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Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice

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Acta Pharmaceutica Sinica b 2024年第7期14卷 3068-3085页

作者： Dongping Li Rongjuan Wei Xianglong Zhang Shenhai Gong Meijuan Wan Fangzhao Wang Jiaxin Li Meiling Chen Ruofan Liu yantong Wan yinghao Hong Zhenhua Zeng Peng Gu Zhang Wang Kutty selva Nandakumar yong Jiang Hongwei Zhou Peng Chen Department of Pathophysiology Guangdong Provincial Key Laboratory of ProteomicsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510000China Department of Critical Care Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China Department of Gastroenterology Shenzhen HospitalSouthern Medical UniversityShenzhen 518000China Institute of Ecological Sciences School of Life SciencesSouth China Normal UniversityGuangzhou 510000China Department of Environmental and biosciences School of BusinessInnovation and SustainabilityKristian IV’s vag 3Halmstad UniversityHalmstad 30004Sweden Microbiome Medicine Center Zhujiang HospitalSouthern Medical UniversityGuangzhou 510000China

Sepsis progression is significantly associated with the disruption of gut ***,the modulatory mechanisms of gut microbiota operating during sepsis are still ***,we investigated how gut commensals impact sepsis development in a pre-clinical *** ligation and puncture(CLP)surgery was used to establish polymicrobial sepsis in *** depleted of gut microbiota by an antibiotic cocktail(AbX)exhibited a significantly higher level of mortality than *** determined by metabolomics analysis,AbX treatment has depleted many metabolites,and subsequent supplementation with L-rhamnose(rhamnose,Rha),a bacterial carbohydrate metabolite,exerted profound immunomodulatory properties with a significant enhancement in macrophage phagocytosis,which in turn improved organ damage and ***,rhamnose binds directly to and activates the solute carrier family 12(potassium-chloride symporter),member 4(SLC12A4)in macrophages and promotes phagocytosis by activating the small G-proteins,Ras-related C3 botulinum toxin substrate1(Rac1)and cell division control protein 42 homolog(Cdc42).Interestingly,rhamnose has enhanced the phagocytosis capacity of macrophages from sepsis *** conclusion,by identifying SLC12A4 as the host interacting protein,we disclosed that the gut commensal metabolite rhamnose is a functional molecular that could promote the phagocytosis capacity of macrophages and protect the host against sepsis.

关键词： Gut microbiota Sepsis Rhamnose SLC12A4 GTP-Rac1 GTP-Cdc42 Macrophage Phagocytosis

Image Segmentation of brain MR Images Using Otsu’s based Hybrid WCMFO Algorithm

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Computers, Materials & Continua 2020年第8期64卷 681-700页

作者： A.Renugambal K.selva bhuvaneswari Department of Mathematics University College of Engineering KancheepuramKanchipuram631552India Department of Computer Science and Engineering University College of Engineering KancheepuramKanchipuram631552India

In this study,a novel hybrid Water Cycle Moth-Flame Optimization(WCMFO)algorithm is proposed for multilevel thresholding brain image segmentation in Magnetic Resonance(MR)image *** constitutes a hybrid between the two techniques,comprising the water cycle and moth-flame optimization *** optimal thresholds are obtained by maximizing the between class variance(Otsu’s function)of the *** test the performance of threshold searching process,the proposed algorithm has been evaluated on standard benchmark of ten axial T2-weighted brain MR images for image *** experimental outcomes infer that it produces better optimal threshold values at a greater and quicker convergence *** contrast to other state-of-the-art methods,namely Adaptive Wind Driven Optimization(AWDO),Adaptive bacterial Foraging(AbF)and Particle Swarm Optimization(PSO),the proposed algorithm has been found to be better at producing the best objective function,Peak Signal-to-Noise Ratio(PSNR),Standard Deviation(STD)and lower computational time ***,it was observed thatthe segmented image gives greater detail when the threshold level ***,the statistical test result confirms that the best and mean values are almost zero and the average difference between best and mean value 1.86 is obtained through the 30 executions of the proposed ***,these images will lead to better segments of gray,white and cerebrospinal fluid that enable better clinical choices and diagnoses using a proposed algorithm.

关键词： Hybrid WCMFO algorithm Otsu’s function multilevel thresholding image segmentation brain MR image

Autophagy induced by STING, an unnoticed and primordial function of cGAS

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Cellular & Molecular Immunology 2019年第8期16卷 683-684页

作者： Junjie yang Xiaoshan Tang Kutty selva Nandakumar Kui Cheng Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Cyclic GMP-AMP synthase(cGAS),combined with dsDNA,produces cyclic GMP-AMP(cGAMP)to stimulate STING and activates the kinases TbK1 and IKK to induce interferon and other cytokines,which play an important role in host *** addition to the traditional interferon inflammatory signaling pathway of cGAS,recently,Chen et al.1 discovered a new mechanism in which cGAS-cGAMP-STING activated autophagy through WIPI2 and *** is a process induced under various cellular stress conditions,such as oxygen deficit,nutrient deprivation,lack of growth factors,and infection,aiming to maintain the basic survival of cells or promote apoptosis of senescent cells.2,3 The activation of the autophagy-related(ATG)1/Unc-51-like kinase(ULK)complex is vital for autophagy *** ATG1/ULK1 complex phosphorylates or recruits its downstream proteins,contributing to autophagosome formation.3 Under the regulation of related genes,“cargo”is transferred to the lysosome and digested by various *** addition,cyclic GMP-AMP synthase(cGAS),which detects exogenous or self-damaged dsDNA in the cytoplasm after binding to dsDNA,produces cGAMP to activate the adaptor protein stimulator of interferon genes(STING),triggering the downstream pathway and secretion of interferon or other cytokines.

关键词： maintain transferred STING

Ellagic acid in strawberry(Fragaria spp.):biological,technological,stability,and human health aspects

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Food Quality and Safety 2017年第4期1卷 227-252页

作者： selva Muthukumaran Carole Tranchant John Shi Xingqian ye Sophia Jun Xue Department of Food Science and Post-Harvest Technology Institute of TechnologyHaramaya UniversityPost Box 138Dire DawaEthiopia School of Food Science Nutrition and Family StudiesFaculty of Health Sciences and Community ServicesUniversitéde MonctonMonctonNew Brunswick E1A 3E9Canada***Guelph Research and Development CenterAgriculture and Agri-Food Canada93 Stone Road WestGuelphOntario N1G 5C9Canada School of biosystems Engineering and Food Science Zhejiang UniversityHangzhouChina

Ellagic acid(EA)is one of the plant phenolics associated with human health *** derives from ellagitannins found in some nuts,seeds,and fruits,especially *** are considered a functional food and nutraceutical source,mainly because of their high concentration of EA and its *** review presents the current state of knowledge regarding EA,focusing on its content in strawberry plants,stability during processing and storage of strawberry-based foods,production methods,and relevance to human *** alternatives to acid-solvent extraction,fermentation-enzymatic bioprocesses hold great promises for more eco-efficient production of EA from plant *** fruits are generally rich in EA,with large variations depending on cultivar,growth conditions and maturity at *** EA contents are also reported in strawberry achenes and leaves,and in wild *** postharvest storage,processing and subsequent storage can influence EA *** low concentration in strawberry juice and wine can be increased by incorporating pre-treated *** recognition of strawberries as functional foods is substantiated by evidence of EA biological effects,including antioxidant,antiinflammatory,antidiabetic,cardioprotective,neuroprotective,and prebiotic *** health benefits attributed to EA-rich foods are thought to involve various protective mechanisms at the cellular *** EA is converted by the intestinal microbiota to urolithins,which are better absorbed than EA and may contribute significantly to the health effects attributed to EA-rich *** on the evidence available,strawberry EA shows strong promises for functional,nutraceutical,and pharmaceutical *** research should be directed at quantifying EA in different parts of the strawberry plant and in their byproducts;optimizing EA production from byproducts;understanding the biological actions of EA-derived metabolites in vivo,inc

关键词： Strawberry plant Ellagic acid Processing Metabolism bioacti

A novel E153X point mutation in the androgen receptor gene in a patient with complete androgen insensitivity syndrome

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Asian Journal of Andrology 1999年第1期1卷 73-77页

作者： Silvia b Copelli Serge Lumbroso Francoise Audran Eliana H Pellizzari Juan J Heinrich selva b Cigorraga Charles Sultan Héctor E Chemes Laboratore d'Hormonologie Hopital Lapeyronie et INSER U 439 Pathologie des recepteurs nucleaires.Unite d'Endocrinologie et Gynecologie PediatriquesHopital A.de VillenetiveMontpellier-France CEDIE-CONICET Division de EndocrinologtaHospital de Niflos"Ricardo Gutierrez"Buenos AiresArgentina

Aim:To study a 46,Xy newborn patient with a phenotype suggestive of an androgen insensitivity syndrome toconfirn an anomaly in the AR ***:Genomic DNA from leukocytes was isolated in order to analyze SRygene by PCR and sequencing of the eight exons of AR *** of human Leydig cell mesenchymal precursorsfrom the testis was performed in order to study testosterone production and response to hCG stimulation in ***:Surgical exploration disclosed two testes,no Wolffian structures and important Mullerian *** gene was present in peripheral blood *** of the AR gene evidenced a previously unreported Gto T transversion in exon 1 that changed the normal glutamine 153 codon to a stop *** cell culturesproduced sizable amounts of testosterone and were responsive to hCG ***:This E153X nonsensepoint mutation has not been described previously in cases of AIS,and could lead to the synthesis of a short truncated(153 vs 919 residues)non functional AR probably responsible for the phenotype of complete androgen insensitivitysyndrome(CAIS).

关键词： testicular feminization androgen receptor point mutation Mullerian ducts

Studies on the seasonal variations in the proximate composition of ascidians from the Palk bay,Southeast coast of India

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Asian Pacific Journal of Tropical biomedicine 2012年第10期2卷 793-797页

作者： Ananthan G Karthikeyan MM selva Prabhu A Raghunathan C Centre of Advanced Study in Marine biology Faculty of Marine SciencesAnnamalai University Zoological Survey of India Andaman and NicobarRegional Station.1Horticulture RoadHaddoPort Blair744102

Objective:To investigate the seasonal fluctuations of the proximate composition of the ascidians ***:The moisture content was estimated by drying 1 g of fresh tissue at a constant temperature at 105(?)for 24 *** loss of weight was taken as moisture *** total protein was estimated using the biuret *** total carbohydrate in dried sample was estimated spectrophotometrically following the phenol-sulphuric acid *** lipid in the dried sample tissue was gravimetrically estimated following the chloroform-methanol mixture *** content was determined gravimetrically by incinerating 1 g dried sample in muffle furnace at about 550℃for 6 h and results are expressed in ***:It was found very difficult to compare the monthly variations,as all the ten species,exhibited wide fluctuations in their proximate *** the sake of convenience,average seasonal values were calculated by summing the monthly ***:The proximate composition of the 10 commonly available ascidians showed high nutritive value and hence these groups especially solitary ascidians can be recommended for human consumption in terms of pickles,soup,curry and others after ensuring the safety of consumers.

关键词： Ascidians biochemical composition Seasonal variations proximate composition

患单侧特发性全层黄斑裂孔的马来西亚患者脉络膜厚度研究(英文)

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国际眼科杂志 2018年第3期18卷 401-405页

作者： Chew y Tan selva R Vengadasalam Amir Samsudin Nurliza Khaliddin 马来亚大学医学院眼科马来西亚吉隆坡50603 Selayang医院眼科马来西亚雪兰莪州68100

目的:比较患单侧特发性全层黄斑裂孔(FTMH)眼、对侧眼以及正常对照组黄斑脉络膜厚度。方法:横断面研究。选取30例单侧特发性全层黄斑裂孔马来西亚患者,以及年龄、性别、种族相匹配的正常对照组。用激光干涉法测量研究对象眼轴长度。利... 详细信息

目的:比较患单侧特发性全层黄斑裂孔(FTMH)眼、对侧眼以及正常对照组黄斑脉络膜厚度。方法:横断面研究。选取30例单侧特发性全层黄斑裂孔马来西亚患者,以及年龄、性别、种族相匹配的正常对照组。用激光干涉法测量研究对象眼轴长度。利用谱域光学相干层析成像技术获取增强深度成像光学相干断层成像。在黄斑中心凹处,距中心凹1 mm和2 mm鼻侧、颞侧、上方、下方测量脉络膜厚度。采用独立统计分析法、配对样本ttests、chi-square tests和Pearson相关性检验进行数据分析。结果:全层黄斑裂孔组平均中心凹脉络膜厚度为201.0±44.0μm,对侧眼平均为225.3±51.4μm,对照组为262.3±70.3μm。相较于对照组,全层黄斑裂孔各部位脉络膜较薄(P0.05)。脉络膜厚度通常在中心凹处最高,在鼻侧最低。黄斑中心凹脉络膜厚度与年龄(r=-0.278,P=0.032)和眼轴长度(r=-0.328,P=0.011)呈负相关。结论:单侧全层黄斑裂孔患眼与对侧眼和健康对照组相比,脉络膜厚度较低。

关键词：脉络膜厚度黄斑裂孔光学相干断层扫描谱域增强深度成像海德尔堡

Periocular necrotising fasciitis after traumatic laceration and concurrent COVID-19 infection:a case report

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Annals of Eye Science 2023年第1期8卷 3-7页

作者： Terence Ang Thomas Rogerson Thilochana Nagolla yugesh Caplash Dinesh selva The University of Adelaide AdelaideSouth AustraliaAustralia Department of Ophthalmology The Royal Adelaide HospitalAdelaideSouth AustraliaAustralia Department of Plastic and Reconstructive Surgery Royal Adelaide HospitalAdelaideSouth AustraliaAustralia

background:Necrotising fasciitis(NF)is a rare but severe necrotising infection of the subcutaneous *** report a case of periocular NF associated with a concurrent COVID-19 infection and explore potential mechanisms of pathogenesis of COVID-19 infection and necrotising *** Description:A 33-year-old previously healthy female presented with right-sided progressive periocular swelling,erythema,pain and fever,two days after sustaining a laceration to the right superolateral brow from a clenched *** had a concurrent COVID-19 infection,detected on nasopharyngeal polymerase chain reaction swab thirteen days prior to presentation and again at *** did not have an oxygen *** was a large bulbous collection of the right upper lid with fluctuance and overlying erythema,and a communicating sinus drained frank pus from the superolateral ***-operative T2-weighted MRI demonstrated fascial hyperintensity involving the pre-septal tissues and extending to the anterior temporal *** was commenced on intravenous meropenem,clindamycin and vancomycin,and underwent early surgical *** debridement demonstrated right upper lid necrosis involving the dermal and pre-septal layers,including the orbicularis,but sparing the *** pyogenes was isolated,and she was continued on a prolonged course of intravenous *** defects were repaired with a right-sided brow adipo-fascial flap based on the supratrochlear artery,browpexy and dual full thickness skin grafts on the right upper lid and ***:NF is an acute fulminant infection rarely affecting the periocular *** represents a unique case of periocular NF associated with a concurrent COVID-19 infection.

关键词： Necrotising fasciitis(NF) periocular COVID-19 infection case report

Antiproliferative role of Indig ofera aspalathoides on 20 methylcholanthrene induced fibrosarcoma in rats

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Asian Pacific Journal of Tropical biomedicine 2012年第12期2卷 966-974页

作者： Sivagnanam selva Kumar Mudiganti Ram Krishna Rao Maruthaiveeran Periyasamy balasubramanian Department of Industrial biotechnology Bharath University Department of Pharmacology and Environmental Toxicology Dr.A.L.M.Post graduate Institute of Basic Medical SciencesUniversity of Madras

Objective:To find out the anticancer effect of indigofera aspalathoides(***)on20-methylcholanthrene induced fibrosarcoma in ***:Fibrosarcoma was induced in Wistar strain male albino rats by ***(i.p.)administration of250 mg/kg body weight/day of aqueous extract of *** for 30 d effectively suppressed chemically induced *** such as body weight,liver and kidney weight,tumor weight,mean survival time,behavioral changes,blood glucose,blood glycogen and marker enzymes such as alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),acid phosphatase(ACP)and 5'-nucleiotidase(5'-NT)in serum,liver and kidney and lipid profiles such as total cholesterel,phospholipids,free fatty acids in liver and kidney of control and experimental animals were ***:Fibrosarcoma bearing animals were ferocious and *** mean survival time was found to increase after the *** body weights were significantly decreased(Pbrosarcoma animals which steadily increased after the treatment with *** liver and kidney weights were significantly increased whereas the tumor weights decreased as compared to the weights in untreated fibrosarcoma bearing *** blood glucose and the liver and kidney glycogen levels were found to decrease significantly(Pymes were observed in serum,liver and kidney of fibrosarcoma bearing GroupⅡanimals which were normalize after *** *** the liver and kidney of GroupⅡanimals the total cholesterol increased whereas the pbospbolipids and free fatty acid levels decreased(Pby *** on fihrosarcoma bearing rats has improved the levels of various parameters indicating its antiproliferative and anticancer activity.

关键词： Chemoprevention Tumor weight Mean survival time Glucose Glycogen Marker enzymes