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Preventive effect of Angelica gigas Nakai extract oral administration on dry eye syndrome

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Asian Pacific Journal of Tropical Medicine 2018年第6期11卷 369-375页

作者： Younje Lee Kang Min kim Jae seon Kang Department of Pharmacy Kyungsung UniversityBusanRepublic of Korea Department of Pharmaceutical Science and Technology Kyungsung UniversityBusanRepublic of Korea

Objective:To identify the preventive effect of Angelica gigas Nakai(*** Nakai)extract in a benzalkonium chloride-induced dry eye ***:A total of 28 mice were divided into 4 groups:1)Normal group:mice received only saline;2)positive control group:mice received an oral solution without *** Nakai extract at 10:00 *** 0.2%benzalkonium chloride eye drops at 2:00 p.m.;3)*** Nakai extract(5 mg);4)*** Nakai extract(10 mg).Both group 3)and group 4)received an oral solution with *** Nakai extract(either 5 mg/kg or 10 mg/kg)at 10:00 *** 0.2%benzalkonium chloride eye drops at2:00 *** 14 d of follow-up,tear volume measurement and fluorescein staining were evaluated for the recovery effects on ocular *** analysis was conducted by hematoxylin and eosin *** on ocular epithelium layer was examined using terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling *** of TNF-a was also measured using western blot ***:An increase in both the tear volume and the sustained fluorescein staining scores was observed,demonstrating the preventive effects of *** Nakai *** changes such as irregularity of the epithelial layer and corneal epithelial cell death were inhibited in the *** Nakai extract *** of TNF-αmoderately declined;however,its expression level was still higher,compared to the normal ***:Results from the current study show the significant preventive effect of *** Nakai extract in a mouse model of benzalkonium chloride-induced dry eye ***,*** Nakai extract could be considered as an oral preventive agent for dry eye syndrome in the future.

关键词： Angelica gigas Nakai Benzalkonium chloride Dry eye syndrome

Glutamic acid supplementation recovers the reduced performance of weanling pigs fed reduced crude protein diets

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Animal Nutrition 2022年第1期8卷 249-255页

作者： Santi D.Upadhaya Sang seon Lee Young Hwa kim Zhenlong Wu In Ho kim Department of Animal Resource and Science Dankook UniversityNo.29 AnseodongCheonanChoongnam 31116South Korea National Institute of Animal Science 114 Sinbangro-1 GilSeongjwan-eupSeobuk-guCheonan-si31000South Korea State Key Laboratory of Animal Nutrition Department of Animal Nutrition and Feed ScienceChina Agricultural UniversityBeijing 100193China

This study was conducted to evaluate the supplementation of glutamic acid(Glu)to reduced protein diets on the performance of weanling *** hundred and eighty crossbred weanling pigs([YorkshireLandrace]Duroc,21 d old)having similar body weight(BW)of 6.45 kg were randomly allotted to 1 of 6 dietary treatments(5 pigs per pen[2 barrows and 3 gilts];6 pens per treatment)based on BW and sex during a 6-week *** treatments consisted of positive control(PC)diet formulated to have 226.9,205.6,and 188.8 g crude protein(CP)during phases 1,2,and 3,respectively,and negative control(NC)diets with 20 g CP reduction from PC diets and addition of Glu with increasing levels,resulting in the calculated Lys-to-Glu ratios of 1:2.25,1:2.30.1:2.35,1:2.40,and 1:2.45,designated as NC,NC1,NC2,NC3,and NC4,*** BW of pigs receiving PC diet was higher(P<0.05)than those receiving NC diet at d 7,21 and 42.A higher(P<0.05)average daily gain(ADG)from d 1 to 7,8 to 21,22 to 42 and during the overall experiment period was observed in pigs fed PC than NC *** fed NC diets including the graded level of Glu linearly increased(P<0.05)BW at d 42,ADG and gain-to-feed ratio(G:F)during the overall experimental *** addition,trends in linear increase in BW(P=0.056)at d 7 and ADG from d 1 to 7 and d 22 to 42(linear effect,P=0.081,P=0.058 respectively)were observed.A tendency in the linear increment of NH3(P=0.082)at d 21 and linear reduction in methyl mercaptans(P=0.054)emission at d 42 was observed in pigs fed NC diets supplemented with graded level of *** conclusion,supplementing the reduced protein diet with Glu enhanced the growth performance in weanling pigs suggesting that supplementation of Glu can compensate the reduction of 2%CP in the basal diets.

关键词： Glu Growth performance Reduced protein diet Weanling pig

Effects of corner modifications on wind loads and local pressures on walls of tall buildings

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Building Simulation 2021年第4期14卷 1109-1126页

作者： K.T.Tse Gang Hu Jie Song Hyo seon Park Bubryur kim Department of Civil and Environmental Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina School of Civil and Environmental Engineering Harbin Institute of TechnologyShenzhen518055China Engineering Research Center of Urban Disasters Prevention and Fire Rescue Technology of Hubei Province School of Civil EngineeringWuhan UniversityWuhan430072China Department of Architectural Engineering Yonsei UniversitySeoul120-749R.O.Korea Department of Architectural Engineering Kyungil UniversityGyeongbukR.O.Korea

In this study, the aerodynamic characteristics of tall buildings with corner modifications (e.g., local wind force coefficients, mean pressure distributions, normalized power spectrum density, and extreme local pressure) were examined. Wind tunnel experiments were conducted to measure the wind pressures on building models with different heights and recessed corners of different ratios. At a wind direction of a = 0° (i.e., wind blowing on the front of a building), corner modifications effectively reduced wind forces in all cases. Specifically, small corner modification ratios reduced wind forces more effectively than their larger counterparts. However, corner modifications resulted in extreme local pressure on building surfaces. In addition, for small corner modification ratios, the probability of extreme local pressure occurring at a = 0° was high. This probability was also high for large corner modification ratios at a = 15° (i.e., wind blowing slightly obliquely on the front of a building) because wind blowing obliquely creates substantial vortex shedding on one side surface and extreme negative pressure over one building side surface. Results of computational fluid dynamic modeling were adopted to determine details of the aerodynamic characteristics of tall buildings with corner modifications.

关键词： tall building aerodynamic modification local pressure extreme local wind loads proper orthogonal decomposition computational fluid dynamics

Identity Formation and Cosmopolitan Vision in Asian-American Literature

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Journal of Foreign Languages and Cultures 2019年第1期3卷 23-29页

作者： Anfeng Sheng seon-Kee kim Tsinghua University

Asian-American literature is often identified as foreign by Asians and considered inauthentic American literature by the American ***,this minority group literature is unique in its characteristics so that it cannot be easily judged by either Asian or American *** order to better understand Asian-American literature,it is necessary to study how the members of Asian immigrant communities tend to form their own unique identities as Asian-Americans and to examine their literature using a new prism in light of cosmopolitanism,and not with any of the conventional *** formation has never been easy and natural for the bewildered and suffering Asian immigrants in the United States of America,especially for the second *** the study of the Korean American writer Chang-rae Lee’s Native Speaker and the Chinese-American writer Maxine Hong Kingston’s The Woman Warrior,we hope to explore the possibilities and impossibilities in cultural and social identification represented in those *** study clearly reveals that the social and psychological conflicts that Asian immigrants experience are frequently projected on the works of the immigrant writers.A cosmopolitan prospect is often envisioned in their works as a way out for both the locals and the diasporas in today’s increasingly globalized world.

关键词： identity formation Asian-American literature Native Speaker The Woman Warrior cosmopolitanism

ESG Discourse Analysis Through BERTopic: Comparing News Articles and Academic Papers

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Computers, Materials & Continua 2023年第6期75卷 6023-6037页

作者： Haein Lee seon Hong Lee Kyeo Re Lee Jang Hyun kim Department of Applied Artificial Intelligence/Department of Human-Artificial Intelligence Interaction Sungkyunkwan UniversitySeoul03063Korea Center for SW Education Hanyang UniversityAnsan15588Korea Department of Interaction Science/Department of Human-Artificial Intelligence Interaction Sungkyunkwan UniversitySeoul03063Korea

Environmental,social,and governance(ESG)factors are critical in achieving sustainability in business management and are used as values aiming to enhance corporate ***,non-financial indicators have been considered as important for the actual valuation of corporations,thus analyzing natural language data related to ESG is *** previous studies limited their focus to specific countries or have not used big *** methodologies are insufficient for obtaining potential insights into the best practices to leverage *** address this problem,in this study,the authors used data from two platforms:LexisNexis,a platform that provides media monitoring,and Web of Science,a platform that provides scientific *** big data were analyzed by topic *** modeling can derive hidden semantic structures within the *** this process,it is possible to collect information on public and academic *** authors explored data from a text-mining perspective using bidirectional encoder representations from transformers topic(BERTopic)—a state-of-the-art topic-modeling *** addition,changes in subject patterns over time were considered using dynamic topic *** a result,concepts proposed in an international organization such as the United Nations(UN)have been discussed in academia,and the media have formed a variety of agendas.

关键词： ESG BERTopic natural language processing topic modeling

Triolein emulsion infusion into the hepatic artery increases vascular permeability to doxorubicin in rabbit liver

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World Journal of Gastroenterology 2021年第2期27卷 152-161页

作者： Yong-Woo kim Hak Jin kim Byung Mann Cho seon Hee Choi Department of Radiology Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalPusan National University College of MedicineYangsan 50612South Korea Department of Radiology Biomedical Research InstitutePusan National University HospitalPusan National University College of MedicineBusan 49241South Korea Preventive Medicine and Occupational Medicine Pusan National University School of MedicineYangsan 50612South Korea Department of Radiology Pusan National UniversityBusan 49241South Korea

BACKGROUND The infusion of triolein emulsion(TE)induced increased vascular permeability and a negligible and temporary decrease in liver function without specific histopathological *** To assess changes in doxorubicin concentration according to the percentage of TE infused via a hepatic artery to study the vascular permeability in the rabbit *** Thirty-nine healthy rabbits were divided into five groups according to the concentration of emulsified triolein infused into the hepatic arteries:Group 0,saline infusion(control group,n=5);group 1,0.3%TE(n=13);group 2,0.6%TE(n=6);group 3,0.9%TE(n=8);and group 4,1.5%TE(n=6).Doxorubicin(2.4 mg/kg)was infused immediately after TE injection via the hepatic *** 2 h,the livers were harvested,and doxorubicin concentrations were calculated *** doxorubicin concentrations were compared between TE groups and the control group,and the optimal concentrations within the TE groups were *** analysis was performed using the nonparametric Mann-Whitney U test and Kruskal-Wallis test.P0.05).CONCLUSION TE infusion into the hepatic arteries significantly increased the doxorubicin concentration approximately twofold but was not different between the TE *** findings suggest that TE infusion might be a useful adjuvant treatment of liver cancers.

关键词： Triolein emulsion Liver tumor Chemotherapy Drug delivery Vascular permeability Dexorubicin

Fast ethylamine gas sensing based on intermolecular charge-transfer complexation

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Chinese Chemical Letters 2012年第4期23卷 484-487页

作者： Eun Mi Lee seon Young Gwon Young A Son Sung Hoon kim BK21 FTIT Department of Advanced Organic Materials and Textile System EngineeringChungnam National UniversityDaejeon 305-764Republic of Korea Department of Textile System Engineering Kyungpook National UniversityDaegu 702-701 Republic of Korea School of Chemistry Science & Technology Zhanjiang Normal UniversityZhanjiang 524048China

We have investigated the fast ethylamine gas sensing of 2-chloro-3,5-dinitrobenzotrifluoride（CDBF） loaded poly（acrylonitrile） nanofiber based on an intermolecular charge-transfer *** response and recovery were ach... 详细信息

关键词： Ethylamine gas Fast gas sensing 2-Chloro-3 5-dinitrobenzotrifluoride(CDBF) Electrospinning PAN nanofiber Intermolecular charge-transfer(CT) complexation

Bioprinting Methods for Fabricating In Vitro Tubular Blood Vessel Models

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Cyborg and Bionic Systems 2023年第1期4卷 178-195页

作者： seon-Jin kim Min-Gyun kim Jangho kim Jessie SJeon Jinsoo Park Hee-Gyeong Yi Department of Rural and Biosystems Engineering College of Agriculture and Life SciencesChonnam National UniversityGwangjuRepublic of Korea Department of Convergence Biosystems Engineering College of Agriculture and Life SciencesChonnam National UniversityGwangjuRepublic of Korea Interdisciplinary Program in IT-Bio Convergence System Chonnam National UniversityGwangju 61186Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Department of Mechanical Engineering Chonnam National UniversityRepublic of Korea

Dysfunctional blood vessels are implicated in various diseases,including cardiovascular diseases,neurodegenerative diseases,and *** studies have attempted to prevent and treat vascular diseases and understand interactions between these diseases and blood vessels across different organs and *** studies were conducted using 2-dimensional(2D)in vitro and animal ***,these models have difficulties in mimicking the 3D microenvironment in human,simulating kinetics related to cell activities,and replicating human pathophysiology;in addition,3D models involve remarkably high ***,in vitro bioengineered models(BMs)have recently gained *** created through biofabrication based on tissue engineering and regenerative medicine are breakthrough models that can overcome limitations of 2D and animal *** can also simulate the natural microenvironment in a patient-and target-specific *** this review,we will introduce 3D bioprinting methods for fabricating bioengineered blood vessel models,which can serve as the basis for treating and preventing various vascular ***,we will describe possible advancements from tubular to vascular ***,we will discuss specific applications,limitations,and future perspectives of fabricated BMs.

关键词： Blood organs printing

Protective Effect of Brassica napus *** against Inflammation Response in RAW 264.7 Cells

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Chinese Journal of Integrative Medicine 2021年第4期27卷 273-279页

作者： Su-Hyeon Cho Song Rae kim Myeong seon Jeong Miri Choi seonJu Park Kil-Nam kim Chuncheon Center Korea Basic Science InstituteChuncheon(24341)Republic of Korea

Objective:To demonstrate the anti-inflammatory activity of Brassica napus ***(BNH)in lipopolysaccharide(LPS)-stimulated RAW 264.7 ***:Composition analysis of BNH was conducted via gas chromatography-mass spectrometry after BNH were *** nitric oxide(NO)production was measured using the Griess *** E2(PGE2)production was evaluated with enzyme-linked immunosorbent *** effects of BNH on LPS-induced pro-inflammatory enzymes including inducible nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2)were evaluated using Western blot ***,phosphorylation of nuclear factor-kappa B(N F-k B)and nuclear translocation of N F-k B p65 were evaluated with Western blot analysis and immunofluorescence staining,***:Compared with LPS-stimulated cells,BNH markedly decreased the generation of NO and PGE_(2)in LPS-stimulated RAW 264.7 cells(P<0.01 or P<0.05).Moreover,BNH inhibited protein levels of iNOS and COX-2(P<0.01).Phosphorylation of NF-k B and nuclear translocation of NF-k B p65 was significantly inhibited by BNH(P<0.01 or P<0.05).Conclusion:The anti-inflammatory activities of BNH were mediated via blockage of the N F-k B signaling pathways in LPS-stimulated RAW 264.7 cells.

关键词： Brassica napus L. inflammation lipopolysaccharide RAW 264.7 cells hydrosols