Colchicine reduces procollagen Ⅲ and increases pseudocholinesterase in chronic liver disease

作     者：Sergio Muntoni Marcos Rojkind Sandro Muntoni 

作者机构：Centre for Metabolic Diseases and AtherosclerosisThe Metabolic Diseases and their Complications Association The George Washington University Medical Center Department of ToxicologyUnit of Oncology and Molecular PathologyUniversity of Cagliari Medical School 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第23期

页      面：2889-2894页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Chronic liver disease Colchicine Liver cirrhosis Liver fibrosis Type Ⅲ procollagen peptide 

摘      要：AIM:To test whether colchicine would be an effective antif ibrotic agent for treatment of chronic liver diseases in patients who could not be treated with α-***:Seventy-four patients(46 males,28 females) aged 40-66 years(mean 53±13 years) participated in the *** patients were affected by chronic liver diseases with cirrhosis which was proven histologically(n=58);by chronic active hepatitis C(n=4),chronic active hepatitis B(n=2),and chronic persistent hepatitis C(n=6).In the four patients lacking histology,cirrhosis was diagnosed from anamnesis,serum laboratory tests,esophageal varices and *** were assigned to colchicine(1 mg/d) or standard treatment as control in a randomized,double-blind trial,and followed for 4.4 years with clinical and laboratory ***:Survival at the end of the study was 94.6% in the colchicine group and 78.4% in the control group(P=0.001).Serum N-terminal peptide of type Ⅲ procollagen levels fell from 34.0 to 18.3 ng/mL(P=0.0001),and pseudocholinesterase levels rose from 4.900 to 5.610 mU/mL(P=0.0001) in the colchicine group,while no signif icant change was seen in *** results were obtained in patients with chronic hepatitis C and in alcoholic ***:Colchicine is an effective and safe antifibrotic drug for long-term treatment of chronic liver disease in which fi brosis progresses towards cirrhosis.