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Higher Episomal/Integrated HPV16 Viral Load are Associated with Cervical Cancer in Korean Women

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Higher Episomal/Integrated HPV16 Viral Load are Associated w...

A Heavy Precipitation Case Study Around the East China Sea in Summer Season,2006

24th International Papillomavirus Conference and Clinical Workshop

作者： Byeong-Sun Choi Dai Ho jang Sung soon Kim Young-Jai Kim Sam Hyun Cho Division of AIDS Center for Immunology and PathologyNational Institute of HealthSeoulRepubhc of Korea Division of AIDS Center for Immunology and PathologyNational Institute of HealthSeoulRepubhc of Korea Division of AIDS Center for Immunology and PathologyNational Institute of HealthSeoulRepubhc of Korea Department of Obstetrics and Gynecology College of MedicineHanyang UniversitySeoulKorea Department of Obstetrics and Gynecology College of MedicineHanyang UniversitySeoulKorea

＜正＞Objectives:Recent studies have reported that HPV16 integration is one of major events for the progression of cervical intraepithelial neoplasia（CIN）Unfortunately,the detailed role of HPV16 integration is still unknown In this study,we tried to examine the association between HPV16 viral load,integrated HPV16 viral load,and the grade of CIN and invasive lesion.

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A Heavy Precipitation Case Study Around the East China Sea i...

Dual-frequency piezoelectric micromachined ultrasound transducer based on polarization switching in ferroelectric thin films

第三届中日韩气象学术会议

作者： Dong-In Lee Ji-Young Gu Min jang Kil-Jong Seo Dong-soon Kim Mi-Young Kang Sang-Min jang Geun-Ok Lee Department of Environmental Atmospheric Sciences Pukyong National University（599-Daeyeon-3-dongNamguBusan 608-737Korea） Department of Environmental Atmospheric Sciences Pukyong National University（599-Daeyeon-3-dongNamguBusan 608-737Korea） Department of Environmental Atmospheric Sciences Pukyong National University（599-Daeyeon-3-dongNamguBusan 608-737Korea） Department of Environmental Atmospheric Sciences Pukyong National University（599-Daeyeon-3-dongNamguBusan 608-737Korea） Department of Environmental Atmospheric Sciences Pukyong National University（599-Daeyeon-3-dongNamguBusan 608-737Korea） Department of Environmental Atmospheric Sciences Pukyong National University（599-Daeyeon-3-dongNamguBusan 608-737Korea） Department of Environmental Atmospheric Sciences Pukyong National University（599-Daeyeon-3-dongNamguBusan 608-737Korea） Department of Environmental Atmospheric Sciences Pukyong National University（599-Daeyeon-3-dongNamguBusan 608-737Korea）

＜正＞In summer season,Korea,Japan,Taiwan and the mainland are influenced several severe weather events such as Changrna/Meiyu/Baiu front,typhoon,strong low pressure,and local heavy *** events are usually accompanied heavy precipitation and *** convective systems developing in a moist environment such as over the East China Sea are one of the major targets to reveal in meteorology as they develop rapidly and produce heavy rainfall on these *** clarify the development of the mechanism of heavy precipitation system and study its occurrence mechanism,we had field experiments in Jejudo and *** analyzed the synoptic condition by using NCEP/NCAR reanalysis data and kinematical characteristics of precipitation system by dual Doppler radar *** several cases observed,especially the case that Changma front influenced indirectly by typhoon "EWINIAR" located in south coast around Jejudo recorded heavy rainfall amount and showed special features and *** field characteristic, vertical thermal condition and synoptic condition played important *** understand occurrence mechanism of these heavy precipitation systems and monsoon etc.,long-term intensive observations should be done continuously around the East China Sea.

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Microsystems & Nanoengineering 2023年第5期9卷 233-243页

作者： Jin Soo Park Soo Young Jung Dong Hun Kim Jung Ho Park Ho Won jang Tae Geun Kim seung-Hyub Baek Byung Chul Lee Bionics Research Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea Center for Electronic Materials Korea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Material Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and Technology(UST)Seoul 02792Republic of Korea KHU-KIST Department of Converging Science and Technology Kyung Hee UniversitySeoul 02447Republic of Korea

Due to its additional frequency response,dual-frequency ultrasound has advantages over conventional ultrasound,which operates at a specific frequency ***,a tunable frequency from a single transducer enables sonographers to achieve ultrasound images with a large detection area and high *** facilitates the availability of more advanced techniques that simultaneously require low-and high-frequency ultrasounds,such as harmonic imaging and image-guided *** this study,we present a novel method for dual-frequency ultrasound generation from a ferroelectric piezoelectric micromachined ultrasound transducer(PMUT).Uniformly designed transducer arrays can be used for both deep low-resolution imaging and shallow high-resolution *** switch the ultrasound frequency,the only requirement is to tune a DC bias to control the polarization state of the ferroelectric *** vibration of the PMUT membrane strongly depends on the polarization state,producing low-and high-frequency ultrasounds from a single excitation *** strategy for dual-frequency ultrasounds meets the requirement for either multielectrode configurations or heterodesigned elements,which are integrated into an ***,this technique significantly reduces the design complexity of transducer arrays and their associated driving circuits.

关键词： piezoelectric ferroelectric enable

Mechanisms Underlying the Antifatigue Effects of the Mycelium Extract of Cordyceps(Paecilomyces hepiali, CBG-CS-2) in Mice in the Forced Swimming Test

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Food and Nutrition Sciences 2015年第2期6卷 287-298页

作者： Soo-Wan Chae Fusako Mitsunaga Su-Jin Jung Ki-Chan Ha Hong-Sig Sin seung-Hwan jang Shin Nakamura Department of Pharmacology Chonbuk National University Medical School Jeonju-si Republic of Korea Clinical Trial Center for Functional Foods (CTCF2) Chonbuk National University Hospital Jeonju-si Republic of Korea Intelligence and Technology Lab Inc. Kaizu Japan NPO Primate Agora Inuyama Japan Healthcare Claims & Management Inc. Jeonju-si Republic of Korea Chebigen Inc. Jeonju-si Republic of Korea

Cordyceps (CS) is used as an alternative medicine and functional food. We examined in vivo mechanisms underlying the antifatigue effects of the cultured mycelium extract of CS (CS extract) in forced swimming mice, a fatigue model that is induced by muscle exercise. Animals orally administered with CS extract significantly extended the loaded forced-swimming time, indicating its antifatigue effects. CS extract modulated the increased levels of blood IL-6 that was induced by forced swimming. CS extract protected the forced swimming-induced increase in NKp46 expression of splenic NK cells, suggesting regulation of fatigue-elicited hyper-reactivity by activated NK cells. By DNA microarray analysis of the quadriceps femoris muscle, it was uncovered that CS extract prevented the forced swimming-mediated upregulation of the expression of 5 genes associating with muscular inflammation (Ccl6, Ccl8, and Wfdc17) and muscle regeneration (Sfrp4 and Nfil3), whereas it regulated the downregulation in the expression of Svs5 participating in actin binding. CS extract exhibits the antifatigue effects through preventing IL-6 accumulation in blood, regulating NK cell activation in the spleen, and alleviating altered expression of genes related to inflammation, regeneration, and actin binding in the local muscle. Thus, CS extract is an effective functional food for preventing fatigue.

关键词： DNA Microarray IL-6 NK Cell Activation Muscle Inflammation

Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis

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World Journal of Gastroenterology 2016年第41期22卷 9205-9213页

作者： Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim soon Koo Baik Byung Seok Lee Jae Young jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoul 06591South Kerea Institute of Medical Science Hanyang UniversitySeoul 04763South Kerea Department of Internal Medicine Samsung Medical CenterSeoul 06351South Kerea Department of Internal Medicine Inje University Sanggye Paik HospitalSeoul 01757South Kerea Department of Internal Medicine Korea University Ansan HospitalAnsan 15355South Korea Department of Internal Medicine Hallym University Chuncheon Sacred Heart HospitalChuncheon 24253South Kerea Department of Internal Medicine Gyeongsang National University HospitalJinju 52727South Kerea Department of Internal Medicine Catholic University of Daegu School of MedicineDaegu 42472South Kerea Department of Internal Medicine Ewha Womans University School of MedicineSeoul 07985South Kerea Department of Internal Medicine Konkuk University School of MedicineSeoul 05030South Kerea Department of Internal Medicine Hallym University Sacred Heart HospitalAnyang 14068South Kerea Department of Internal Medicine Yonsei University Wonju College of MedicineWonju 26426South Kerea Department of Internal Medicine Chungnam National UniversitySchool of MedicineDaejeon 35015South Kerea Department of Internal Medicine Soonchunhyang University College of MedicineSeoul 04401South Kerea Department of Internal Medicine Soonchunhyang University Bucheon HospitalBucheon 14584South Kerea Department of Internal Medicine Hanyang University Guri HospitalGuri 11923South Kerea Department of Internal Medicine Yeungnam University College of MedicineDaegu 42415South Kerea Department of Internal Medicine Inje University Haeundae Paik-HospitalInje University College of MedicineBusan 48108South Kerea Institute of Lifestyle Medicine Yonsei University Wonju College of MedicineWonju 26426South Kerea 不详

AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic *** We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and *** Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d *** CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis.

关键词： Acute-on-chronic liver failure Alcoholic hepatitis Mortality Prognosis Scoring system

Nutrigenomic Study on Immunomodulatory Function of CordycepsMycelium Extract (Paecilomyces hepiali) in Mitomycin C–Treated Mice

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Food and Nutrition Sciences 2014年第22期5卷 2217-2224页

作者： Soo-Wan Chae Fusako Mitsunaga Su-Jin Jung Ki-Chan Ha Hong-Sig Sin seung-Hwan jang Shin Nakamura Department of Pharmacology Chonbuk National University Medical School Jeonju Republic of Korea Clinical Trial Center for Functional Foods (CTCF2) Chonbuk National University Hospital Jeonju Republic of Korea Intelligence and Technology Lab Inc. Kaizu Japan NPO Primate Agora Inuyama Japan Healthcare Claims & Management Inc. Jeonju Republic of Korea Chebigen Inc. Jeonju Republic of Korea

Cordyceps (CS) is a Chinese herb that produces various effects including immune modulation, and now CS culture product is interested in the use as a functional food. We prepared CS mycelium culture extract (Paecilomyces hepiali, CBG-CS-2), CS extract, for functional foods. This study aimed to deduce the molecular mechanism of immunomodulatory effect of CS extract in Peyer’s patches (PPs), a main gut immune site, in mice that treated with mitomycin C (MMC), an immunosuppressing antibiotics. Nutrigenomics give us invaluable molecular information about both of foods and nutrition to improve or maintain good health. Here we performed nutrigenomics using DNA microarray to investigate the effect of CS extract on gene expression altered in PPs of the immunosuppressed mice. Interestingly, CS extract protected from the MMC-mediated downregulation of 22 genes, which are associated with IgA production and other immune response in PPs. These suggested that CS extract alleviated the downregulated expression of immune related genes in the gut immune site in an immunosuppressed state. Thus CS extract appears to be practical functional food for immunodepression and/or its related hypofunction.

关键词： DNA Microarray Functional Food Gene Expression Immunosuppression

Outcome of transarterial chemoembolization-based multi-modal treatment in patients with unresectable hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第8期21卷 2395-2404页

作者： Do Seon Song soon Woo Nam Si Hyun Bae Jin Dong Kim Jeong Won jang Myeong Jun Song Sung Won Lee Hee Yeon Kim Young Joon Lee Ho Jong Chun Young Kyoung You Jong Young Choi seung Kew Yoon Department of Internal Medicine College of Medicine The Catholic University of Korea Department of Internal Medicine Cheju Halla General Hospital Department of Radiology College of Medicine The Catholic University of Korea Department of Surgery College of Medicine The Catholic University of Korea

AIM:To investigate the efficacy and safety of transarterial chemoembolization(TACE)-based multimodal treatment in patients with large hepatocellular carcinoma(HCC).METHODS:A total of 146 consecutive patients were included in the analysis,and their medical records and radiological data were reviewed ***:In total,119 patients received TACE-based multi-modal treatments,and the remaining 27 received conservative *** survival(P<0.001)and objective tumor response(P=0.003)were significantly better in the treatment group than in the conservative *** subgroup analysis,survival benefits were observed not only in the multi-modal treatment group compared with the TACE-only group(P=0.002)but also in the surgical treatment group compared with the loco-regional treatment-only group(P<0.001).Multivariate analysis identified tumor stage(P<0.001)and tumor type(P=0.009)as two independent pre-treatment factors for *** adjusting for significant pre-treatment prognostic factors,objective response(P<0.001),surgical treatment(P=0.009),and multi-modal treatment(P=0.002)were identified as independent post-treatment prognostic ***:TACE-based multi-modal treatments were safe and more beneficial than conservative *** surgery after successful downstaging resultedin long-term survival in patients with large,unresectable HCC.

关键词： Hepatocellular carcinoma Multimodal treatment Tran

Attenuated FOLFIRINOX in the salvage treatment of gemcitabine-refractory advanced pancreatic cancer: a phase II study

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Cancer Communications 2018年第1期38卷 344-351页

作者： Jung Hoon Kim Sang-Cheol Lee Sung Yong Oh Seo-Young Song Namsu Lee Eun Mi Nam soonil Lee In Gyu Hwang Hyo Rak Lee Kyu Taek Lee Sang-Byung Bae Han Jo Kim Joung soon jang Do Hyoung Lim Hyun Woo Lee Seok Yun Kang Jung Hun Kang Department of Internal Medicine Institute of Health SciencesGyeongsang National University15 Jinju-daero 816beon-gilJinju 52727Republic of Korea Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University Hospital CheonanCheonan 31151Republic of Korea Department of Internal Medicine Dong-A University HospitalBusan 49201Republic of Korea Department of Internal Medicine Kangwon National University School of MedicineChuncheon 24289Republic of Korea Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University Hospital SeoulSeoul 04401Republic of Korea Department of Internal Medicine Ewha Womans UniversityCollege of MedicineSeoul 07985Republic of Korea Department of Internal Medicine Dankook University HospitalCheonan 31116Republic of Korea Department of Internal Medicine Chung-Ang UniversityCollege of MedicineSeoul 06973Republic of Korea Division of Hematology and Medical Oncology Department of Internal MedicineKorea Cancer HospitalSeoul 01812Republic of Korea Department of Hematology-Oncology Ajou University HospitalSuwon 16499Republic of Korea

Background:Combination therapy with oxaliplatin,irinotecan,fluorouracil,and leucovorin(FOLFIRINOX)chemotherapy drastically improves survival of advanced pancreatic cancer ***,the efficacy of FOLFIRINOX as a second-line treatment after gemcitabine failure has not been tested *** investigated the feasibility and safety of attenuated FOLFIRINOX in patients with gemcitabine-refractory advanced pancreatic ***:A multicenter phase II prospective open-label,single-arm study was conducted at 14 *** with histologically proven invasive ductal pancreatic adenocarcinoma,a measurable or evaluable lesion,Eastern Cooperative Oncology Group performance status 0 or 1,adequate organ function,and aged 19 years or older were *** FOLFIRINOX consisted of oxaliplatin 65 mg/m2,irinotecan 135 mg/m2,and leucovorin 400 mg/m2 injected intravenously on day 1 and 5-fluorouracil 2000 mg/m2 continuously infused intravenously over 46 h on days 1-2,repeated every 2 *** primary endpoint was progression-free survival from the initiation of *** endpoints were the objective response rate,disease control rate,overall survival,safety,and *** estimated overall survival and progression-free survival using the Kaplan-Meier ***:We enrolled 39 patients from 14 *** objective response rate was 10.3%,while the disease control rate was 64.1%.The 6-month and 1-year overall survival rates were 59.0%and 15.4%,*** progression-free survival and overall survival were 3.8 months(95%confidence interval[CI]1.5-6.0 months)and 8.5 months(95%CI 5.6-11.4 months),*** 3 or 4 adverse events were neutropenia(41.0%),nausea(10.3%),anorexia(10.3%),anemia(7.7%),mucositis(7.7%),pneumonia/pleural effusion(5.1%),and fatigue(5.1%).One treatment-related death attributable to septic shock ***:Attenuated FOLFIRINOX may be promising as a second-line therapy for gemcitabin

关键词： Attenuated FOLFIRINOX Second-line Pancreatic cancer Gemcitabine

Comparison of Protein Profiles in Sputum between COPD and Acute Exacerbation of COPD

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Open Journal of Respiratory Diseases 2012年第2期2卷 25-30页

作者： Soo-Taek Uh seung Ah Ko An Soo jang Sung Woo Park Yong-Hoon Kim Young-Ki Paik Choon Sik Park Division of Respiratory and Allergy Medicine Soon Chun Hyang University Hospital Seoul South Korea Division of Respiratory Medicine Soonchunhyang University Chunan Hospital Asan South Korea Genome Research Center for Allergy and Respiratory Disease Soonchunhyang University Bucheon Hospital Bucheon South Korea Yonsei Proteome Research Center Department of Biochemistry and Biomedical Science College of Life Science and Biotechnology Yonsei University Seoul South Korea

Background and objective: Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation that is associated with an abnormal inflammatory response of the lung to noxious particles or gases. Cigarette smoking is the major risk factor for the development of COPD. This study evaluated the levels of cyclophilin B in sputa from patients with COPD and COPD with acute exacerbation (AECOPD). Materials and Methods: Two-dimensional electrophoresis was used for differential display proteomics. Western blotting was used to identify and quantify cyclophilin B in sputum from subjects with AECOPD and COPD. Results: Forty-nine protein spots differed in relative intensity between the AECOPD (n = 6) and COPD (n = 6) subjects. Twenty proteins showed increased expression in the sputum of AECOPD subjects, and 29 proteins were present at lower levels in AECOPD sputum compared with COPD sputum. One of these proteins was associated with cyclophilin B. Cyclophilin B concentrations were lower in sputum from subjects with COPD (n = 4) versus AECOPD (n = 4). Conclusion: The sputum proteomic analysis suggests that changes in various proteins are associated with the development of AECOPD.

关键词： Proteomics COPD Acute Exacerbation Chromatography Liquid Mass Spectrometry