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Development of highly sensitive and rapid antigen detection assay for diagnosis of COVID-19 utilizing optical waveguide immunosensor

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Journal of Molecular Cell Biology 2021年第10期13卷 763-766页

作者： Rikako Funabashi Kei Miyakawa Yutaro Yamaoka seiko yoshimura Satoshi Yamane Sundararaj Stanleyraj Jeremiah Kohei Shimizu Hiroki Ozawa Chiharu Kawakami Shuzo Usuku Nobuko Tanaka Etsuko Yamazaki Hirokazu Kimura Hideki Hasegawa Akihide Ryo Department of Microbiology Yokohama City University Graduate School of MedicineKanagawajapan Life Science Laboratory Technology and Development DivisionKanto Chemical Co.Inc.KanagawaJapan Primary Care Testing Solution Development Department Canon Medical Systems CorporationTochigiJapan Yokohama City Institute of Public Health KanagawaJapan Clinical Laboratory Department Yokohama City University HospitalKanagawaJapan Department of Health Science Gunma Paz University Graduate SchoolGunmajapan Center for Influenza and Respiratory Virus Research National Institute of Infectious DiseasesMusashimurayamaTokyoJapan

Ever since its outbreak,the COVID-19 pandemic caused by SARS-CoV-2 has been spreading rapidly causing a global health *** diagnosis and instituting appropriate intervention to relevant individuals are essential not only to slow down the spread of this pandemic but also to manage our resources *** date,testing for SARS-CoV-2 infection mostly relies on reverse transcription-quantitative polymerase chain reaction(RT-qPCR)on a nasopharyngeal or saliva specimen and remains the gold standard for diagnosis as it exhibits high sensitivity and specificity.

关键词： diagnosis specificity nasopharyngeal

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A Human T Lymphotropic Virus Type 1 Carrier Coinfected with <i>Mycobacterium intracellulare</i>and <i>Pneumocystis jirovecii</i>with a Characteristic Compositional Change of Bone Marrow Cells

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Open Journal of Respiratory Diseases 2017年第3期7卷 110-116页

作者： Sayaka Uda Shinsuke Shiotsu Ayaka Omura Ryosuke Hamashima Akihiro yoshimura Naoko Kurisu Tomoya Sagawa Koichi Hasegawa Tatsuya Yuba Chieko Takumi seiko Ono Noriya Hiraoka Noriya Hiraoka Department of Respiratory Medicine Japanese Red Cross Kyoto Daiichi HospitalKyotoJapan Department of Respiratory Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Infection Control and Prevention Japanese Red Cross Kyoto Daiichi HospitalKyotoJapan

Human T lymphotropic virus type 1 (HTLV-1) is endemic in the southern part of Japan. Infection of the virus can cause adult T cell leukemia/lymphoma (ATL), while most infected individuals remain in a carrier state for a long period of time. Although rare cases of carriers, like ATL patients, who developed opportunistic infections, have been reported, hematological changes of carriers who are prone to opportunistic infections have not been well defined. Here, we present a case of an HTLV-1 carrier who developed Mycobacterium intracellulare infection and Pneumocystis jirovecii pneumonia (PcP) simultaneously. Flow cytometric analysis of bone marrow cells revealed an aberrant compositional change similar to that in ATL patients. This suggests the presence of a pre-ATL state prior to the development of ATL, which is notable in terms of underlying cellular immunodeficiency.

关键词： Human T Lymphotropic Virus Type 1 Carrier Immunodeficiency Pneumocystis jirovecii

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