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Study of capillary transit time distribution in coherent hemodynamics spectroscopy

Journal of Innovative Optical Health Sciences 2015年第2期8卷 78-86页

作者： Angelo Sassaroli Jana Kainerstorfer sergio Fantini Department of Biomedical Engineering Tufts University 4 Colby StreetMedfordMA 02155USA

A recently proposed analytical hemodynamie modell[***,Neurolmage 85,202-221(2014)]is able to predict the changes of oxy,deoxy,and total hemoglobin concentrations(model outputs)given arbitrary changes in blood flow,blood volume,and rate of oygen consumption(model inputs).One asumption of this model is that the capillary compartment is characterized by a single blood transit *** this work,we have extended the original model by considering a distribution of capillary transit times and we have compared the outputs of both models(original and extended)for the case of sinusoidal input signals at different frequencies,which realizes the new technique of coherent hemodynamics spectroscopy(CHS).For the calculations with the original model,we have used the mean value of the distribution of capillary transit times con-sidered in the extended *** have found that,for distributions of capillary transit times having mean values around 1 s and a standard deviation less than about 45%of the mean value,the original and extended models yield the same CHS spectra(i.e.,model outputs versus fre-quency of ocillation)within typical experimental *** wider capillary transit time dis-tributions,the two models yield different CHS *** assuming that Poiseuille's law is valid in the capillary compartment,we have related the distribution of capillary transit times to the distributions of capillary lengths and capillary speed of blood flow to calculate the average capillary and venous *** have found that,for standard deviations of the capillanry transit time distrilbution that are less than about 80%of the mean value,the average capillary saturation is always larger than the venous *** contrast,the average capillary satu-ration may be less than the venous saturation for wider distributions of the capillary transit times.

关键词： Coherent hemodynamics spectroscopy hermodynamie model near-infrared spectros-copy capillary transit time hemoglobin saturation

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Colchicine reduces procollagen Ⅲ and increases pseudocholinesterase in chronic liver disease

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World Journal of Gastroenterology 2010年第23期16卷 2889-2894页

作者： sergio Muntoni Marcos Rojkind Sandro Muntoni Centre for Metabolic Diseases and Atherosclerosis The Metabolic Diseases and their Complications Association The George Washington University Medical Center Department of Toxicology Unit of Oncology and Molecular PathologyUniversity of Cagliari Medical School

AIM:To test whether colchicine would be an effective antif ibrotic agent for treatment of chronic liver diseases in patients who could not be treated with α-***:Seventy-four patients(46 males,28 females) aged 40-66 years(mean 53±13 years) participated in the *** patients were affected by chronic liver diseases with cirrhosis which was proven histologically(n=58);by chronic active hepatitis C(n=4),chronic active hepatitis B(n=2),and chronic persistent hepatitis C(n=6).In the four patients lacking histology,cirrhosis was diagnosed from anamnesis,serum laboratory tests,esophageal varices and *** were assigned to colchicine(1 mg/d) or standard treatment as control in a randomized,double-blind trial,and followed for 4.4 years with clinical and laboratory ***:Survival at the end of the study was 94.6% in the colchicine group and 78.4% in the control group(P=0.001).Serum N-terminal peptide of type Ⅲ procollagen levels fell from 34.0 to 18.3 ng/mL(P=0.0001),and pseudocholinesterase levels rose from 4.900 to 5.610 mU/mL(P=0.0001) in the colchicine group,while no signif icant change was seen in *** results were obtained in patients with chronic hepatitis C and in alcoholic ***:Colchicine is an effective and safe antifibrotic drug for long-term treatment of chronic liver disease in which fi brosis progresses towards cirrhosis.

关键词： Chronic liver disease Colchicine Liver cirrhosis Liver fibrosis Type Ⅲ procollagen peptide

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On the Foundations of Statistical Mechanics: Ergodicity, Many Degrees of Freedom and Inference

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Communications in Theoretical Physics 2014年第10期61卷 469-475页

作者： sergio Chibbaro Lamberto Rondoni Angelo Vulpiani Sorbonne Universités UPMC Univ Paris 06CNRSUMR7190Institut Jean Le Rond d’AlembertF-75005 ParisFrance Kavli Institute for Theoretical Physics China CAS Dip.Scienze Matematiche Politecnico di TorinoC.Duca degli Abruzzi 24TorinoItaly INFN Sezione di TorinoVia P.Giuria 1TorinoItaly Dipartimento di Fisica Università "La Sapienza" RomaItaly ISC-CNR Piazzale A.Moro 2 – 00185 RomaItaly

We review the main aspects of the foundations of statistical mechanics. In particular we explain why many degrees of freedom are necessary, while chaos(in the sense of positive Lyapunov exponents) is only marginally r... 详细信息

关键词： ergodic hypothesis chaos emergent properties statical inference

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Glial regenerative response in the imaginal discs of Drosophila melanogaster

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Neural Regeneration Research 2023年第1期18卷 109-110页

作者： sergio B.Velarde Antonio Baonza Centro de Biología Molecular“Severo Ochoa” CSIC/UAMMadridSpain

Glial cells play a key role during nervous system development and actively participate in all the cellular processes involved in maintaining its structural robustness and functional *** response to neuronal damage,glial cells proliferate,migrate to the injured region and change their morphology,function,and behavior(Gallo and Deneen,2014;Kato et al.,2018).This glial regenerative response is associated with the repairing function of these cells and is found across species,suggesting that it may reflect a common underlying genetic mechanism(Kato et al.,2018).

关键词： damage migrate

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Rhynchophorus ferrugineus attack affects a group of compounds rather than rearranging Phoenix canariensis metabolic pathways

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Journal of Integrative Plant Biology 2016年第4期58卷 388-396页

作者： Antonio Giovino Federico Martinelli sergio Saia Consiglio per la Ricerca in Agricoltura e l'analisi dell'economia agraria(CREA) Unita di ricerca per il recupero e la valorizzazione delle Specie Floricole Mediterranee(CREA-SFM)90011 Bagheria(PA)Italy Dipartimento di Scienze Agrarie e Forestali(SAF) University of PalermoViale delle ScienzeEdif.490128 PalermoItaly Istituto Euromediterraneo di Scienza e Tecnologia(IEMEST) Via E.Amari 12390139 PalermoItaly

The red palm weevil（RPW; Rhynchophorus ferrugineus） is spreading worldwide and severely harming many palm species. However, most studies on RPW focused on insect biology, and little information is available about the plant response to the attack. In the present experiment, we used metabolomics to study the alteration of the leaf metabolome of Phoenix canariensis at initial（1^（st） stage） or advanced（2^（nd） stage）attack by RPW compared with healthy（unattacked） *** leaf metabolome significantly varied among treatments. At the 1^（st） stage of attack, plants showed a reprogramming of carbohydrate and organic acid metabolism; in contrast, peptides and lipid metabolic pathways underwent more changes during the 2^（nd） than 1^（st） stage of attack. Enrichment metabolomics analysis indicated that RPW attack mostly affected a particular group of compounds rather than rearranging plant metabolic pathways. Some compounds selectively affected during the 1^（st） rather than 2^（nd） stage（e.g. phenylalanine; tryptophan; cellobiose;xylose; quinate; xylonite; idonate; and iso-threonate; cellobiotol and arbutine） are upstream events in the phenylpropanoid,terpenoid and alkaloid biosynthesis. These compounds could be designated as potential markers of initial RPW attack. However,further investigation is needed to determine efficient early screening methods of RPW attack based on the concentrations of these molecules.

关键词： Early detection Mediterranean environment metabolomics palms plant borer

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Inequalities for the Extended Best Polynomial Approximation Operator in Orlicz Spaces

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Acta Mathematica Sinica,English Series 2019年第2期35卷 185-203页

作者： Sonia ACINAS sergio FAVIER Felipe ZO Departamento de Matemática Facultad de Ciencias y Exactas NaturalesUniversidad Nacional de La Pampa Instituto de Matemática Aplicada San Luis IMASLUniversidad Nacional de San Luis and CONICET Departamento de Matemática Universidad Nacional de San Luis

In this paper we pursue the study of the best approximation operator extended from L~Φ to L~φ, where φ denotes the derivative of the function Φ. We get pointwise convergence for the coefficients of the extended best approximation polynomials for a wide class of function f, closely related to the Calder′on–Zygmund class t_m^p(x) which had been introduced in 1961. We also obtain weak and strong type inequalities for a maximal operator related to the extended best polynomial approximation and a norm convergence result for the coefficients is derived. In most of these results, we have to consider Matuszewska–Orlicz indices for the function φ.

关键词： Orlicz spaces extended best polynomial approximation pointwise and norm convergence weak and strong type inequalities Orlicz indices

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Windmills： Ancestors of the wind power generation

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Frontiers of Mechanical Engineering 2017年第3期12卷 389-396页

作者： Cesare ROSSI Flavio RUSSO sergio SAVINO Department of Industrial Engineering University of Naples "Federico Ⅱ" via Claudio Naples 80125 Italy Consultant of Ufficio Storico Stato Maggiore Esercito Torre Del Greco 80059 Italy

A brief description of the windmills from the second millennium BC to the Renaissance is presented. This survey is a part of several studies conducted by the authors on technology in the ancient world. The windmills are the first motor, other than human muscles, and are the ancestors of the modem wind turbines. Some authors＇ virtual reconstructions of old windmills are also presented. The paper shows that the operating principle of many modem machines had already been conceived in the ancient times by using a technology that was more advanced than expected, but with two main differences, as follows： Similar tasks were accomplished by using much less energy; and the environmental impact was nil or very low. Modem designers should sometimes consider simplicity rather than the use of a large amount of energy.

关键词： windmills ancient machines history of windmill

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Analysis of suitable geometrical parameters for designing a tendon-driven under-actuated mechanical finger

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Frontiers of Mechanical Engineering 2016年第2期11卷 184-194页

作者： Francesco PENTA Cesare ROSSI sergio SAVINO Department of Industrial Engineering University of Naples 'FedericoII' Naples 80125 Italy

This study aims to optimize the geometrical parameters of an under-actuated mechanical finger by conducting a theoretical analysis of these parameters. The finger is actuated by a flexion tendon and an extension tendon. The considered parameters are the tendon guide positions with respect to the hinges. By applying such an optimization, the correct kinematical and dynamical behavior of the closing cycle of the finger can be obtained. The results of this study are useful for avoiding the snap- through and the single joint hyperflexion, which are the two breakdowns most frequently observed during experi- mentation on prototypes. Diagrams are established to identify the optimum values for the tendon guides position of a finger with specified dimensions. The findings of this study can serve as guide for future finger design.

关键词： tendon-driven fingers mechanical fingerdesign under-actuated mechanical systems

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Assessment of an alternative to deep foundations in compressible clays： the structural cell foundation

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Frontiers of Structural and Civil Engineering 2018年第1期12卷 67-80页

作者： sergio A. MARTINEZ-GALVAN Miguel P. ROMO Institute of Engineering National University of Mexico Mexico City 04510 Mexico

The new type of deep foundation for buildings on saturated, compressible-low strength clayey soil deposits, branded structural cell essentially consists of a rigid concrete top slab, structurally connected to reinforced concrete peripheral walls （diaphragms） that enclose the natural soil. Accordingly, as the initial volume of the confined soft clays within the lateral stiff diaphragms will remain constant upon loading, the hollowed structural cell will be ＂transformed＂ into a very large cross-section pillar of unit weight slightly higher than that of the natural soft clayey soil. This type of foundation seems to be a highly competitive alternative to the friction pile-box foundations （widely used in Mexico City clays）, due to its economic and environmental advantages. Economies result, for example, from the absence of huge excavations hence sparing the need of earth retaining structures. Further savings result from appreciably smaller concrete volumes required for building the structural cell than the friction pile-box foundation; moreover, the construction time of the former is much shorter than that of the latter. Regarding the impact to the environment, less air contamination follows from the fact that both traffic jams and soil excavation lessen appreciably. Considering these facts and others regarding scheduling, it was decided to replace 48-friction pile-box foundations specified in the master plan project by this new type of foundation. The overall behavior of these cell foundations over a five-year period is fared from close visual observations and their leveling during the first three years after their construction.

关键词： deep foundations bearing capacity resistant moment structural cell 3D numerical modeling

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Practical autoencoder based anomaly detection by using vector reconstruction error

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Cybersecurity 2023年第2期6卷 1-13页

作者： Hasan Torabi Seyedeh Leili Mirtaheri sergio Greco Department of Electrical and Computer Engineering Faculty of EngineeringKharazmi UniversityTehranIran Department of Informatics ModelingElectronics and System EngineeringUniversity of CalabriaArcavacataItaly.

Nowadays,cloud computing provides easy access to a set of variable and configurable computing resources based on user demand through the *** computing services are available through common internet protocols and network standards.n addition to the unique benefits of cloud computing,insecure communication and attacks on cloud networks cannot be *** are several techniques for dealing with network *** this end,network anomaly detection systems are widely used as an effective countermeasure against network *** anomaly-based approach generally learns normal traffic patterns in various ways and identifies patterns of *** anomaly detection systems have gained much attention in intelligently monitoring network traffic using machine learning *** paper presents an efficient model based on autoencoders for anomaly detection in cloud computing *** autoencoder learns a basic representation of the normal data and its reconstruction with minimum ***,the reconstruction error is used as an anomaly or classification *** addition,to detecting anomaly data from normal data,the classification of anomaly types has also been *** have proposed a new approach by examining an autoencoder's anomaly detection method based on data reconstruction *** the existing autoencoder-based anomaly detection techniques that consider the reconstruction error of all input features as a single value,we assume that the reconstruction error is a *** enables our model to use the reconstruction error of every input feature as an anomaly or classification *** further propose a multi-class classification structure to classify the *** use the CIDDS-001 dataset as a commonly accepted dataset in the *** evaluations show that the performance of the proposed method has improved considerably compared to the existing ones in terms of accuracy,recall,false-positive rate,and F1-score

关键词： Cloud Practical Anomaly detection Autoencoder Reconstruction error Machine learning

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