检索结果-南通市图书馆

Investigation of the pharmacokinetics and determination of certain cephalosporins in rabbit plasma by a kinetic spectrophotometric method with the aid of chemometrics

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2011年第5期54卷 827-834页

作者： kokot serge Chemistry Faculty of Science and Technology Queensland University of Technology

This paper describes a kinetic spectrophotometric method for simultaneous determination of three cephalosporin antibiotics,cephradine,cefaclor and cefixime,with the aid of chemometrics. The method relies on their oxidation with KMnO4 to produce green manganate with different kinetic rates in alkaline medium. The proposed method was successfully applied to a pharmacokinetic study of three cephalosporin antibiotics in rabbit plasma via intravenous injections. The results indicated that the amount of cephradine,cefaclor and cefixime were reduced rapidly in rabbit blood,showing clear dose-dependency and the half-life of cefixime (160 min) was longer than those of cephradine (60 min) and cefaclor (60 min).

关键词： pharmacokinetics cephalosporin cefaclor cefixime cephradine kinetic spectrophotometry chemometrics

Authentication of Cassia seeds on the basis of two-wavelength HPLC fingerprinting with the use of chemometrics

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2010年第2期21卷 213-216页

作者： serge kokot School of Physical and Chemical Sciences Queensland University of TechnologyBrisbaneQld 4001Australia

High performance liquid chromatographic(HPLC) fingerprints of Cassia seed,a traditional Chinese medicine(TCM),were developed by means of the chromatograms at two wavelengths of 238 and 282 ***,the two data sets were combined into one *** application of principal component analysis(PCA) for this data matrix showed that the samples were clustered into four groups in accordance with the plant sources and preparation ***,partial least squares(PLS),back propagation artificial neural...

关键词： Two-wavelength HPLC fingerprinting Cassia seeds Chemometrics Authentication

Understanding nutrient build-up on urban road surfaces

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2010年第6期22卷 806-812页

作者： Nandika Prasadani Miguntanna Ashantha Goonetilleke Prasanna Egodowatta serge kokot School of Urban Development Queensland University of Technology School of Physical and Chemical Sciences Queensland University of Technology

This article discusses the outcomes of a research project on nutrients build-up on urban road surfaces. Nutrient build-up was investigated on road sites belonging to residential, industrial and commercial land use. Collected build-up samples were separated into five particle size ranges and were tested for total nitrogen （TN）, total phosphorus （TP） and sub species of nutrients, namely, NO2^-, NO3^-, TKN and PO4^3-. Multivariate analytical techniques were used to analyse the data and to develop detailed understanding on build- up. Data analysis revealed that the solids loads on urban road surfaces are highly influenced by factors such as land use, antecedent dry period and traffic volume. However, the nutrient build-up process was found to be independent of the type of land use. It was solely dependent on the particle size of solids build-up. Most of the nutrients were associated with the particle size range 〈150 μm. Therefore, the removal of particles below 150 μm from road surfaces is of importance for the removal of nitrogen and phosphorus from road surface solids build-up. It is also important to consider the difference in the composition of nitrogen and phosphorus build-up in the context of designing effective stormwater quality mitigation strategies.

关键词： nutrient pollution pollutant build-up stormwater pollution

Application of artificial neural networks to the determination of pesticides by linear sweep stripping voltammetry

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2013年第3期24卷 246-248页

作者： Ping Qiu Yong-Nian Ni serge kokot Key Laboratory of Food Science and Technology Nanchang University Department of Chemistry Nanchang University School of Chemistry Physics and Mechanical EngineeringFaculty of Science and EngineeringQueensland University of Technology

In this work, artificial neural network （ANN）, a powerful chemometrics approach for linear and nonlinear calibration models, was applied to detect three pesticides in mixtures by linear sweep stripping voltammetry （LSSV） despite their overlapped voltammograms. Electrochemical parameters for the voltammetry, such as scan rate, deposit time and deposit potential, were evaluated and optimized from the signal response data using ANN model by minimizing the relative prediction error （RPE）. The proposed method was successfully applied to the detection of pesticides in synthetic samples and several commercial fruit samples.

关键词： Artificial neural networksLinear sweep stripping voltammetryPesticidesOverlapped peaks resolution

Simultaneous determination of three 5-nitroimidazoles in foodstuffs by differential pulse voltammetry and chemometrics

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2011年第5期22卷 591-594页

作者： Yi Gui Yong Nian Ni serge kokot State Key Laboratory of Food Science and Technology Nanchang University Nanchang 330047 China Department of Chemistry Nanchang University Nanchang 330031 China Chemistry Faculty of Science and Technology Queensland University of Technology Brisbane 4001 Australia

The voltammetric behaviour of three 5-nitroimidazoles,metronidazole,tinidazole and ornidazole,was investigated,and a method was developed for the simultaneous determination of these compounds,based on their reduction at a hanging mercury drop electrode（HMDE） in pH 8.95 buffer with differential pulse voltammetric（DPV） *** defined voltammetric waves with peak potentials of -692,-640 and -652 mV were observed for these compounds,*** is difficult to determine them individually from their mixtures without preseparation,for their voltammetric peaks overlapped seriously,so the chemometrics were used to resolve the overlapped voltammogram and quantify the *** proposed method was successfully applied to the determination of three 5-nitroimidazoles in milk and honey samples.

关键词： Nitroimidazoles Metronidazole Tinidazole Ornidazole Chemometrics Differential pulse voltammetry

Osteryoung square wave voltammetric determination of lactose in food samples by a derivative procedure

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2008年第12期19卷 1491-1494页

作者： Yong Nian Ni Yue Rong Wang serge kokot State Key Laboratory of Food Science and Technology Nanchang University Nanchang 330047 China Department of Chemistry Nanchang University Nanchang 330031 China School of Physical and Chemical Sciences Queensland University of Technology Brisbane 4001 Australia

A method for determination of lactose in food samples by Osteryoung square wave voltammetry （OSWV） was developed. It was based on the nucleophilic addition reaction between lactose and aqua ammonia. The carbonyl group of lactose can be changed into imido group, and this increases the electrochemical activity in reduction and the sensitivity. The optimal condition for the nucleophilic addition reaction was investigated and it was found that in NH4C1-NH3 buffer of pH 10.1, the linear range between the peak current and the concentration of lactose was 0.6-8.4 mg L-l, and the detection limits was 0.44 mg L- 1. The proposed method was applied to the ＇determination of lactose in food samples and satisfactory results were obtained.

关键词： Osteryoung square wave voltammetry Lactose Food Milk

Application of differential pulse stripping voltammetry and chemometrics for the determination of three antibiotic drugs in food samples

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2012年第3期23卷 339-342页

作者： Yong Sheng Zhong Yong Nian Ni serge kokot State Key Laboratory of Food Science and Technology Nanchang UniversityNanchang 330047China Department of Chemistry Nanchang UniversityNanchang 330031China Chemistry Faculty of Science and TechnologyQueensland University of TechnologyBrisbane 4001Australia

A reliable method for simultaneous determination of three antibiotic drugs（levofloxacin,gatifloxacin and lomefloxacin） by differential pulse stripping voltammetry（DPSV） in Britton-Robinson buffer（pH 7.96） was *** method is based on adsorptive accumulation of the antibacterial drugs on a hanging mercury dropping electrode（HMDE）,followed by the reduction of the adsorptive species by the technique of *** conditions,the deposition time of 80 s,the deposition potential of—1250 mV,and the scan rate of 25 mV/s,were *** linear concentration ranges of 0.010-0.080μg/mL were obtained for all these three antibiotic drugs,while the detection limits were 2.38,3.20 and 1.60ng/mL for levofloxacin,gatifloxacin and lomefloxacin,*** this work,chemometrics methods,such as classical least squares（CLS）,partial least squares（PLS）, principle component regression（PCR） and radial basis function-artificial neural networks（RBF-ANN）,were used to quantitatively resolve the overlapping *** was found that PCR gave the best results with total relative prediction error（RPE_T） of 7.71%.The proposed method was applied to determine these three drugs in several commercial food samples with spiked method and yielded satisfactory recoveries.

关键词： Differential pulse stripping voltammetry Fluoroquinolone antibiotics Chemometrics Food samples

Investigation of the interaction of carbofuran and DNA by voltammetry and fluorescence with the aid of chemometrics

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2010年第8期21卷 963-967页

作者： Ying Xia Wang Yong Nian Ni serge kokot State Key Laboratory of Food Science and Technology Nanchang University Nanchang 330047 China Department of Chemistry Nanchang University Nanchang 330031 China School of Physical and Chemical Sciences Queensland University of Technology Brisbane QId 4001 Australia

The interactions of carbofuran and DNA were studied using voltammetry and fluorescence *** formation of carbofuran-DNA makes the current peak of DNA decreased by voltammetry *** binding number（n） and constant（Ka） for complex carbofuran-DNA were calculated to be 1.06±0.04 and 0.11±0.03mol^-1 L,respectively by fluorescence *** approach,such as singular value decomposition（SVD） was used to evaluate the number of spectral species in the drug-DNA binding *** the pure spectra and concentration profiles in the kinetic system were clearly deduced by multivariate curve resolution alternating least squares（MCR-ALS） with the initial estimates by evolving factor analysis（EFA）.

关键词： Carbofuran DNA Voltammetry Chemometrics

The Effects of Building Characteristics on the Chemical Composition of Surface Films on Residential Glass Windows

在线全文

学校读者我要写书评

暂无评论

The Effects of Building Characteristics on the Chemical Comp...