Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis

作     者：Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group 

作者机构：Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 06591South Kerea Institute of Medical ScienceHanyang UniversitySeoul 04763South Kerea Department of Internal MedicineSamsung Medical CenterSeoul 06351South Kerea Department of Internal MedicineInje University Sanggye Paik HospitalSeoul 01757South Kerea Department of Internal MedicineKorea University Ansan HospitalAnsan 15355South Korea Department of Internal MedicineHallym University Chuncheon Sacred Heart HospitalChuncheon 24253South Kerea Department of Internal MedicineGyeongsang National University HospitalJinju 52727South Kerea Department of Internal MedicineCatholic University of Daegu School of MedicineDaegu 42472South Kerea Department of Internal MedicineEwha Womans University School of MedicineSeoul 07985South Kerea Department of Internal MedicineKonkuk University School of MedicineSeoul 05030South Kerea Department of Internal MedicineHallym University Sacred Heart HospitalAnyang 14068South Kerea Department of Internal MedicineYonsei University Wonju College of MedicineWonju 26426South Kerea Department of Internal MedicineChungnam National UniversitySchool of MedicineDaejeon 35015South Kerea Department of Internal MedicineSoonchunhyang University College of MedicineSeoul 04401South Kerea Department of Internal MedicineSoonchunhyang University Bucheon HospitalBucheon 14584South Kerea Department of Internal MedicineHanyang University Guri HospitalGuri 11923South Kerea Department of Internal MedicineYeungnam University College of MedicineDaegu 42415South Kerea Department of Internal MedicineInje University Haeundae Paik-HospitalInje University College of MedicineBusan 48108South Kerea Institute of Lifestyle MedicineYonsei University Wonju College of MedicineWonju 26426South Kerea 不详 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2016年第22卷第41期

页      面：9205-9213页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by the Korean Association for the Study of the Liver (KASL) and the Korean Liver Foundation 

主　　题：Acute-on-chronic liver failure Alcoholic hepatitis Mortality Prognosis Scoring system 

摘      要：AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic *** We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and *** Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d *** CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis.