Autophagy induced by STING, an unnoticed and primordial function of cGAS

作     者：Junjie Yang Xiaoshan Tang Kutty Selva Nandakumar Kui Cheng 

作者机构：Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and TreatmentSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2019年第16卷第8期

页      面：683-684页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by National Natural Science Foundation of China(No.81773558) Guangzhou Science and Technology Project(No.201904010380) 

主　　题：maintain transferred STING 

摘      要：Cyclic GMP-AMP synthase(cGAS),combined with dsDNA,produces cyclic GMP-AMP(cGAMP)to stimulate STING and activates the kinases TBK1 and IKK to induce interferon and other cytokines,which play an important role in host *** addition to the traditional interferon inflammatory signaling pathway of cGAS,recently,Chen et al.1 discovered a new mechanism in which cGAS-cGAMP-STING activated autophagy through WIPI2 and *** is a process induced under various cellular stress conditions,such as oxygen deficit,nutrient deprivation,lack of growth factors,and infection,aiming to maintain the basic survival of cells or promote apoptosis of senescent cells.2,3 The activation of the autophagy-related(ATG)1/Unc-51-like kinase(ULK)complex is vital for autophagy *** ATG1/ULK1 complex phosphorylates or recruits its downstream proteins,contributing to autophagosome formation.3 Under the regulation of related genes,“cargois transferred to the lysosome and digested by various *** addition,cyclic GMP-AMP synthase(cGAS),which detects exogenous or self-damaged dsDNA in the cytoplasm after binding to dsDNA,produces cGAMP to activate the adaptor protein stimulator of interferon genes(STING),triggering the downstream pathway and secretion of interferon or other cytokines.