Bioprinting Methods for Fabricating In Vitro Tubular Blood Vessel Models
作者机构：Department of Rural and Biosystems EngineeringCollege of Agriculture and Life SciencesChonnam National UniversityGwangjuRepublic of Korea Department of Convergence Biosystems EngineeringCollege of Agriculture and Life SciencesChonnam National UniversityGwangjuRepublic of Korea Interdisciplinary Program in IT-Bio Convergence SystemChonnam National UniversityGwangju 61186Republic of Korea Department of Mechanical EngineeringKorea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Department of Mechanical EngineeringChonnam National UniversityRepublic of Korea
出 版 物：《Cyborg and Bionic Systems》 (类生命系统（英文）)
年 卷 期：2023年第4卷第1期
页 面：178-195页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程]
基 金：supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(no.2020R1A5A8018367) the Technology Innovation Program(or Industrial Strategic Technology Development Program(20015148,Development of Neural/Vascular/Muscular-Specific Peptides-conjugated Bioink and Volumetric Muscle Tissue)funded By the Ministry of Trade,Industry&Energy(MOTIE,Korea)
摘 要：Dysfunctional blood vessels are implicated in various diseases,including cardiovascular diseases,neurodegenerative diseases,and *** studies have attempted to prevent and treat vascular diseases and understand interactions between these diseases and blood vessels across different organs and *** studies were conducted using 2-dimensional(2D)in vitro and animal ***,these models have difficulties in mimicking the 3D microenvironment in human,simulating kinetics related to cell activities,and replicating human pathophysiology;in addition,3D models involve remarkably high ***,in vitro bioengineered models(BMs)have recently gained *** created through biofabrication based on tissue engineering and regenerative medicine are breakthrough models that can overcome limitations of 2D and animal *** can also simulate the natural microenvironment in a patient-and target-specific *** this review,we will introduce 3D bioprinting methods for fabricating bioengineered blood vessel models,which can serve as the basis for treating and preventing various vascular ***,we will describe possible advancements from tubular to vascular ***,we will discuss specific applications,limitations,and future perspectives of fabricated BMs.
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