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Oral Manifestations, Gingival Index and Dental State of Vesiculobullous Diseases

International Journal of Clinical Medicine 2018年第5期9卷 408-422页

作者： sergio eduardo migliorini Vanessa Gallego Arias Pecorari Marcio Zaffalon Casati Claudia Giuli Santi Cyro Festa Neto Luciano Lauria Dib Paulista University (UNIP) S&atilde o Paulo Brazil Department of Bioestatistic Paulist University (UNIP) S&atilde o Paulo Brazil Department of Peridontal Campinas State University S&atilde o Paulo Brazil Department of Dermatology University of S&atilde o Paulo S&atilde o Paulo Brazil Department of Stomatology Paulist University (UNIP) S&atilde o Paulo Brazil

Objective: To determine the occurrence of oral manifestations, gingival index, dental state and associated therapeutic aspects in patients with vesiculobullous diseases. Study design: Prospective and observational study conducted with 69 patients from May 2013 to May 2014 at the Dermatology Outpatient Clinic of the Clinical Hospital, University of São Paulo Medical School, Brazil. Data were analyzed for frequency in absolute values, percentage and correlation using the Chi-square test. Results: 84.1% of the patients had oral manifestations of vesiculobullous diseases (p = 0.001);25% had gingival lesions;18.2% had lesions in the buccal mucosa, and 17.6% in the lips, with no correlation between the location and the type of disease (p = 0.990). Among all patients with bullous pemphigoid, linear IgA dermatosis, and mucous membrane pemphigoid, 59 (93.6%) patients had gingival inflammation of dental origin but without significant correlation (p = 0.42). There was correlation between pemphigus vulgaris and periodontal disease (p = 0.05). Conclusion: Gingival inflammation seems to interfere negatively with the clinical course of these diseases. Further studies should be conducted to better clarify the interrelations between dental and gingival state, and between vesiculobullous diseases and oral involvement.

关键词： Oral Medicine Autoimmune Diseases Pemphigus Periodontal Diseases Bullous Pemphigoid

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Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas sergio Cuenca-Lopez eduardo Andres-Leon Laura Carmen Terron-Camero Blanca Cano-Gutierrez Jose Manuel Cozar Jose Antonio Lorente Fernando Vazquez-Alonso Luis Javier Martinez-Gonzalez Maria Jesus Alvarez-Cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

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Robotic surgery for rectal cancer: Current immediate clinical and oncological outcomes

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World Journal of Gastroenterology 2014年第39期20卷 14359-14370页

作者： sergio eduardo Alonso Araujo Victor Edmond Seid Sidney Klajner Department of Gastroenterology University of Sao Paulo Medical School Sao Paulo (SP) 05403-000 Brazil Albert Einstein Hospital Sao Paulo (SP) 05652-901 Brazil

Laparoscopic rectal surgery continues to be a challenging operation associated to a steep learning curve. Robotic surgical systems have dramatically changed minimally invasive surgery. Three-dimensional, magnified and stable view, articulated instruments, and reduction of physiologic tremors leading to superior dexterity and ergonomics. Therefore, robotic platforms could potentially address limitations of laparoscopic rectal surgery. It was aimed at reviewing current literature on short-term clinical and oncological(pathological) outcomes after robotic rectal cancer surgery in comparison with laparoscopic surgery. A systematic review was performed for the period 2002 to 2014. A total of 1776 patients with rectal cancer underwent minimally invasive robotic treatment in 32 studies. After robotic and laparoscopic approach to oncologic rectal surgery, respectively, mean operating time varied from 192-385 min, and from 158-297 min; mean estimated blood loss was between 33 and 283 mL, and between 127 and 300 mL; mean length of stay varied from 4-10 d; and from 6-15 d. Conversion after robotic rectal surgery varied from 0% to 9.4%, and from 0 to 22% after laparoscopy. There was no difference between robotic(0%-41.3%) and laparoscopic(5.5%-29.3%) surgery regarding morbidity and anastomotic complications(respectively, 0%-13.5%, and 0%-11.1%). Regarding immediate oncologic outcomes, respectively among robotic and laparoscopic cases, positive circumferential margins varied from 0% to 7.5%, and from 0% to 8.8%; the mean number of retrieved lymph nodes was between 10 and 20, and between 11 and 21; and the mean distal resection margin was from 0.8 to 4.7 cm, and from 1.9 to 4.5 cm. Robotic rectal cancer surgery is being undertaken by experienced surgeons. However, the quality of the assembled evidence does not support definite conclusions about most studies variables. Robotic rectal cancer surgery is associated to increased costs and operating time. It also seems to be associated

关键词： Surgical procedures Minimally invasive Rectal neoplasms Robotics Colorectal surgery

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Comparison of Control Techniques in a Weight Lifting Exoskeleton

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Journal of Bionic Engineering 2019年第4期16卷 663-673页

作者： Irving Rosales-Diaz Jesus Ricardo Lopez-Gutierrez Angel eduardo Zamora Suarez sergio Rosario Salazar Antonio Osorio-Cordero Hipolito Aguilar-Sierra Rogelio Lozano CINVESTAV Av.Institute Politecnico Nacional 2508Col.San Pedro Zacatenco07360Mexico CityMexico CONACYT-CINVESTAV Av.Institute Politecnico Nacional 2508Col.San Pedro Zacatenco07360Mexico CityMexico Polytechnic University of Tulancingo St.Ingenierias 100Col.Huapalcalco43629TulancingoHidalgoMexico Centre de Recherches de Royalieu UTC-HEUDIASyCCompiegne60205France

The back pain is the most common injury in human activities where heavy objects must be lifted or must be suspended for a long time.A weight lifting exoskeleton also known as force augmentation exoskeleton is designed to reduce the strain on the back and the limbs and reduce the risk to suffer *** the other hand,different kinds of controllers have been implemented to achieve whit this goal,for example,a conventional PD Control,PD Control with Gravity Compensation,PD Control with Adaptive Desired Gravity Compensation and PD Control with Robust *** paper aims to evaluate and compare the performance from the previously cited controllers used to reduce the strain in the back,through the implementation of each controller in a three Degrees Of Freedom(DOF)exoskeleton powered by pneumatic muscle actuators;some numerical simulations as well as experimental trials have been conducted and three different performance indices were used in order to determine the effectiveness of each one with respect to the simple PD controller when the mass to be lifted is unknown.

关键词： augmenting force device exoskeleton robot pneumatic artificial muscles adaptive control robust control

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Biliary tract reconstruction using jejunal tube:an experimental study in dogs

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Hepatobiliary & Pancreatic Diseases International 2009年第2期8卷 179-185页

作者： Eliane Anrain Trentini eduardo Crema Juan Carlos Llanos Mauro Masson Lerco Luiz Alberto Magna Luiz sergio Leonardi State University of Campinas Faculty of Medical SciencesDepartment of Surgery Federal University of Triangulo Mineiro So Paulo State University "Júlio de Mesquita Filho" Faculty of Medicine of BotucatuDepartment of Surgery and Orthopedics

BACKGROUND:To physiologically reconstruct the biliary tract,Crema et al suggested the application of the Monti principle to the biliary tract,already used in humans for the urinary *** this technique,a jejunal segment is transversely *** study aimed to evaluate the efficacy of jejunal tube interposition between the common bile duct and duodenum in ***:Thirteen dogs underwent a laparoscopic common bile duct ligature,followed by a biliodigestive connection by jejunal tube interposition after one *** levels of glutamic-pyruvic and glutamic-oxalacetic transaminases,total bilirubins,alkaline phosphatase and gamma-glutamyltransferase were assessed before surgery and thereafter weekly until euthanasia,which was performed 6 weeks after biliodigestive ***:Data on 9 dogs were analyzed *** dogs presented with obstructive jaundice after common bile duct ligature,as confirmed by biochemical *** showed a statistically significant reduction in cholestasis after biliodigestive connection by jejunal tube interposition and were healthy until the end of the ***:A statistically significant reduction was seen in total bilirubin and canalicular enzymes(alkaline phosphatase and gamma-glutamyltransferase)in the 9 dogs 6 weeks after biliodigestive connetion by jejunal tube interposition.

关键词： biliary tract surgical procedures monti principle obstructive jaundice

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Role of pancreatography in the endoscopic management of encapsulated pancreatic collections-review and new proposed classification

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World Journal of Gastroenterology 2020年第45期26卷 7104-7117页

作者： Igor Mendonca Proença Marcos eduardo Lera dos Santos Diogo Turiani Hourneaux de Moura Igor Braga Ribeiro sergio Eiji Matuguma Spencer Cheng Thomas R McCarty Epifanio Silvino do Monte Junior Paulo Sakai eduardo Guimaraes Hourneaux de Moura Gastrointestinal Endoscopy Unit Department of GastroenterologyHospital das ClinicasUniversity of Sao PauloSao Paulo 05403000Brazil Division of Gastroenterology Hepatology and EndoscopyBrigham and Women’s Hospital-Harvard Medical SchoolBostonMA 02115United States

Pancreatic fluids collections are local complications related to acute or chronic pancreatitis and may require intervention when symptomatic and/or *** the last decade,endoscopic management of these collections via endoscopic ultrasound-guided transmural drainage has become the gold standard treatment for encapsulated pancreatic collections with high clinical success and lower morbidity compared to traditional surgery and percutaneous *** understanding of anatomic landmarks,including assessment of the main pancreatic duct and any associated lesions–such as disruptions and strictures-are key to achieving clinical success,reducing the need for reintervention or recurrence,especially in cases with suspected disconnected pancreatic duct ***,proper review of imaging and anatomic landmarks,including collection location,are pivotal to determine type and size of pancreatic stenting as well as approach using long-term transmural indwelling plastic *** to adequately assess the main pancreatic duct may be performed by two methods:Either non-invasively using magnetic resonance cholangiopancreatography or endoscopically via retrograde *** the critical need to understand anatomy via pancrea tography and assess the main pancreatic duct,a standardized approach or uniform assessment strategy has not been described in the ***,the aim of this review was to clarify the role of pancreatography in the endoscopic management of encapsulated pancreatic collections and to propose a new classification system to aid in proper assessment and endoscopic treatment.

关键词： Endoscopic retrograde cholangiopancreatography Endoscopy Endoscopic ultrasound Pseudocyst Endosonography Pancreatic ducts

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Cloning and characterization of gene-resistant analogs(RGAs)involved in rust(Puccinia psidii) resistance in Eucalyptus grandis

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Journal of Forestry Research 2015年第3期26卷 711-718页

作者： Marcelo Luiz Laia Acelino Couto Alfenas sergio Hermínio Brommonschenkel Shinitiro Oda eduardo José de Melo Inaê Mariêde Araú jo Silva Janaína Fernandes Gonalves Ariadne Marques Departamento de Engenharia Florestal Universidade Federal dos Vales do Jequitinhonha e Mucuri DiamantinaMinas Gerais 39100-000 Brazil Departamento de Fitopatologia Universidade Federal de Viosa Viosa Minas Gerais 36570-900 Brazil Suzano Bahia Sul Celulose S/A Suzano So Paulo Brazil

Disease-resistant genes play an important role in defending against a variety of pathogens and insect pests in plants. Most of the disease-resistant genes encode pro- teins with conserved leucine rich repeat and nucleotide binding site domains. In this study, we cloned and char- acterized gene-resistant analogs （RGAs） from Eucalyptus grandis using degenerate PCR, with primers specifically targeting these two domains. The amplified fragments were cloned into the pGEM-T vector and transformed into Escherichia coli. Among the 90 clones obtained, 13 were sequenced and compared with each other and with previ- ously identified gene-resistant diseases. A BLASTX search in GenBank revealed high similarities among the con- served domains of these cloned genes with RGA genes. Some clones, however, showed no significant similarity with DNA sequences in GenBank. Southern blotting ana- lysis identified several polymorphic RFLP loci between distinct genotypes. However, none of them co-segregated with the Puccinia psidii Winter resistance gene 1 （Ppr1） in a population study.

关键词： Cloning Conserved domains RGAs Rust Eucalyptus

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Phenotypic Variation among and within Three Peppers Species(Capsicum)from Mexico

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Phyton-International Journal of Experimental Botany 2021年第1期90卷 259-275页

作者： Carlos eduardo Ornelas-Ramírez sergio Hernández-Verdugo Jesús Enrique Retes-Manjarrez Angel Valdez-Ortiz Antonio Pacheco-Olvera Tomás Osuna-Enciso Flor Porras Facultad de Agronomía Universidad Autónoma de SinaloaCuliacánSinaloa80000México Programa Regional de Posgrado en Biotecnología Facultad de Ciencias Químico-BiológicasUniversidad Autónoma de SinaloaCuliacánSinaloa80030México Centro de Investigación en Alimentación y Desarrollo A.C.Unidad Culiacán CuliacánSinaloa80110México

The phenotypic variation and its distribution among species,morphotypes,and among and within populations was estimated in 71 populations pertaining to 15 morphotypes of three domesticated species of Capsicum from *** were made in the states of Sinaloa,Nayarit,Oaxaca,Tabasco,and Yucatán in two agroecosystems:Backyard-garden and *** phenotypic characteristics were analyzed through one-way variance analysis and multivariate analyses of principal components analysis(PCA)and hierarchical clustering using Ward’s *** study was performed in a uniform greenhouse experiment.A high variation was found among and within populations in all the measured *** the total variation,13.0%was distributed among species,27.9%among morphotypes,8.1%among populations,and 51.0%within *** plants grew in a uniform environment,these results indicate that the differences observed among and within species,morphotypes,and populations have a genetic *** and multivariate analyses clearly differentiated morphotypes,suggesting that the category of morphotypes must be used to nominate the infraspecific variation in the domesticated *** principal components analysis identified a total of 15 principal components that contributed to explain the total *** first two components explained 59.64%of the total variation and seven components explained more than 90%of the total *** the measured characteristics,number of seed per fruit,weight of the fruit,width of the fruit,length of the fruit,stem diameter,days to flowering,and height of the plant contributed to component 1 variation,whereas width of the leaf,length of the leaf,and number of locules,number of fruits and number of seeds per plant contributed to component *** hierarchical clustering separated the populations and the morphotypes in two large different *** group consisted of populations collected in monoculture conditions and the oth

关键词： Phenotypic variation Capsicum annuum Capsicum chinense Capsicum frutescens morphotype

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Real-time fluorescence image-guided gastrointestinal oncologic surgery:Towards a new era

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World Journal of Gastrointestinal Oncology 2021年第9期13卷 1029-1042页

作者： Elías Martínez-López Aleix Martínez-Pérez sergio Navarro-Martínez Juan Carlos Sebastián-Tomás Nicola de'Angelis eduardo García-Granero Department of Surgery University of ValenciaValencia 46010Spain Department of General and Digestive Surgery Hospital Universitario Doctor PesetValencia 46017Spain Faculty of Health Sciences Valencian International UniversityValencia 46002Spain Minimally Invasive and Robotic Digestive Surgery Unit Miulli HospitalAcquaviva delle Fonti 70021Italy Department of General and Digestive Surgery Hospital Universitario y Politécnico La FeValencia 46026Spain

Technological improvements are crucial in the evolution of ***-time fluorescence-guided surgery(FGS)has spread worldwide,mainly because of its usefulness during the intraoperative decision-making *** success of any gastrointestinal oncologic resection is based on the anatomical identification of the primary tumor and its regional lymph *** allows also to evaluate the blood perfusion at the gastrointestinal stumps after colorectal or esophageal ***,a reduction on the anastomotic leak rates has been postulated as one of the foreseeable benefits provided by the use of FGS in these *** the use of fluorescence in lymph node detection was initially described in breast cancer surgery,the technique is currently applied in gastric or splenic flexure cancers,as they both present complex and variable lymphatic *** allows also to perform intraoperative lymphograms or sentinel lymph node *** applications of FGS are being developed to assist in the detection of peritoneal metastases or in the evaluation of the tumor resection *** present review aims to provide a general overview of the current status of real-time FGS in gastrointestinal oncologic *** put a special focus on the different applications of FGS,discussing the main findings and limitations found in the contemporary literature and also the promising near future applications.

关键词： Surgery Colorectal cancer Esophageal cancer Fluorescence Image-guided surgery Anastomotic leak Lymph node

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Short Term Stability Using Phase Plane

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Journal of Power and Energy Engineering 2015年第5期3卷 82-88页

作者： Luis Aromataris sergio Preidikman Marcos Galetto Fabian Rinaudo eduardo Toledo Grupo de Aná lisis de Sistemas Elé ctricos de Potencia Facultad de Ingenier&iacute a UNRC C&oacute rdoba Argentina Departamento de Estructuras Facultad de Ciencias Exactas F&iacute sicas y Naturales Universidad Nacional de C&oacute rdoba C&oacute rdoba Argentina Centro de Estudios de Energí a para el Desarrollo (CEED) Facultad de Ingenier&iacute a UNAM Ober&aacute Argentina

One of the most important problems in the study of transient stability of power systems is the determination of perturbation’s maximum time of permanence without losing the synchronism of the generators that feed the network. The problem is generally solved by either the application of the equal-area criterion or through numerical integration methods. In the present work, the phase-plane is proposed as an alternative tool to solve the above-mentioned problem with greater efficiency.

关键词： Short Term Stability Phase Plane Swing Equation

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