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Risk factors for ribavirin treatment failure in Asian organ transplant recipients with chronic hepatitis E infection

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World Journal of Hepatology 2019年第6期11卷 553-561页

作者： En Xian Sarah Low Edhel Tripon Kieron Lim Poh seng Tan How Cheng Low Yock Young Dan Yin Mei Lee Mark Muthiah Wai Mun Loo Calvin Jianyi Koh Wah Wah Phyo JunXiong Pang seng Gee Lim Guan-Huei Lee Department of Medicine Ng Teng Fong General HospitalNational University Health SystemSingapore 609606Singapore Centre for Liver Disease Management and Transplant of Medical City Manila 1605Philippines Mount Elizabeth Medical Centre Singapore 228510Singapore Division of Gastroenterology and Hepatology National University Health SystemSingapore 119228Singapore Department of Medicine National University of SingaporeSingapore 119077Singapore Centre for Infectious Disease Epidemiology and Research National University of SingaporeSingapore 117549Singapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore

BACKGROUND Hepatitis E virus(HEV)infection is a cause of chronic hepatitis in immunosuppressed *** virologic response rates to a 12-wk course of ribavirin therapy were reported to be>70%in the *** study describes the outcome of HEV treatment in a transplant center in *** To study the outcome of ribavirin treatment in a series of chronic HEV patients,and the cause of treatment *** We studied all of the transplant recipients who were diagnosed with HEV infection between 2012 to *** outcome of therapy and virologic relapse are monitored for three years after the end of *** Ten transplant recipients(4 liver,5 kidney,and 1 bone marrow transplantation)with positive HEV RNA were *** patients received at least 12 wk of ribavirin therapy,and the remaining patient resolved after reducing immunosuppression *** subjects had prolonged viremia that lasted more than one year,despite continuous ribavirin *** ribavirin-treated patients(44.4%)had HEV RNA relapse after achieving a virologic response by the end of *** overall failure rate is 66.7%.Being a kidney transplant recipient is the strongest risk factor for not achieving an initial sustained virologic response(0/5 treated,Chi-Square test,P<0.05).The most common side effect of ribavirin is anemia(100%)(haemoglobin reduction of 3-6.2 g/dL).Seven patients required either a blood transfusion or erythropoietin *** The sustained virologic response rate of 12-wk ribavirin therapy for HEV infection in this Asian series was lower than *** transplant recipients had a higher rate of treatment failure due to higher immunosuppression requirements and adverse effects.

关键词： Toxicity Antiviral agents Hepatitis E virus Virus classification Systemic immunity Immune responses Persistent infection

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Effect of ginger on gastric motility and symptoms of functional dyspepsia

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World Journal of Gastroenterology 2011年第1期17卷 105-110页

作者： Ming-Luen Hu Christophan K Rayner Keng-Liang Wu seng-Kee Chuah Wei-Chen Tai Yeh-Pin Chou Yi-Chun Chiu King-Wah Chiu Tsung-Hui Hu Division of Hepatogastroenterology Department of Internal Medicine Chang Gung Memorial Hospital- Kaohsiung Medical Center Chang Gung University College of Medicine Kaohsiung 83301 Taiwan Discipline of Medicine University ofAdelaide Royal Adelaide Hospital Adelaide SA 5000 Australia

AIM:To evaluate the effects of ginger on gastric motility and emptying,abdominal symptoms,and hormones that influence motility in ***:Eleven patients with functional dyspepsia were studied twice in a randomized double-blind *** an 8-h fast,the patients ingested three capsules that contained ginger(total 1.2 g) or placebo,followed after 1 h by 500 mL low-nutrient *** area,fundus area and diameter,and the frequency of antral contractions were measured using ultrasound at frequent intervals,and the gastric half-emptying time was calculated from the change in antral *** sensations and appetite were scored using visual analog questionnaires,and blood was taken for measurement of plasma glucagon-like peptide-1(GLP-1),motilin and ghrelin concentrations,at intervals throughout the ***:Gastric emptying was more rapid after ginger than placebo [median(range) half-emptying time 12.3(8.5-17.0) min after ginger,16.1(8.3-22.6) min after placebo,P ≤ 0.05].There was a trend for more antral contractions(P = 0.06),but fundus dimensions and gastrointestinal symptoms did not differ,nor did serum concentrations of GLP-1,motilin and ***:Ginger stimulated gastric emptying and antral contractions in patients with functional dyspepsia,but had no impact on gastrointestinal symptoms or gut peptides.

关键词： Ginger(Zinger offinale) Functional dyspepsia Gastric emptying Antral contraction Abdominal ultrasound Ghrelin Glucagon-like peptide-1 Motilin

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Performance of U-tube Solar Water Heaters Facing Different Directions

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Journal of Energy and Power Engineering 2013年第9期7卷 1729-1734页

作者： Ong Kok-seng Tong Wei-Li David Cheong Universiti Tunku Abdul Rahman Jalan Universiti Bandar Barat Kampar 31900 Perak Malaysia Monash University Sunway Campus Jalan Lagoon Selatan Bandar Sunway 46150 Selangor Malaysia

System performance of solar water heaters depends upon collector and storage tank designs, solar radiation intensity and ambient temperature, amongst others. Evacuated glass tube collectors with U-tubes inside are less prone to leakages than the all-glass or the heat pipe types. U-tube solar water heaters suspended on walls and balconies could help overcome present day roof space restriction and increasing apartment-style housing. As such, their performance would depend upon its orientation when mounted in a vertical position. This paper reports the results of outdoor tests conducted on natural convection U-tube solar water heaters oriented towards different directions. Long and short term test procedures were employed to allow us to compare their performances as if they were tested simultaneously side-by-side.

关键词： Solar water heater evacuated glass tube U-tube collector natural convection long and short term tests directional effects.

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THE OPTICAL TARGET-A NEW FIVE DIMENSIONAL TRANSDUCER USING LASER HOLOGRAPHY

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天津大学学报 1983年第2期 97-106页

作者： Xu Bing-ting Ye seng-hua Wei Shang-chen

This paper introduces principal problems of design and practical applying-the result of balance calibration-concerning the fundamental principle of five dimensional transducer of laser holographic light splitting carr... 详细信息

关键词： THE OPTICAL TARGET-A NEW FIVE DIMENSIONAL TRANSDUCER USING LASER HOLOGRAPHY Work

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Enzymatic recovery of glycopeptides from different industrial grades edible bird’s nest and its by-products:nutrient,probiotic and antioxidant activities,and physicochemical characteristics

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Food Science and Human Wellness 2022年第6期11卷 1555-1564页

作者： Hidayati Syamimi Mohd Noor Rafi dah Mohd Ariff Lee Sin Chang Xin Yi Chai Hui Yan Tan Nur’Aliah Daud Abdul Salam Babji seng Joe Lim Faculty of Science and Technology Universiti Kebangsaan MalaysiaBangi 43600Malaysia International Institute for Halal Research and Training(INHART) International Islamic University Malaysia(IIUM)Jalan Gombak 53100Malaysia Faculty of Applied Sciences UCSI University Kuala LumpurCheras 56000Malaysia Faculty of Agriculture Science and Technology Universiti Putra Malaysia Bintulu CampusBintulu 97008Malaysia Innovative Centre for Confectionery Technology(MANIS) Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaBangi 43600Malaysia

This study was conducted to recover edible bird’s nest(EBN)hydrolysates from different grades of EBN,including the industrial by-products,using enzymatic *** nutrient,physicochemical properties and antioxidant activities of the recovered hydrolysates at different hydrolysis times were *** showed that the recovery yield of enzymatic hydrolysis was above 89%for all grades of EBN and the degree of hydrolysis increased over *** content(0.321-0.433 mg/L)was below the permissible tolerance level for all ***,the antioxidant activities(DPPH and ABTS scavenging activities and ferric reducing antioxidant powder(FRAP)activity)were significantly higher(P≤0.05)in hydrolysates recovered from EBN by-products(EBNhC and EBNhD)as compared to the high grade EBN hydrolysates(EBNhA and EBNhB).The in-vitro probiotic activity of EBN and its hydrolysates were examined using the probiotic bacterium Lactobacillus ***,EBN by-products hydrolysate(EBNhD)recorded the highest number of ***(1.1×1011 CFU/mL),indicating that low grade EBN has the potential as prebiotic material that promotes probiotic *** study demonstrated the concept of using EBN by-products hydrolysates for various applications,such as functional ingredients with enhanced bioactivities,to improve its economic value.

关键词： Edible bird’s nest by-products Enzymatic hydrolysis Glycopeptides Lactobacillus plantarum Probiotic activity

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Various Collocated Circular Loop Antennas: Theory, Analysis and Design

Various Collocated Circular Loop Antennas: Theory, Analysis ...

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2004无线电科学国际会议

作者： eong Mook-seng Sivanand Krishnan ECE Dept. National University of Singapore 10 Kent Ridge Crescent Singapore 119260 ECE Dept. National University of Singapore 10 Kent Ridge Crescent Singapore 119260Institute for Infocomm Research 20 Science Park Road #02-21/25 Singapore 117674

Collocated circular loops form an important class of antenna structures with potential for use in direction-finding and many other applications. In this paper, a general formulation

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Improved Multiple-Scenario Radio Network Dimensioning for WCDMA

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International Journal of Communications, Network and System Sciences 2012年第1期5卷 17-27页

作者： Thiaw seng Ng Teong Chee Chuah Yifei Tan 不详

In wideband code division multiple access (WCDMA) cellular systems, the coverage radius of a cell depends on its current capacity level. As a result, existing WCDMA radio network dimensioning approaches require that coverage and capacity planning be carried out jointly in an iterative manner in order to obtain the minimum site count needed while fulfilling both coverage and capacity requirements. This requires relatively long computational time, particularly when there are many scenarios or what-if cases to be considered. To overcome this problem, we propose an alternative radio network dimensioning approach where coverage planning and capacity planning can be carried out separately to reduce computational time. Besides, a portion of the values calculated in the initial iteration is preserved in a lookup graph, allowing future what-if analysis to be accomplished rapidly. Simulation results show that, unlike the existing approach, the planning and what-if analysis times of the proposed dimensioning approach are independent of the number of sce-narios considered. Lastly, we present a few case studies and show that the proposed dimensioning method can give the same prediction accuracy as the existing method.

关键词： WCDMA Dimensioning

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全膝关节置换的放射学力线测量

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中华骨科杂志 2005年第9期25卷 57-59页

作者：王大伟 Lo Nagi Nung Yeo seng Jing 山东省聊城市人民医院骨科 252000 新加坡中央医院成人关节重建外科

全膝关节置换(total knee replacement,TKR)术后下肢力线是骨科医生比较关心的问题,根据下肢力线正确安放假体是手术成功的关键.如果假体位置不当,会导致疼痛、关节活动度受限、松动、磨损和关节不稳定.许多研究认为TKR的使用寿命在某... 详细信息

全膝关节置换(total knee replacement,TKR)术后下肢力线是骨科医生比较关心的问题,根据下肢力线正确安放假体是手术成功的关键.如果假体位置不当,会导致疼痛、关节活动度受限、松动、磨损和关节不稳定.许多研究认为TKR的使用寿命在某种程度上取决于术后下肢力线是否合适[1]。

关键词：力线全膝关节置换股骨髁部解剖轴外翻角计算机导航导向器外旋 femoral 关节间隙

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太赫兹新型探测器的研究进展及应用

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红外与毫米波学报 2020年第2期39卷 191-210页

作者：张玉平唐利斌刘玉菲 Kar seng Teng 吴刚胡伟达韩福忠昆明物理研究所云南昆明650223 重庆大学光电技术及系统教育部重点实验室重庆400044 斯旺西大学工程学院英国斯旺西SA18EN 中国科学院上海技术物理研究所上海200083

太赫兹波由于其独特的光学和电学性质,在物理学、生物学、公共安全检查、局域通信、信息安全、环境监测、无损检测和国防科技等民用或军事领域都有着广阔的应用前景。太赫兹探测器作为太赫兹领域的核心器件,在太赫兹系统中扮演着重要角... 详细信息

太赫兹波由于其独特的光学和电学性质,在物理学、生物学、公共安全检查、局域通信、信息安全、环境监测、无损检测和国防科技等民用或军事领域都有着广阔的应用前景。太赫兹探测器作为太赫兹领域的核心器件,在太赫兹系统中扮演着重要角色。因此太赫兹探测器的性能,决定了太赫兹系统的应用市场。近年来,太赫兹探测器的发展已取得突破性的成果,但是太赫兹探测器还存在着一些普遍的问题,制冷的太赫兹探测器虽然有响应速率快和噪声等效功率低等优点,但是其紧凑性不好,并且成本较高。室温可工作的太赫兹探测器虽然不需要制冷环境,但是噪声等效功率偏大,灵敏度也不高。该综述从太赫兹探测器的制备材料和器件形式等方面,阐述了太赫兹探测器的发展现状及其应用领域。

关键词：太赫兹探测器材料研究进展应用现状

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两汉之际 “河西五郡” 共同体的建构与解体——兼论金城郡的地缘关系

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中国历史地理论丛 2022年第1期37卷 92-99页

作者：僧海霞西北大学历史学院陕西西安710127

更始末,张掖属国都尉窦融基于黄河为河西地区屏障的地理认知,以河西四郡跨越乌鞘岭联合金城郡,形成了据境自保的“河西五郡”地域共同体,自任“河西五郡大将军”。窦融此举更改了金城郡的地缘关系,使其进入河西、陇右和中原的区域互动... 详细信息

更始末,张掖属国都尉窦融基于黄河为河西地区屏障的地理认知,以河西四郡跨越乌鞘岭联合金城郡,形成了据境自保的“河西五郡”地域共同体,自任“河西五郡大将军”。窦融此举更改了金城郡的地缘关系,使其进入河西、陇右和中原的区域互动关系中。东汉建立后,刘秀联合窦融的河西集团,夹击并消灭割据陇右的隗嚣势力集团;后公孙述败,“河西五郡”完全失去战略联盟的价值,其解体成为必然。“河西五郡”地域共同体的形成,是窦融将隗嚣视为阻隔其与中原政权交通的独立集团,是多区域结构性关联的结果。两汉之际人们对河西自然区地理界线认识的模糊,是金城郡被纳入“河西五郡”体系的直接原因,而窦融集团的政治需要则是其重要推动力,但此举未能根本改变金城郡的地理区位,也未能结成稳定的地缘关系。

关键词：金城郡河西五郡窦融结构性关联地缘政治

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