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Comparison of anterior segment optical coherence tomography findings in acanthamoeba keratitis and herpetic epithelial keratitis

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International Journal of Ophthalmology(English edition) 2018年第8期11卷 1416-1420页

作者： Young Min Park jong Soo Lee Ji-Myong Yoo jong Moon Park seong-wook seo In-Young Chun seong Jae Kim Department of Ophthalmology School of Medicine Gyeongsang National University Jinju 52727 South Korea Gyeongsang National University Changwon Hospital Samjeongja-ro Seongsan-gu Changwon-si Gyeongsangnamdo 51472 South Korea Department of Ophthalmology School of Medicine Pusan National University and Medical Research Institute Pusan National University Hospital Pusan 49241 South Korea Institute of Health Science Gyeongsang National UniversityJinju 52727 South Korea

This study is to investigate the characteristic features of Acanthamoeba keratitis（AK） that differentiating it from herpetic epithelial keratitis（HEK） using anterior segment optical coherence tomography（AS-OCT）. Medical records of three eyes of each AK and herpetic keratitis who had AS-OCT examination were reviewed in this study. Slitlamp biomicroscopy and AS-OCT was performed on the initial visit and on every follow-up visits in all patients. In all three AK cases, reflective bands in the corneal stroma that correspond to the area of radial keratoneuritis were observed. The depth of the reflective bands varied in each case. After AK treatment, slit-lamp biomicroscopy confirmed that radial keratoneuritis had resolved and AS-OCT confirmed that reflective bands in the corneal stroma had also disappeared in all patients. Unlike the AS-OCT results found in AK, highly reflective HEK lesions were observed only in the subepithelial area, not in the stroma. AS-OCT seems to be helpful analyzing the specific depth of the lesion which enables to distinguish AK from HEK.

关键词： acanthamoeba optical coherence tomography herpes herpetic keratitis

Optimization of thermoelectric properties of n-type Bi_2(Te,Se)_3 with optimizing ball milling time

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Rare Metals 2018年第4期37卷 351-359页

作者： Ji-Hee Son Min-wook Oh Bong-seo Kim Su-Dong Park Thermoelectric Conversion Research Center Korea Electrotechnology Research Institute Department of Materials Science and Engineering Hanbat National University

The thermoelectric properties at elevated temperature were investigated for n-type Bi2（Te,Se）3 which is obtained from ball milling processed powder with various milling times. Electrical properties such as electrical resistivity and Seebeck coefficient are clearly dependent on milling time, in which the carrier concentration is attributed to the change of the electrical properties. The concentrations of the defects are also varied with the ball milling time, which is the origin of the carrier concentration variation. Even though finer grain sizes are obtained after the long ball milling time, the temperature dependence of the thermal conductivity is not solely understood with the grain size, whereas the electrical contribution to the thermal conductivity should be also considered. The highest figure of merit value of ZT = 0.83 is achieved at 373 K for the optimized samples, in which ball milling time is 10 h. The obtained ZT value is 48% improvement over that of the 0.5-h sample at 373 K.

关键词： Thermoelectric properties Ball milling Bi2Te3 Seebeck coefficient Grain size Thermalconductivity

Suppression of laser-induced choroidal neovascularization by intravitreal injection of tristetraprolin

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 952-958页

作者： Yong Wun Cho Yong seop Han In Young Chung seong Jae Kim seong wook seo Ji Myong Yoo jong Moon Park Department of Ophthalmology Gyeongsang National University School of Medicine Gyeongsang Institute of Health Science Gyeongsang National University

AIM: To examine the effect of intravitreal adenoviral vector-mediated tristetraprolin(Ad-TTP) on VEGF m RNA expression in a rat model of laser-induced choroidal ***: Ad-TTP was prepared using a commercial kit. Retinal laser-induced photocoagulation(10 spots per eye) was performed on rats in this experimental choroidal neovascularization(CNV) model. Rats were divided into four groups: control(single intravitreal injection of balanced salt solution, n =10), laser-induced CNV(photocoagulation only, n =20), laser-induced CNV plus Ad-TTP injection(photocoagulation plus a single intravitreal Ad-TTP injection, n =20) and Ad-TTP injection only(n =10). Changes in choroidal morphology were evaluated in ten rats in the laser only and the laser plus Ad-TTP groups. Two weeks after laser injury, the size of CNV was calculated by perfusion with high-molecular-weight fluorescein isothiocyanate(FITC)-dextran. VEGF m RNA expression in retina-choroid tissue from ten rats in each group was measured by reverse transcription polymerase chain reaction(RT-PCR). RESULTS: Two weeks after treatment, the area of laser-induced CNV was reduced by approximately 60% in the rats given the Ad-TTP injection compared with that in the laser-only group. There was a tendency toward decreased VEGF m RNA expression in the Ad-TTP injection ***: A single intravitreal injection of Ad-TTP significantly suppressed CNV size in this experimental laser-induced CNV model. Ad-TTP injection also decreased VEGF m RNA expression compared with that inthe laser-induced CNV group. The present study is meaningful as the first study to investigate the effect of tristetraprolin delivered via intravitreal injection.

关键词： laser-induced choroidal neovascularization tristetraprolin adenoviral vectors

Effects of asphalt types and aging on healing performance of asphalt mixtures using induction heating method

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第2期7卷 227-236页

作者： Hai Viet Vo Dae-wook Park Jung-Woo seo Tri Ho Minh Le Faculty of Civil Engineering Ton Duc Thang UniversityHo Chi Minh CityVietnam Department of Civil Engineering Kunsan National UniversityKimsan 54150South Korea

This paper investigates the effects of types and aging of asphalt binder on healing performance of asphalt mixture modified with steel wool fibers(SWF)using induction heating *** binders PG58-22,PG64-22 and PG76-22,widely used in Korea,were applied in this *** rolling thin film oven(RTFO)and pressure ageing vessel(PAV)tests were conducted to simulate the aging process of asphalt *** healing performance of mixtures was evaluated by the crack-heal process,which included semi-circular bending and induction heating *** cooking oil waste was used as a rejuvenator in order to refresh the aged binder and its healing performance was also *** results indicated that the performance grade(PG)of asphalt binder slightly affected the healing performance of mixtures due to the difference of binder *** addition,the healing level of asphalt mixture was reduced significantly by aged asphalt ***,it was found that using cooking oil waste as a rejuvenator for the aged asphalt mixture can improve its healing performance.

关键词： Asphalt mixture Induction heating Steel wool fibers Healing Aging Cooking oil waste

Electrochemical Performance and ex situ Analysis of ZnMn2O4 Nanowires as Anode Materials for Lithium Rechargeable Batteries

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Nano Research 2011年第5期4卷 505-510页

作者： Sung-wook Kim Hyun-wook Lee Pandurangan Muralidharan Dong-Hwa seo Won-Sub Yoon Do Kyung Kim Kisuk Kang Research Institute of Advanced Materials Seoul National University 599 Kwanak-ro Kwanak-gu Seoul 151-742 Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology 335 Gwahangno Yuseong-gu Daejeon 305-701 Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology 335 Gwahangno Yuseong-gu Daejeon 305-701 Republic of Korea Department of Materials Science and Engineering Seoul National University 599 Kwanak-ro Kwanak-gu Seoul 151-742 Republic of Korea

One-dimensional ZnMn2O4 nanowires have been prepared and investigated as anode materials in Li rechargeable batteries. The highly crystalline ZnMn2O4 nanowires about 15 nm in width and 500 nm in length showed a high specific capacity of about 650 mAh.g-1 at a current rate of 100 mA.g-1 after 40 cycles. They also exhibited high power capability at elevated current rates, i.e., 450 and 350 mAh.g 1 at current rates of 500 and 1000 mA.g 1, respectively. Formation of Mn3O4 and ZnO phases was identified by ex situ X-ray diffraction （XRD） and transmission electron microscopy （TEM） studies after the initial discharge-charge cycle, which indicates that the ZnMn2O4 phase was converted to a nanocomposite of Mn3O4 and ZnO phases immediately after the electrochemical conversion reaction.

关键词： Energy storage lithium rechargeable battery anode ZnMn204 nanowire

Prevalence and risk factors of wound complications after transtibial amputation in patients with diabetic foot

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World Journal of Diabetes 2024年第4期15卷 629-637页

作者： Young Uk Park seong Hyuk Eim Young wook seo Department of Orthopedic Surgery Ajou University School of MedicineAjou University HospitalSuwon 16499South Korea

BACKGROUND Diabetic foot(DMF)complications are common and are increasing in *** factors related to wound complications are yet to be established after transtibial amputation under the diagnosis of DMF *** To analyze the prognosis and risk factors related to wound complications after transtibial amputation in patients with *** This retrospective cohort study included seventy-two patients with DMF complications who underwent transtibial amputation between April 2014 and March *** groups were categorized based on the occurrence of wound complications,and we compared demographic data between the complication group and the non-complication group to analyze risk ***,a multivariate logistic regression analysis was performed to identify risk *** The average follow-up period was 36.2 *** the 72 cases,31(43.1%)had wound *** these,12 cases(16.7%)received further treatment,such as debridement,soft tissue stump revision,and re-amputation at the proximal *** a group that required further management due to wound complications after transtibial amputation,the hemoglobin A1c(HbA1c)level was 9.32,while the other group that did not require any treatment had a 7.54 HbA1c *** prevalence of a history of kidney transplantation with wound complications after transtibial amputation surgery in DMF patients was significantly greater than in cases without wound complications(P=0.02).Other factors did not show significant *** Approximately 43.1%of the patients with transtibial amputation surgery experienced wound complications,and 16.7%required additional surgical *** HbA1c levels and kidney transplant history are risk factors for postoperative wound complications.

关键词： Diabetic foot Transtibial amputation Wound complications Risk factor

Cost-effective screening using a two-antibody panel for detecting mismatch repair deficiency in sporadic colorectal cancer

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World Journal of Clinical Cases 2021年第24期9卷 6999-7008页

作者： jong Beom Kim Young Il Kim Yong Sik Yoon Jihun Kim seo Young Park jong Lyul Lee Chan wook Kim In Ja Park seok-Byung Lim Chang Sik Yu Jin Cheon Kim Division of Colon and Rectal Surgery University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Pathology University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Clinical Epidemiology and Biostatistics University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND The microsatellite instability(MSI)test and immunohistochemistry(IHC)are widely used to screen DNA mismatch repair(MMR)deficiency in sporadic colorectal cancer(CRC).For IHC,a two-antibody panel of MLH1 and MSH2 or four-antibody panel of MLH1,MSH2,PMS2,and MSH6 are *** general,MSI is known as a more accurate screening test than *** To compare two-and four-antibody panels of IHC in terms of accuracy and cost benefit on the basis of MSI testing for detecting MMR *** We retrospectively analyzed patients with CRC who underwent curative surgery between 2015 and 2017 at a tertiary referral *** IHC with four antibodies and MSI tests were routinely *** sensitivity and specificity of a fourand two types of two-antibody panels(PMS2/MSH6 and MLH1/MSH2)were compared on the basis of MSI testing for detecting MMR *** High-frequency MSI was found in 5.5%(n=193)of the patients(n=3486).The sensitivities of the four-and two types of two-antibody panels were 97.4%,92.2%,and 87.6%,*** specificities of the three types of panels did not differ significantly(99.6%for the four-antibody and PMS2/MSH6 panels,99.7%for the MLH1/MSH2 panel).Based on Cohen's kappa statistic(κ),four-and twoantibody panels were in almost perfect agreement with the MSI test(κ>0.9).The costs of the MSI test and the four-and two-antibody panels of IHC were approximately$200,$160,and$80,*** Considering the cost of the four-antibody panel IHC compared to that of the twoantibody panel IHC,a two-antibody panel of PMS2/MSH6 might be the best choice in terms of balancing cost-effectiveness and accuracy.

关键词： Adenocarcinoma DNA mismatch repair Immunochemistry Monoclonal antibody Microsatellite instability Cost-effectiveness

Realizing High Thermoelectric Performance in n-Type Se-Free Bi_(2)Te_(3)Materials by Spontaneous Incorporation of FeTe_(2)Nanoinclusions

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Energy & Environmental Materials 2024年第4期7卷 344-354页

作者： Jamil Ur Rahman Woo Hyun Nam Yong-Jae Jung jong Ho Won jong-Min Oh Nguyen Van Du Gul Rahman Víctor M.García-Suárez Ran He Kornelius Nielsch Jung Young Cho Won-seon seo jong wook Roh Sang-il Kim Soonil Lee Kyu Hyoung Lee Hyun Sik Kim Weon Ho Shin Leibniz Institute for Solid State and Materials Research Dresden 01069Germany Advanced Materials Convergence R&D Division Korea Institute of Ceramic Engineering&TechnologyJinju 52861South Korea Department of Electronic Materials Engineering Kwangwoon UniversitySeoul 01897South Korea Department of Energy Engineering Dankook UniversityCheonan 31116South Korea Faculty of Fundamental Science Phenikaa UniversityHanoi 10000Vietnam Department of Physics Quaid-i-Azam UniversityIslamabad 45320Pakistan Departamento de FAısica Universidad de OviedoOviedo 33007Spain Nanomaterials and Nanotechnology Research Center-CINN El Entrego 33940Spain Department of Materials Science and Engineering Yonsei UniversitySeoul 03722South Korea School of Nano&Materials Science and Engineering Kyungpook National UniversitySangju 37224South Korea Department of Materials Science and Engineering University of SeoulSeoul 02504South Korea School of Materials Science and Engineering Changwon National UniversityChangwon 51140South Korea

Bi_(2)Te_(3)-based materials have drawn much attention from the thermoelectric community due to their excellent thermoelectric performance near room ***,the stability of existing n-type Bi_(2)(Te,Se)_(3)materials is still low due to the evaporation energy of Se(37.70 kJ mol^(-1))being much lower than that of Te(52.55 kJ mol^(-1)).The evaporated Se from the material causes problems in interconnects of the module while degrading the ***,we have developed a new approach for the high-performance and stable n-type Se-free Bi_(2)Te_(3)-based materials bymaximizing the electronic transport while suppressing the phonon transport,at the same *** generated FeTe_(2)nanoinclusions within the matrix during the melt-spinning and subsequent spark plasma sintering is the key to simultaneous engineering of the power factor and lattice thermal *** nanoinclusions change the fermi level of the matrix while intensifying the phonon scattering via *** a fine-tuning of the fermi level with Cu doping in the n-type Bi_(2)Te_(3)-0.02FeTe_(2),a high power factor of∼41×10^(-4)Wm^(-1)K^(-2)with an average zT of 1.01 at the temperature range 300-470 K are achieved,which are comparable to those obtained in n-type Bi_(2)(Te,Se)_(3)*** proposed approach enables the fabrication of high-performance n-type Bi_(2)Te_(3)-based materials without having to include volatile Se element,which guarantees the stability of the ***,widespread application of thermoelectric devices utilizing the n-type Bi_(2)Te_(3)-based materials will become possible.

关键词： Bi_(2)Te_(3) energy harvesting FeTe_(2) nanoinclusion n-type materials thermoelectric

Resveratrol prevents hypoxia-induced retinal ganglion cell death related with ErbB2

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 394-400页

作者： Hyemin seong Joo Yeon Jeong Jinhyun Ryu Juyeong Park Yong‑seop Han Hyun-Kyung Cho seong Jae Kim jong Moon Park Sang Soo Kang seong wook seo Department of Ophthalmology Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinjuGyeongnam 52727Republic of Korea Department of Anatomy and Convergence Medical Science Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinjuGyeongnam 52727Republic of Korea Department of Ophthalmology Gyeongsang National University Changwon HospitalGyeongsang National UniversityCollege of MedicineChangwon 51472Republic of Korea

AIM: To confirm the changes in proteins related with hypoxia-induced retinal cell death and to assess the effects of resveratrol(Res).METHODS: The therapeutic effect of Res was verified using an ischemic/reperfusion(I/R) model in vivo and a hypoxia modelin retinal ganglion cells(RGCs) in *** of RGCs were confirmed by TUNEL *** expression was confirmed by Western blotting and *** addition, flow cytometric analysis was used to confirm the response in the cell unit to obtain more accurate ***: ErbB2 expression and apoptosis in the ganglion cell layer(GCL) increased after I/R *** of Res rescued I/R-induced ganglion cell death, downregulated apoptosis and ErbB2 protein expression in the *** subsequent in vitro models, Res affects apoptosis by regulating the phosphorylation and expression of mouse double minute 2 homolog(MDM2), along with those of *** results suggest that Res reverses GCL-specific apoptosis via downregulation of ErbB2 in ischemic ***: In light of Res favorable properties, it should be evaluated in the treatment of RGC death and related retinal disease characterized by ErbB2 and MDM2 ***, Res is appropriate therapeutic agent for treating ischemic injury-related eye diseases by targeting the expression of ErbB2 and MDM2.

关键词： ischemia/reperfusion injury hypoxia retinal ganglion cell resveratrol ErbB2