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Intermittent, low-dose, antiandrogen monotherapy as an alternative therapeutic option for patients with positive surgical margins after radical prostatectomy

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Asian Journal of Andrology 2018年第3期20卷 270-275页

作者： Kyung Hwa Choi Seung Ryeol Lee young kwon Hong Dong Soo Park Department Urology CHA Bundang Medical Center CHA University Seongnam Korea.

The aim of the present study was to determine whether oncologic outcomes and adverse events associated with active on/off intermittent antiandrogen monotherapy （daily bicalutamide, 50 mg per day） are comparable with those of standard external beam radiation therapy （EBRT） or combined androgen blockade （CAB） therapy in prostate cancers with positive surgical margins after radical prostatectomy. Two hundred twenty-three patients with positive surgical margins post-radical prostatectomy who underwent active surveillance （AS, n = 32）, EBRT without hormone therapy （n = 55）, intermittent antiandrogen monotherapy without EBRT （IAAM, n= 50）, or CAB without EBRT （n = 86）, between 2007 and 2014, were reviewed retrospectively. Pathologic outcomes, biochemical recurrence rates, radiological disease progression, and adverse events were collected from medical records. Biochemical recurrence rates, biochemical recurrence-free survival rates, and radiological recurrence were not different between the groups （P = 0.225, 0.896, and 0.284, respectively）. Adverse event rates and severities were lower for IAAM compared with EBRT or CAB （both P 〈 0.05）, but were comparable to those for AS （P = 0.591 and 0.990, respectively）. Grade ：〉3 adverse events were not reported in the IAAM or AS groups. Erectile dysfunction and loss of libido rates were lower in the IAAM group compared with the EBRT and CAB groups （P = 0.032）. Gastrointestinal complications were more frequently reported in the EBRT group （P = 0.008）. Active on/off IAAM treatment might be an appropriate treatment option for patients with positive surgical margins after radical prostatectomy. Furthermore, regarding oncologic outcomes, IAAM was comparable to standard EBRT but had a milder adverse event profile.

关键词： androgen receptor antagonists disease progression margins of excision prostatectomy prostatic neoplasms

Risks of non-conservative design according to ASME B31.1 for high-temperature piping subjected to long-term operation in the creep range

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Nuclear Science and Techniques 2019年第5期30卷 59-69页

作者： Hyeong-Yeon Lee Seok-kwon Son Min-Gu Won Ji-young Jeong Korea Atomic Energy Research Institute National Fusion Research Institute School of Mechanical Engineering Sungkyunkwan University

This study investigates the risks of non-conservative piping design according to ASME B31.1 for hightemperature piping subjected to long-term operation at high temperature in a creep regime based on a sensitivity analysis of the hold time. Design evaluations of hightemperature piping were conducted over a range of hold times in the creep regime according to ASME B31.1,which implicitly considers the creep effects, and the French high-temperature design code of the RCC-MRx, which explicitly considers the creep effects. Conservatisms were quantified among the codes in terms of the hold times. In the case of B31.1, the design evaluation results do not change depending on the hold time at high temperature,whereas in the case of RCC-MRx, they do. It was shown that the design limits of RCC-MRx were exceeded when the hold time exceeded certain values, whereas those of B31.1 were satisfied regardless of the hold times. Thus, the design evaluations according to B31.1 did not consistently yield conservative results and might lead to non-conservative results in the case of long-term operations in the creep range.

关键词： ASME B31.1 Creep Hold time Hightemperature piping RCC-MRx Sensitivity analysis

Mapping bathymetry based on waterlines observed from low altitude Helikite remote sensing platform

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Acta Oceanologica Sinica 2015年第9期34卷 110-116页

作者： JO young-Heon SHA Jin kwon Jae-Il JUN Kicheon PARK Jinku Department of Oceanography Pusan National University College of Earth Oceanand EnvironmentUniversity of Delaware Coastal Disaster Research Center Korea Institute of Ocean Science & Technology China-Korea Joint Ocean Research Center

Mapping shoreline changes along coastal regions is critically important in monitoring continuously rising sea surface heights due to climate change and frequent severe storms. Thus, it is especially important if the region has very high tidal ranges over very gentle tidal flats, which is a very vulnerable region. Although the various remote sensing platforms can be used to map shoreline changes, the spatial and temporal resolutions are not enough to obtain it for a short time. Accordingly, in this study we introduce the newly developed low altitude Helikite remote sensing platform to achieve much better resolutions of shorelines and a bathymetry. The Helikite stands for Helium balloon and Kite, which is a kind of aerial platform that uses the advantages of both a Helium balloon and a kite. Field experiments were conducted in the Jaebu Island, off the coast of the west Korean Peninsula in January 29, 2011. In order to extract shorelines from the consecutive images taken by the low altitude Helikite remote sensing platform, active contours without edges （ACWE） is used. Edges or boundaries exist primarily on places between one type of objective and the other. Since the hydrodynamic pressure has an effect everywhere, the locations of the waterlines can be the isobath lines. We could map several waterlines, which would enable us to complete a local bathymetry map ranges from 35 to 60 cm depth. The error resulting from applying ACWE algorithm to the imagery to determine the waterline is approximately less than 1 m. Therefore, it is very unique way to obtain such high resolutions of bathymetry with high accuracy for the regions of extremely high tidal ranges for a short time.

关键词： Helikite mapping shoreline active contours without edges (ACWE) remote sensing

Evaluation of immobilizing agents as soil quality conditioners in addition to their metal(loid) immobilizing effect

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Pedosphere 2022年第2期32卷 307-316页

作者： Chaw Su LWIN Mina LEE young-Nam KIM Gary OWENS kwon-Rae KIM Department of Soil and Water Science Yezin Agricultural UniversityYezinNaypyitaw 15013Myanmar Department of Smart-Agro Industry Gyeongsang National UniversityJinju 52725Korea Institute of Agriculture and Life Science(IALS) Gyeongsang National UniversityJinju 52828Korea Environmental Contaminants Group Future Industries InstituteUniversity of South AustralianMawson Lakes SA 5095Australia

In trace metal (TM)-contaminated agricultural soils,management of TM availability is important for safe crop *** addition,maintenance or improvement of soil quality is vital for sustainable crop *** TM phytoavailability and increased soil quality can be achieved by the application of various immobilizing agents to soil,which can supply both macronutrients and organic *** study investigated the long-term influences of four common immobilizing agents on soil biogeochemical properties and the phytoavailability of TMs in mixed metal-contaminated soil from a cultivated upland near an abandoned mining *** (L),gypsum (G),fly ash (F),and animal manure-based compost (C) were applied to pots containing contaminated soil,either individually or in *** incubation for three years under sequential cultivation of two crops and fallow,soil biogeochemical properties were determined,and Brassica rapa plant bioassay was *** phytoavailability of all TMs (both cationic metals and anionic metalloids) remained significantly lower in soils treated with immobilizing agents even after three years,when compared with the no-agent control (CK) *** addition,the soil quality was significantly improved by treatment with immobilizing *** instance,the C and L+C treatments were the most effective in improving soil physical (bulk density,porosity,and water-resistant aggregate stability),chemical (pH,organic matter,total nitrogen,cation exchange capacity,and plant-available phosphorus,magnesium,and potassium),and biological (microbial biomass carbon and dehydrogenase activity) *** improvement of soil properties and lowering of TM bioavailability were also consistent with the most significant increase in *** biomass production observed in the C treatment,followed by the L+C,G+F,L,G,F,and L+G treatments,as compared with that in *** results indicate that the function of the TM-immobilizing agent as a soil qualit

关键词： crop production metal bioavailability metal immobilization metal phytoavailability soil amendments soil biogeochemical properties soil remediation trace metals

Radiolarians from the Pohang Basin,Southeast Korea and Paleoceanographic Implications

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Acta Geologica Sinica(English Edition) 2012年第6期86卷 1426-1433页

作者： young-Suk BAK Jong-Deock LEE Hyesu YUN Jinyong OH seong-Joo LEE Kyungpook National University Chonbuk National University Chungnam National University

We identified a total of 101 species and two subspecies of radiolarians belonging to 56 genera from 95 samples collected from the Hagjeon and Duho Formations in the Pohang Basin of the southeastern Korean Peninsula. On the basis of the biostratigraphic range of Cyrtocapsella cornuta and Theocorys redondoensis, the depositional period of the upper Hagjeon and lowest Duho Formations was determined to be early to late Middle Miocene. The occurrence of deep-dwelling radiolarians indicates that the paleobathymetry seems to become gradually progressing toward an upper bathyal environment in the middle part of the Hagjeon Formation. However, we prefer to accept another interpretation for the occurrence of deep-sea indicators in the Hagjeon and the lowest part of the Duho Formations, and consider the presence of a region of upwelling cold water that might have simulated a deep-water environment in relatively shallow water. This interpretation is based on the present upwelling of a cold-water mass off the southeast coast of Korea, the occurrence of upwelling microfossils from the Pohang Basin, and the effect of the closing of the Korea Strait approximately 15 Ma. We also considered that the uppermost part of the studied section represents a shallow-water environment.

关键词： radiolarian depositional environment upweHing Pohang Basin

Clinical applicability of gastroscopy with narrow-band imaging for the diagnosis of Helicobacter pylori gastritis, precancerous gastric lesion, and neoplasia

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World Journal of Clinical Cases 2020年第14期8卷 2902-2916页

作者： Jun-Hyung Cho seong Ran Jeon So-young Jin Digestive Disease Center Soonchunhyang University HospitalSeoul 04401South Korea Department of Pathology Soonchunhyang University HospitalSeoul 04401South Korea

Premalignant gastric lesions such as atrophic gastritis and intestinal metaplasia frequently occur in subjects with long-term Helicobacter pylori(***)*** regular arrangement of collecting venules(RAC)is seen in the normal gastric corpus,whereas mucosal swelling and redness without RAC are observed in ***-infected *** successful *** eradication,the presence of atrophic gastritis and/or gastric intestinal metaplasia(GIM)is a risk factor for gastric *** the development of advanced imaging technologies,recent studies have reported the usefulness of narrow-band imaging(NBI)for endoscopic diagnosis of atrophic gastritis and *** NBI endoscopy with magnification(M-NBI),atrophic gastritis is presented as irregular coiled microvessels and loss of gastric *** M-NBI endoscopic findings of GIM are a light blue crest and a white opaque *** on the microvascular patterns,fine network,core vascular,and unclear patterns are useful for predicting gastric dysplasia in polypoid *** diagnosis of early gastric cancer(EGC),a systematic classification using M-NBI endoscopy has been proposed on the basis of the presence of a demarcation line and an irregular microvascular/microsurface ***,M-NBI endoscopy has been found to be more accurate for determining the horizontal margin of EGC compared to conventional *** this review,we present up-to-date results on the clinical usefulness of gastroscopy with NBI for the diagnosis of *** gastritis,precancerous gastric lesion,and neoplasia.

关键词： Gastroscopy Narrow-band imaging Magnification Helicobacter pylori Atrophic gastritis Intestinal metaplasia Dysplasia Cancer

Standard vs magnifying narrow-band imaging endoscopy for diagnosis of Helicobacter pylori infection and gastric precancerous conditions

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World Journal of Gastroenterology 2021年第18期27卷 2238-2250页

作者： Jun-Hyung Cho seong Ran Jeon So-young Jin Suyeon Park Digestive Disease Center Soonchunhyang University HospitalSeoul 04401South Korea Department of PathologySoonchunhyang University HospitalSeoul 04401South Korea Department of Pathology Soonchunhyang University HospitalSeoul 04401South Korea Department of Medical Biostatistics Soonchunhyang University HospitalSeoul 04401South Korea

BACKGROUND Advances in endoscopic imaging enable the identification of patients at high risk of gastric ***,there are no comparative data on the utility of standard and magnifying narrow-band imaging(M-NBI)endoscopy for diagnosing Helicobacter pylori(***)infection,gastric atrophy,and intestinal *** To compare the diagnostic performance of standard and M-NBI endoscopy for *** gastritis and precancerous *** In 254 patients,standard endoscopy findings were classified into mosaic-like appearance(type A),diffuse homogenous redness(type B),and irregular redness with groove(type C).Gastric mucosal patterns visualized by M-NBI were classified as regular round pits with polygonal sulci(type Z-1),more dilated and linear pits without sulci(type Z-2),and loss of gastric pits with coiled vessels(type Z-3).RESULTS The diagnostic accuracy of standard and M-NBI endoscopy for *** gastritis was 93.3%and 96.1%,*** gastric precancerous conditions,the accuracy of standard and M-NBI endoscopy was 72.0%vs 72.6%for moderate to severe atrophy,and 61.7%vs.61.1%for intestinal metaplasia in the corpus,*** to type A and Z-1,types B+C and Z-2+Z-3 were significantly associated with moderate to severe atrophy[odds ratio(OR)=5.56 and 8.67]and serum pepsinogen I/II ratio of≤3(OR=4.48 and 5.69).CONCLUSION Close observation of the gastric mucosa by standard and M-NBI endoscopy is useful for the diagnosis of *** gastritis and precancerous conditions.

关键词： Endoscopy Magnifying narrow-band imaging Helicobacter pylori Gastric atrophy Intestinal metaplasia Pepsinogen

Beta-nerve growth factor gene therapy alleviates pyridoxine-induced neuropathic damage by increasing doublecortin and tyrosine kinase A in the dorsal root ganglion

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Neural Regeneration Research 2020年第1期15卷 162-168页

作者： Hyun-Kee Cho Woosuk Kim kwon-young Lee Jin-Ok Ahn Jung Hoon Choi In Koo Hwang Jin-young Chung Department of Veterinary Internal Medicine and Institute of Veterinary Science College of Veterinary MedicineKangwon National UniversityChuncheonKangwon-doSouth Korea Department of Anatomy and Cell Biology College of Veterinary MedicineResearch Institute for Veterinary ScienceSeoul National UniversitySeoulSouth Korea Department of Anatomy College of Veterinary MedicineKangwon National UniversityChuncheonKangwon-doSouth Korea

Beta-nerve growth factor(β-NGF) is known to be a major leading cause of neuronal plasticity. To identify the possible action mechanisms of β-NGF gene therapy for sciatic nerve recovery, experimental dogs were randomly divided into control, pyridoxine, and pyridoxine + β-NGF groups. We observed chronological changes of morphology in the dorsal root ganglia in response to pyridoxine toxicity based on cresyl violet staining. The number of large neurons positive for cresyl violet was dramatically decreased after pyridoxine intoxication for 7 days in the dorsal root ganglia and the neuron number was gradually increased after pyridoxine withdrawal. In addition, we also investigated the effects of β-NGF gene therapy on neuronal plasticity in pyridoxine-induced neuropathic dogs. To accomplish this, tyrosine kinase receptor A(TrkA), βIII-tubulin and doublecortin(DCX) immunohistochemical staining was performed at 3 days after the last pyridoxine treatment. TrkA-immunoreactive neurons were dramatically decreased in the pyridoxine group compared to the control group, but strong TrkA immunoreactivity was observed in the small-sized dorsal root ganglia in this group. TrkA immunoreactivity in the dorsal root ganglia was similar between β-NGF and control groups. The numbers of βIII-tubulin-and DCX-immunoreactive cells decreased significantly in the pyridoxine group compared to the control group. However, the reduction of βIII-tubulin-and DCX-immunoreactive cells in the dorsal root ganglia in the β-NGF group was significantly ameliorated than that in the pyridoxine group. These results indicate that β-NGF gene therapy is a powerful treatment of pyridoxine-induced neuropathic damage by increasing the TrkA and DCX levels in the dorsal root ganglia. The experimental protocol was approved by the Institutional Animal Care and Use Committee(IACUC) of Seoul National University, South Korea(approval No. SNU-060623-1, SNU-091009-1) on June 23, 2006 and October 9, 2009, respectively.

关键词： β-nerve growth factor βIII-tubulin doublecortin gene therapy neuron-glial antigen 2 neuropathy pyridoxine

Dipole-assisted carrier transport in bis(trifluoromethane) sulfonamide-treated O-ReS_(2) field-effect transistor

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Nano Research 2021年第7期14卷 2207-2214页

作者： Jae young Park SangHyuk Yoo Byeongho Park Taekyeong Kim young Tea Chun Jong Min Kim Keonwook Kang Soo Hyun Lee seong Chan Jun Department of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea Center for Biomicrosystem Brain Science InstituteKorea Institute of Science and TechnologySeoul 02792Republic of Korea Sensor System Research Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Physics Hankuk University of Foreign StudiesYongin 17035Republic of Korea Division of Electronics and Electrical Information Engineering Korea Maritime and Ocean UniversityBusan 49112Republic of Korea Electrical Engineering Division Engineering Department University of CambridgeCambridgeCB3 OFAUK

We demonstrate the dipole-assisted carrier transport properties of bis(trifluoromethane)sulfonamide(TFSI)-treated O-ReS_(2) field-effect *** ReS_(2) was compared with defect-mediated ReS_(2) to confirm whether the presence of defects on the interface enhances the interaction between O-ReS_(2) and TFSI *** to the experiment,density functional theory(DFT)calculation was performed,and the result indicated that the charge transfer between TFSI and O-ReS_(2) is more sensitive to external electric fields than that between TFSI and pristine ReS_(2).After TFSI treatment,the drain current of O-ReS_(2) FET was significantly increased up to 1,113.4 times except in the range of−0.32–0.76 V owing to Schottky barrier modulation from dipole polarization of TFSI molecules,contrary to a significant degradation in device performance in pristine ReS_(2) ***,in the treated O-ReS_(2) device,the dipole direction was highly influenced by the voltage sweep direction,generating a significant area of hysteresis in I–V and transfer characteristics,which was further verified by the surface potential ***,the dipole state was enhanced according to the wavelength of the light source and *** results indicate that TFSI-treated ReS_(2) FET has large potential for use as next-generation memristor,memory,and photodetector.

关键词： Two-dimensional material ReS_(2) field-effect transistor TFSI superacid dipole