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Oncologic efficacy of gonadotropin-releasing hormone agonist in hormone receptor-positive very young breast cancer patients treated with neoadjuvant chemotherapy

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World Journal of Clinical Cases 2023年第27期11卷 6398-6406页

作者： Hee Jun Choi Jun Ho Lee Chang Shin Jung Jai Min Ryu Byung Joo Chae Se Kyung Lee Jong Han Yu seok Won Kim seok jin nam Jeong Eon Lee Youn Joo Jung Hyun Yul Kim Department of Surgery Samsung Changwon HospitalSungkyunkwan University School of MedicineChangwon 51353South Korea Division of Breast Surgery Department of SurgerySamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Department of Surgery Pusan National University Yangsan HospitalPusan National University School of MedicineGyeongnam 50612South Korea

BACKGROUND Breast cancer in young women has been shown to have an aggressive behavior and poor *** To evaluate the outcomes of young hormone receptor(HR)-positive patients with breast cancer treated with neoadjuvant chemotherapy(NAC),and the oncologic efficacy of gonadotropin-releasing hormone(GnRH)*** This retrospective study involved a prospectively enrolled *** included patients diagnosed with invasive breast cancer who were treated with NAC followed by curative surgery at the Samsung Medical Center and Samsung Changwon Hospital between January 2006 and December *** patients with HR-positive and human epidermal grow factor 2(HER2)-negative breast cancer,we analyzed the characteristics and oncology outcomes between the patients equal to or younger than 35 years and the patients older than 35 *** Among 431 patients with NAC and HR-positive/HER2-negative breast cancer,78 were 35 years old or younger,and 353 patients were older than 35 *** median follow-up was 71.0 *** was no statistically significant difference in disease free survival(DFS,P=0.565)and overall survival(P=0.820)between the patients equal to or younger than 35 years and the patients older than 35 *** two groups differed in that the GnRH agonist was used more frequently in the group of patients equal to or younger than 35 years than in the other group(52.4%vs 11.2%,P<0.001).Interestingly,for the DFS according to the GnRH agonist in the group of patients equal to or younger than 35 years,patients treated with the GnRH agonist had better DFS(P=0.037).CONCLUSION Administration of GnRH agonists might improve the DFS rate of HR-positive/HER2-negative breast cancer in the equal to or younger than 35 years group of patients with NAC.

关键词： Gonadotropin-releasing hormone Agonist Young Breast Cancer

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Combating Drug Resistance in Colorectal Cancer Using Herbal Medicines

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Chinese Journal of Integrative Medicine 2021年第7期27卷 551-560页

作者： Lee Ga-Young Lee jin-seok Son Chang-Gue Lee nam-Hun Department of Clinical Oncology Cheonan Korean Medicine Hospital of Daejeon UniversityCheonan31099Republic of Korea Liver&Immunology Research Center Dunsan Korean Medicine Hospital of Daejeon UniversityDaejeon35235Republic of Korea Department of Internal Medicine Graduated School of Korean MedicineUniversity of DaejeonDaejeon34520Republic of Korea

Colorectal cancer(CRC)is one of the most prevalent and lethal cancer types around the *** of the CRC patients are treated with chemotherapeutic drugs alone or ***,up to 90%of metastatic cancer patients experience the failure of treatment mostly because of the acquired drug resistance,which can be led to multidrug resistance(MDR).In this study,we reviewed the recent literature which studied potential CRC MDR reversal agents among herbal medicines(HMs).Among abundant HMs,6 single herbs,Andrographis paniculata,Salvia miltiorrhiza,Hedyotis diffusa,Sophora flavescens,Curcuma longa,Bufo gargarizans,and 2 formulae,Pien Tze Huang and Zhi Zhen Fang,were found to overcome CRC MDR by two or more different mechanisms,which could be a promising candidate in the development of new drugs for adjuvant CRC chemotherapy.

关键词： colorectal cancer drug resistance herbal medicine

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Optimization of roller shape for roller-type onion pot-seeding machine

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International Journal of Agricultural and Biological Engineering 2020年第1期13卷 111-119页

作者： seok-Joon Hwang Ju-seok nam Dept.of Biosystems Engineering Kangwon National University1 Kangwondaehak-gilChuncheonGangwon-do24341Republic of Korea

In this study,roller shape optimization was performed on a roller-type pot-seeding machine used for sowing onion *** parameters for optimization were derived by analyzing the operating characteristics of the pot-seeding *** on this,the roller shape was determined to minimize weight while satisfying the required *** the optimized roller shape was applied,it was possible to reduce the weight of the roller by 17.7%compared with the conventional one,while satisfying the safety factor of 2.0 or *** optimum bed soil compaction required for onion sowing was also ***,applying the roller shape derived from this study to an existing roller-type pot-seeding machine may increase the production efficiency of healthy seedling.

关键词： onion pot-seeding machine roller-type shape optimization

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Wire-Shaped 3D-Hybrid Supercapacitors as Substitutes for Batteries

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Nano-Micro Letters 2020年第2期12卷 211-223页

作者： Kyeong‑nam Kang Ananthakumar Ramadoss jin‑Wook Min Jong‑Chul Yoon Deokjung Lee seok Ju Kang Ji‑Hyun Jang School of Energy and Chemical Engineering Low Dimensional Carbon Materials CenterUlsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Laboratory for Advanced Research in Polymeric Materials Central Institute of Plastic Engineering and TechnologyBhubaneswar 751024India School of Mechanical Aerospace and Nuclear EngineeringUlsan National Institute of Science and TechnologyUlsan 44919Republic of Korea

We report a wire-shaped three-dimensional(3D)-hybrid supercapacitor with high volumetric capacitance and high energy density due to an interconnected 3D-configuration of the electrode allowing for large number of electrochemical active sites,easy access of electrolyte ions,and facile charge transport for flexible wearable *** interconnected and compact electrode delivers a high volumetric capacitance(gravimetric capacitance)of 73 F cm−3(2446 F g−1),excellent rate capability,and cycle *** 3D-nickel cobalt-layered double hydroxide onto 3D-nickel wire(NiCo LDH/3D-Ni)//the 3D-manganese oxide onto 3D-nickel wire(Mn3O4/3D-Ni)hybrid supercapacitor exhibits energy density of 153.3 Wh kg−1 and power density of 8810 W kg−*** red lightemitting diode powered by the as-prepared hybrid supercapacitor can operate for 80 min after being charged for tens of seconds and exhibit excellent electrochemical stability under various deformation *** results verify that such wire-shaped 3D-hybrid supercapacitors are promising alternatives for batteries with long charge–discharge times,for smart wearable and implantable devices.

关键词： Three-dimensional(3D)metal current collector Flexible hybrid supercapacitor Wire-shaped supercapacitor High energy density device Fast charging energy storage system

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Omnidirectional color wavelength tuning of stretchable chiral liquid crystal elastomers

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Light(Science & Applications) 2024年第6期13卷 1062-1074页

作者： Seungmin nam Wontae Jung Jun Hyuk Shin Su seok Choi Department of Electrical Engineering Pohang University of Science and Technology(POSTECH)PohangKorea

Wavelength-tunable structural colors using stimuli-responsive materials,such as chiral liquid crystals(CLCs),have attracted increasing attention owing to their high functionality in various tunable photonic ***,on-demand omnidirectional wavelength control is highly desirable from the perspective of wavelength-tuning ***,despite numerous previous research efforts on tunable CLC structural colors,only mono-directional wavelength tuning toward shorter wavelengths has been employed in most studies to *** this study,we report the ideally desired omnidirectional wavelength control toward longer and shorter wavelengths with significantly improved tunability over a broadband wavelength *** using areal expanding and contractive strain control of dielectric elastomer actuators(DEAs)with chiral liquid crystal elastomers(CLCEs),simultaneous and omnidirectional structural color-tuning control was *** breakthrough in omnidirectional wavelength control enhances the achievable tuning freedom and versatility,making it applicable to a broad range of high-functional photonic applications.

关键词： tuning tunable directional

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Effect of solid-solution strengthening on deformation mechanisms and strain hardening in medium-entropy V_(1-x)Cr_(x)CoNi alloys

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Journal of Materials Science & Technology 2022年第13期108卷 270-280页

作者： Hyun Chung Dae Woong Kim Woo jin Cho Heung nam Han Yuji Ikeda Shoji Ishibashi Fritz Körmann seok Su Sohn Department of Materials Science and Engineering Korea UniversitySeoul 02841South Korea Center for High Entropy Alloys Pohang University of Science and TechnologyPohang 37673South Korea Department of Materials Science and Engineering and Research Institute of Advanced Materials Seoul National UniversitySeoul 08826South Korea Institute for Materials Science University of StuttgartPfaffenwaldring 55Stuttgart 70569Germany Computational Materials Design Max-Planck-Institut für Eisenforschung GmbHMax-Planck-Strabe 1Düsseldorf 40237Germany Research Center for Computational Design of Advanced Functional Materials(CD-Fmat) National Institute of Advanced Industrial Science and Technology(AIST)TsukubaIbaraki 305-8568Japan Department of Materials Science and Engineering Delft University of TechnologyMekelweg2Delft 2628 CDthe Netherlands

High-and medium-entropy alloys(HEAs and MEAs)possess high solid-solution *** investigations have been conducted on its impact on yield strength,however,there are limited reports regarding the relation between solid-solution strengthening and strain-hardening *** addition,no attempt has been made to account for the dislocation-mediated plasticity;most works focused on twinning-or transformation-induced plasticity(TWIP or TRIP).In this work we reveal the role of solidsolution strengthening on the strain-hardening rate via systematically investigating evolutions of deformation structures by controlling the Cr/V ratio in prototypical V_(1-x)Cr_(x)CoNi *** the TWIP of CrCoNi with the dislocation slip of V_(0.4)Cr_(0.6)CoNi,the hardening rate of CrCoNi was superior to slip-band refinements of V_(0.4)Cr_(0.6)CoNi due to the dynamic Hall-Petch ***,as V content increased further to V_(0.7)Cr_(0.3)CoNi and VCoNi,their rate of slip-band refinement in V_(0.7)Cr_(0.3)CoNi and VCoNi with high solid-solution strength surpassed that of *** it is generally accepted in conventional alloys that deformation twinning results in a higher strain-hardening rate than dislocation-mediated plasticity,we observed that the latter can be predominant in the former under an activated huge solid-solution strengthening *** high solid-solution strength lowered the cross-slip activation and consequently retarded the dislocation rearrangement rate,i.e.,the dynamic *** delay in the hardening rate decrease,therefore,increased the strain-hardening rate,results in an overall higher strain-hardening rate of V-rich alloys.

关键词： Medium-entropy alloy Tensile property Solid-solution strength Strain-hardening rate Stacking fault energy

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Effect of an Artificial Caudal Fin on the Performance of a Biomimetic Fish Robot Propelled by Piezoelectric Actuators

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Journal of Bionic Engineering 2007年第3期4卷 151-158页

作者： seok Heo Tedy Wiguna Hoon Cheol Park nam Seo Goo Artificial Muscle Research Center Konkuk UniversitySeoul 143-701Korea Department of Advanced Technology Fusion Konkuk UniversitySeoul 143-701Korea Department of Advanced Technology Fusion Artificial Muscle Research Center and Smart Robot CenterKonkuk UniversitySeoul 143-701Korea

This paper addresses the design of a biomimetic fish robot actuated by piezoeeramic actuators and the effect of artificial caudal fins on the fish robot＇s performance. The limited bending displacement produced by a lightweight piezocomposite actuator was amplified and transformed into a large tail beat motion by means of a linkage system. Caudal fins that mimic the shape of a mackerel fin were fabricated for the purpose of examining the effect of caudal fm characteristics on thrust production at an operating frequency range. The thickness distribution of a real mackerel＇s fin was measured and used to design artificial caudal fins. The thrust performance of the biomimetic fish robot propelled by fins of various thicknesses was examined in terms of the Strouhal number, the Froude number, the Reynolds number, and the power consumption. For the same fm area and aspect ratio, an artificial caudal fin with a distributed thickness shows the best forward speed and the least power consumption.

关键词： LIPCA biomimetic fish robot caudal fro Strouhal number Froude number Reynolds number

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Role of kaempferol to increase bioavailability and pharmacokinetics of nifedipine in rats

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Chinese Journal of Natural Medicines 2019年第9期17卷 690-697页

作者： PARK Ji-Won CHOI jin-seok Hazardous Substances Analysis Division Gwangju Regional Office of Food and Drug SafetyGwangju 61012Republic of Korea Department of Medical Management Chodang UniversityJeollanam-do 58530Republic of Korea

Herein,the purpose of this study is to evaluate the effects of kaempferol on bioavailability and pharmacokinetics of nifedipine and its metabolite dehydronifedipine in *** experimental design is based on with or without kaempferol in the oral and intravenous administration of nifedipine in ***,the pharmacokinetic parameters including nifedipine and dehydronifedipine were evaluated in *** in vitro studies of kaempferol were investigated on P-glycoprotein(P-gp)and cytochrome P450(CYP)3A4 *** reduced a 50%inhibitory concentration(IC50)of 8.6μmol·L-1 on CYP3A4 enzyme ***,kaempferol clearly improved the cell internalization of rhodamine-123 in MCF-7/ADR cells overexpressing *** on increased concentrations of kaempferol,the areas under the plasma concentration–time curve(AUC0-∞)and the peak concentration(Cmax)of nifedipine were increased after oral and intravenous ***,the absolute bioavailability(AB)and relative bioavailability(RB)of nifedipine in the presence of kaempferol was significantly higher than those of the control group after oral and intravenous *** of bioavailability of nifedipine by kaempferol may be mainly because of the inhibition of the P-gp-mediated efflux transporter in the small intestine and CYP3A4-mediated metabolism in the small intestine or liver,or both.

关键词： Nifedipine Kaempferol CYP3A4 P-gp Pharmacokinetics Bioavailability

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Effects of methotrexate on collagen-induced arthritis in male Wistar rats

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The Journal of Biomedical Research 2019年第4期33卷 244-249页

作者： jin seok Kang Department of Biomedical Laboratory Science Namseoul University

To evaluate the effect of methotrexate on collagen-induced arthritis,micro-computed tomography(micro-CT)and histopathological analyses were used in male Wistar *** were divided randomly into three *** 1 was treated with 0.9% saline,and groups 2 and 3 were boosted with type II *** day 21 to 42,groups 1 and 2 were orally treated with 0.9% saline and group 3 was orally treated with 1.5 mg/kg *** rats were sacrificed at day 42 after the first collagen ***-CT analyses showed bony parameters,such as bone volume and trabecular number,were decreased in group 2 compared to group 1,and these parameters were recovered in group *** examination and pathological parameter scoring showed that the knee joints of rats in group 2 had severe joint destruction,showing cartilage and bone erosion,enlarged cavities with inflammatory cell infiltration and activation of synovial *** contrast,these changes were reduced in group *** together,methotrexate treatment showed therapeutic potential in male rat collageninduced arthritis model,and micro-CT analysis and histopathological tools could be integrated to assess the quantification/qualification of arthritic lesions.

关键词： arthritis rat collagen micro-computed tomography histopathology

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Advantage of endoscopic mucosal resection with a cap for rectal neuroendocrine tumors

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World Journal of Gastroenterology 2015年第31期21卷 9387-9393页

作者： Su Bum Park Hyung Wook Kim Dae Hwan Kang Cheol Woong Choi Su jin Kim Hyeong seok nam Department of Internal Medicine Pusan National University School of Medicine Research institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital

AIM: To compare the outcomes of endoscopic mucosal resection with a cap(EMR-C) with those of endoscopic submucosal dissection(ESD) for the resection of rectal neuroendocrine ***: One hundred and sixteen lesions in 114 patients with rectal neuroendocrine tumor(NET) resected with EMR-C or ESD were included in the study. This study was performed at Pusan National University Yangsan Hospital between July 2009 and August 2014. We analyzed endoscopic complete resection rate,pathologic complete resection rate,procedure time,and adverse events in the EMR-C(n = 65) and ESD(n = 51) groups. We also performed a subgroup analysis by tumor ***: Mean tumor size was 4.62 ± 1.66 mm in the EMR-C group and 7.73 ± 3.14 mm in the ESD group(P < 0.001). Endoscopic complete resection rate was 100% in both groups. Histologic complete resection rate was significantly greater in the EMR-C group(92.3%) than in the ESD group(78.4%)(P = 0.042). Mean procedure time was significantly longer in the ESD group(14.43 ± 7.26 min) than in the EMR-C group(3.83 ± 1.17 min)(P < 0.001). Rates of histologic complete resection without complication were similar for tumor diameter ≤ 5 mm(EMR-C,96%; ESD,100%,P = 0.472) as well as in cases of 5 mm < tumor diameter ≤ 10 mm(EMR-C,80%; ESD,71.0%,P = 0.524).CONCLUSION: EMR-C may be simple,faster,and more effective than ESD in removing rectal NETs and may be preferable for resection of small rectal NETs.

关键词： Neuroendocrine tumor Endoscopic mucosal resection

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