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Effect of smoking on the risk of gastrointestinal cancer after cholecystectomy: A national population-based cohort study

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2796-2807页

作者： Minseob Kim Kyung-Do Han seung-hyun Ko Yoonkyung Woo Jae hyun Han Department of Surgery Graduate School of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea Division of Endocrinology and Metabolism Department of Internal MedicineSt Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwon 16247South Korea Division of Hepatobiliary-Pancreas Surgery and Liver Transplantation Department of SurgerySt Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwon 16247South Korea

BACKGROUND The role of smoking in the incidence of colorectal cancer(CRC)or gastric cancer(GC)in populations undergoing cholecystectomy has not been *** To evaluate the effect of smoking on CRC or GC development in cholecystectomy *** A total of 174874 patients who underwent cholecystectomy between January 1,2010 and December 31,2017 were identified using the Korean National Health Insurance Service claims *** patients were matched 1:1 with mem-bers of a healthy population according to age and *** or GC risk after cholecystectomy and the association between smoking and CRC or GC risk in cholecystectomy patients were evaluated using adjusted hazard ratios(HRs)and 95%*** The risks of CRC(adjusted HR:1.15;95%CI:1.06-1.25;P=0.0013)and GC(adjusted HR:1.11;95%CI:1.01-1.22;P=0.0027)were significantly higher in cholecystectomy *** the population who underwent cholecystectomy,both CRC and GC risk were higher in those who had smoked compared to those who had never *** both cancers,the risk tended to increase in the order of non-smokers,ex-smokers,and current *** addition,a positive correlation was observed between the amount of smoking and the risks of both CRC and *** Careful follow-up and screening should be performed,focusing on the increased risk of gastrointestinal cancer in the cholecystectomy group,particularly considering the individual smoking habits.

关键词： Cholecystectomy Smoking,Gastric cancer Colon cancer Risk factor Hazard ratio

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Mobile Digital Signage System Based on Service Delivery Platform for Targeted Advertising

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通讯和计算机（中英文版） 2012年第9期9卷 1069-1076页

作者： Changwoo Yoon Hoyeon Lee seung hyun jeon hyunwoo Lee Smart Screen Convergence Research Department ETR1 Daejeon 305-700 Korea

Digital signage service is a type of bi-directional digital broadcasting service displaying advertisement contents on big screen display unit. Mobile digital signage is mobile version of digital signage service giving advertising through customer"s mobile terminal. To provide convergence signage service easily, we used SOA (service oriented architecture). We present location based targeted digital signage system using SDP (service delivery platform), that is a common system name implementing SOA concept. We present SDP based mobile digital signage system architecture, features and service scenarios. Our system provides location based and targeted advertisement efficiently.

关键词：广播服务移动终端广告内容标牌系统平台交付面向服务的架构

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Survival benefit of concurrent chemoradiotherapy for advanced ampulla of Vater cancer

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World Journal of Clinical Cases 2024年第2期12卷 267-275页

作者： Chae Hwa Kwon hyung Il Seo Dong Uk Kim Sung Yong Han Suk Kim Nam Kyung Lee seung Baek Hong Ji hyun Ahn Young Mok Park Byeong Gwan Noh BioMedical Research Institute Pusan National University HospitalBusan 49241South Korea Department of Surgery Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology and Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Currently,there is no standard adjuvant therapy for patients with resected ampulla of Vater(AoV)*** To evaluate the effectiveness of adjuvant concurrent chemoradiotherapy(CCRT)in patients with advanced AoV cancer who underwent curative *** This single-centered,retrospective study included 29 patients with advanced AoV cancer who underwent pancreaticoduodenectomy between 2006 and *** impact of CCRT on advanced AoV cancer was *** The 1-,3-,and 5-yr recurrence-free survival(RFS)rates for patients with advanced AoV cancer were 82.8%,48.3%,and 40.8%,respectively,and the overall survival(OS)rates were 89.7%,62.1%,and 51.7%,***-cular invasion was found to be a significant risk factor for RFS and OS in patients with advanced AoV cancer in the univariate analysis,whereas T stage and lymph node metastasis were significantly associated with OS in the multivariate *** to the patients who did not receive adjuvant CCRT,those who received adjuvant CCRT did not show statistically significant improvements in the RFS and OS,although they had a significantly lower average age and significantly higher platelet-to-lymphocyte *** Adjuvant CCRT did not improve survival outcomes in patients with advanced AoV *** findings contribute to existing knowledge on the effectiveness of CCRT in this patient population and provide important insights for clinical decision-making.

关键词： Advanced ampulla of Vater cancer Adjuvant concurrent chemoradiotherapy Recurrence Survival Vater cancer

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Functionally graded structure of a nitride-strengthened Mg_(2)Si-based hybrid composite

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Journal of Magnesium and Alloys 2024年第3期12卷 1239-1256页

作者： jeongho Yang Woongbeom Heogh Hogi Ju Sukhyun Kang Tae-Sik Jang hyun-Do Jung Mohammad Jahazi seung Chul Han Seong Je Park Hyoung Seop Kim Susmita Bose Amit Bandyopadhyay Martin Byung-Guk Jun Young Won Kim Dae-kyeom Kim Rigoberto CAdvincula Clodualdo Aranas Jr Sang Hoon Kim School of Mechanical Engineering Pusan National UniversityBusan 46241Republic of Korea Department of Mechanical Design Engineering Hanyang UniversitySeoul 04763Republic of Korea Process Research 3 Team LG Display Co.Ltd.PajuGyeonggi-do 10845Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea Institute of Well-Aging Medicare&Chosun University LAMP Center Chosun UniversityGwangju 61452Republic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul 04763Republic of Korea Department of Mechanical Engineering École de Technologie SupérieureMontrealQuebec H3C 1K3Canada Material&Component Convergence R&D Center Korea Construction Equipment Technology InstituteGunsanJeollabuk-do 54002Republic of Korea School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Graduate Institute of Ferrous&Eco Materials Technology Pohang University of Science and TechnologyPohangGyeongsangbuk-do 37673Republic of Korea Advanced Institute for Materials Research Tohoku UniversitySendai 980-8577Japan Institute for Convergence Research and Education in Advanced Technology Yonsei UniversitySeoul 03722Republic of Korea School of Mechanical and Materials Engineering Washington State UniversityPullmanWashington 99164USA School of Mechanical Engineering Purdue UniversityWest LafayetteIndiana 47907USA Research Institute of Advanced Manufacturing Technology Korea Institute of Industrial TechnologyIncheon 21999Republic of Korea Department of Macromolecular Science and Engineering Case Western Reserve UniversityClevelandOhio 44106USA Department of Chemical and Biomolecular Engineering and Joint Institute for Advanced Materials University of TennesseeKnoxvilleTennessee 37996USA Center for Nanophase Materials and Sciences Oak Ridge National LaboratoryOak RidgeTennessee 37830USA Department of Mechanical Engineering University of New BrunswickFrederictonNew Brunswick E3B 5A3Cana

The ex-situ incorporation of the secondary SiC reinforcement,along with the in-situ incorporation of the tertiary and quaternary Mg_(3)N_(2) and Si_(3)N_(4) phases,in the primary matrix of Mg_(2)Si is employed in order to provide ultimate wear resistance based on the laser-irradiation-induced inclusion of N_(2) gas during laser powder bed *** is substantialized based on both the thermal diffusion-and chemical reactionbased metallurgy of the Mg_(2)Si–SiC/nitride hybrid *** study also proposes a functional platform for systematically modulating a functionally graded structure and modeling build-direction-dependent architectonics during additive *** strategy enables the development of a compositional gradient from the center to the edge of each melt pool of the Mg_(2)Si–SiC/nitride hybrid ***,the coefficient of friction of the hybrid composite exhibits a 309.3%decrease to–1.67 compared to–0.54 for the conventional nonreinforced Mg_(2)Si structure,while the tensile strength exhibits a 171.3%increase to 831.5 MPa compared to 485.3 MPa for the conventional *** outstanding mechanical behavior is due to the(1)the complementary and synergistic reinforcement effects of the SiC and nitride compounds,each of which possesses an intrinsically high hardness,and(2)the strong adhesion of these compounds to the Mg_(2)Si matrix despite their small sizes and low concentrations.

关键词： Laser powder bed fusion Mg_(2)Si-SiC/nitride hybrid composite Both the thermal diffusion-and chemical reaction-based metallurgy Functionally graded structure Compositional gradient Wear resistance.

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Catalpa bignonioides extract improves exercise performance through regulation of growth and metabolism in skeletal muscles

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 47-54页

作者： Hoibin jeong Dong-joo Lee Sung-Pil Kwon SeonJu Park Song-Rae Kim seung hyun Kim Jae-Il Park Deug-chan Lee Kyung-Min Choi WonWoo Lee Ji-Won Park Bohyun Yun Su-Hyeon Cho Kil-Nam Kim Seoul Center Korea Basic Science InstituteSeoul 02841Republic of Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Research&Development Center Chungdam CDC JNPharm LLC.Chuncheon 24341Republic of Korea Department of Biomedical Technology Kangwon National UniversityChuncheon 24341Republic of Korea Yonsei Institute of Pharmaceutical Sciences College of PharmacyYonsei UniversityIncheon 21983Republic of Korea Gwangju Center Korea Basic Science InstituteGwangju 61751Republic of Korea Honam National Institute of Biological Resources 99Gohadoan-gilMokpo-siJeollanam-do58762Republic of Korea Department of Bio-analysis Science University of Science&TechnologyDaejeon34113Republic of Korea

Objective:To evaluate the effects of Catalpa bignonioides fruit extract on the promotion of muscle growth and muscular capacity in vitro and in ***:Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** proliferation was assessed using a 5-bromo-2’-deoxyuridine(BrdU)assay *** blot analysis was performed to determine the protein expressions of related *** effects of Catalpa bignonioides extract were investigated in mice using the treadmill exhaustion test and whole-limb grip strength *** composition analysis was performed using high-performance liquid chromatography(HPLC).Results:Catalpa bignonioides extract increased the proliferation of C2C12 mouse myoblasts by activating the Akt/mTOR signaling *** also induced metabolic changes,increasing the number of mitochondria and glucose metabolism by phosphorylating adenosine monophosphate-activated protein *** an in vivo study,the extract-treated mice showed improved motor abilities,such as muscular endurance and grip ***,HPLC analysis showed that vanillic acid may be the main component of the Catalpa bignonioides extract that enhanced muscle ***:Catalpa bignonioides improves exercise performance through regulation of growth and metabolism in skeletal muscles,suggesting its potential as an effective natural agent for improving muscular strength.

关键词： Catalpa bignonioides Skeletal muscle Cell proliferation Mitochondria Energy metabolism C2C12

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Posterior reversible encephalopathy syndrome in a patient with metastatic breast cancer:A case report

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World Journal of Clinical Cases 2022年第7期10卷 2281-2285页

作者： Chae hyun Song seung Jun Lee Ha Ra jeon Department of Physical Medicine and Rehabilitation National Health Insurance Service Ilsan HospitalGoyang-si Gyeonggi-do 10444South Korea Department of Physical Medicine and Rehabilitation National Health Insurance Service Ilsan HospitalGoyang-si Gyeonggi-do ASI/KR/KS009/GoyangSouth Korea

BACKGROUND Posterior reversible encephalopathy syndrome(PRES)is a neurotoxic encephalopathic state with clinical symptoms such as headache,altered consciousness,visual disturbances,and *** edema occurs predominantly in the posterior occipital and parietal lobes of the *** is caused by various diseases,and its mechanism remains ***,it can be easily diagnosed based on characteristic lesions on magnetic resonance *** SUMMARY A 51-year-old woman with unremarkable past medical history presented with progressively worsening back pain since 2 *** examinations revealed paralumbar muscle tenderness,a large lesion on the right breast and several masslike lesions on both *** blood pressure(BP)was elevated(150/90 mmHg),and did not respond to antihypertensive *** the seventh day of hospitalization,she exhibited a confused mental status and generalized tonicclonic *** magnetic resonance imaging,bilateral cortical and subcortical edema of the occipital lobes,suggestive of PRES,was *** serum calcium was 15.8 mg/*** two days of treatment with nicardipine,elcatonin,and zolendronic acid,her BP was 130/91 mmHg and serum calcium was 10.1 mg/*** patient regained consciousness and her mental status ***-positron emission tomography revealed right breast cancer with extensive *** Although rare,hypercalcemia can lead to PRES by causing uncontrolled *** diagnosis can help prevent severe mental disturbances and even death.

关键词： Posterior reversible encephalopathy syndrome Breast cancer Hypercalcemia Hypertension Case report

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Flow Characteristics in Compact Thermal Spray Coating Systems with Minimum Length Nozzle

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Plasma Science and Technology 2009年第5期11卷 550-554页

作者： seung-hyun KIM Youn-Jea KIM School of Mechanical Engineering Sungkyunkwan University

In this study, numerical analysis is performed to adopt the equivalence ratio on the high velocity oxygen fuel （HVOF） thermal spray coating systems equipped with a minimum length nozzle. The analysis is applied to investigate the axisymmetric, steady-state, turbulent, and chemically combusting flow both within the torch and in a free jet region between the torch and the substrate to be coated. The combustion is modeled using a single-step and eddy-dissipation model which assumes that the reaction rate is limited by the turbulent mixing rate of the fuel and oxidant. As the diameter of the nozzle throat is increased, the location of the Mach shock disc moves backward from the nozzle exit. As the throat diameter and the divergent portion are 6 mm and 8 mm, respectively, the pressure in the HVOF system is the lowest at the chamber and the expanding gas is steadily maintained with both high velocity and high temperature for different equivalence ratios. Thus, relatively minor amendments of the equivalence ratio and the geometry of HVOF can lead to improved control over coating characteristics.

关键词： minimum length nozzle HVOF equivalence ratio

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Psychological predictors of bipolarity in panic disorder

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World Journal of Psychiatry 2021年第6期11卷 242-252页

作者： Da Hye Oh Doo-Heum Park seung-Ho Ryu Jee hyun Ha Hong Jun jeon Department of Psychiatry Konkuk University Medical CenterSeoul 05030South Korea Department of Psychiatry Konkuk University School of MedicineSeoul 05029South Korea

BACKGROUND Panic disorders frequently occur with affective disorders,particularly bipolar *** with panic disorder and bipolar disorder are more likely to present with severe symptoms,such as high rates of suicidal behavior,poor symptomatic and functional recovery,and poor drug *** To investigate the psychological characteristics of panic disorder patients related to *** A total of 254 patients(136 men and 118 women,mean age=33.48±3.2 years)who were diagnosed with panic disorder were included in the *** disorder with bipolarity(BP+)was defined as a score of≥7 on the Korean version of the Mood Disorder Questionnaire(K-MDQ),and a score lower than 7 was considered as a panic disorder without bipolarity(BP-).Self-report questionnaires were analyzed to examine their association with *** tests used in the study were the Mood Disorder Questionnaire(MDQ),Panic Disorder Severity Scale,Beck Depression Inventory,State-Trait Anxiety Inventory(STAI),Temperament and Character Inventory(TCI),and Minnesota Multiphasic Personality Inventory(MMPI).Statistical analyses were performed to evaluate the correlation between bipolarity of panic disorder patients and various psychological test results indicative of psychological *** Patients with a K-MDQ score of 7 or more were considered to have a history of manic or hypomanic episodes(BP+group,n=128),while patients with K-MDQ scores below 7 were defined as those without bipolarity(BP-group,n=126).The BP+group were more likely to be unmarried(single 56.2%vs 44.4%,P=0.008)and younger(30.78±0.59 vs 37.11±3.21,P<0.001).Additionally,the BP+group had significantly higher scores on psychological assessment scales,such as the hypochondriasis,psychopathic deviate,masculinity-femininity,psychasthenia,schizophrenia,and hypomania(Ma)in MMPI,and novelty seeking,harm avoidance and self-transcendence in TCI,and STAI(state and trait)compared to the *** logistic

关键词： Panic disorder Bipolar disorder Bipolarity Anxiety Minnesota Multiphasic Personality Inventory Temperament and Character Inventory

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LARGE EDDY SIMULATION (LES) OF TURBULENT FLOW BY FINITE DIFFERENCE METHOD

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Journal of Hydrodynamics 2004年第4期16卷 403-409页

作者： KWAG seung hyun DOI Yasuaki PARK Jong Chun School of Applied System Engineering Halla University KoreaDepartment of Social and Environmental Engineering Hiroshima University Japan Department of Naval Arch and Ocean Engineering Pusan National University Korea

A Large Eddy Simulation (LES) technique was applied to solve the turbulentchannel flow for Re_τ = 150 . Three types of turbulence models are employed, such as theSmagorinsky model, the Dynamic Sub-Grid Scale(SGS) model and the Generalized Normal Stress (GNS)model. The simulated data in time series for the LES were averaged in both time and space to carryout the statistical analysis. Results of LES were compared with that of a DNS. As an application, aLES technique was used for 2D body in order to check the validation by investigating the turbulentvortical motion around the afterbody with a slant angle.

关键词： large eddy simulation (LES) turbulent flow finite difference method smagorinsky model dynamic sub-grid Scale ( SGS) model generalized normal stress (GNS) model

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MOF‑Derived CoSe2@N‑Doped Carbon Matrix Confined in Hollow Mesoporous Carbon Nanospheres as High‑Performance Anodes for Potassium‑Ion Batteries

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Nano-Micro Letters 2021年第1期13卷 123-137页

作者： Su hyun Yang seung‑Keun Park Yun Chan Kang Department of Materials Science and Engineering Korea UniversityAnam‑DongSeongbuk‑GuSeoul 136‑713Republic of Korea Department of Chemical Engineering Kongju National University1223‑24 Cheonan‑daeroSeobuk‑guCheonan 31080Republic of Korea

In this work,a novel vacuum-assisted strategy is proposed to homogenously form Metal-organic frameworks within hollow mesoporous carbon nanospheres(HMCSs)via a solid-state *** method is applied to synthesize an ultrafine CoSe2 nanocrystal@N-doped carbon matrix confined within HMCSs(denoted as CoSe2@NC/HMCS)for use as advanced anodes in highperformance potassium-ion batteries(KIBs).The approach involves a solvent-free thermal treatment to form a Co-based zeolitic imidazolate framework(ZIF-67)within the HMCS templates under vacuum conditions and the subsequent *** treatment under vacuum facilitates the infiltration of the cobalt precursor and organic linker into the HMCS and simultaneously transforms them into stable ZIF-67 particles without any *** the subsequent selenization process,the“dual confinement system”,composed of both the N-doped carbon matrix derived from the organic linker and the small-sized pores of HMCS,can effectively suppress the overgrowth of CoSe2 ***,the resulting uniquely structured composite exhibits a stable cycling performance(442 mAh g^−1 at 0.1 A g^−1 after 120 cycles)and excellent rate capability(263 mAh g^−1 at 2.0 A g^−1)as the anode material for KIBs.

关键词： Metal-organic frameworks Hollow mesoporous carbon nanospheres Potassium-ion batteries Cobalt selenides Electrode materials

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