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Human neural stem cells promote proliferation of endogenous neural stem cells and enhance angiogenesis in ischemic rat brain

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Neural Regeneration Research 2016年第2期11卷 298-304页

作者： Sun Ryu seung-Hoon Lee seung u.kim Byung-Woo Yoon Department of Neurology and Clinical Research Institute Seoul National University Hospital Seoul National University Medical Research Center Seoul National University Medical Research Institute Chung-Ang University School of Medicine Department of Neurology UBC Hospital University of British Columbia

Transplantation of human neural stem cells into the dentate gyrus or ventricle of rodents has been reportedly to enhance neurogenesis. In this study, we examined endogenous stem cell proliferation and angiogenesis in the ischemic rat brain after the transplantation of human neural stem cells. Focal cerebral ischemia in the rat brain was induced by middle cerebral artery occlusion. Human neural stem cells were transplanted into the subventricular zone. The behavioral performance of human neural stem cells-treated ischemic rats was significantly improved and cerebral infarct volumes were reduced compared to those in untreated animals. Numerous transplanted human neural stem cells were alive and preferentially localized to the ipsilateral ischemic hemisphere. Furthermore, 5-bromo-2′-deoxyuridine-labeled endogenous neural stem cells were observed in the subventricular zone and hippocampus, where they differentiated into cells immunoreactive for the neural markers doublecortin, neuronal nuclear antigen Neu N, and astrocyte marker glial fibrillary acidic protein in human neural stem cells-treated rats, but not in the untreated ischemic animals. The number of 5-bromo-2′-deoxyuridine-positive ？ anti-von Willebrand factor-positive proliferating endothelial cells was higher in the ischemic boundary zone of human neural stem cells-treated rats than in controls. Finally, transplantation of human neural stem cells in the brains of rats with focal cerebral ischemia promoted the proliferation of endogenous neural stem cells and their differentiation into mature neural-like cells, and enhanced angiogenesis. This study provides valuable insights into the effect of human neural stem cell transplantation on focal cerebral ischemia, which can be applied to the development of an effective therapy for stroke.

关键词： nerve regeneration focal cerebral ischemia middle cerebral artery occlusion human neural stem cells transplantation differentiation infarct size behavioral analysis endogenous neurogenesis angiogenesis rats neural regeneration

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A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang Ding Zixun Geng Chencheng Hu Long Yang Zitong Kan Biao Dong Miae Won Hongwei Song Lin Xu Jong seung kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

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Radial Pulse and Electrocardiography Modulation by Mild Thermal Stresses Applied to Feet: An Exploratory Study with Randomized, Crossover Design

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Chinese Journal of Integrative Medicine 2020年第4期26卷 299-306页

作者： Jang-Han Bae Boncho Ku Young Ju Jeon Hyunho kim Jihye kim Haebeom Lee Jong Yeol kim Jaeuk u.kim Korea n Medici ne Fun dame ntal Research Divisi on Korea Institute of Oriental MedicineDaejeon(34054)Republic of Korea Department of Biofunctional Medicine and Diagnostics College of Korea n MedicineKyung Hee UniversitySeoul(02453)Republic of Korea Department of Human Informatics of Korean Medicine Interdisciplinary ProgramsKyung Hee UniversitySeoul(02453)Republic of Korea

Objective:To investigate the changes in radial pulse induced by thermal stresses(TSs).Methods:Sixty subjects were *** an open-label,2x2 crossover randomization design,both feet of each subject were immersed in 15%:water for cold stress(CS)and in 40 X:water for heat stress(HS)for 5 min *** pulse,respiration and electrocardiogram(ECG)signals were recorded before,during and immediately after the ***:The an alysis of heart rate variability revealed that CS in creased the low-freque ncy(LF)and high-frequency(HF)components(Puced the LF and HF components(Puced the normalized LF,increased the normalized HF,and reduced the LF/HF *** differences in the ECG signals were more dominant during the TS sessions,but those in the radial pulse signals became more domi nant immediately after the TS sessi *** decreased the pulse depth(Pugme ntation in dex(Pulse pressure(Pube ndocardial viability ratio(Pulse rate during the three time sequences of each *** respiration rate was increased(Pulse rate per respiration(P/R ratio)was significantly decreased(Pulse spectral density was suppressed during both ***:CS induced vasoconstriction and sympathetic reactions,and HS induced vasodilation and parasympathetic reacti *** on defi nitions used in pulse diag no sis,we made the novel discoveries that the pulse became slower(decreased P/R ratio),more floating and tenser under CS and that the HF region of the spectral power decreased significantly under both TSs.

关键词： radial pulse pulse diag no sis thermal stress electrocardiography heart rate variability

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Effects of intravenous administration of polysaccharide purified from fermented barley on tumor metastasis inhibition via immunostimulating activities

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Food Bioscience 2022年第5期49卷 130-138页

作者： seung-u Son Han Wool kim Min seung Park Kwang-Soon Shin Department of Food Science and Biotechnology Kyonggi UniversitySuwon16227Republic of Korea Transdisciplinary Major in Learning Health System Department of Integrated Biomedical and Life ScienceGraduate SchoolKorea UniversitySeoul02841Republic of Korea

The present study was aimed that determine the effects of polysaccharide isolated from fermented barley about tumor metastasis inhibition via immune related factors such as complementary system,macrophages,natural killer(NK)cells,and cytotoxic T lymphocyte(CTL).To characterize the tumor inhibition effects through immunostimulation of polysaccharides purified from fermented barley,the active crude polysaccharide(BF-CP)was isolated from fermented barley and further fractionated into three purified polysaccharides(BF-I,-II,and-III)with different molecular weights through gel permeation ***-I was mainly composed of four monosaccharides,including xylose(32.90%),arabinose(26.71%),and glucose(33.43%).BF-I augmented the secretion of cytokines,such as interleukin(IL)-6,IL-12,and tumor necrosis factor-α,through peritoneal macrophages and potently activated the complement *** the experiment for NK cells and CTL activities,intravenous(i.v.)administration of BF-I significantly augmented the cytotoxicity of NK cells and CTL-mediated cytotoxicity against tumor *** addition,*** of BF-I potently inhibited tumor metastasis in a mouse model of lung cancer and tumor metastasis in mice with suppressed NK cell function through anti-asialo ***,BF-I shows potent tumor inhibition effects,and these effects are related to various immune factors such as macrophages,the complement system,NK cells,and ***,BF-I,the polysaccharide purified from fermented barley possess the new possibility for developing functional foods and medical ingredients.

关键词： Fermented barley Polysaccharide Immune system Anti-cancer

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Structural identification of active moiety in anti-tumor metastatic polysaccharide purified from fermented barley by sequential enzymatic hydrolysis

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Food Bioscience 2022年第6期50卷 139-149页

作者： seung-u Son Han Wool kim Kwang-Soon Shin Department of Food Science and Biotechnology Kyonggi UniversitySuwon16227Republic of Korea Transdisciplinary Major in Learning Health System Department of Integrated Biomedical and Life ScienceKorea UniversitySeoul02841Republic of Korea

The potent anti-cancer metastatic effects induced by the immunostimulatory activities of intravenously administered BF–I,an active polysaccharide purified from fermented barley,were previously *** study aimed to evaluate the anti-cancer metastatic effect of orally administered BF–I and elucidated the microstructure and active moiety of BF–I using sequential enzymatic *** experiments using Colon26-M3.1 carcinoma,prophylactic oral administration of BF–I potently suppressed lung cancer ***,gas chromatography-mass spectrometry analysis of partially methylated alditol acetate showed that BF–I comprised 15 different glycosyl linkages,including 4-linked Xylp(16.1%),terminal Araf(12.4%),4-linked Glcp(32.8%),3-linked Glcp(13.5%),3,6-linked Glcp(1.5%),and 3,6-linked Galp(5.3%).These glycosyl linkage combinations are typical for arabinoxylan,yeast-derivedβ-glucan,barley-derivedβ-glucan,and type II *** clarify the microstructure,BF–I was sequentially degraded via linkage-specific enzymatic hydrolysis using five ***,the sugar composition,glycosyl linkage,and reactivity with theβ-glucosyl Yariv reagent were analyzed,along with sequencing based on tandem mass spectra of partially degraded fragment *** results confirmed that BF–I comprises a mixture of four different types of polysaccharides(arabinoxylan,yeast-derivedβ-glucan,barley-derivedβ-glucan,and type II arabinogalactan)with similar molecular ***,different polysaccharides contribute significantly to cytokine(interleukin-6,-12,and tumor necrosis factor-α)secretion by peritoneal ***,the potent anti-cancer metastatic activity of BF–I is proposed to be related to the immunostimulatory activities of the four different types of polysaccharides.

关键词： Barley Polysaccharide structure Anti-cancer Enzymatic hydrolysis

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Influence of sulfides on the tribological properties of composites produced by pulse electric current sintering

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International Journal of Minerals,Metallurgy and Materials 2014年第1期21卷 95-103页

作者： seung Ho kim Department of Electronics Engineering Dankook University

Self-lubricating A1203-15wt% ZrO2 composites with sulfides, such as molybdenum disulfide （MoS2） and tungsten disulfide （WSz） serving as solid lubricants, were fabricated by using the pulse electric current sintering （PECS） technique. The coefficient of friction （COF） of the A1203-15wt% ZrO2 composite without/with sulfides was in the range of 0.37-0.48 and 0.27-0.49, respectively. As the amoant of sul- fides increased, the COF and the wear rate decreased. The reduction in COF and wear rate of the sulfide-containing composite is caused by a reduction in shear stresses between the specimen and the tribological medium due to the formation of a lubricating film resulting from the lamellar structure of sulfides located on the worn surface.

关键词： ceramic composites coefficient of friction solid lubricants sulfides wear of materials

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Computational approaches for fast generation of digital 3D video holograms(Invited Paper)

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Chinese Optics Letters 2009年第12期7卷 1083-1091页

作者： seung-Cheol kim Eun-Soo kim 3D Display Research Center Department of Electronic Engineering Kwangwoon University

Several approaches for fast generation of digital holograms of a three-dimensional （3D） object have been discussed. Among them, the novel look-up table （N-LuT） method is analyzed to dramatically reduce the number of pre-calculated fringe patterns required for computation of digital holograms of a 3D object by employing a new concept of principal fringe patterns, so that problems of computational complexity and huge memory size of the conventional ray-tracing and look-up table methods have been considerably alleviated. Meanwhile, as the 3D video images have a lot of temporally or spatially redundant data in their inter- and intra-frames, computation time of the 3D video holograms could be also reduced just by removing these redundant data. Thus, a couple of computational methods for generation of 3D video holograms by combined use of the N-LuT method and data compression algorithms are also presented and discussed. Some experimental results finally reveal that by using this approach a great reduction of computation time of 3D video holograms could be achieved.

关键词： LuT Computational approaches for fast generation of digital 3D video holograms CGH

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Flow Characteristics in Compact Thermal Spray Coating Systems with Minimum Length Nozzle

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Plasma Science and Technology 2009年第5期11卷 550-554页

作者： seung-Hyun kim Youn-Jea kim School of Mechanical Engineering Sungkyunkwan University

In this study, numerical analysis is performed to adopt the equivalence ratio on the high velocity oxygen fuel （HVOF） thermal spray coating systems equipped with a minimum length nozzle. The analysis is applied to investigate the axisymmetric, steady-state, turbulent, and chemically combusting flow both within the torch and in a free jet region between the torch and the substrate to be coated. The combustion is modeled using a single-step and eddy-dissipation model which assumes that the reaction rate is limited by the turbulent mixing rate of the fuel and oxidant. As the diameter of the nozzle throat is increased, the location of the Mach shock disc moves backward from the nozzle exit. As the throat diameter and the divergent portion are 6 mm and 8 mm, respectively, the pressure in the HVOF system is the lowest at the chamber and the expanding gas is steadily maintained with both high velocity and high temperature for different equivalence ratios. Thus, relatively minor amendments of the equivalence ratio and the geometry of HVOF can lead to improved control over coating characteristics.

关键词： minimum length nozzle HVOF equivalence ratio

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Effect of Plastic Anisotropy on the Formability of Aluminum 6016-T4 Sheet Material

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Chinese Journal of Mechanical Engineering 2017年第3期30卷 625-631页

作者： Young-Suk kim seung-Han YANG kyungpook national university Daegu 41566Republic of Korea

Sheet metal formed of lightweight materials such as aluminum sheeting has received great attention related to the reduction of vehicle emissions. This paper evaluates the anisotropic yield locus using Kuwabara＇s biaxial tensile tester and stretches formability using Hecker＇s hemispheri- cal punch stretching test for aluminum 6016-T4 sheet material. The anisotropic yield locus of the A16016-T4 sheet measured is fitted well by the modified Drucker yield func- tion. Moreover the best fitting to the experimental stress- strain curve from the tensile test was obtained by taking an appropriate hardening model. Analytical study to predict the stretch formability by using Hora＇s Modified Maximum Force Criterion （MMFC） was performed. The predicted forming limit curves （FLC） based on various yield functions were compared with the experiments and discussed.

关键词： Anisotropic yield function AluminumA16016-T4 Biaxial tensile test Forming limit curve

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Progress in light-to-frequency conversion circuits based on low dimensional semiconductors

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Nano Research 2021年第9期14卷 2938-2964页

作者： seung Gi Seo seung Yeob kim Jinheon Jeong Sung Hun Jin Department of Electronic Engineering Incheon National UniversityAcademy-ro 119Yeongsu-guIncheon 22012Republic of Korea

As the scaling down of Si devices in the range less than few nm has been expedited up to a physical limit of Si,low dimensional materials have been regarded as one of next generation *** a variety of applications,studies on photodetectors have been actively investigated with their novel optical properties as well as astonishing electrical ***,most of research has focused on single device-type photodetector(i.e.,photo-diode or photo-transistor).Contrary to common photodetector,light-to-frequency circuits(LFCs)are based on frequency reading with photosensitive ring oscillators,which has better noise immunity and reduced system complexity,thus,can be utilized to novel application even in internet of things(loT)and bio&medical *** this review,low dimensional materials based circuit level photodetectors,which are core elements as the form of either inverters or ring oscillators for demonstration of LFCs,are *** with the introduction of low dimensional materials and their optical properties for optoelectronics,a fundamental concept for LFCs is specifically ***,research progress on low dimensional material based photosensitive inverters is addressed according to the types of ***,as one of practical method for the improvement of photodetector performance,molecular doping technology is ***,complete system of LFCs and its digitization for demonstration of production level,and potential application in the respective four aspects,(i)medical SpO_(2) detection,(ii)biological fluidic system,(iii)auto-lighting in agriculture,and(iv)optical feedback and sensing systems,are presented as systematic way to address the envisioned practical applications for the future displays including virtual reality and augmented reality,and *** a remark,LFCs based on low dimensional semiconductors are expected to be one of core components in trillion’s sensor area.

关键词： photodetector light-to-frequency conversion circuit transition metal dichalcogenide carbon nanotube

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