science 2021年第2期13卷 117-128页

作者： sevda Pouraghaei Sevari Sahar Ansari Alireza Moshaverinia Weintraub Center for Reconstructive Biotechnology Division of Advanced ProsthodonticsSchool of DentistryUniversity of CaliforniaLos AngelesLos AngelesCAUSA California NanoSystems Institute University of CaliforniaLos AngelesLos AngelesCAUSA

Tissue engineering approaches have emerged recently to circumvent many limitations associated with current clinical *** elegant approach utilizes a natural/synthetic biomaterial with optimized physiomechanical properties to serve as a vehicle for delivery of exogenous stem cells and bioactive factors or induce local recruitment of endogenous cells for in situ tissue *** by the natural microenvironment,biomaterials could act as a biomimetic three-dimensional(3D)structure to help the cells establish their natural *** a strategy should not only employ a biocompatible biomaterial to induce new tissue formation but also benefit from an easily accessible and abundant source of stem cells with potent tissue regenerative *** human teeth and oral cavity harbor various populations of mesenchymal stem cells(MSCs)with self-renewing and multilineage differentiation *** the current review article,we seek to highlight recent progress and future opportunities in dental MSC-mediated therapeutic strategies for tissue regeneration using two possible approaches,cell transplantation and cell ***,this paper develops a general picture of current innovative strategies to employ dental-derived MSCs combined with biomaterials and bioactive factors for regenerating the lost or defective tissues and offers information regarding the available scientific data and possible applications.

关键词： biomaterials utilizing utilize

Real-time Energy Management of Grid-connected Microgrid with Flexible and Delay-tolerant Loads

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Journal of Modern Power Systems and Clean Energy 2020年第6期8卷 1196-1207页

作者： sevda Zeinal-Kheiri Amin Mohammadpour Shotorbani Behnam Mohammadi-Ivatloo IEEE the Faculty of Electrical and Computer Engineering University of TabrizTabrizIran the School of Engineering University of British Columbia OkanaganKelownaCanada the Institute of Research and Development Duy Tan UniversityDa NangVietnam

For optimal operation of microgrids,energy management is indispensable to reduce the operation cost and the emission of conventional *** goals can be impeded by several factors including uncertainties of market price,renewable generation,and ***-time energy management system(EMS)can effectively address uncertainties due to the online information of market price,renewable generation,and ***,some issues arise in real-time EMS as batterylimited energy *** this paper,Lyapunov optimization is used to minimize the operation cost of the microgrid and the emission of conventional ***,the problem is multiobjective and a Pareto front is derived to compromise between the operation cost and the *** a modified IEEE 33-bus distribution system,general algebraic modeling system(GAMS)is utilized for implementing the proposed EMS on two case studies to verify its applicability.

关键词： Battery energy management system(EMS) flexible and delay-tolerant load Lyapunov optimization microgrid optimal power flow renewable generation

HIGHLY OSCILLATORY DIFFUSION-TYPE EQUATIONS

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Journal of Computational Mathematics 2013年第6期31卷 549-572页

作者： sevda Uskiiplii Altlnbasak Marissa Condon Alfredo Deano Arieh Iserles Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK School of Electronic Engineering Dublin City University Dublin Ireland Department of Mathematics University Carlos III de Madrid Madrid Spain Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK

We explore new asymptotic-numeric solvers for partial differential equations with highly oscillatory forcing terms. Such methods represent the solution as an asymptotic series, whose terms can be evaluated by solving non-oscillatory problems and they guarantee high accuracy at a low computational cost. We consider two forms of oscillatory forcing terms, namely when the oscillation is in time or in space： each lends itself to different treatment. Numerical examples highlight the salient features of the new approach.

关键词： Diffusion-type PDEs High oscillation Asymptotic expansions Modulated Fourier expansions.

Soil chronosequence and biosequence on old lake sediments of the Burdur Lake in Turkey

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Pedosphere 2021年第6期31卷 882-891页

作者： Gafur GOZUKARA Yakun ZHANG Alfred EHARTEMINK sevda ALTUNBAS Mustafa SARI Department of Soil Science and Plant Nutrition Eskisehir Osmangazi UniversityEskisehir 26160(Turkey) Department of Soil Science FD Hole Soils Lab1525 Observatory DriveUniversity of Wisconsin-MadisonMadison 53706(USA) Department of Soil Science and Plant Nutrition Akdeniz UniversityAntalya 07059(Turkey)

The Burdur Lake is located in the southwest of Turkey,and its area has decreased by 40% from 211 km^(2) in 1975 to 126 km^(2) in *** this study,we investigated how the soil has changed in the lacustrine *** soil profiles were sampled from the former lakebed(chronosequence profiles:P1,2007;P2,1994;and P3,1975),and three soil profiles under different land use types(biosequence profiles:P4,native forest vegetation;P5,agriculture;and P6,lakebed)were *** chronosequence and biosequence soil profiles represented various distances from the Burdur Lake and showed different stages of lacustrine *** electrical conductivity(EC;18.1 to 0.4 dS m^(-1)),exchangeable Na^(+)(34.7 to 1.4 cmol kg^(-1))and K^(+)(0.61 to 0.56 cmol kg^(-1)),and water-soluble Cl^(-)(70.3 to 2.1 cmol L^(-1))and SO_(4)^(2-)(275.9 to 25.0 cmol L^(-1))decreased with increasing distance from the Burdur Lake,whereas the A horizon thickness(10 to 48 cm),structure formation(0 to 48 cm),gleization-oxidation depth(0 to 79 cm),and montmorillonite and organic matter(OM;25.9 to 46.0 g kg^(-1))contents increased in the chronosequence soil *** formation of P3 in the chronosequence and P5 in the biosequence soil profiles increased due to longer exposure to pedogenic processes(time,land use,vegetation,etc.).Changes in EC,exchangeable cation(Na^(+) and K^(+))and water-soluble anion(Cl^(-) and SO_(4)^(2-))concentrations of the salt-enriched horizon,OM,gleization-oxidation depth,A horizon thickness,and structure formation of the chronosequence and biosequence soil profiles(especially the topsoil horizon)were highly related to the distance from the Burdur Lake,time,and land use.

关键词： biosequence soil profile chronosequence soil profile lacustrine material lakebed soil formation