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Asian Pacific Journal of Tropical Biomedicine 2016年第12期6卷 989-994页

作者： Saeed Reza jamali moghadam Samaneh Bayrami sepideh jamali moghadam Raheleh Golrokhi Fatemeh Golsoorat Pahlaviani SeyedAhmad SeyedAlinaghi Ziaeian Hospital Tehran University of Medical Sciences Iranian Research Center for HIV/AIDS(IRCHA) Iranian Institute for Reduction of High-Risk BehaviorsTehran University of Medical Sciences

Zika virus(ZIKV) has two lineages:African and ***-borne flaviviruses are thought to replicate initially in dendritic cells and then spread to lymph nodes and the blood *** for infection through blood transfusion,sexual practices and perinatal transmission *** possible routes of perinatal transmission are during delivery,breastfeeding and by close contact between the mother and her ***,mucocutaneous exposures to the virus by infected blood or monkey bite,organ transplantation or hemodialysis are the other routes of ZIKV *** are two types of ZIKV infection;Zika fever and congenital *** presentation of Zika fever varies from asymptomatic infections to a self-limiting febrile disease with low grade fever,conjunctivitis,maculopapular rash,headache,retro-orbital pain and arthritis/arthralgia with periarticular edema,myalgia,vertigo,vomiting and *** clinical feature could be mistaken for dengue or chikungunya *** is the most important and frequently reported clinical picture of suspected congenital Zika *** tests are needed for diagnosis of ZIKV infection,because there is no known pathognomonic clinical,biochemical or radiological ***-PCR is the most wellliked *** samples are tested by immunoglobulin G ELISA with ZIKV *** are also tested by immunoglobulin M *** is no certified vaccine or therapeutic *** asymptomatic or uncomplicated patients,treatment is not necessary.

关键词： Zika virus Microcephaly Serologic tests Vaccine Treatment Supportive therapy

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Ebola viral disease: a review literature

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Asian Pacific Journal of Tropical Biomedicine 2015年第4期5卷 260-267页

作者： Saeed Reza jamali moghadam Negar Omidi Samaneh Bayrami sepideh jamali moghadam SeyedAhmad SeyedAlinaghi Ziaeian Hospital Tehran University of Medical Sciences Iranian Research Center for HIV/AIDS (IRCHA) Iranian Institute for Reduction of High-Risk Behaviors Tehran University of Medical Sciences

Ebola virus is transmitted to people as a result of direct contact with body fluids containing virus of an infected patient. The incubation period usually lasts 5 to 7 d and approximately95% of the patients appear signs within 21 d after exposure. Typical features include fever,profound weakness, diarrhea, abdominal pain, cramping, nausea and vomiting for 3-5days and maybe persisting for up to a week. Laboratory complications including elevated aminotransferase levels, marked lymphocytopenia, and thrombocytopenia may have *** fever occurs in less than half of patients and it takes place most commonly in the gastrointestinal tract. The symptoms progress over the time and patients suffer from dehydration, stupor, confusion, hypotension, multi-organ failure, leading to fulminant shock and eventually death. The most general assays used for antibody detection are direct IgG and IgM ELISAs and IgM capture ELISA. An IgM or rising IgG titer(four-fold) contributes to strong presumptive diagnosis. Currently neither a licensed vaccine nor an approved treatment is available for human use. Passive transfer of serum collected from survivors of Junin virus or Lassa virus, equine IgG product from horses hypervaccinated with Ebola virus, a "cocktail"of humanized-mouse antibodies(ZMapp), recombinant inhibitor of factor VIIa/tissue factor,activated protein C, RNA-polymerase inhibitors and small interfering RNA nano particles are among the therapies in development. Preclinical evaluation is also underway for various vaccine candidates. One is a chimpanzee adenovirus vector vaccine; other vaccines involve replication-defective adenovirus serotype 5 and recombinant vesicular stomatitis virus.

关键词： Filoviridae Ebola Outbreak Reservoir Transmission Symptoms Hemorrhagic fever Index case ELISA Vaccine

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碱性溶液中电聚酪胺-铜草酸盐纳米复合物修饰铜电极电催化甲醇氧化(英文)

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催化学报 2014年第7期35卷 1098-1104页

作者： Robab Abbasi Khalil Farhadi sepideh Banisaei Nader Nowroozi Pesyan Arezu jamali Fatemeh Rahmani Department of Analytical Chemistry Faculty of ChemistryUrmia University Department of Biological Science Faculty of ScienceUrmia University

A polytyramine-copper oxalate nanocomposite modified copper(PTCOxNMC) electrode prepared by electropolymerization was examined for electrocatalytic activity towards the oxidation of methanol in alkaline solution using cyclic voltammetry and impedance spectroscopy. The prepared PTCOxNMC electrode showed a significantly high response for adsorbed methanol oxidation. The effects of various parameters such as potential scan rate and methanol concentration on the electrocatalytic oxidation at the surface of the PTCOxNMC electrode were investigated. Spectrometry techniques such as Fourier transform infrared spectroscopy and scanning electron microscopy were used to determine the surface physical characteristics of the modified electrode and revealed that the polytyramine-copper oxalate nanocomposite particles were highly dispersed on the surface of the copper electrode with a narrow size up to 40 nm. The very high current density obtained for the catalytic oxidation may have resulted from the high electrode surface area caused by modification with the poly-tyramine-copper oxalate nanocomposite.

关键词：纳米复合材料电催化氧化铜电极甲醇氧化草酸铜酪胺碱性介质扫描电子显微镜

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