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Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan

World Journal of Gastroenterology 2010年第40期16卷 5084-5091页

作者： Yutaka Suzuki Seryna Tamez Akihiko Murakami Akihiko Taira Akihiro Mizuhara Akira Horiuchi Chie Mihara Eiji Ako Hirohito Muramatsu Hitoshi Okano Hitoshi Suenaga Kazuaki Jomoto Junya Kobayashi Katsunari Takifuji Kazuhiro Akiyama Koh Tahara Koji Onishi Makoto Shimazaki Masami Matsumoto Masashi Ijima Masato Murakami Masato Nakahori Michiaki Kudo Michio Maruyama Mikako Takahashi Naohiro Washizawa Shigeru Onozawa Satoshi Goshi Satoyoshi Yamashita Shigeki Ono Shin Imazato Shinji Nishiwaki Shuichirou Kitahara Takao Endo Takao Iiri Takeshi Nagahama Takuto Hikichi tatsuya Mikami Tetsuo Yamamoto Tetsushi Ogawa Tomoko Ogawa Tomoyuki Ohta Toshifumi Matsumoto Toshiroh Kura Tsutomu Kikuchi Tsuyoshi Iwase Tsuyotoshi Tsuji Yukio Nishiguchi Mitsuyoshi Urashima Department of Surgery International Universi-ty of Health and Welfare Hospital Department of Molecular Epidemiology Jikei University School of Medicine Endoscopy Unit Iwate prefectural Central Hospital Department of Internal Medicine Tsuyama Chuo Hospital Department of Surgery Higashi Washi-nomiya Hospital Digestive Disease Center Showa Inan General Hospital Department of Neurology Ebina Medical Sup-port Center Department of Surgery Sumitomo Hospital Department of Gastroenterology Kiyota Hospital Department of Gastroenterology Okano Clinic Department of Geriatrics Hitachikoh Hospital Department of Internal Medicine Jomoto Gastroenteric and Internal Medical Clinic Department of Surgery Fujiyoshida Munici-pal Hospital 2nd Department of Surgery Wakayama Medical University Hospital Department of Surgery Tokatsu-clinic Hospital Department of Surgery Kure Kyosai Hospital Department of Internal Medicine Matsue Sei-kyo Genaral Hospital Department of Gastroenterology Hirano General Hospital Department of Internal Medicin Nara Prefectural Gojo Hospital Department of Internal Medicine Isesaki Mu-nicipal Hospital Department of Internal Medicine Muraka-mi Memorial Hospital Digestive Endoscopy Center Sendai Kousei Hospital Department of Surgery Onishi Hospital Department of Surgery Tokyo Metropoli-tan Ohkubo Hospital Department of Internal Medicine Tsuruoka Kyoritsu Hospital Nutritional Therapy Center Toho Uni-versity Omori Medical Center Home Care Department Kameda Medical Hospital Endoscopic Treatment Center Japan Labour Health and Welfare Organization Niigata Rousai Hospital Department of Gastroenterology and Hepatology Social Insurance Shimonoseki Welfare Hospital Department of Gastroenterology Ako City Hospital Percutaneous Endoscopic Gastrostomy Center Oita Kensei Hospital Department of Internal Medicine Nishimino Kosei Hospital Department of Pediatric Surgery Nagano Red Cross Hospital Department of Internal Medicine Sapporo Shirakaba-dai hospital Department of Gastroenterology Tachikawa

AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P < 0.001) and no previous history of ischemic heart disease (HR, 0.69; 95% CI: 0.54-0.88, P = 0.003) were markedly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors.

关键词： Percutaneous endoscopic gastrostomy Enteral nutrition Comorbidity Survival Risk factor

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Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

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静脉泵注瑞芬太尼对福尔马林致痛大鼠脊髓敏感化的影响

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中国疼痛医学杂志 2010年第5期16卷 280-284页

作者：邓立琴二階哲朗齐藤洋司桥本龍也滕部由贵子孟尽海宁夏医科大学附属医院麻醉科银川750004 日本岛根大学医学部麻醉科出云693-8501

目的：观察短期静脉泵注不同剂量瑞芬太尼后对福尔马林致痛大鼠行为学和脊髓后角c-Fos蛋白表达的影响。方法：选择体重250~300g,右侧颈内静脉置管后恢复良好的雄性SD大鼠18只,随机分为3组（n=6）：对照组（C组）、低剂量瑞芬太尼组（LR... 详细信息

目的：观察短期静脉泵注不同剂量瑞芬太尼后对福尔马林致痛大鼠行为学和脊髓后角c-Fos蛋白表达的影响。方法：选择体重250~300g,右侧颈内静脉置管后恢复良好的雄性SD大鼠18只,随机分为3组（n=6）：对照组（C组）、低剂量瑞芬太尼组（LR组）和高剂量瑞芬太尼组（HR组）。三组大鼠均在右侧跖底皮下注射5%福尔马林50μl,注射前5min LR组和HR组分别经右侧颈内静脉持续泵注瑞芬太尼5μg/kg/min、30μg/kg/min,对照组（C组）泵注生理盐水至注射后5min停止泵注。记录福尔马林注射后第一阶段（0~5min）和第二阶段（15~90min）内累计舔爪时间和注射后2h,L4~5脊髓后角Ⅰ-Ⅱ、Ⅲ-Ⅳ、Ⅴ-Ⅵ板层c-Fos蛋白表达阳性的神经细胞数量。结果：持续静脉泵注瑞芬太尼5μg/kg/min和30μg/kg/min均可完全抑制第一阶段疼痛行为,推迟第二阶段的疼痛行为开始和中止,HR组尤为显著（P〈0.01）,但第二阶段总的累计舔爪时间三组差异无统计学意义。三组脊髓c-Fos蛋白表达阳性的神经细胞数量差异也无统计学意义。结论：短期应用瑞芬太尼不加重福尔马林致痛大鼠的痛觉过敏。

关键词：瑞芬太尼福尔马林痛觉过敏 c-Fos

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Evaluation of the amorphous-forming ability of M-Si-B ternary alloys using CALPHAD approach

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材料与冶金学报 2005年第2期4卷 110-110页

作者：長谷部光弘 OHTANI Hiroshi HASEBE Mitsuhiro 日本九州工业大学 Department of Materials Science and Engineering Kyushu Institute of Technology Department of Materials Science and Engineering

A thermodynamic study has been carried out on M-Si-B (M=Fe, Ni) ternary systems. A regular solution approximation based on the sublattice model was adopted to describe the Gibbs energy for the individual phases in the binary and ternary systems. Thermodynamic parameters for each phase were evaluated by using the experimental data. These parameters enabled us to obtain reproducible calculations of the isothermal and vertical section diagrams. The amorphous-forming ability of M-Si-B ternary alloys has been evaluated by introducing thermodynamic quantities obtained from the phase diagram calculations into Davies-Uhlmann kinetic formulations. For the computation, the time-temperature- transformation (TTT) diagram, which gives the time necessary for the formation of the detectable amount of crystal during transformation, was obtained at a finite temperature. The critical cooling rate for amorphization could be defined as the minimum cooling speed that does not intersect the TTT curve and, hence, these critical cooling rates enable us to evaluate the glass-forming ability of M-Si-B ternary alloys. The driving force for the crystallization of the crystalline phase was derived, on the basis of the thermodynamic functions of each phase formulated by the present study. The calculated results showed good agreement with the experimental data on the compositional range of amorphization in these alloy systems.

关键词： M-Si-B合金非晶形成能力 CALPHAD 模式评估

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塑料晶体的庞压卡效应

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家电科技 2019年第3期 9-9页

作者： Bing Li Yukinobu Kawakita Seiko Ohira-Kawamura Takeshi Sugahara Hui Wang Jingfan Wang Yanna Chen Saori I.Kawaguchi Shogo Kawaguchi Koji Ohara Kuo Li Dehong Yu Richard Mole Takanori Hattori tatsuya Kikuchi Shin-ichiro Yano Zhao Zhang Zhe Zhang Weijun Ren Shangchao Lin Osami Sakata Kenji Nakajima Zhidong Zhang 李巧红中科院金属研究所

制冷对现代社会至关重要,世界上25%到30%的电力用于制冷。例如,食品储存和空调的使用等都需要耗费大量的电力。目前的制冷技术主要还是以传统蒸汽压缩循环为主,但由于具有加剧全球变暖的潜力危险,人们一直尝试找到更好的替代方案。在这... 详细信息

制冷对现代社会至关重要,世界上25%到30%的电力用于制冷。例如,食品储存和空调的使用等都需要耗费大量的电力。目前的制冷技术主要还是以传统蒸汽压缩循环为主,但由于具有加剧全球变暖的潜力危险,人们一直尝试找到更好的替代方案。在这背景下,基于固态相变热效应的制冷技术作为一种很有前途的替代技术,在近几十年来一直是研究者们关注的重点。但是,由于其等温爛变化小,所需驱动动能大以及材料性能有限等种种劣势均限制了其应用推广。

关键词：制冷技术晶体塑料蒸汽压缩全球变暖固态相变材料性能热效应

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